LncRNA OIP5-AS1 Promotes the Proliferation of Hemangioma Vascular Endothelial Cells via Regulating miR-195-5p/NOB1 Axis

Conclusion: Taken together, lncRNA OIP5-AS1 acted as a ceRNA to drive proliferation, migration and invasion of HemECs through regulating miR-195-5p/NOB1 axis. Introduction Infant hemangioma (IH) is a benign neoplasm commonly seen in childhood, which is more common in premature infants and infants with low birth weight (Smith et al., 2017). There are three distinct clinical histological stages in IH: the early proliferative stage, when undeveloped blood vessels are rapidly growing; plateau stage and final regressive stage, with scattered capillaries and large drainage vessels (Csoma et al., 2017). IH is characterized by spontaneous regression of blood vessels. IH can cause defects in some cases, which is also the main cause of pathogenesis of children with IH (Ji et al., 2014; Goelz and Poets, 2015; Khan et al., 2017). IH treatments include propranolol (Smithson et al., 2017), pulsed dye laser (Chinnadurai et al., 2016), nadolol (Villalba-Moreno et al., 2015), etc., the effects of which have been improved a lot in recent years. Nevertheless, the main clinical problem up to date is still the deficiency of reliable parameters to aid treatment against lesion in patients with IH. Therefore, identification of the genetic and epigenetic changes in IH lesions is of great value to clarify the molecular mechanism of IH occurrence. Long non-coding RNAs (lncRNAs) are a group of transcripts without protein coding ability (Sun et al., 2018). lncRNAs form diversified non-coding RNA...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research