Norepinephrine Inhibition of Mesenchymal Stem Cell and Chondrogenic Progenitor Cell Chondrogenesis and Acceleration of Chondrogenic Hypertrophy
ConclusionOur findings demonstrate NE‐dependent inhibition of chondrogenesis and acceleration of hypertrophic differentiation. By inhibiting cartilage repair, these sympathetic influences can be important after joint trauma. These findings may be a basis for novel neurochondrogenic therapeutic options. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - August 26, 2014 Category: Rheumatology Authors: Zsuzsa Jenei‐Lanzl, Susanne Grässel, Georg Pongratz, Frieder Kees, Nicolai Miosge, Peter Angele, Rainer H. Straub Tags: Chondrocyte Biology Source Type: research
Drug efficacy in treating stable angina pectoris: a protocol for network meta-analysis of randomised controlled trials
This study aims to fill this gap of research by conducting a Bayesian network meta-analysis to compare all these antianginal drugs.
Methods and analyses
Randomised controlled trials (RCT) on the drug therapy of stable angina pectoris with multiple outcome measures, selected from symptomatic relief, ECG tests, exercise tests, heart rates and blood pressures, etc, will be included. Overall effect sizes will be represented as mean differences with 95% credible intervals (CrI) for continuous outcome data and as ORs with 95% CrI for dichotomous outcome data. Bayesian network meta-analysis by WinBUGS will be conducted to compar...
Source: BMJ Open - June 19, 2014 Category: Journals (General) Authors: Jia, Y., Leung, S.-w. Tags: Open access, Cardiovascular medicine, Evidence based practice Protocol Source Type: research
Norepinephrine inhibits mesenchymal stem cell and chondrogenic progenitor cell chondrogenesis and accelerates chondrogenic hypertrophy
Conclusions. This study demonstrated NE‐dependent inhibition of chondrogenesis and acceleration of hypertrophic differentiation. By inhibition of cartilage repair, these sympathetic influences can be important after joint traumata. These findings can be a basis for novel neuro‐chondrogenic therapeutic options. © 2014 American College of Rheumatology. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - May 12, 2014 Category: Rheumatology Authors: Zsuzsa Jenei‐Lanzl, Susanne Grässel, Georg Pongratz, Frieder Kees, Nicolai Miosge, Peter Angele, Rainer H. Straub Tags: Full Length Source Type: research
The Effect of Green Tea with Exceptionally High Catechin Content on Nadolol Plasma Concentration.
PMID: 24553283 [PubMed - as supplied by publisher] (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - February 19, 2014 Category: Drugs & Pharmacology Authors: Ide K, Park M, Yamada H Tags: Clin Pharmacol Ther Source Type: research
Combined therapies versus monotherapies for the first variceal bleeding in patients with high‐risk varices: A meta‐analysis of randomized controlled trials
ConclusionsBased on the available evidences, no combined therapy can be recommended as the first‐line treatment for the primary prevention of variceal bleeding currently. Further studies with large sample sizes and long‐term follow up are warranted. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - February 19, 2014 Category: Gastroenterology Authors: Ming Bai, Xingshun Qi, Man Yang, Guohong Han, Daiming Fan Tags: Meta‐Analysis and Systematic Review Source Type: research
Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects.
This study aimed at evaluating effects of green tea on pharmacokinetics and pharmacodynamics of the β-blocker nadolol. Ten healthy volunteers received a single oral dose of 30 mg nadolol with green tea or water after repeated consumption of green tea (700 mL/day) or water for 14 days. Catechin concentrations in green tea and plasma were determined. Green tea markedly decreased Cmax and AUC0-48 of nadolol by 85.3% and 85.0%, respectively (P < 0.01) without altering renal clearance of nadolol. Nadolol effects on systolic blood pressure were significantly reduced by green tea. [(3)H]Nadolol uptake assays in HEK293 cel...
Source: Clinical Pharmacology and Therapeutics - January 13, 2014 Category: Drugs & Pharmacology Authors: Misaka S, Yatabe J, Müller F, Takano K, Kawabe K, Glaeser H, Yatabe M, Onoue S, Werba J, Watanabe H, Yamada S, Fromm M, Kimura J Tags: Clin Pharmacol Ther Source Type: research
β3-Adrenoceptor-mediated responses in diabetic rat heart.
Abstract
β3-adrenoceptors mediate negative inotropic effect in contrast to classical β1- and β2-adrenoceptors. Cardiac β3-adrenoceptors are upregulated in experimental diabetes. Thus, cardiodepressant effect mediated by β3-adrenoceptors has been proposed to contribute to the impaired cardiac function in this pathology. In our study, we investigated the influence of streptozotocin-diabetes on cardiac contractility to β3-adrenoceptors stimulation by using Langendorff-perfused rat hearts. BRL 37344, a selective β3-adrenoceptor agonist, induced dose-dependent decreases in left ventricular developed pres...
Source: General Physiology and Biophysics - December 13, 2013 Category: Physiology Authors: Kayki-Mutlu G, Arioglu-Inan E, Ozakca I, Ozcelikay AT, Altan VM Tags: Gen Physiol Biophys Source Type: research
Beta‐blockers in portal hypertension: new developments and controversies
Abstract
AbstractThere are many studies investigating the role of non‐selective beta‐blockers in portal hypertension. Satisfactory reduction in portal pressure is possible in a third to half of patients with propranolol and nadolol, although combining these drugs with nitrates may be more effective. Carvedilol is a more potent agent than propranolol in reducing portal pressure, particularly in non‐responders, and is better tolerated. All these drugs have been studied in primary and secondary prophylaxis, sometimes in combination with band ligation and/or nitrates. There is some evidence to support combining these age...
Source: Liver International - November 20, 2013 Category: Gastroenterology Authors: Dhiraj Tripathi, Peter C. Hayes Tags: Review Article Source Type: research
Beta blockers in portal hypertension: new developments and controversies.
This article is protected by copyright. All rights reserved. (Source: Liver International)
Source: Liver International - October 17, 2013 Category: Gastroenterology Authors: D Tripathi, PC Hayes Tags: Review Source Type: research
Combined‐therapies vs. monotherapies for the first variceal bleeding in patients with high‐risk varices: a meta‐analysis of RCTs
ConclusionsBase on the available evidences, no combined‐therapy can be recommended as the first‐line treatment for the primary prevention of variceal bleeding currently. Further studies with large sample sizes and long‐term follow‐up are warranted. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - October 3, 2013 Category: Gastroenterology Authors: Ming Bai, Xingshun Qi, Man Yang, Guohong Han, Daiming Fan Tags: Meta‐Analyses Source Type: research
Impact of wastewater treatment plants on receiving surface waters and a tentative risk evaluation: the case of estrogens and beta blockers.
Abstract
Five estrogenic hormones (unconjugated + conjugated fractions) and 10 beta blockers were analyzed in three wastewater treatment plant (WWTP) effluents and receiving river waters in the area of Lyon, France. In the different samples, only two estrogens were quantified: estrone and estriol. Some beta blockers, such as atenolol, acebutolol, and sotalol, were almost always quantified, but others, e.g., betaxolol, nadolol, and oxprenolol were rarely quantified. Concentrations measured in river waters were in the nanogram per liter range for estrogens and between 0.3 and 210 ng/L for beta blockers ...
Source: Environmental Science and Pollution Research International - August 24, 2013 Category: Environmental Health Authors: Gabet-Giraud V, Miège C, Jacquet R, Coquery M Tags: Environ Sci Pollut Res Int Source Type: research
Effects of green tea extract and (−)-epigallocatechin-3-gallate on pharmacokinetics of nadolol in rats
Abstract: Green tea catechins have been shown to affect the activities of drug transporters in vitro, including P-glycoprotein and organic anion transporting polypeptides. However, it remains unclear whether catechins influence the in vivo disposition of substrate drugs for these transporters. In the present study, we investigated effects of green tea extract (GTE) and (−)-epigallocatechin-3-gallate (EGCG) on pharmacokinetics of a non-selective hydrophilic β-blocker nadolol, which is reported to be a substrate for several drug transporters and is not metabolized by cytochrome P450 enzymes. Male Sprague-Dawley rats recei...
Source: Phytomedicine - August 5, 2013 Category: Drugs & Pharmacology Authors: S. Misaka, N. Miyazaki, T. Fukushima, S. Yamada, J. Kimura Tags: Cardiovascular System Source Type: research
Pharmacokinetic and Pharmacodynamic Interaction of Nadolol With Itraconazole, Rifampicin and Grapefruit Juice in Healthy Volunteers.
Abstract
To evaluate effects of itraconazole, rifampicin and grapefruit juice on pharmacokinetics and pharmacodynamics of a hydrophilic non-selective β-adrenoceptor blocker nadolol, we conducted an open-label, four-way crossover study in 10 healthy male volunteers. A single oral dose of 30 mg nadolol was administered with water (control), itraconazole (100 mg), or grapefruit juice (300 mL), or after a 6-day pretreatment with rifampicin (450 mg/day). Plasma concentrations and urinary excretions of nadolol were measured over 48 hours after its dosing. Systolic and diastolic blood pressures and pul...
Source: The Journal of Clinical Pharmacology - May 16, 2013 Category: Drugs & Pharmacology Authors: Misaka S, Miyazaki N, Yatabe MS, Ono T, Shikama Y, Fukushima T, Kimura J Tags: J Clin Pharmacol Source Type: research
Role of Bisoprolol in Patients with Long QT Syndrome
ConclusionsBeta‐blocking therapy is the cornerstone of LQTS therapy but actually there is no clear indication about which beta‐blocker should be used. In our experience bisoprolol proved to be less harmful and easier to manage than propranolol and nadolol in patients with LQTS, with the same effectiveness in preventing major cardiovascular events. (Source: Annals of Noninvasive Electrocardiology)
Source: Annals of Noninvasive Electrocardiology - May 3, 2013 Category: Cardiology Authors: Giovanni Fazio, Federica Vernuccio, Giuseppe Lo Re, Giuseppe Grutta, Maurizio Mongiovì Tags: ORIGINAL ARTICLE Source Type: research
Epilepsy Misdiagnosed as Long QT Syndrome: It Can Go Both Ways
Abstract
Cardiogenic seizures are common and could be the sentinel event heralding the presence of congenital long QT syndrome (LQTS). Distinguishing a cardiogenic seizure from a neurogenic one is of the utmost importance. Herein, we present the case of a 12‐year‐old boy with recurrent episodes of syncope and seizures. Despite absence of QT prolongation on electrocardiogram, absence of documented arrhythmias, a negative LQTS genetic test, and recurrent episodes while on nadolol beta‐blocker therapy, he was diagnosed with LQTS and implanted with an implantable cardioverter defibrillator (ICD). When syncope and seizure...
Source: Congenital Heart Disease - May 1, 2013 Category: Cardiology Authors: Beth A. Medford, J. Martijn Bos, Michael J. Ackerman Tags: Case Report Source Type: research
