Norepinephrine Inhibition of Mesenchymal Stem Cell and Chondrogenic Progenitor Cell Chondrogenesis and Acceleration of Chondrogenic Hypertrophy

ConclusionOur findings demonstrate NE‐dependent inhibition of chondrogenesis and acceleration of hypertrophic differentiation. By inhibiting cartilage repair, these sympathetic influences can be important after joint trauma. These findings may be a basis for novel neurochondrogenic therapeutic options.

Source: Arthritis and Rheumatism - August 26, 2014 Category: Rheumatology Authors: Zsuzsa Jenei‐Lanzl, Susanne Grässel, Georg Pongratz, Frieder Kees, Nicolai Miosge, Peter Angele, Rainer H. Straub Tags: Chondrocyte Biology Source Type: research