β1‐Adrenoceptor, but not β2‐adrenoceptor, subtype regulates heart rate in type 2 diabetic rats in vivo
In conclusion, the β1‐adrenoceptor is the main subtype to modulate chronotropic β‐adrenoceptor responses in healthy and diabetic rats. This study provides new insights into the pathological basis of dysregulation of heart rate in type 2 diabetes, which could be important for improving the current therapeutic strategies targeting diabetic chronotropic incompetence. (Source: Experimental Physiology)
Source: Experimental Physiology - June 9, 2017 Category: Physiology Authors: Rosalind F. Cook, Carol T. Bussey, Kimberley M. Mellor, Patricia A. Cragg, Regis R. Lamberts Tags: Research Paper Source Type: research
Hypoglycemia in oral nadolol therapy for an ulcerated infantile hemangioma: Report of an adverse event
We report a case of hypoglycemia in an otherwise well infant occurring 4 months after initiating nadolol for an ulcerated infantile hemangioma. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - May 31, 2017 Category: Dermatology Source Type: research
β1‐adrenoceptor, but not β2‐adrenoceptor, subtype regulates heart rate in type 2 diabetes rats in vivo
ConclusionThe β1‐adrenoceptor is the main subtype to modulate chronotropic β‐adrenoceptor responses in healthy, as well as diabetic rats. This study provides novel insights in the understanding of the pathological basis of dysregulation of heart rate in type 2 diabetes, which could be important for improving the current therapeutic strategies targeting the diabetic chronotropic incompetence.This article is protected by copyright. All rights reserved (Source: Experimental Physiology)
Source: Experimental Physiology - May 1, 2017 Category: Physiology Authors: Rosalind F. Cook, Carol T. Bussey, Kimberley M. Mellor, Patricia A. Cragg, Regis R. Lamberts Tags: Research Paper Source Type: research
Oral Nadolol for the Treatment of SVT in Young Children
(Source: AAP Grand Rounds)
Source: AAP Grand Rounds - February 28, 2017 Category: Pediatrics Authors: Spar, D. Tags: Cardiology Source Type: research
Oral Nadolol for the Treatment of SVT in Young Children
Investigators from Children’s Hospital Colorado and University of Michigan conducted a retrospective cohort study to assess the clinical course of infants with supraventricular tachycardia (SVT) treated with nadolol. Children were eligible if they were <2 years old and had received nadolol for SVT at the University of Michigan Congenital Heart Center. Participants were identified through patient and pharmacy databases. Participant demographics and clinical characteristics and course, as well as nadolol dose, frequency of administration, and side effects, were obtained from the medical record of study participants....
Source: AAP Grand Rounds - February 28, 2017 Category: Pediatrics Authors: Spar, D. Tags: Cardiology Source Type: research
An Appraisal of Drug-Drug Interactions with Green Tea (Camellia sinensis)
In conclusion, the ingestion of green tea extract or its associated catechins is not expected to result in clinically significant influences on major cytochrome P450 or uridine 5′-diphospho-glucuronosyltransferase enzyme substrates or drugs serving as substrates of P-glycoprotein. However, some caution is advised in the consumption of significant amounts of green tea beverages or green tea extract in patients prescribed known substrates of organic anion transporting polypeptide, particularly those with a narrow therapeutic index. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of cont...
Source: Planta Medica - January 23, 2017 Category: Drugs & Pharmacology Authors: Albassam, Ahmed A. Markowitz, John S. Tags: Reviews Source Type: research
A Randomized trial to assess whether portal pressure guided therapy to prevent variceal rebleeding improves survival in cirrhosis
Conclusion: HVPG‐monitoring, by stratifying risk and targeting therapy, improves the survival achieved with currently recommended treatment to prevent variceal rebleeding using β‐blockers and ligation. HVPG‐guided‐therapy achieved a greater reduction in portal pressure, which may have contributed to reduce the risk of rebleeding and of further decompensation of cirrhosis, thus contributing to a better survival. This article is protected by copyright. All rights reserved. (Source: Hepatology)
Source: Hepatology - January 17, 2017 Category: Internal Medicine Authors: C àndid Villanueva, Isabel Graupera, Carles Aracil, Edilmar Alvarado, Josep Miñana, Ángela Puente, Virginia Hernandez‐Gea, Alba Ardevol, Oana Pavel, Alan Colomo, Mar Concepción, María Poca, Xavier Torras, Josep M a Reñe, Carlos Guarner Tags: Liver Failure, Cirrhosis and Portal Hypertension Source Type: research
Nadolol for Treatment of Supraventricular Tachycardia in Infants and Young Children
AbstractSupraventricular tachycardia (SVT) is a common infant arrhythmia, for which beta-blockers are frequently chosen as therapy. Propranolol is a common choice though it is dosed every 6 –8 h. We reviewed the clinical results of treating infant SVT with an extemporaneous preparation of nadolol. Retrospective cohort study of patients under 2 years old receiving nadolol for SVT at a single center. Patients were ascertained by patient and pharmacy databases. Twenty-eight infants re ceived nadolol, of whom 25 had regular narrow complex tachycardia, 2 atrial flutter, and 1 focal atrial tachycardia. Patient age at initiat...
Source: Mammalian Genome - December 18, 2016 Category: Genetics & Stem Cells Source Type: research
Nadolol reduces insulin sensitivity in liver cirrhosis: a randomized double ‐blind crossover trial
ConclusionsNadolol significantly worsened insulin sensitivity, glycemia, and disposition index in patients with liver cirrhosis. These findings may have significant clinical implications because cirrhosis is already associated with an increased prevalence of diabetes. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - November 9, 2016 Category: Endocrinology Authors: Wai Gin Lee, Rinki Murphy, John L. McCall, Edward J. Gane, Mattias Soop, Andrea Tura, Lindsay D. Plank Tags: RESEARCH ARTICLE Source Type: research
Beta -adrenergic antagonism modulates functional connectivity in the default mode network of individuals with and without autism spectrum disorder
The objective in the current investigation was to examine the effect of propranolol on FC at rest and determine whether ASD-specific effects exist. Participants with and without ASD attended three sessions in which propranolol, nadolol (abeta-adrenergic antagonist that does not cross the blood-brain barrier), or placebo were administered. Resting-state fMRI data were acquired, and graph theory techniques were utilized to assess additional aspects of FC. Compared to placebo, propranolol administration was associated with decreased FC in the dorsal medial prefrontal cortex subnetwork of the default mode network and increased...
Source: Brain Imaging and Behavior - October 5, 2016 Category: Neurology Source Type: research
Nadolol reduces insulin sensitivity in liver cirrhosis: a double ‐blind randomized cross‐over trial
ConclusionsNadolol significantly worsened insulin sensitivity, glycemia and disposition index in patients with liver cirrhosis. These findings may have significant clinical implications because cirrhosis is already associated with an increased prevalence of diabetes. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - September 25, 2016 Category: Endocrinology Authors: Wai Gin Lee, Rinki Murphy, John L. McCall, Edward J. Gane, Mattias Soop, Andrea Tura, Lindsay D. Plank Tags: RESEARCH ARTICLE Source Type: research
A human pluripotent stem cell model of catecholaminergic polymorphic ventricular tachycardia recapitulates patient-specific drug responses [RESEARCH ARTICLE]
This study assessed whether the inadequacy of β-blocker therapy in an individual can be observed in vitro using patient-derived CPVT iPSC-CMs. An individual with CPVT harboring a novel mutation in the type 2 cardiac ryanodine receptor (RyR2) was identified whose persistent ventricular arrhythmias during β-blockade with nadolol were abolished during flecainide treatment. iPSC-CMs generated from this patient and two control individuals expressed comparable levels of excitation-contraction genes, but assessment of the sarcoplasmic reticulum Ca2+ leak and load relationship revealed intracellular Ca2+ homeostasis was ...
Source: DMM Disease Models and Mechanisms - September 6, 2016 Category: Biomedical Science Authors: Preininger, M. K., Jha, R., Maxwell, J. T., Wu, Q., Singh, M., Wang, B., Dalal, A., Mceachin, Z. T., Rossoll, W., Hales, C. M., Fischbach, P. S., Wagner, M. B., Xu, C. Tags: Stem Cells, Model Systems in Drug Discovery RESEARCH ARTICLE Source Type: research
Exploring the Feasibility of Biowaiver Extension of BCS Class III Drugs with Site-Specific Absorption Using Gastrointestinal Simulation Technology
Conclusions < /h3 > < p class= " a-plus-plus " > Based on the results of this study, we suggest that for BCS class III drug with high < em class= " a-plus-plus " > F < /em > < sub class= " a-plus-plus " > a < /sub > (about & gt;80 %), the biowaiver should extend to rapid dissolution ( < em class= " a-plus-plus " > T < /em > < sub class= " a-plus-plus " > 85 % < /sub > = 30 min), and 30 % of < em class= " a-plus-plus " > F < /em > < sub class= " a-plus-plus " > a < /sub > as the boundary of intermediate permeability class (30 % & lt; < em class= " a-plus-plus " > F < /em > < sub class= " a-plus-plus " > a ...
Source: European Journal of Drug Metabolism and Pharmacokinetics - July 21, 2016 Category: Drugs & Pharmacology Source Type: research
Experience with bisoprolol in long-QT1 and long-QT2 syndrome
Conclusions
Bisoprolol treatment results in QTc shortening in gene-positive LQT1 and LQT2 patients and is well tolerated during long-term administration. The equivalence of bisoprolol for protection from ventricular arrhythmia in LQT patients compared to established beta-blockers remains unknown. Further large-scale studies are required. (Source: Journal of Interventional Cardiac Electrophysiology)
Source: Journal of Interventional Cardiac Electrophysiology - July 8, 2016 Category: Cardiology Source Type: research
Role of β-Adrenoceptors and L-Type Ca 2+ -Channels in the Mechanism of Reperfusion-Induced Heart Injury
We studied the effects of β-adrenoceptor antagonists propranolol and nadolol and L-type Ca2+-channel blocker verapamil on cardiac reperfusion injury developed after 45-min coronary occlusion. The substances were injected intravenously 5 min before reperfusion. The results indicate that activation of β-adrenoceptors and opening of L-type Ca2+-channels promote the development of cardiac reperfusion injury, while blockage of β-adrenoceptors and/or L-type Ca2+-channels prevents reoxygenation-induced myocardial injury. Propranolol, nadolol, and verapamil can produce infraction-limiting effects after onset of ischemic heart i...
Source: Bulletin of Experimental Biology and Medicine - June 5, 2016 Category: Biology Source Type: research
