Limits to the generalizability of resting-state functional magnetic resonance imaging studies of youth: An examination of ABCD Study ® baseline data
This study examined how resting-state functional magnetic resonance imaging (rs-fMRI) data quality and availability relate to clinical and sociodemographic variables within the Adolescent Brain Cognitive Development Study. A sample of participants with an adequate sample of quality baseline rs-fMRI data containing low average motion (framewise displacement  ≤ 0.15; low-noise;n = 4,356) was compared to a sample of participants without an adequate sample of quality data and/or containing high average motion (higher-noise;n = 7,437) using Chi-squared analyses and t-tests. A linear mixed model examined relationships betwee...
Source: Brain Imaging and Behavior - May 12, 2022 Category: Neurology Source Type: research

History of suicide attempts associated with the thinning right superior temporal gyrus among individuals with schizophrenia
AbstractIndividuals with schizophrenia have higher rates of suicide attempts than the general population. Specific cortical abnormalities (e.g., the cortical surface area and thickness) may be associated with a history of suicide attempts. We recruited 74 individuals with schizophrenia (37 suicide attempters were individually matched with 37 non-attempters on age, sex, phase of illness, and study center) and 37 healthy volunteers. The cortical surface area and thickness data were extracted from structural MRI and compared between the groups. Suicide attempters showed significantly smaller surface areas in the whole brain (...
Source: Brain Imaging and Behavior - May 12, 2022 Category: Neurology Source Type: research

Alterations to cognitive abilities and functional networks in rats post broad-band intense noise exposure
This study aimed to investigate the alterations of cognition and functional connectivity post noise, and find the progress and neural substrates of noise induced hearing loss (NIHL)-associated cognitive impairment. We exposed rats to 122  dB broad-band noise for 2 h to induce hearing loss and the auditory function was assessed by measuring auditory brainstem response thresholds. Morris water maze test and resting state MRI were computed at 0 day, 1, 3, 6 months post noise to reveal cognitive ability and neural substrate. The int erregional connections in the auditory network and default mode network, as well as the con...
Source: Brain Imaging and Behavior - May 11, 2022 Category: Neurology Source Type: research

Volume, density, and thickness brain abnormalities in mild cognitive impairment: an ALE meta-analysis controlling for age and education.
This study aims to address these issues using activation likelihood estimation (ALE) analyses with a sample size more than twice that of prior meta-analyses. A total of 71 studies were identified and entered into the ALE analysis which consisted of 2262 with MCI and 1902 healthy controls. Three major clusters were identified showing decreased gray matter volume in the MCI group compared to controls, with the most salient decreases being in the hippocampus, parahippocampal gyrus, and the amygdala. Reduced thalamic volume was also observed, but to a lesser extent. Density was reduced in the left hippocampus, while thickness ...
Source: Brain Imaging and Behavior - April 13, 2022 Category: Neurology Source Type: research

Altered topological properties of the intrinsic functional brain network in patients with right-sided unilateral hearing loss caused by acoustic neuroma
AbstractNeuroimaging studies have identified alterations in functional connectivity between specific brain regions in patients with unilateral hearing loss (UHL) and different influence of the side of UHL on neural plasticity. However, little is known about changes of whole-brain functional networks in patients with UHL and whether differences exist in topological organization between right-sided UHL (RUHL) and left-sided UHL (LUHL). To address this issue, we employed resting-state fMRI (rs-fMRI) and graph-theoretical approaches to investigate the topological alterations of brain functional connectomes in patients with RUH...
Source: Brain Imaging and Behavior - April 9, 2022 Category: Neurology Source Type: research

Effects of Mild Traumatic Brain Injury on Resting State Brain Network Connectivity in Older Adults
AbstractOlder age is associated with worsened outcome after mild traumatic brain injury (mTBI) and a higher risk of developing persistent post-traumatic complaints. However, the effects of mTBI sequelae on brain connectivity at older age and their association with post-traumatic complaints remain understudied.We analyzed multi-echo resting-state functional magnetic resonance imaging data from 25 older adults with mTBI (mean age: 68  years, SD: 5 years) in the subacute phase (mean injury to scan interval: 38 days, SD: 9 days) and 20 age-matched controls. Severity of complaints (e.g. fatigue, dizziness) was assessed usin...
Source: Brain Imaging and Behavior - April 8, 2022 Category: Neurology Source Type: research

Association of cognitive impairment and reduced cortical thickness in prefrontal cortex and anterior cingulate cortex with treatment-resistant depression
AbstractAccumulating evidence suggests the critical role of cortical thinning in the pathophysiology of major depressive disorder. However, the association of cortical thickness and cognitive impairment with treatment-resistant depression (TRD) has rarely been investigated. In total, 48 adult patients with TRD and 48 healthy controls were recruited and administered a series of neurocognitive and neuroimaging examinations, including 1-back and 2-back working memory tasks and brain magnetic resonance imaging (MRI). Whole-brain cortical thickness analysis was performed to investigate the differences in the cortical thickness ...
Source: Brain Imaging and Behavior - April 7, 2022 Category: Neurology Source Type: research

Altered intrinsic brain activity in patients with CSF1R-related leukoencephalopathy
This study introduced amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) based on resting-state functional magnetic resonance imaging(rsfMRI) to compare the spontaneous brain activities of patients and healthy controls, aiming to enhance our understanding of the disease. RsfMRI was performed on 16 patients and 23 healthy controls, and preprocessed for calculation of ALFF and ReHo. Permutation tests with threshold free cluster enhancement (TFCE) was applied for comparison (number of permutations  = 5,000). The TFCE significance threshold was set at\({P}_{FWE}\)< 0.05. In addition, 10 was s...
Source: Brain Imaging and Behavior - April 7, 2022 Category: Neurology Source Type: research

The fMRI correlates of visuo-spatial abilities: sex differences and gender dysphoria
AbstractThe contribution of brain regions to visuospatial abilities according to sex differences and gender identity is inconsistently described. One potential explaining factor may be the different tasks employed requiring a variable load of working memory and other cognitive resources. Here we asked to 20 cis and 20 transgender participants to undergo functional Magnetic Resonance Imaging during performance of a judgement line of orientation test that was adapted to explore the basic visuospatial processing while minimizing the working memory load. We show that V1 activation may be viewed as a brain area with enhanced ac...
Source: Brain Imaging and Behavior - April 6, 2022 Category: Neurology Source Type: research

Resting-state functional connectivity of the sensory/somatomotor network associated with sleep quality: evidence from 202 young male samples
AbstractPrevious neuroimaging studies have demonstrated that sleep is associated with brain functional changes in some specific brain regions. However, few studies have examined the relationship between all possible functional connectivities (FCs) within the sensory/somatomotor network (SSN) and the sleep quality of young male samples. The SSN consists of two motor cortices and is known to play a critical role in sleep. Poor sleep quality may be associated with increased sensory/somatomotor functional connectivity during rest. Hence, 202 young male participants underwent a resting-state functional magnetic resonance imagin...
Source: Brain Imaging and Behavior - April 5, 2022 Category: Neurology Source Type: research

Mapping cognitive deficits in cancer patients after chemotherapy: An Activation Likelihood Estimation meta-analysis of task-related fMRI studies
AbstractRecent neuroimaging studies have reported alterations in brain activation during cognitive tasks in cancer patients who have undergone chemotherapy treatment. However, the location of these altered brain activation patterns after chemotherapy varies considerably across studies. The aim of the present meta-analysis was to quantitatively synthesise this body of evidence using Activation Likelihood Estimation to identify reliable regions of altered brain activation in cancer patients treated with chemotherapy, compared to healthy controls and no chemotherapy controls. Our systematic search identified 12 studies that a...
Source: Brain Imaging and Behavior - April 2, 2022 Category: Neurology Source Type: research

Alternative labeling tool: a minimal algorithm for denoising single-subject resting-state fMRI data with ICA-MELODIC
In conclusion, ALT can be extended to small and large-scale datasets when the use of more complex tools such as ICA-FIX is not possible. ALT will thus allow for more widespread adopt ion of ICA-based denoising of resting-state fMRI data. (Source: Brain Imaging and Behavior)
Source: Brain Imaging and Behavior - March 29, 2022 Category: Neurology Source Type: research

Post-stroke enriched auditory environment induces structural connectome plasticity: secondary analysis from a randomized controlled trial
This study shows that listening to music, either vocal or instrumental promotes wide-spread structural connectivity changes in the post-stroke brain, provi ding a fertile ground for functional restoration. (Source: Brain Imaging and Behavior)
Source: Brain Imaging and Behavior - March 29, 2022 Category: Neurology Source Type: research

White matter alterations in heart-kidney imbalance insomnia and Jiao-Tai-Wan treatment: A diffusion-tensor imaging study
AbstractPrevious studies have reported changes in white matter microstructures in patients with insomnia. However, few neuroimaging studies have focused specifically on white matter tracts in insomnia patients after having received treatment. In this prospective study, diffusion-tensor imaging was used in two samples of heart-kidney imbalance insomnia patients who were treated with placebo or Jiao-Tai-Wan, a traditional Chinese medicine commonly used to treat heart-kidney imbalance insomnia, to assess the changes in white matter tracts. Tract-based spatial statistical analyses were first applied to compare the changes in m...
Source: Brain Imaging and Behavior - March 25, 2022 Category: Neurology Source Type: research

Functional connectivity modulations during offset analgesia in chronic pain patients: an fMRI study
AbstractPatients with neuropathic pain and fibromyalgia showed reduced or absent offset analgesia (OA) response and attenuated cerebral activity in descending pain modulatory and reward systems in patients. However, neural network modifications of OA in chronic pain have not been determined. We enrolled 23 patients with various chronic pain and 17 age- and gender- matched healthy controls. All participants were given OA-related noxious thermal stimuli, including 3 repeats of offset analgesia paradigm at 46 –47-46 °C and constant paradigm at 46 °C on the left volar forearm under whole-brain functional magnitude resona...
Source: Brain Imaging and Behavior - March 22, 2022 Category: Neurology Source Type: research