Po-03-145 beta blockers in patients with long qt syndrome: moving away from one-size-fits-all?
Experts in the field recommend using nadolol at 1mg/kg/day and propranolol at 2-3mg/kg/day for patients with long QT syndrome (LQTS), but there are no available studies defining the most effective dose. In our experience, most but not all patients tolerate beta blocker at full dose. (Source: Heart Rhythm)
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Iqbal El Assaad, Akash R. Patel, Peter F. Aziz Source Type: research
α/β- and β-Blocker Exposure in Pregnancy and the Risk of Neonatal Hypoglycemia and Small for Gestational Age
CONCLUSIONS: Carvedilol administration during pregnancy was associated with neonatal hypoglycemia; however, it did not occur in a time- or dose-dependent manner. Routine monitoring of blood glucose levels in newborns exposed to α/β- and β-blockers is essential.PMID:36823100 | DOI:10.1253/circj.CJ-22-0647 (Source: Circulation Journal)
Source: Circulation Journal - February 23, 2023 Category: Cardiology Authors: Kana Kubota Kei Inai Eriko Shimada Tokuko Shinohara Source Type: research
α/β- and β-Blocker Exposure in Pregnancy and the Risk of Neonatal Hypoglycemia and Small for Gestational Age
CONCLUSIONS: Carvedilol administration during pregnancy was associated with neonatal hypoglycemia; however, it did not occur in a time- or dose-dependent manner. Routine monitoring of blood glucose levels in newborns exposed to α/β- and β-blockers is essential.PMID:36823100 | DOI:10.1253/circj.CJ-22-0647 (Source: Circulation Journal)
Source: Circulation Journal - February 23, 2023 Category: Cardiology Authors: Kana Kubota Kei Inai Eriko Shimada Tokuko Shinohara Source Type: research
α/β- and β-Blocker Exposure in Pregnancy and the Risk of Neonatal Hypoglycemia and Small for Gestational Age
CONCLUSIONS: Carvedilol administration during pregnancy was associated with neonatal hypoglycemia; however, it did not occur in a time- or dose-dependent manner. Routine monitoring of blood glucose levels in newborns exposed to α/β- and β-blockers is essential.PMID:36823100 | DOI:10.1253/circj.CJ-22-0647 (Source: Circulation Journal)
Source: Circulation Journal - February 23, 2023 Category: Cardiology Authors: Kana Kubota Kei Inai Eriko Shimada Tokuko Shinohara Source Type: research
Pharmacotherapies for Portal Hypertension: Current Status and Expanding Indications
AbstractPurposeNon-selective beta blockers remain the pharmacotherapy of choice for prevention of the first episode of variceal bleeding (primary prevention) and for prevention of its recurrence after initial hemostasis (secondary prophylaxis). This review will update the current and emerging pharmacological therapies for portal hypertension.Recent FindingsData have emerged on carvedilol in preventing hepatic decompensation and improving patient survival among patients with clinically significant portal hypertension. Because measurement of WHVP is invasive and not feasible in routine practice, non-invasive tests with liver...
Source: Current Hepatitis Reports - February 20, 2023 Category: Infectious Diseases Source Type: research
Molecules, Vol. 28, Pages 655: Photocatalytic Activity of the V2O5 Catalyst toward Selected Pharmaceuticals and Their Mixture: Influence of the Molecular Structure on the Efficiency of the Process
In this study, the photocatalytic activity of V2O5 was investigated through the degradation of nadolol (NAD), pindolol (PIN), metoprolol (MET), and their mixture under ultraviolet (UV) irradiation in water. For the preparation of V2O5, facile hydrothermal synthesis was used. The structural, morphological, and surface properties and purity of synthesized V2O5 powder were investigated by scanning electron microscopy (SEM), X-ray, and Raman spectroscopy. SEM micrographs showed hexagonal-shaped platelets with well-defined morphology of materials with diameters in the range of 10–65 µm and thickness ...
Source: Molecules - January 9, 2023 Category: Chemistry Authors: Sanja J. Armakovi ć Aleksandra Jovanoski Kosti ć Andrijana Bili ć Maria M. Savanovi ć Nata ša Tomić Aleksandar Kremenovi ć Maja Šćepanović Mirjana Gruji ć-Brojčin Jovana Ćirković Stevan Armakovi ć Tags: Article Source Type: research
Phytochemicals That Interfere With Drug Metabolism and Transport, Modifying Plasma Concentration in Humans and Animals
Dose Response. 2022 Sep 21;20(3):15593258221120485. doi: 10.1177/15593258221120485. eCollection 2022 Jul-Sep.ABSTRACTPhytochemicals (Pch) present in fruits, vegetables and other foods, are known to inhibit or induce drug metabolism and transport. An exhaustive search was performed in five databases covering from 2000 to 2021. Twenty-one compounds from plants were found to modulate CYP3A and/or P-gp activities and modified the pharmacokinetics and the therapeutic effect of 27 different drugs. Flavonols, flavanones, flavones, stilbenes, diferuloylmethanes, tannins, protoalkaloids, flavans, hyperforin and terpenes, reduce pla...
Source: Dose Response - September 26, 2022 Category: Drugs & Pharmacology Authors: Josefina G ómez-Garduño Renato Le ón-Rodríguez Radam és Alemón-Medina Beatriz E P érez-Guillé Rosa E Soriano-Rosales Ailema Gonz ález-Ortiz Juan L Ch ávez-Pacheco Edelmira Solorio-L ópez Paola Fernandez-P érez Liliana Rivera-Espinosa Source Type: research
Phytochemicals That Interfere With Drug Metabolism and Transport, Modifying Plasma Concentration in Humans and Animals
Dose Response. 2022 Sep 21;20(3):15593258221120485. doi: 10.1177/15593258221120485. eCollection 2022 Jul-Sep.ABSTRACTPhytochemicals (Pch) present in fruits, vegetables and other foods, are known to inhibit or induce drug metabolism and transport. An exhaustive search was performed in five databases covering from 2000 to 2021. Twenty-one compounds from plants were found to modulate CYP3A and/or P-gp activities and modified the pharmacokinetics and the therapeutic effect of 27 different drugs. Flavonols, flavanones, flavones, stilbenes, diferuloylmethanes, tannins, protoalkaloids, flavans, hyperforin and terpenes, reduce pla...
Source: Dose Response - September 26, 2022 Category: Drugs & Pharmacology Authors: Josefina G ómez-Garduño Renato Le ón-Rodríguez Radam és Alemón-Medina Beatriz E P érez-Guillé Rosa E Soriano-Rosales Ailema Gonz ález-Ortiz Juan L Ch ávez-Pacheco Edelmira Solorio-L ópez Paola Fernandez-P érez Liliana Rivera-Espinosa Source Type: research
Phytochemicals That Interfere With Drug Metabolism and Transport, Modifying Plasma Concentration in Humans and Animals
Dose Response. 2022 Sep 21;20(3):15593258221120485. doi: 10.1177/15593258221120485. eCollection 2022 Jul-Sep.ABSTRACTPhytochemicals (Pch) present in fruits, vegetables and other foods, are known to inhibit or induce drug metabolism and transport. An exhaustive search was performed in five databases covering from 2000 to 2021. Twenty-one compounds from plants were found to modulate CYP3A and/or P-gp activities and modified the pharmacokinetics and the therapeutic effect of 27 different drugs. Flavonols, flavanones, flavones, stilbenes, diferuloylmethanes, tannins, protoalkaloids, flavans, hyperforin and terpenes, reduce pla...
Source: Dose Response - September 26, 2022 Category: Drugs & Pharmacology Authors: Josefina G ómez-Garduño Renato Le ón-Rodríguez Radam és Alemón-Medina Beatriz E P érez-Guillé Rosa E Soriano-Rosales Ailema Gonz ález-Ortiz Juan L Ch ávez-Pacheco Edelmira Solorio-L ópez Paola Fernandez-P érez Liliana Rivera-Espinosa Source Type: research
Hair analysis for beta ‐blockers and calcium‐channel blockers by using liquid chromatography‐tandem mass spectrometry as a tool for monitoring adherence to antihypertensive therapy
The present work aimed at verifying the possibility to use liquid chromatography coupled with mass spectrometry to quantitatively determine antihypertensive drugs in the hair of subjects undergoing chronic treatments. The study includes seven beta-blockers (viz., atenolol, bisoprolol, labetalol, metoprolol, sotalol, nebivolol, and nadolol) and two calcium channel blockers (amlodipine and lercanidipine). The practical applicability of the method was also verified by analyzing 34 authentic hair samples collected from subjects under chronic therapy with those cardiovascular drugs. AbstractAdherence to therapy is the key to a ...
Source: Drug Testing and Analysis - July 21, 2022 Category: Drugs & Pharmacology Authors: Francesco Taus,
Rossella Gottardo,
Marco Ballotari,
Chiara Utzeri,
Franco Tagliaro Tags: SHORT COMMUNICATION Source Type: research
Long QT syndrome, pregnancy, and nonselective β-blockers: Efficacious for mom and safe for baby?
Long QT syndrome (LQTS) is a heritable disorder of cardiac repolarization characterized clinically by the presence of heart rate –corrected QT (QTc) prolongation on the electrocardiogram and an increased risk of LQTS-triggered torsadogenic events such as syncope, generalized seizures, and tragically sudden cardiac death.1 In addition to basic QTc preventive measures (QTc prolonging medication avoidance and recognition/corre ction of electrolyte abnormalities), nonselective β-blockers (nadolol and propranolol) represent a key constituent of “first-line” LQTS-directed therapy for those with higher-risk clinically mani...
Source: Heart Rhythm - June 11, 2022 Category: Cardiology Authors: John R. Giudicessi, Michael J. Ackerman Tags: Editorial Commentary Source Type: research
Long QT Syndrome, Pregnancy and Nonselective β-blockers: Efficacious for Mom and Safe for Baby?
Long QT syndrome (LQTS) is a heritable disorder of cardiac repolarization characterized clinically by the presence of heart rate-corrected QT interval (QTc) prolongation on ECG and an increased risk of LQTS-triggered torsadogenic events such as syncope, generalized seizures, and tragically sudden cardiac death.1 In addition to basic QTc preventative measures (QTc prolonging medication avoidance and recognition/correction of electrolyte abnormalities), non-selective beta-blockers (nadolol and propranolol) represent a key constituent of “first-line” LQTS-directed therapy for those with higher risk clinically manifest (e....
Source: Heart Rhythm - June 11, 2022 Category: Cardiology Authors: John R. Giudicessi, Michael J. Ackerman Source Type: research
Exposure of fexofenadine, but not pseudoephedrine, is markedly decreased by green tea extract in healthy volunteers
Clin Pharmacol Ther. 2022 Jun 8. doi: 10.1002/cpt.2682. Online ahead of print.ABSTRACTGreen tea (GT) alters the disposition of a number of drugs such as nadolol and lisinopril. However, it is unknown whether GT affects disposition of hydrophilic anti-allergic drugs. The purpose of this study was to investigate whether pharmacokinetics of fexofenadine and pseudoephedrine are affected by catechins, major GT components. A randomized, open, 2-phase crossover study was conducted in 10 healthy Japanese volunteers. After overnight fasting, subjects were simultaneously administered fexofenadine (60 mg) and pseudoephedrine (120 mg)...
Source: Clinical Pharmacology and Therapeutics - June 9, 2022 Category: Drugs & Pharmacology Authors: Shingen Misaka Yuko Ono R Verena Taudte Eva Hoier Hiroshi Ogata Tomoyuki Ono J örg König Hiroshi Watanabe Martin F Fromm Kenju Shimomura Source Type: research
Exposure of fexofenadine, but not pseudoephedrine, is markedly decreased by green tea extract in healthy volunteers
Clin Pharmacol Ther. 2022 Jun 8. doi: 10.1002/cpt.2682. Online ahead of print.ABSTRACTGreen tea (GT) alters the disposition of a number of drugs such as nadolol and lisinopril. However, it is unknown whether GT affects disposition of hydrophilic anti-allergic drugs. The purpose of this study was to investigate whether pharmacokinetics of fexofenadine and pseudoephedrine are affected by catechins, major GT components. A randomized, open, 2-phase crossover study was conducted in 10 healthy Japanese volunteers. After overnight fasting, subjects were simultaneously administered fexofenadine (60 mg) and pseudoephedrine (120 mg)...
Source: Clinical Pharmacology and Therapeutics - June 9, 2022 Category: Drugs & Pharmacology Authors: Shingen Misaka Yuko Ono R Verena Taudte Eva Hoier Hiroshi Ogata Tomoyuki Ono J örg König Hiroshi Watanabe Martin F Fromm Kenju Shimomura Source Type: research
