Preventive Migraine Treatment
This article reviews the evidence base for the preventive treatment of migraine.
Recent Findings:: Evidence-based guidelines for the preventive treatment of migraine have recently been published by the American Academy of Neurology (AAN) and the Canadian Headache Society (CHS), providing valuable guidance for clinicians. Strong evidence exists to support the use of metoprolol, timolol, propranolol, divalproex sodium, sodium valproate, and topiramate for migraine prevention, according to the AAN. Based on best available evidence, adverse event profile, and expert consensus, topiramate, propranolol, nadolol, metoprolol, amit...
Source: CONTINUUM - August 1, 2015 Category: Neurology Tags: Review Articles Source Type: research
Oral Nadolol for the Treatment of Infantile Hemangiomas: A Single‐Institution Retrospective Cohort Study
ConclusionsOral nadolol is efficacious in patients with problematic IHs. Further large‐scale prospective comparative studies are warranted to compare nadolol with other beta‐blockers. (Source: Pediatric Dermatology)
Source: Pediatric Dermatology - July 27, 2015 Category: Dermatology Authors: Harkamal Kaur Randhawa, Cathryn Sibbald, Maria Teresa Garcia Romero, Elena Pope Tags: Original Article Source Type: research
Beta‐blockers have differential effects on the murine asthma phenotype
CONCLUSION AND IMPLICATIONSBeta‐blockers have different effects on the murine asthma phenotype that correlate with reported differences in activation or inhibition of downstream β2AR signaling pathways. This article is protected by copyright. All rights reserved. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - July 25, 2015 Category: Drugs & Pharmacology Authors: V J Thanawala, D J Valdez, R Joshi, G S Forkuo, S Parra, B J Knoll, M Bouvier, P Leff, R A Bond Tags: RESEARCH PAPER Source Type: research
Beta-blockers for childhood vascular tumors
Purpose of review: Since 2008, beta-blockers have become first-line treatment for infantile hemangiomas, the most common tumor of infancy. Their role is also being explored in the treatment of other childhood vascular tumors.
Recent findings: Recent research has demonstrated that propranolol is a more effective and safer treatment for infantile hemangiomas than previous therapeutic options. It is most effective when initiated during the tumor's proliferative phase. Other oral beta-blockers such as atenolol and nadolol are less studied, but may offer similar efficacy. Topical beta-blockers such as timolol appear to be effec...
Source: Current Opinion in Pediatrics - July 13, 2015 Category: Pediatrics Tags: DERMATOLOGY: Edited by James G. Dinulos Source Type: research
PHACE(S) Syndrome With Absent Intracranial Internal Carotid Artery and Anomalous Circle of Willis
Abstract: The authors present a case of PHACE(S) (posterior fossa malformations, hemangioma, arterial anomalies, cardiac defects, eye anomalies, and sternal cleft or supraumbilical raphe) syndrome with a right-sided segmental infantile hemangioma, and describe in detail, the associated absent ipsilateral intracranial internal carotid artery and anomalous Circle of Willis. Propranolol therapy led to accelerated, complete involution. Nadolol may reduce the theoretical risk of treating PHACE(S) patients with β-blockers. (Source: Journal of Craniofacial Surgery)
Source: Journal of Craniofacial Surgery - June 1, 2015 Category: Surgery Tags: Brief Clinical Studies Source Type: research
Pharmacological and non pharmacological strategies in the management of coronary artery disease and chronic kidney disease.
Authors: Agrawal H, Aggarwal K, Littrell R, Velagapudi P, Turagam MK, Mittal M, Alpert MA
Abstract
Patients with advanced chronic kidney disease (CKD), including those treated with dialysis, are at high risk for the development of cardiovascular disease (CVD). CVD accounts for 45-50% of deaths among dialysis patients. Therapy of acute and chronic coronary heart disease (CHD) that is effective in the general population is frequently less effective in patients with advanced CKD. Drug therapy in such patients may require dose modification in some cases. Oral anti-platelet drugs are less effective in those wit...
Source: Current Cardiology Reviews - May 20, 2015 Category: Cardiology Tags: Curr Cardiol Rev Source Type: research
Beta-Blocker Variability in Treatment of Long QT Syndrome What Is the Confounder?
This study was conducted in the background of studies implicating propranolol as having a higher propensity to block wild-type hERG (human ether-a-go-go related gene) channel, which is involved in the pathogenesis of LQT2 (2); and differed from a recent study showing no difference in the efficacy of different beta-blockers in preventing cardiac events in a smaller sample of LQTS patients (3). (Source: Journal of the American College of Cardiology: Cardiovascular Interventions)
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - May 4, 2015 Category: Cardiology Source Type: research
Biomimetic PVPA in vitro model for estimation of the intestinal drug permeability using fasted and fed state simulated intestinal fluids.
Abstract
A prerequisite for successful oral drug therapy is the drug's ability to cross the gastrointestinal barrier. Considering the increasing number of new chemical entities in modern drug discovery, reliable and fast in vitro models are required for early and efficient prediction of intestinal permeability. To mimic the intestinal environment, use of biorelevant media may provide valuable information on in vivo drug permeation. The present study aims at improving the novel biomimetic phospholipid vesicle-based permeation assay's (PVPAbiomimetic) biorelevance by investigating the applicability of the bi...
Source: European Journal of Pharmaceutical Sciences - March 31, 2015 Category: Drugs & Pharmacology Authors: Naderkhani E, Vasskog T, Flaten GE Tags: Eur J Pharm Sci Source Type: research
Photocatalytic degradation of β-blockers by using immobilized titania/silica on glass slides
Publication date: Available online 3 March 2015 Source:Journal of Photochemistry and Photobiology A: Chemistry Author(s): Veronika Píšťková , Minoo Tasbihi , Milada Vávrová , Urška Lavrenčič Štangar Photocatalytic degradation of five β-blockers (acebutolol, atenolol, metoprolol, nadolol and propranolol) was investigated in aqueous media using immobilized TiO2 as a photocatalyst. The analyzed parameters were pharmaceutical removal and non purgable organic carbon. Two different types of photocatalyst incorporated in sol-gel matrix were compared; P25 exhibited a higher photocatalytic activity compared to P9...
Source: Journal of Photochemistry and Photobiology A: Chemistry - March 5, 2015 Category: Chemistry Source Type: research
A New System for Profiling Drug-Induced Calcium Signal Perturbation in Human Embryonic Stem Cell-Derived Cardiomyocytes
The emergence of human stem cell–derived cardiomyocyte (hSCCM)–based assays in the cardiovascular (CV) drug discovery sphere requires the development of improved systems for interrogating the rich information that these cell models have the potential to yield. We developed a new analytical framework termed SALVO (synchronization, amplitude, length, and variability of oscillation) to profile the amplitude and temporal patterning of intra- and intercellular calcium signals in hSCCM. SALVO quantified drug-induced perturbations in the calcium signaling "fingerprint" in spontaneously contractile hSCCM. Multiparametr...
Source: Journal of Biomolecular Screening - February 19, 2015 Category: Molecular Biology Authors: Lewis, K. J., Silvester, N. C., Barberini-Jammaers, S., Mason, S. A., Marsh, S. A., Lipka, M., George, C. H. Tags: Original Research Source Type: research
Nadolol for the treatment of infantile hemangioma.
CONCLUSION: Nadolol was an effective alternative to propranolol in three pediatric patients with hemangiomas.
PMID: 25511837 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - December 19, 2014 Category: Drugs & Pharmacology Authors: Villalba-Moreno AM, Cotrina-Luque J, Del Vayo-Benito CA, Flores-Moreno S, Bautista-Paloma FJ Tags: Am J Health Syst Pharm Source Type: research
Propranolol, doxycycline and combination therapy for the treatment of rosacea
Abstract
Doxycycline is the standard systemic treatment for rosacea. Recently, there have been a few reports on β‐adrenergic blockers such as nadolol, carvedilol and propranolol for suppressing flushing reactions in rosacea. To our knowledge, there are no comparative studies of propranolol and doxycycline, and combination therapy using both. The aim of this study was to investigate and compare the efficacy and safety of monotherapy of propranolol, doxycycline and combination therapy. A total of 78 patients who visited Pusan National University Hospital and were diagnosed with rosacea were included in this study. Among t...
Source: The Journal of Dermatology - November 12, 2014 Category: Dermatology Authors: Jung‐Min Park, Je‐Ho Mun, Margaret Song, Hoon‐Soo Kim, Byung‐Soo Kim, Moon‐Bum Kim, Hyun‐Chang Ko Tags: Original Article Source Type: research
Breastfeeding and migraine drugs
Conclusions
According to our review, the majority of the revised AMDs were assessed to be compatible with breastfeeding. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 16, 2014 Category: Drugs & Pharmacology Source Type: research
Overview of Green Tea Interaction with Cardiovascular Drugs.
Abstract
Sensitive to the massive diffusion of purported metabolic and cardiovascular positive effects of green tea and catechin-containing extracts, many consumers of cardiovascular drugs assume these products as a "natural" and presumably innocuous adjunctive way to increase their overall health. However, green tea may interfere with the oral bioavailability or activity of cardiovascular drugs by various mechanisms, potentially leading to reduced drug efficacy or increased drug toxicity. Available data about interactions between green tea and cardiovascular drugs in humans, updated in this review, are li...
Source: Current Pharmaceutical Design - October 13, 2014 Category: Drugs & Pharmacology Authors: Werba JP, Misaka S, Giroli MG, Yamada S, Cavalca V, Kawabe K, Squellerio I, Laguzzi F, Onoue S, Veglia F, Myasoedova V, Takeuchi K, Adachi E, Inui N, Tremoli E, Watanabe H Tags: Curr Pharm Des Source Type: research
Efficacy of Different Beta-Blockers in the Treatment of Long QT Syndrome
ConclusionsAlthough the 4 β-blockers are equally effective in reducing the risk of a first cardiac event in LQTS, their efficacy differed by genotype; nadolol was the only β-blocker associated with a significant risk reduction in patients with LQT2. Patients experiencing cardiac events during β-blocker therapy are at high risk for subsequent cardiac events, and propranolol is the least effective drug in this high-risk group. (Source: Journal of the American College of Cardiology: Cardiovascular Interventions)
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - September 22, 2014 Category: Cardiology Source Type: research
