Impact of helical elongation of symmetric oxa[n]helicenes on their structural, photophysical, and chiroptical characteristics
Chirality. 2024 May;36(5):e23673. doi: 10.1002/chir.23673.ABSTRACTThe adjustment of the main helical scaffold in helicenes is a fundamental strategy for modulating their optical features, thereby enhancing their potential for diverse applications. This work explores the influence of helical elongation (n = 5-9) on the structural, photophysical, and chiroptical features of symmetric oxa[n]helicenes. Crystal structure analyses revealed structural variations with helical extension, impacting torsion angles, helical pitch, and packing arrangements. Through theoretical investigations using density functional theory (DFT) calcul...
Source: Chirality - May 3, 2024 Category: Molecular Biology Authors: Mohamed S H Salem Rubal Sharma Seika Suzuki Yoshitane Imai Mitsuhiro Arisawa Shinobu Takizawa Source Type: research
Enantiomeric separation of tryptophan via novel chiral polyamide composite membrane
This study offers fresh insights into membrane-based chiral separations.PMID:38699859 | DOI:10.1002/chir.23674 (Source: Chirality)
Source: Chirality - May 3, 2024 Category: Molecular Biology Authors: Xinwei Peng Yongming Wei Yangfeng Peng Hongliang Zhao Tianzhong Tong Quan He Source Type: research
Circular dichroism spectrum of (R)-(+)-3,3'-dibromo-1,1'-bi-2-naphthol in albumin: Alterations caused by complexation-Experimental and in silico investigation
This study describes the interaction of human serum albumin (HSA) with the binol derivative (R)-(+)-3,3'-dibromo-1,1'-bi-2-naphthol (R-BrB), which has its optical activity based on the prohibitive energetic barrier for conversion into the enantiomer (S)-(+)-3,3'-dibromo-1,1'-bi-2-naphthol (S-BrB). The objective was to assess the ability of HSA to differentiate axial enantiomers based on their binding efficiency and their impact on the CD spectra. We discovered that both enantiomers were effective ligands, and the CD signal disappeared when equimolar amounts of R-BrB and S-BrB were simultaneously added, indicating no prefer...
Source: Chirality - May 3, 2024 Category: Molecular Biology Authors: Valdecir Farias Ximenes Maur ício Ikeda Yoguim Aguinaldo Robinson de Souza Nelson Henrique Morgon Source Type: research
Impact of helical elongation of symmetric oxa[n]helicenes on their structural, photophysical, and chiroptical characteristics
Chirality. 2024 May;36(5):e23673. doi: 10.1002/chir.23673.ABSTRACTThe adjustment of the main helical scaffold in helicenes is a fundamental strategy for modulating their optical features, thereby enhancing their potential for diverse applications. This work explores the influence of helical elongation (n = 5-9) on the structural, photophysical, and chiroptical features of symmetric oxa[n]helicenes. Crystal structure analyses revealed structural variations with helical extension, impacting torsion angles, helical pitch, and packing arrangements. Through theoretical investigations using density functional theory (DFT) calcul...
Source: Chirality - May 3, 2024 Category: Molecular Biology Authors: Mohamed S H Salem Rubal Sharma Seika Suzuki Yoshitane Imai Mitsuhiro Arisawa Shinobu Takizawa Source Type: research
Enantiomeric separation of tryptophan via novel chiral polyamide composite membrane
This study offers fresh insights into membrane-based chiral separations.PMID:38699859 | DOI:10.1002/chir.23674 (Source: Chirality)
Source: Chirality - May 3, 2024 Category: Molecular Biology Authors: Xinwei Peng Yongming Wei Yangfeng Peng Hongliang Zhao Tianzhong Tong Quan He Source Type: research
Circular dichroism spectrum of (R)-(+)-3,3'-dibromo-1,1'-bi-2-naphthol in albumin: Alterations caused by complexation-Experimental and in silico investigation
This study describes the interaction of human serum albumin (HSA) with the binol derivative (R)-(+)-3,3'-dibromo-1,1'-bi-2-naphthol (R-BrB), which has its optical activity based on the prohibitive energetic barrier for conversion into the enantiomer (S)-(+)-3,3'-dibromo-1,1'-bi-2-naphthol (S-BrB). The objective was to assess the ability of HSA to differentiate axial enantiomers based on their binding efficiency and their impact on the CD spectra. We discovered that both enantiomers were effective ligands, and the CD signal disappeared when equimolar amounts of R-BrB and S-BrB were simultaneously added, indicating no prefer...
Source: Chirality - May 3, 2024 Category: Molecular Biology Authors: Valdecir Farias Ximenes Maur ício Ikeda Yoguim Aguinaldo Robinson de Souza Nelson Henrique Morgon Source Type: research
Impact of helical elongation of symmetric oxa[n]helicenes on their structural, photophysical, and chiroptical characteristics
Chirality. 2024 May;36(5):e23673. doi: 10.1002/chir.23673.ABSTRACTThe adjustment of the main helical scaffold in helicenes is a fundamental strategy for modulating their optical features, thereby enhancing their potential for diverse applications. This work explores the influence of helical elongation (n = 5-9) on the structural, photophysical, and chiroptical features of symmetric oxa[n]helicenes. Crystal structure analyses revealed structural variations with helical extension, impacting torsion angles, helical pitch, and packing arrangements. Through theoretical investigations using density functional theory (DFT) calcul...
Source: Chirality - May 3, 2024 Category: Molecular Biology Authors: Mohamed S H Salem Rubal Sharma Seika Suzuki Yoshitane Imai Mitsuhiro Arisawa Shinobu Takizawa Source Type: research
Enantiomeric separation of tryptophan via novel chiral polyamide composite membrane
This study offers fresh insights into membrane-based chiral separations.PMID:38699859 | DOI:10.1002/chir.23674 (Source: Chirality)
Source: Chirality - May 3, 2024 Category: Molecular Biology Authors: Xinwei Peng Yongming Wei Yangfeng Peng Hongliang Zhao Tianzhong Tong Quan He Source Type: research
Circular dichroism spectrum of (R)-(+)-3,3'-dibromo-1,1'-bi-2-naphthol in albumin: Alterations caused by complexation-Experimental and in silico investigation
This study describes the interaction of human serum albumin (HSA) with the binol derivative (R)-(+)-3,3'-dibromo-1,1'-bi-2-naphthol (R-BrB), which has its optical activity based on the prohibitive energetic barrier for conversion into the enantiomer (S)-(+)-3,3'-dibromo-1,1'-bi-2-naphthol (S-BrB). The objective was to assess the ability of HSA to differentiate axial enantiomers based on their binding efficiency and their impact on the CD spectra. We discovered that both enantiomers were effective ligands, and the CD signal disappeared when equimolar amounts of R-BrB and S-BrB were simultaneously added, indicating no prefer...
Source: Chirality - May 3, 2024 Category: Molecular Biology Authors: Valdecir Farias Ximenes Maur ício Ikeda Yoguim Aguinaldo Robinson de Souza Nelson Henrique Morgon Source Type: research
New methods for resolution of hydroxychloroquine by forming diastereomeric salt and adding chiral mobile phase agent on RP-HPLC
Chirality. 2024 May;36(5):e23672. doi: 10.1002/chir.23672.ABSTRACTHydroxychloroquine (HCQ), 2-([4-([7-Chloro-4-quinolyl]amino)pentyl]ethylamino)ethanol, exhibited significant biological activity, while its side effects cannot be overlooked. The RP-HPLC enantio-separation was investigated for cost-effective and convenient optical purity analysis of HCQ. The thermodynamic resolution of Rac-HCQ, driven by enthalpy and entropy, was achieved on the C18 column using Carboxymethyl-β-cyclodextrin (CM-β-CD) as the chiral mobile phase agent (CMPA). The effects of CCM-β-CD, pH, and triethylamine (TEA) V% on the enantio-separation ...
Source: Chirality - May 2, 2024 Category: Molecular Biology Authors: Chen Chen Yangfeng Peng Yongming Wei Mengyuan Liu Yu Wang Siqi Xiong Huiyi Li Quan He Source Type: research
Asymmetric catalysis by chiral FLPs: A computational mini-review
Chirality. 2024 May;36(5):e23671. doi: 10.1002/chir.23671.ABSTRACTSteric hindrance in Lewis acid (LA) and Lewis base (LB) obstruct the Lewis acid-base adduct formation, and the pair was termed as frustrated Lewis pair (FLP). In the past 16 years, the field of enantioselective catalysis by chiral FLPs has been slowly growing. It was shown that chiral LAs are significant as they are involved in the hydrogen transfer (HT) step to the imine, resulting in enantioselectivity. After H2 activation, the borohydride can exist in a number of plausible conformations and their stability is governed by the presence of noncovalent intera...
Source: Chirality - April 25, 2024 Category: Molecular Biology Authors: Shanti Gopal Patra Source Type: research
Asymmetric catalysis by chiral FLPs: A computational mini-review
Chirality. 2024 May;36(5):e23671. doi: 10.1002/chir.23671.ABSTRACTSteric hindrance in Lewis acid (LA) and Lewis base (LB) obstruct the Lewis acid-base adduct formation, and the pair was termed as frustrated Lewis pair (FLP). In the past 16 years, the field of enantioselective catalysis by chiral FLPs has been slowly growing. It was shown that chiral LAs are significant as they are involved in the hydrogen transfer (HT) step to the imine, resulting in enantioselectivity. After H2 activation, the borohydride can exist in a number of plausible conformations and their stability is governed by the presence of noncovalent intera...
Source: Chirality - April 25, 2024 Category: Molecular Biology Authors: Shanti Gopal Patra Source Type: research
Asymmetric catalysis by chiral FLPs: A computational mini-review
Chirality. 2024 May;36(5):e23671. doi: 10.1002/chir.23671.ABSTRACTSteric hindrance in Lewis acid (LA) and Lewis base (LB) obstruct the Lewis acid-base adduct formation, and the pair was termed as frustrated Lewis pair (FLP). In the past 16 years, the field of enantioselective catalysis by chiral FLPs has been slowly growing. It was shown that chiral LAs are significant as they are involved in the hydrogen transfer (HT) step to the imine, resulting in enantioselectivity. After H2 activation, the borohydride can exist in a number of plausible conformations and their stability is governed by the presence of noncovalent intera...
Source: Chirality - April 25, 2024 Category: Molecular Biology Authors: Shanti Gopal Patra Source Type: research
Asymmetric catalysis by chiral FLPs: A computational mini-review
Chirality. 2024 May;36(5):e23671. doi: 10.1002/chir.23671.ABSTRACTSteric hindrance in Lewis acid (LA) and Lewis base (LB) obstruct the Lewis acid-base adduct formation, and the pair was termed as frustrated Lewis pair (FLP). In the past 16 years, the field of enantioselective catalysis by chiral FLPs has been slowly growing. It was shown that chiral LAs are significant as they are involved in the hydrogen transfer (HT) step to the imine, resulting in enantioselectivity. After H2 activation, the borohydride can exist in a number of plausible conformations and their stability is governed by the presence of noncovalent intera...
Source: Chirality - April 25, 2024 Category: Molecular Biology Authors: Shanti Gopal Patra Source Type: research
Asymmetric catalysis by chiral FLPs: A computational mini-review
Chirality. 2024 May;36(5):e23671. doi: 10.1002/chir.23671.ABSTRACTSteric hindrance in Lewis acid (LA) and Lewis base (LB) obstruct the Lewis acid-base adduct formation, and the pair was termed as frustrated Lewis pair (FLP). In the past 16 years, the field of enantioselective catalysis by chiral FLPs has been slowly growing. It was shown that chiral LAs are significant as they are involved in the hydrogen transfer (HT) step to the imine, resulting in enantioselectivity. After H2 activation, the borohydride can exist in a number of plausible conformations and their stability is governed by the presence of noncovalent intera...
Source: Chirality - April 25, 2024 Category: Molecular Biology Authors: Shanti Gopal Patra Source Type: research
