Investigation into the performance and stability of immobilized and coated polysaccharide columns in supercritical fluid chromatography
In this study, the performance of the widely used "golden four" coated chiral stationary phases (Chiralpak AD-3, Chiralcel OD-3, Chiralpak AS-3, and Chiralcel OJ-3) was compared with their corresponding immobilized versions (Chiralpak IA-3, Chiralpak IB-3, Chiralpak IB N-3, Chiralpak IH-3, and Chiralpak IJ-3) under supercritical fluid chromatography (SFC) conditions with a set of 30 racemic compounds. Using the traditional modifiers, methanol and isopropanol, the immobilized columns (Chiralpak IB N-3 and Chiralpak IH-3) showed an improved general ability to successfully resolve the enantiomers of the target analytes relati...
Source: Chirality - November 3, 2023 Category: Molecular Biology Authors: Lei Yue Madeline Yeh John Reilly Bing Wang Christopher J Welch Maria Phan Source Type: research
Investigation into the performance and stability of immobilized and coated polysaccharide columns in supercritical fluid chromatography
In this study, the performance of the widely used "golden four" coated chiral stationary phases (Chiralpak AD-3, Chiralcel OD-3, Chiralpak AS-3, and Chiralcel OJ-3) was compared with their corresponding immobilized versions (Chiralpak IA-3, Chiralpak IB-3, Chiralpak IB N-3, Chiralpak IH-3, and Chiralpak IJ-3) under supercritical fluid chromatography (SFC) conditions with a set of 30 racemic compounds. Using the traditional modifiers, methanol and isopropanol, the immobilized columns (Chiralpak IB N-3 and Chiralpak IH-3) showed an improved general ability to successfully resolve the enantiomers of the target analytes relati...
Source: Chirality - November 3, 2023 Category: Molecular Biology Authors: Lei Yue Madeline Yeh John Reilly Bing Wang Christopher J Welch Maria Phan Source Type: research
Electronic structure analysis of phthalocyanine complexes using magnetic circular dichroism and magnetic circularly polarized luminescence spectroscopy
Chirality. 2023 Oct 25. doi: 10.1002/chir.23625. Online ahead of print.ABSTRACTIn the study of phthalocyanine complexes using magnetic circular dichroism (MCD) spectroscopy, the electronic structure of excited states is generally discussed based on the rigid-shift approximation, in which the band profiles for left-handed circularly polarized (lcp) and right-handed circularly polarized (rcp) light are assumed to be the same. This assumption may not necessarily be valid for cases where there are multiple initial states having different geometries. Magnetic circularly polarized luminescence (MCPL) from phthalocyanine complexe...
Source: Chirality - October 25, 2023 Category: Molecular Biology Authors: Satoko Suzuki Anas Santria Taiji Oyama Ken-Ichi Akao Naoto Ishikawa Source Type: research
Electronic structure analysis of phthalocyanine complexes using magnetic circular dichroism and magnetic circularly polarized luminescence spectroscopy
Chirality. 2023 Oct 25. doi: 10.1002/chir.23625. Online ahead of print.ABSTRACTIn the study of phthalocyanine complexes using magnetic circular dichroism (MCD) spectroscopy, the electronic structure of excited states is generally discussed based on the rigid-shift approximation, in which the band profiles for left-handed circularly polarized (lcp) and right-handed circularly polarized (rcp) light are assumed to be the same. This assumption may not necessarily be valid for cases where there are multiple initial states having different geometries. Magnetic circularly polarized luminescence (MCPL) from phthalocyanine complexe...
Source: Chirality - October 25, 2023 Category: Molecular Biology Authors: Satoko Suzuki Anas Santria Taiji Oyama Ken-Ichi Akao Naoto Ishikawa Source Type: research
Electronic structure analysis of phthalocyanine complexes using magnetic circular dichroism and magnetic circularly polarized luminescence spectroscopy
Chirality. 2023 Oct 25. doi: 10.1002/chir.23625. Online ahead of print.ABSTRACTIn the study of phthalocyanine complexes using magnetic circular dichroism (MCD) spectroscopy, the electronic structure of excited states is generally discussed based on the rigid-shift approximation, in which the band profiles for left-handed circularly polarized (lcp) and right-handed circularly polarized (rcp) light are assumed to be the same. This assumption may not necessarily be valid for cases where there are multiple initial states having different geometries. Magnetic circularly polarized luminescence (MCPL) from phthalocyanine complexe...
Source: Chirality - October 25, 2023 Category: Molecular Biology Authors: Satoko Suzuki Anas Santria Taiji Oyama Ken-Ichi Akao Naoto Ishikawa Source Type: research
Electronic structure analysis of phthalocyanine complexes using magnetic circular dichroism and magnetic circularly polarized luminescence spectroscopy
Chirality. 2023 Oct 25. doi: 10.1002/chir.23625. Online ahead of print.ABSTRACTIn the study of phthalocyanine complexes using magnetic circular dichroism (MCD) spectroscopy, the electronic structure of excited states is generally discussed based on the rigid-shift approximation, in which the band profiles for left-handed circularly polarized (lcp) and right-handed circularly polarized (rcp) light are assumed to be the same. This assumption may not necessarily be valid for cases where there are multiple initial states having different geometries. Magnetic circularly polarized luminescence (MCPL) from phthalocyanine complexe...
Source: Chirality - October 25, 2023 Category: Molecular Biology Authors: Satoko Suzuki Anas Santria Taiji Oyama Ken-Ichi Akao Naoto Ishikawa Source Type: research
Electronic structure analysis of phthalocyanine complexes using magnetic circular dichroism and magnetic circularly polarized luminescence spectroscopy
Chirality. 2023 Oct 25. doi: 10.1002/chir.23625. Online ahead of print.ABSTRACTIn the study of phthalocyanine complexes using magnetic circular dichroism (MCD) spectroscopy, the electronic structure of excited states is generally discussed based on the rigid-shift approximation, in which the band profiles for left-handed circularly polarized (lcp) and right-handed circularly polarized (rcp) light are assumed to be the same. This assumption may not necessarily be valid for cases where there are multiple initial states having different geometries. Magnetic circularly polarized luminescence (MCPL) from phthalocyanine complexe...
Source: Chirality - October 25, 2023 Category: Molecular Biology Authors: Satoko Suzuki Anas Santria Taiji Oyama Ken-Ichi Akao Naoto Ishikawa Source Type: research
Electronic structure analysis of phthalocyanine complexes using magnetic circular dichroism and magnetic circularly polarized luminescence spectroscopy
Chirality. 2023 Oct 25. doi: 10.1002/chir.23625. Online ahead of print.ABSTRACTIn the study of phthalocyanine complexes using magnetic circular dichroism (MCD) spectroscopy, the electronic structure of excited states is generally discussed based on the rigid-shift approximation, in which the band profiles for left-handed circularly polarized (lcp) and right-handed circularly polarized (rcp) light are assumed to be the same. This assumption may not necessarily be valid for cases where there are multiple initial states having different geometries. Magnetic circularly polarized luminescence (MCPL) from phthalocyanine complexe...
Source: Chirality - October 25, 2023 Category: Molecular Biology Authors: Satoko Suzuki Anas Santria Taiji Oyama Ken-Ichi Akao Naoto Ishikawa Source Type: research
Electronic structure analysis of phthalocyanine complexes using magnetic circular dichroism and magnetic circularly polarized luminescence spectroscopy
Chirality. 2023 Oct 25. doi: 10.1002/chir.23625. Online ahead of print.ABSTRACTIn the study of phthalocyanine complexes using magnetic circular dichroism (MCD) spectroscopy, the electronic structure of excited states is generally discussed based on the rigid-shift approximation, in which the band profiles for left-handed circularly polarized (lcp) and right-handed circularly polarized (rcp) light are assumed to be the same. This assumption may not necessarily be valid for cases where there are multiple initial states having different geometries. Magnetic circularly polarized luminescence (MCPL) from phthalocyanine complexe...
Source: Chirality - October 25, 2023 Category: Molecular Biology Authors: Satoko Suzuki Anas Santria Taiji Oyama Ken-Ichi Akao Naoto Ishikawa Source Type: research
Development of robust chiroptical systems through spirobifluorenes
Chirality. 2023 Oct 12. doi: 10.1002/chir.23624. Online ahead of print.ABSTRACTChiroptical responses are valuable for the structural determination of dissymmetric molecules. However, the development of everyday applications based on chiroptical systems is yet to come. We have been earlier using axially chiral allenes for the construction of linear, cyclic, and cage-shaped molecules that present remarkable chiroptical responses. Additionally, we have developed chiral surfaces through upstanding chiral architectures. Since the goal is to obtain robust chiroptical materials, more recently we have been studying spirobifluorene...
Source: Chirality - October 12, 2023 Category: Molecular Biology Authors: Julia Portela-Pino Mar ía Talavera Stefano Chiussi Sandra Bola ño Ángeles Peña-Gallego J Lorenzo Alonso-G ómez Source Type: research
Differentiation and identification of enantiomers by nuclear magnetic resonance spectroscopy with support of quantum mechanical computations
We report nuclear magnetic resonance studies of two chiral building blocks of solifenacin, phenyltetrahydroisoquinoline and quinuclidinol, in which chiral solvating agents, Mosher's acid, and Pirkle's alcohol were used for spectral discrimination between enantiomers of solifenacin constituents. Based on the constraints following from measurements of the nuclear Overhauser effect, structures of phenyltetrahydroisoquinoline and Pirkle's alcohol solvates were found. Next, shifts of nuclear magnetic resonance signals of phenyltetrahydroisoquinoline due to the application of Pirkle's alcohol were computed using density function...
Source: Chirality - October 12, 2023 Category: Molecular Biology Authors: Artur Brzezicki Piotr Garbacz Source Type: research
Development of robust chiroptical systems through spirobifluorenes
Chirality. 2023 Oct 12. doi: 10.1002/chir.23624. Online ahead of print.ABSTRACTChiroptical responses are valuable for the structural determination of dissymmetric molecules. However, the development of everyday applications based on chiroptical systems is yet to come. We have been earlier using axially chiral allenes for the construction of linear, cyclic, and cage-shaped molecules that present remarkable chiroptical responses. Additionally, we have developed chiral surfaces through upstanding chiral architectures. Since the goal is to obtain robust chiroptical materials, more recently we have been studying spirobifluorene...
Source: Chirality - October 12, 2023 Category: Molecular Biology Authors: Julia Portela-Pino Mar ía Talavera Stefano Chiussi Sandra Bola ño Ángeles Peña-Gallego J Lorenzo Alonso-G ómez Source Type: research
Differentiation and identification of enantiomers by nuclear magnetic resonance spectroscopy with support of quantum mechanical computations
We report nuclear magnetic resonance studies of two chiral building blocks of solifenacin, phenyltetrahydroisoquinoline and quinuclidinol, in which chiral solvating agents, Mosher's acid, and Pirkle's alcohol were used for spectral discrimination between enantiomers of solifenacin constituents. Based on the constraints following from measurements of the nuclear Overhauser effect, structures of phenyltetrahydroisoquinoline and Pirkle's alcohol solvates were found. Next, shifts of nuclear magnetic resonance signals of phenyltetrahydroisoquinoline due to the application of Pirkle's alcohol were computed using density function...
Source: Chirality - October 12, 2023 Category: Molecular Biology Authors: Artur Brzezicki Piotr Garbacz Source Type: research
Development of robust chiroptical systems through spirobifluorenes
Chirality. 2023 Oct 12. doi: 10.1002/chir.23624. Online ahead of print.ABSTRACTChiroptical responses are valuable for the structural determination of dissymmetric molecules. However, the development of everyday applications based on chiroptical systems is yet to come. We have been earlier using axially chiral allenes for the construction of linear, cyclic, and cage-shaped molecules that present remarkable chiroptical responses. Additionally, we have developed chiral surfaces through upstanding chiral architectures. Since the goal is to obtain robust chiroptical materials, more recently we have been studying spirobifluorene...
Source: Chirality - October 12, 2023 Category: Molecular Biology Authors: Julia Portela-Pino Mar ía Talavera Stefano Chiussi Sandra Bola ño Ángeles Peña-Gallego J Lorenzo Alonso-G ómez Source Type: research
Differentiation and identification of enantiomers by nuclear magnetic resonance spectroscopy with support of quantum mechanical computations
We report nuclear magnetic resonance studies of two chiral building blocks of solifenacin, phenyltetrahydroisoquinoline and quinuclidinol, in which chiral solvating agents, Mosher's acid, and Pirkle's alcohol were used for spectral discrimination between enantiomers of solifenacin constituents. Based on the constraints following from measurements of the nuclear Overhauser effect, structures of phenyltetrahydroisoquinoline and Pirkle's alcohol solvates were found. Next, shifts of nuclear magnetic resonance signals of phenyltetrahydroisoquinoline due to the application of Pirkle's alcohol were computed using density function...
Source: Chirality - October 12, 2023 Category: Molecular Biology Authors: Artur Brzezicki Piotr Garbacz Source Type: research
