Resolving phenylephrine HCl and guaifenesin enantiomers on cellulose-based chiral stationary phases: Separation of four enantiomers on 50-mm column
Chirality. 2023 Aug 13. doi: 10.1002/chir.23616. Online ahead of print.ABSTRACTChiral high performance liquid chromatographic technique usually employs polysaccharide-based stationary phases in a normal phase mode. This frequently generates large waste of organic solvents. Using shorter columns of 50 mm length as well as a mobile phase with a high water percentage are common approaches for greening this analytical technique. In this context, a new chiral chromatographic technique was developed for simultaneous enantio-separation of phenylephrine HCl and guaifenesin racemates. Four 50 mm cellulose-based columns were experim...
Source: Chirality - August 14, 2023 Category: Molecular Biology Authors: Mahmoud A Tantawy Hassan Y Aboul-Enein Ali M Yehia Source Type: research
Resolving phenylephrine HCl and guaifenesin enantiomers on cellulose-based chiral stationary phases: Separation of four enantiomers on 50-mm column
Chirality. 2023 Aug 13. doi: 10.1002/chir.23616. Online ahead of print.ABSTRACTChiral high performance liquid chromatographic technique usually employs polysaccharide-based stationary phases in a normal phase mode. This frequently generates large waste of organic solvents. Using shorter columns of 50 mm length as well as a mobile phase with a high water percentage are common approaches for greening this analytical technique. In this context, a new chiral chromatographic technique was developed for simultaneous enantio-separation of phenylephrine HCl and guaifenesin racemates. Four 50 mm cellulose-based columns were experim...
Source: Chirality - August 14, 2023 Category: Molecular Biology Authors: Mahmoud A Tantawy Hassan Y Aboul-Enein Ali M Yehia Source Type: research
Resolving phenylephrine HCl and guaifenesin enantiomers on cellulose-based chiral stationary phases: Separation of four enantiomers on 50-mm column
Chirality. 2023 Aug 13. doi: 10.1002/chir.23616. Online ahead of print.ABSTRACTChiral high performance liquid chromatographic technique usually employs polysaccharide-based stationary phases in a normal phase mode. This frequently generates large waste of organic solvents. Using shorter columns of 50 mm length as well as a mobile phase with a high water percentage are common approaches for greening this analytical technique. In this context, a new chiral chromatographic technique was developed for simultaneous enantio-separation of phenylephrine HCl and guaifenesin racemates. Four 50 mm cellulose-based columns were experim...
Source: Chirality - August 14, 2023 Category: Molecular Biology Authors: Mahmoud A Tantawy Hassan Y Aboul-Enein Ali M Yehia Source Type: research
Resolving phenylephrine HCl and guaifenesin enantiomers on cellulose-based chiral stationary phases: Separation of four enantiomers on 50-mm column
Chirality. 2023 Aug 13. doi: 10.1002/chir.23616. Online ahead of print.ABSTRACTChiral high performance liquid chromatographic technique usually employs polysaccharide-based stationary phases in a normal phase mode. This frequently generates large waste of organic solvents. Using shorter columns of 50 mm length as well as a mobile phase with a high water percentage are common approaches for greening this analytical technique. In this context, a new chiral chromatographic technique was developed for simultaneous enantio-separation of phenylephrine HCl and guaifenesin racemates. Four 50 mm cellulose-based columns were experim...
Source: Chirality - August 14, 2023 Category: Molecular Biology Authors: Mahmoud A Tantawy Hassan Y Aboul-Enein Ali M Yehia Source Type: research
Resolving phenylephrine HCl and guaifenesin enantiomers on cellulose-based chiral stationary phases: Separation of four enantiomers on 50-mm column
Chirality. 2023 Aug 13. doi: 10.1002/chir.23616. Online ahead of print.ABSTRACTChiral high performance liquid chromatographic technique usually employs polysaccharide-based stationary phases in a normal phase mode. This frequently generates large waste of organic solvents. Using shorter columns of 50 mm length as well as a mobile phase with a high water percentage are common approaches for greening this analytical technique. In this context, a new chiral chromatographic technique was developed for simultaneous enantio-separation of phenylephrine HCl and guaifenesin racemates. Four 50 mm cellulose-based columns were experim...
Source: Chirality - August 14, 2023 Category: Molecular Biology Authors: Mahmoud A Tantawy Hassan Y Aboul-Enein Ali M Yehia Source Type: research
Resolving phenylephrine HCl and guaifenesin enantiomers on cellulose-based chiral stationary phases: Separation of four enantiomers on 50-mm column
Chirality. 2023 Aug 13. doi: 10.1002/chir.23616. Online ahead of print.ABSTRACTChiral high performance liquid chromatographic technique usually employs polysaccharide-based stationary phases in a normal phase mode. This frequently generates large waste of organic solvents. Using shorter columns of 50 mm length as well as a mobile phase with a high water percentage are common approaches for greening this analytical technique. In this context, a new chiral chromatographic technique was developed for simultaneous enantio-separation of phenylephrine HCl and guaifenesin racemates. Four 50 mm cellulose-based columns were experim...
Source: Chirality - August 14, 2023 Category: Molecular Biology Authors: Mahmoud A Tantawy Hassan Y Aboul-Enein Ali M Yehia Source Type: research
Resolving phenylephrine HCl and guaifenesin enantiomers on cellulose-based chiral stationary phases: Separation of four enantiomers on 50-mm column
Chirality. 2023 Aug 13. doi: 10.1002/chir.23616. Online ahead of print.ABSTRACTChiral high performance liquid chromatographic technique usually employs polysaccharide-based stationary phases in a normal phase mode. This frequently generates large waste of organic solvents. Using shorter columns of 50 mm length as well as a mobile phase with a high water percentage are common approaches for greening this analytical technique. In this context, a new chiral chromatographic technique was developed for simultaneous enantio-separation of phenylephrine HCl and guaifenesin racemates. Four 50 mm cellulose-based columns were experim...
Source: Chirality - August 14, 2023 Category: Molecular Biology Authors: Mahmoud A Tantawy Hassan Y Aboul-Enein Ali M Yehia Source Type: research
Resolving phenylephrine HCl and guaifenesin enantiomers on cellulose-based chiral stationary phases: Separation of four enantiomers on 50-mm column
Chirality. 2023 Aug 13. doi: 10.1002/chir.23616. Online ahead of print.ABSTRACTChiral high performance liquid chromatographic technique usually employs polysaccharide-based stationary phases in a normal phase mode. This frequently generates large waste of organic solvents. Using shorter columns of 50 mm length as well as a mobile phase with a high water percentage are common approaches for greening this analytical technique. In this context, a new chiral chromatographic technique was developed for simultaneous enantio-separation of phenylephrine HCl and guaifenesin racemates. Four 50 mm cellulose-based columns were experim...
Source: Chirality - August 14, 2023 Category: Molecular Biology Authors: Mahmoud A Tantawy Hassan Y Aboul-Enein Ali M Yehia Source Type: research
Resolving phenylephrine HCl and guaifenesin enantiomers on cellulose-based chiral stationary phases: Separation of four enantiomers on 50-mm column
Chirality. 2023 Aug 13. doi: 10.1002/chir.23616. Online ahead of print.ABSTRACTChiral high performance liquid chromatographic technique usually employs polysaccharide-based stationary phases in a normal phase mode. This frequently generates large waste of organic solvents. Using shorter columns of 50 mm length as well as a mobile phase with a high water percentage are common approaches for greening this analytical technique. In this context, a new chiral chromatographic technique was developed for simultaneous enantio-separation of phenylephrine HCl and guaifenesin racemates. Four 50 mm cellulose-based columns were experim...
Source: Chirality - August 14, 2023 Category: Molecular Biology Authors: Mahmoud A Tantawy Hassan Y Aboul-Enein Ali M Yehia Source Type: research
Isolated and solvated chiroptical behavior in conformationally flexible butanamines
Chirality. 2023 Sep;35(9):586-618. doi: 10.1002/chir.23570. Epub 2023 Jun 13.ABSTRACTThe nonresonant optical activity of two highly flexible aliphatic amines, (2R)-3-methyl-2-butanamine (R-MBA) and (2R)-(3,3)-dimethyl-2-butanamine (R-DMBA), has been probed under isolated and solvated conditions to examine the roles of conformational isomerism and to explore the influence of extrinsic perturbations. The optical rotatory dispersion (ORD) measured in six solvents presented uniformly negative rotatory powers over the 320-590 nm region, with the long-wavelength magnitude of chiroptical response growing nearly monotonically as t...
Source: Chirality - August 7, 2023 Category: Molecular Biology Authors: Paul M Lemler Clayton L Craft Corina H Pollok Thomas P Regan Patrick H Vaccaro Source Type: research
Isolated and solvated chiroptical behavior in conformationally flexible butanamines
Chirality. 2023 Sep;35(9):586-618. doi: 10.1002/chir.23570. Epub 2023 Jun 13.ABSTRACTThe nonresonant optical activity of two highly flexible aliphatic amines, (2R)-3-methyl-2-butanamine (R-MBA) and (2R)-(3,3)-dimethyl-2-butanamine (R-DMBA), has been probed under isolated and solvated conditions to examine the roles of conformational isomerism and to explore the influence of extrinsic perturbations. The optical rotatory dispersion (ORD) measured in six solvents presented uniformly negative rotatory powers over the 320-590 nm region, with the long-wavelength magnitude of chiroptical response growing nearly monotonically as t...
Source: Chirality - August 7, 2023 Category: Molecular Biology Authors: Paul M Lemler Clayton L Craft Corina H Pollok Thomas P Regan Patrick H Vaccaro Source Type: research
Isolated and solvated chiroptical behavior in conformationally flexible butanamines
Chirality. 2023 Sep;35(9):586-618. doi: 10.1002/chir.23570. Epub 2023 Jun 13.ABSTRACTThe nonresonant optical activity of two highly flexible aliphatic amines, (2R)-3-methyl-2-butanamine (R-MBA) and (2R)-(3,3)-dimethyl-2-butanamine (R-DMBA), has been probed under isolated and solvated conditions to examine the roles of conformational isomerism and to explore the influence of extrinsic perturbations. The optical rotatory dispersion (ORD) measured in six solvents presented uniformly negative rotatory powers over the 320-590 nm region, with the long-wavelength magnitude of chiroptical response growing nearly monotonically as t...
Source: Chirality - August 7, 2023 Category: Molecular Biology Authors: Paul M Lemler Clayton L Craft Corina H Pollok Thomas P Regan Patrick H Vaccaro Source Type: research
Isolated and solvated chiroptical behavior in conformationally flexible butanamines
Chirality. 2023 Sep;35(9):586-618. doi: 10.1002/chir.23570. Epub 2023 Jun 13.ABSTRACTThe nonresonant optical activity of two highly flexible aliphatic amines, (2R)-3-methyl-2-butanamine (R-MBA) and (2R)-(3,3)-dimethyl-2-butanamine (R-DMBA), has been probed under isolated and solvated conditions to examine the roles of conformational isomerism and to explore the influence of extrinsic perturbations. The optical rotatory dispersion (ORD) measured in six solvents presented uniformly negative rotatory powers over the 320-590 nm region, with the long-wavelength magnitude of chiroptical response growing nearly monotonically as t...
Source: Chirality - August 7, 2023 Category: Molecular Biology Authors: Paul M Lemler Clayton L Craft Corina H Pollok Thomas P Regan Patrick H Vaccaro Source Type: research
Isolated and solvated chiroptical behavior in conformationally flexible butanamines
Chirality. 2023 Sep;35(9):586-618. doi: 10.1002/chir.23570. Epub 2023 Jun 13.ABSTRACTThe nonresonant optical activity of two highly flexible aliphatic amines, (2R)-3-methyl-2-butanamine (R-MBA) and (2R)-(3,3)-dimethyl-2-butanamine (R-DMBA), has been probed under isolated and solvated conditions to examine the roles of conformational isomerism and to explore the influence of extrinsic perturbations. The optical rotatory dispersion (ORD) measured in six solvents presented uniformly negative rotatory powers over the 320-590 nm region, with the long-wavelength magnitude of chiroptical response growing nearly monotonically as t...
Source: Chirality - August 7, 2023 Category: Molecular Biology Authors: Paul M Lemler Clayton L Craft Corina H Pollok Thomas P Regan Patrick H Vaccaro Source Type: research
Circular dichroism and UV-Vis detection of UV-induced damage to nucleic acids
In this report, we demonstrate that CD spectroscopy can be used as a tool to detect changes to DNA upon irradiation with UV light. We follow the spectroscopic response of DNA samples irradiated at selected exposure times with both CD and UV-Vis spectroscopy. We analyzed four different nucleic acids to evaluate the effect of the sequence on photodegradation. Only one polymer, calf thymus DNA, was a natural nucleic acid and contained all four nucleobases. The other three were synthetic polymers and contained only one type of base pair: poly (deoxyadenylic-deoxythymidylic) acid [poly (dA-dT)2 ] and poly (deoxyadenylic acid) Â...
Source: Chirality - July 28, 2023 Category: Molecular Biology Authors: Reed C Dowling Gregory T Carroll David L Kirschman Mark B Masthay Angela Mammana Source Type: research
