Resolution of trans-1,2-cyclohexanedicarboxylic acid containing two carboxylic groups by forming diastereomeric salts based on feeding molar ratio control
Chirality. 2023 Dec 6. doi: 10.1002/chir.23634. Online ahead of print.ABSTRACTTo investigate the thermodynamic and molecular self-assembly mechanism of trans-1,2-cyclohexane dicarboxylic acid containing two carboxylic acid groups in the chiral resolution process, (S)-phenylethylamine was used as the chiral resolving agent. Two stoichiometric salts were formed when the raw materials were fed at different molar ratios: cyclohexane dicarboxylate monophenylethylamine salt and cyclohexane dicarboxylate diphenylethylamine salt. When the molar ratio of the (S)-phenylethylamine to trans-1,2-cyclohexane dicarboxylic acid was less t...
Source: Chirality - December 7, 2023 Category: Molecular Biology Authors: Xiaoyu Xin Junjie Zhou Quan He Yangfeng Peng Yongming Wei Hongliang Zhao Tianzhong Tong Source Type: research
Resolution of trans-1,2-cyclohexanedicarboxylic acid containing two carboxylic groups by forming diastereomeric salts based on feeding molar ratio control
Chirality. 2023 Dec 6. doi: 10.1002/chir.23634. Online ahead of print.ABSTRACTTo investigate the thermodynamic and molecular self-assembly mechanism of trans-1,2-cyclohexane dicarboxylic acid containing two carboxylic acid groups in the chiral resolution process, (S)-phenylethylamine was used as the chiral resolving agent. Two stoichiometric salts were formed when the raw materials were fed at different molar ratios: cyclohexane dicarboxylate monophenylethylamine salt and cyclohexane dicarboxylate diphenylethylamine salt. When the molar ratio of the (S)-phenylethylamine to trans-1,2-cyclohexane dicarboxylic acid was less t...
Source: Chirality - December 7, 2023 Category: Molecular Biology Authors: Xiaoyu Xin Junjie Zhou Quan He Yangfeng Peng Yongming Wei Hongliang Zhao Tianzhong Tong Source Type: research
Resolution of trans-1,2-cyclohexanedicarboxylic acid containing two carboxylic groups by forming diastereomeric salts based on feeding molar ratio control
Chirality. 2023 Dec 6. doi: 10.1002/chir.23634. Online ahead of print.ABSTRACTTo investigate the thermodynamic and molecular self-assembly mechanism of trans-1,2-cyclohexane dicarboxylic acid containing two carboxylic acid groups in the chiral resolution process, (S)-phenylethylamine was used as the chiral resolving agent. Two stoichiometric salts were formed when the raw materials were fed at different molar ratios: cyclohexane dicarboxylate monophenylethylamine salt and cyclohexane dicarboxylate diphenylethylamine salt. When the molar ratio of the (S)-phenylethylamine to trans-1,2-cyclohexane dicarboxylic acid was less t...
Source: Chirality - December 7, 2023 Category: Molecular Biology Authors: Xiaoyu Xin Junjie Zhou Quan He Yangfeng Peng Yongming Wei Hongliang Zhao Tianzhong Tong Source Type: research
Resolution of trans-1,2-cyclohexanedicarboxylic acid containing two carboxylic groups by forming diastereomeric salts based on feeding molar ratio control
Chirality. 2023 Dec 6. doi: 10.1002/chir.23634. Online ahead of print.ABSTRACTTo investigate the thermodynamic and molecular self-assembly mechanism of trans-1,2-cyclohexane dicarboxylic acid containing two carboxylic acid groups in the chiral resolution process, (S)-phenylethylamine was used as the chiral resolving agent. Two stoichiometric salts were formed when the raw materials were fed at different molar ratios: cyclohexane dicarboxylate monophenylethylamine salt and cyclohexane dicarboxylate diphenylethylamine salt. When the molar ratio of the (S)-phenylethylamine to trans-1,2-cyclohexane dicarboxylic acid was less t...
Source: Chirality - December 7, 2023 Category: Molecular Biology Authors: Xiaoyu Xin Junjie Zhou Quan He Yangfeng Peng Yongming Wei Hongliang Zhao Tianzhong Tong Source Type: research
Resolution of trans-1,2-cyclohexanedicarboxylic acid containing two carboxylic groups by forming diastereomeric salts based on feeding molar ratio control
Chirality. 2023 Dec 6. doi: 10.1002/chir.23634. Online ahead of print.ABSTRACTTo investigate the thermodynamic and molecular self-assembly mechanism of trans-1,2-cyclohexane dicarboxylic acid containing two carboxylic acid groups in the chiral resolution process, (S)-phenylethylamine was used as the chiral resolving agent. Two stoichiometric salts were formed when the raw materials were fed at different molar ratios: cyclohexane dicarboxylate monophenylethylamine salt and cyclohexane dicarboxylate diphenylethylamine salt. When the molar ratio of the (S)-phenylethylamine to trans-1,2-cyclohexane dicarboxylic acid was less t...
Source: Chirality - December 7, 2023 Category: Molecular Biology Authors: Xiaoyu Xin Junjie Zhou Quan He Yangfeng Peng Yongming Wei Hongliang Zhao Tianzhong Tong Source Type: research
Resolution of trans-1,2-cyclohexanedicarboxylic acid containing two carboxylic groups by forming diastereomeric salts based on feeding molar ratio control
Chirality. 2023 Dec 6. doi: 10.1002/chir.23634. Online ahead of print.ABSTRACTTo investigate the thermodynamic and molecular self-assembly mechanism of trans-1,2-cyclohexane dicarboxylic acid containing two carboxylic acid groups in the chiral resolution process, (S)-phenylethylamine was used as the chiral resolving agent. Two stoichiometric salts were formed when the raw materials were fed at different molar ratios: cyclohexane dicarboxylate monophenylethylamine salt and cyclohexane dicarboxylate diphenylethylamine salt. When the molar ratio of the (S)-phenylethylamine to trans-1,2-cyclohexane dicarboxylic acid was less t...
Source: Chirality - December 7, 2023 Category: Molecular Biology Authors: Xiaoyu Xin Junjie Zhou Quan He Yangfeng Peng Yongming Wei Hongliang Zhao Tianzhong Tong Source Type: research
Resolution of trans-1,2-cyclohexanedicarboxylic acid containing two carboxylic groups by forming diastereomeric salts based on feeding molar ratio control
Chirality. 2023 Dec 6. doi: 10.1002/chir.23634. Online ahead of print.ABSTRACTTo investigate the thermodynamic and molecular self-assembly mechanism of trans-1,2-cyclohexane dicarboxylic acid containing two carboxylic acid groups in the chiral resolution process, (S)-phenylethylamine was used as the chiral resolving agent. Two stoichiometric salts were formed when the raw materials were fed at different molar ratios: cyclohexane dicarboxylate monophenylethylamine salt and cyclohexane dicarboxylate diphenylethylamine salt. When the molar ratio of the (S)-phenylethylamine to trans-1,2-cyclohexane dicarboxylic acid was less t...
Source: Chirality - December 7, 2023 Category: Molecular Biology Authors: Xiaoyu Xin Junjie Zhou Quan He Yangfeng Peng Yongming Wei Hongliang Zhao Tianzhong Tong Source Type: research
Resolution of trans-1,2-cyclohexanedicarboxylic acid containing two carboxylic groups by forming diastereomeric salts based on feeding molar ratio control
Chirality. 2023 Dec 6. doi: 10.1002/chir.23634. Online ahead of print.ABSTRACTTo investigate the thermodynamic and molecular self-assembly mechanism of trans-1,2-cyclohexane dicarboxylic acid containing two carboxylic acid groups in the chiral resolution process, (S)-phenylethylamine was used as the chiral resolving agent. Two stoichiometric salts were formed when the raw materials were fed at different molar ratios: cyclohexane dicarboxylate monophenylethylamine salt and cyclohexane dicarboxylate diphenylethylamine salt. When the molar ratio of the (S)-phenylethylamine to trans-1,2-cyclohexane dicarboxylic acid was less t...
Source: Chirality - December 7, 2023 Category: Molecular Biology Authors: Xiaoyu Xin Junjie Zhou Quan He Yangfeng Peng Yongming Wei Hongliang Zhao Tianzhong Tong Source Type: research
Resolution of trans-1,2-cyclohexanedicarboxylic acid containing two carboxylic groups by forming diastereomeric salts based on feeding molar ratio control
Chirality. 2023 Dec 6. doi: 10.1002/chir.23634. Online ahead of print.ABSTRACTTo investigate the thermodynamic and molecular self-assembly mechanism of trans-1,2-cyclohexane dicarboxylic acid containing two carboxylic acid groups in the chiral resolution process, (S)-phenylethylamine was used as the chiral resolving agent. Two stoichiometric salts were formed when the raw materials were fed at different molar ratios: cyclohexane dicarboxylate monophenylethylamine salt and cyclohexane dicarboxylate diphenylethylamine salt. When the molar ratio of the (S)-phenylethylamine to trans-1,2-cyclohexane dicarboxylic acid was less t...
Source: Chirality - December 7, 2023 Category: Molecular Biology Authors: Xiaoyu Xin Junjie Zhou Quan He Yangfeng Peng Yongming Wei Hongliang Zhao Tianzhong Tong Source Type: research
Resolution of trans-1,2-cyclohexanedicarboxylic acid containing two carboxylic groups by forming diastereomeric salts based on feeding molar ratio control
Chirality. 2023 Dec 6. doi: 10.1002/chir.23634. Online ahead of print.ABSTRACTTo investigate the thermodynamic and molecular self-assembly mechanism of trans-1,2-cyclohexane dicarboxylic acid containing two carboxylic acid groups in the chiral resolution process, (S)-phenylethylamine was used as the chiral resolving agent. Two stoichiometric salts were formed when the raw materials were fed at different molar ratios: cyclohexane dicarboxylate monophenylethylamine salt and cyclohexane dicarboxylate diphenylethylamine salt. When the molar ratio of the (S)-phenylethylamine to trans-1,2-cyclohexane dicarboxylic acid was less t...
Source: Chirality - December 7, 2023 Category: Molecular Biology Authors: Xiaoyu Xin Junjie Zhou Quan He Yangfeng Peng Yongming Wei Hongliang Zhao Tianzhong Tong Source Type: research
Resolution of trans-1,2-cyclohexanedicarboxylic acid containing two carboxylic groups by forming diastereomeric salts based on feeding molar ratio control
Chirality. 2023 Dec 6. doi: 10.1002/chir.23634. Online ahead of print.ABSTRACTTo investigate the thermodynamic and molecular self-assembly mechanism of trans-1,2-cyclohexane dicarboxylic acid containing two carboxylic acid groups in the chiral resolution process, (S)-phenylethylamine was used as the chiral resolving agent. Two stoichiometric salts were formed when the raw materials were fed at different molar ratios: cyclohexane dicarboxylate monophenylethylamine salt and cyclohexane dicarboxylate diphenylethylamine salt. When the molar ratio of the (S)-phenylethylamine to trans-1,2-cyclohexane dicarboxylic acid was less t...
Source: Chirality - December 7, 2023 Category: Molecular Biology Authors: Xiaoyu Xin Junjie Zhou Quan He Yangfeng Peng Yongming Wei Hongliang Zhao Tianzhong Tong Source Type: research
Resolution of trans-1,2-cyclohexanedicarboxylic acid containing two carboxylic groups by forming diastereomeric salts based on feeding molar ratio control
Chirality. 2023 Dec 6. doi: 10.1002/chir.23634. Online ahead of print.ABSTRACTTo investigate the thermodynamic and molecular self-assembly mechanism of trans-1,2-cyclohexane dicarboxylic acid containing two carboxylic acid groups in the chiral resolution process, (S)-phenylethylamine was used as the chiral resolving agent. Two stoichiometric salts were formed when the raw materials were fed at different molar ratios: cyclohexane dicarboxylate monophenylethylamine salt and cyclohexane dicarboxylate diphenylethylamine salt. When the molar ratio of the (S)-phenylethylamine to trans-1,2-cyclohexane dicarboxylic acid was less t...
Source: Chirality - December 7, 2023 Category: Molecular Biology Authors: Xiaoyu Xin Junjie Zhou Quan He Yangfeng Peng Yongming Wei Hongliang Zhao Tianzhong Tong Source Type: research
Separation and simultaneous estimation of enantiomers and Diastereomers of muscarinic receptor antagonist Solifenacin using stability-indicating Normal-phase HPLC technique with chiral stationary phase amylose tris-(3,5-dimethylphenylcarbamate)
Chirality. 2023 Nov 23. doi: 10.1002/chir.23632. Online ahead of print.ABSTRACTThe R,S-enantiomer impurity and diastereomer impurities (S,S-isomer and R,R-isomer) of the solifenacin (S,R-enantiomer) were effectively separated and quantified simultaneously utilizing normal-phase high-performance liquid chromatography with a chiral stationary phase consisting of amylose tris (3,5-dimethylphenylcarbamate) coated on silica-gel (Chiralpak, AD-H). The enantiomeric and stereo-selective separation was achieved within a run time of 35 minutes using a mobile phase of 'n-hexane, ethanol, and diethylamine' in an isocratic elution mode...
Source: Chirality - November 23, 2023 Category: Molecular Biology Authors: Niroja Vadagam Sharath Babu Haridasyam Muvvala Venkatanarayana Narasimha S Lakka Sanjeeva R Chinnakadoori Source Type: research
Separation and simultaneous estimation of enantiomers and Diastereomers of muscarinic receptor antagonist Solifenacin using stability-indicating Normal-phase HPLC technique with chiral stationary phase amylose tris-(3,5-dimethylphenylcarbamate)
Chirality. 2023 Nov 23. doi: 10.1002/chir.23632. Online ahead of print.ABSTRACTThe R,S-enantiomer impurity and diastereomer impurities (S,S-isomer and R,R-isomer) of the solifenacin (S,R-enantiomer) were effectively separated and quantified simultaneously utilizing normal-phase high-performance liquid chromatography with a chiral stationary phase consisting of amylose tris (3,5-dimethylphenylcarbamate) coated on silica-gel (Chiralpak, AD-H). The enantiomeric and stereo-selective separation was achieved within a run time of 35 minutes using a mobile phase of 'n-hexane, ethanol, and diethylamine' in an isocratic elution mode...
Source: Chirality - November 23, 2023 Category: Molecular Biology Authors: Niroja Vadagam Sharath Babu Haridasyam Muvvala Venkatanarayana Narasimha S Lakka Sanjeeva R Chinnakadoori Source Type: research
Separation and simultaneous estimation of enantiomers and Diastereomers of muscarinic receptor antagonist Solifenacin using stability-indicating Normal-phase HPLC technique with chiral stationary phase amylose tris-(3,5-dimethylphenylcarbamate)
Chirality. 2023 Nov 23. doi: 10.1002/chir.23632. Online ahead of print.ABSTRACTThe R,S-enantiomer impurity and diastereomer impurities (S,S-isomer and R,R-isomer) of the solifenacin (S,R-enantiomer) were effectively separated and quantified simultaneously utilizing normal-phase high-performance liquid chromatography with a chiral stationary phase consisting of amylose tris (3,5-dimethylphenylcarbamate) coated on silica-gel (Chiralpak, AD-H). The enantiomeric and stereo-selective separation was achieved within a run time of 35 minutes using a mobile phase of 'n-hexane, ethanol, and diethylamine' in an isocratic elution mode...
Source: Chirality - November 23, 2023 Category: Molecular Biology Authors: Niroja Vadagam Sharath Babu Haridasyam Muvvala Venkatanarayana Narasimha S Lakka Sanjeeva R Chinnakadoori Source Type: research
