Enantioselective separation and determination of ibuprofen: Stereoselective pharmacokinetics, pharmacodynamics and analytical methods
Chirality. 2024 Feb;36(2):e23647. doi: 10.1002/chir.23647.ABSTRACTIbuprofen (IBP), the 29th most prescribed drug in the United States in 2019, is a widely used nonsteroidal anti-inflammatory drug (NSAID) comprising two enantiomers, (R)-IBP and (S)-IBP, collectively known as (RS)-IBP. This critical review examines analytical techniques for the enantioselective separation and determination of IBP enantiomers, crucial for pharmaceutical and clinical applications. The review focuses on state-of-the-art methods, including chromatographic techniques including high-performance liquid chromatography, gas chromatography, liquid chr...
Source: Chirality - February 15, 2024 Category: Molecular Biology Authors: Vinod Kumar Vashistha Tarun Kumar Suman Yadav Dipak Kumar Das Source Type: research

Enantioselective separation and determination of ibuprofen: Stereoselective pharmacokinetics, pharmacodynamics and analytical methods
Chirality. 2024 Feb;36(2):e23647. doi: 10.1002/chir.23647.ABSTRACTIbuprofen (IBP), the 29th most prescribed drug in the United States in 2019, is a widely used nonsteroidal anti-inflammatory drug (NSAID) comprising two enantiomers, (R)-IBP and (S)-IBP, collectively known as (RS)-IBP. This critical review examines analytical techniques for the enantioselective separation and determination of IBP enantiomers, crucial for pharmaceutical and clinical applications. The review focuses on state-of-the-art methods, including chromatographic techniques including high-performance liquid chromatography, gas chromatography, liquid chr...
Source: Chirality - February 15, 2024 Category: Molecular Biology Authors: Vinod Kumar Vashistha Tarun Kumar Suman Yadav Dipak Kumar Das Source Type: research

Enantioselective separation and determination of ibuprofen: Stereoselective pharmacokinetics, pharmacodynamics and analytical methods
Chirality. 2024 Feb;36(2):e23647. doi: 10.1002/chir.23647.ABSTRACTIbuprofen (IBP), the 29th most prescribed drug in the United States in 2019, is a widely used nonsteroidal anti-inflammatory drug (NSAID) comprising two enantiomers, (R)-IBP and (S)-IBP, collectively known as (RS)-IBP. This critical review examines analytical techniques for the enantioselective separation and determination of IBP enantiomers, crucial for pharmaceutical and clinical applications. The review focuses on state-of-the-art methods, including chromatographic techniques including high-performance liquid chromatography, gas chromatography, liquid chr...
Source: Chirality - February 15, 2024 Category: Molecular Biology Authors: Vinod Kumar Vashistha Tarun Kumar Suman Yadav Dipak Kumar Das Source Type: research

Enantioselective separation and determination of ibuprofen: Stereoselective pharmacokinetics, pharmacodynamics and analytical methods
Chirality. 2024 Feb;36(2):e23647. doi: 10.1002/chir.23647.ABSTRACTIbuprofen (IBP), the 29th most prescribed drug in the United States in 2019, is a widely used nonsteroidal anti-inflammatory drug (NSAID) comprising two enantiomers, (R)-IBP and (S)-IBP, collectively known as (RS)-IBP. This critical review examines analytical techniques for the enantioselective separation and determination of IBP enantiomers, crucial for pharmaceutical and clinical applications. The review focuses on state-of-the-art methods, including chromatographic techniques including high-performance liquid chromatography, gas chromatography, liquid chr...
Source: Chirality - February 15, 2024 Category: Molecular Biology Authors: Vinod Kumar Vashistha Tarun Kumar Suman Yadav Dipak Kumar Das Source Type: research

Enantioselective separation and determination of ibuprofen: Stereoselective pharmacokinetics, pharmacodynamics and analytical methods
Chirality. 2024 Feb;36(2):e23647. doi: 10.1002/chir.23647.ABSTRACTIbuprofen (IBP), the 29th most prescribed drug in the United States in 2019, is a widely used nonsteroidal anti-inflammatory drug (NSAID) comprising two enantiomers, (R)-IBP and (S)-IBP, collectively known as (RS)-IBP. This critical review examines analytical techniques for the enantioselective separation and determination of IBP enantiomers, crucial for pharmaceutical and clinical applications. The review focuses on state-of-the-art methods, including chromatographic techniques including high-performance liquid chromatography, gas chromatography, liquid chr...
Source: Chirality - February 15, 2024 Category: Molecular Biology Authors: Vinod Kumar Vashistha Tarun Kumar Suman Yadav Dipak Kumar Das Source Type: research

Synthesis and absolute configuration of cyclic synthetic cathinones derived from α-tetralone
Chirality. 2024 Feb;36(2):e23646. doi: 10.1002/chir.23646.ABSTRACTThe emergence of new synthetic cathinones continues to be a matter of public health concern. In fact, already known products (drugs) are being rapidly replaced by new structurally related alternatives, whereby modifications in the basic cathinone structure are used by manufacturers to circumvent the legislation. On the other hand, some derivatives of synthetic cathinones represent important pharmaceuticals with antidepressant properties. In the search for pharmaceutically relevant analogs, the main goal of the present study was to design and characterize nov...
Source: Chirality - February 14, 2024 Category: Molecular Biology Authors: Martin Pa škan Krist ýna Dobšíková Martin Kucha ř Vladim ír Setnička Michal Kohout Source Type: research

Preparation of a bis-triazolyl bridged β-cyclodextrin stationary phase and its application for enantioseparation of chiral compounds by HPLC
Chirality. 2024 Feb;36(2):e23644. doi: 10.1002/chir.23644.ABSTRACTA novel bis-triazolyl bridged β-cyclodextrin was first synthesized by the Click reaction between azido-β-cyclodextrin and 1,6-heptadiyne. Then it was bonded onto silica gel to obtain a bis-triazolyl bridged β-cyclodextrin-based chiral stationary phase (BCDP). After structure characterization, the HPLC performance of BCDP was systematically evaluated by using different types of compounds as probes. The results showed that BCDP could well separate 18 kinds of achiral aromatic compounds (homologues, positional isomers, etc.) and 35 kinds of chiral drugs or p...
Source: Chirality - February 14, 2024 Category: Molecular Biology Authors: Qingli Zeng Zhiqin Huang Dan Li Laisheng Li Source Type: research

Resolution of trans-1,2-cyclohexanedicarboxylic acid containing two carboxylic groups by forming diastereomeric salts based on feeding molar ratio control
Chirality. 2023 Dec 6. doi: 10.1002/chir.23634. Online ahead of print.ABSTRACTTo investigate the thermodynamic and molecular self-assembly mechanism of trans-1,2-cyclohexane dicarboxylic acid containing two carboxylic acid groups in the chiral resolution process, (S)-phenylethylamine was used as the chiral resolving agent. Two stoichiometric salts were formed when the raw materials were fed at different molar ratios: cyclohexane dicarboxylate monophenylethylamine salt and cyclohexane dicarboxylate diphenylethylamine salt. When the molar ratio of the (S)-phenylethylamine to trans-1,2-cyclohexane dicarboxylic acid was less t...
Source: Chirality - December 7, 2023 Category: Molecular Biology Authors: Xiaoyu Xin Junjie Zhou Quan He Yangfeng Peng Yongming Wei Hongliang Zhao Tianzhong Tong Source Type: research

Resolution of trans-1,2-cyclohexanedicarboxylic acid containing two carboxylic groups by forming diastereomeric salts based on feeding molar ratio control
Chirality. 2023 Dec 6. doi: 10.1002/chir.23634. Online ahead of print.ABSTRACTTo investigate the thermodynamic and molecular self-assembly mechanism of trans-1,2-cyclohexane dicarboxylic acid containing two carboxylic acid groups in the chiral resolution process, (S)-phenylethylamine was used as the chiral resolving agent. Two stoichiometric salts were formed when the raw materials were fed at different molar ratios: cyclohexane dicarboxylate monophenylethylamine salt and cyclohexane dicarboxylate diphenylethylamine salt. When the molar ratio of the (S)-phenylethylamine to trans-1,2-cyclohexane dicarboxylic acid was less t...
Source: Chirality - December 7, 2023 Category: Molecular Biology Authors: Xiaoyu Xin Junjie Zhou Quan He Yangfeng Peng Yongming Wei Hongliang Zhao Tianzhong Tong Source Type: research

Resolution of trans-1,2-cyclohexanedicarboxylic acid containing two carboxylic groups by forming diastereomeric salts based on feeding molar ratio control
Chirality. 2023 Dec 6. doi: 10.1002/chir.23634. Online ahead of print.ABSTRACTTo investigate the thermodynamic and molecular self-assembly mechanism of trans-1,2-cyclohexane dicarboxylic acid containing two carboxylic acid groups in the chiral resolution process, (S)-phenylethylamine was used as the chiral resolving agent. Two stoichiometric salts were formed when the raw materials were fed at different molar ratios: cyclohexane dicarboxylate monophenylethylamine salt and cyclohexane dicarboxylate diphenylethylamine salt. When the molar ratio of the (S)-phenylethylamine to trans-1,2-cyclohexane dicarboxylic acid was less t...
Source: Chirality - December 7, 2023 Category: Molecular Biology Authors: Xiaoyu Xin Junjie Zhou Quan He Yangfeng Peng Yongming Wei Hongliang Zhao Tianzhong Tong Source Type: research

Resolution of trans-1,2-cyclohexanedicarboxylic acid containing two carboxylic groups by forming diastereomeric salts based on feeding molar ratio control
Chirality. 2023 Dec 6. doi: 10.1002/chir.23634. Online ahead of print.ABSTRACTTo investigate the thermodynamic and molecular self-assembly mechanism of trans-1,2-cyclohexane dicarboxylic acid containing two carboxylic acid groups in the chiral resolution process, (S)-phenylethylamine was used as the chiral resolving agent. Two stoichiometric salts were formed when the raw materials were fed at different molar ratios: cyclohexane dicarboxylate monophenylethylamine salt and cyclohexane dicarboxylate diphenylethylamine salt. When the molar ratio of the (S)-phenylethylamine to trans-1,2-cyclohexane dicarboxylic acid was less t...
Source: Chirality - December 7, 2023 Category: Molecular Biology Authors: Xiaoyu Xin Junjie Zhou Quan He Yangfeng Peng Yongming Wei Hongliang Zhao Tianzhong Tong Source Type: research

Resolution of trans-1,2-cyclohexanedicarboxylic acid containing two carboxylic groups by forming diastereomeric salts based on feeding molar ratio control
Chirality. 2023 Dec 6. doi: 10.1002/chir.23634. Online ahead of print.ABSTRACTTo investigate the thermodynamic and molecular self-assembly mechanism of trans-1,2-cyclohexane dicarboxylic acid containing two carboxylic acid groups in the chiral resolution process, (S)-phenylethylamine was used as the chiral resolving agent. Two stoichiometric salts were formed when the raw materials were fed at different molar ratios: cyclohexane dicarboxylate monophenylethylamine salt and cyclohexane dicarboxylate diphenylethylamine salt. When the molar ratio of the (S)-phenylethylamine to trans-1,2-cyclohexane dicarboxylic acid was less t...
Source: Chirality - December 7, 2023 Category: Molecular Biology Authors: Xiaoyu Xin Junjie Zhou Quan He Yangfeng Peng Yongming Wei Hongliang Zhao Tianzhong Tong Source Type: research

Resolution of trans-1,2-cyclohexanedicarboxylic acid containing two carboxylic groups by forming diastereomeric salts based on feeding molar ratio control
Chirality. 2023 Dec 6. doi: 10.1002/chir.23634. Online ahead of print.ABSTRACTTo investigate the thermodynamic and molecular self-assembly mechanism of trans-1,2-cyclohexane dicarboxylic acid containing two carboxylic acid groups in the chiral resolution process, (S)-phenylethylamine was used as the chiral resolving agent. Two stoichiometric salts were formed when the raw materials were fed at different molar ratios: cyclohexane dicarboxylate monophenylethylamine salt and cyclohexane dicarboxylate diphenylethylamine salt. When the molar ratio of the (S)-phenylethylamine to trans-1,2-cyclohexane dicarboxylic acid was less t...
Source: Chirality - December 7, 2023 Category: Molecular Biology Authors: Xiaoyu Xin Junjie Zhou Quan He Yangfeng Peng Yongming Wei Hongliang Zhao Tianzhong Tong Source Type: research

Resolution of trans-1,2-cyclohexanedicarboxylic acid containing two carboxylic groups by forming diastereomeric salts based on feeding molar ratio control
Chirality. 2023 Dec 6. doi: 10.1002/chir.23634. Online ahead of print.ABSTRACTTo investigate the thermodynamic and molecular self-assembly mechanism of trans-1,2-cyclohexane dicarboxylic acid containing two carboxylic acid groups in the chiral resolution process, (S)-phenylethylamine was used as the chiral resolving agent. Two stoichiometric salts were formed when the raw materials were fed at different molar ratios: cyclohexane dicarboxylate monophenylethylamine salt and cyclohexane dicarboxylate diphenylethylamine salt. When the molar ratio of the (S)-phenylethylamine to trans-1,2-cyclohexane dicarboxylic acid was less t...
Source: Chirality - December 7, 2023 Category: Molecular Biology Authors: Xiaoyu Xin Junjie Zhou Quan He Yangfeng Peng Yongming Wei Hongliang Zhao Tianzhong Tong Source Type: research

Resolution of trans-1,2-cyclohexanedicarboxylic acid containing two carboxylic groups by forming diastereomeric salts based on feeding molar ratio control
Chirality. 2023 Dec 6. doi: 10.1002/chir.23634. Online ahead of print.ABSTRACTTo investigate the thermodynamic and molecular self-assembly mechanism of trans-1,2-cyclohexane dicarboxylic acid containing two carboxylic acid groups in the chiral resolution process, (S)-phenylethylamine was used as the chiral resolving agent. Two stoichiometric salts were formed when the raw materials were fed at different molar ratios: cyclohexane dicarboxylate monophenylethylamine salt and cyclohexane dicarboxylate diphenylethylamine salt. When the molar ratio of the (S)-phenylethylamine to trans-1,2-cyclohexane dicarboxylic acid was less t...
Source: Chirality - December 7, 2023 Category: Molecular Biology Authors: Xiaoyu Xin Junjie Zhou Quan He Yangfeng Peng Yongming Wei Hongliang Zhao Tianzhong Tong Source Type: research