Characterization of Brighton Collaboration criteria for myocarditis and pericarditis following COVID-19 vaccine in Korean adolescents
CONCLUSION: The Brighton Collaboration case definition proved valuable for classifying and assessing AEFI data, enhancing our understanding of the potential relationship between myocarditis and the COVID-19 vaccine.PMID:38604914 | DOI:10.1016/j.vaccine.2024.04.032 (Source: Vaccine)
Source: Vaccine - April 11, 2024 Category: Allergy & Immunology Authors: Jue Seong Lee HyoSug Choi Seung Hwan Shin Myung-Jae Hwang Sara Na Jong Hee Kim Sangshin Park Yoonsun Yoon Hyun Mi Kang Bin Ahn Kyoungsan Seo Young June Choe Source Type: research
Assessment of Risk for Sudden Cardiac Death Among Adolescents and Young Adults After Receipt of COVID-19 Vaccine - Oregon, June 2021-December 2022
MMWR Morb Mortal Wkly Rep. 2024 Apr 11;73(14):317-320. doi: 10.15585/mmwr.mm7314a5.ABSTRACTCOVID-19 vaccination has been associated with myocarditis in adolescents and young adults, and concerns have been raised about possible vaccine-related cardiac fatalities in this age group. In April 2021, cases of myocarditis after COVID-19 vaccination, particularly among young male vaccine recipients, were reported to the Vaccine Adverse Event Reporting System. To assess this possibility, investigators searched death certificates for Oregon residents aged 16-30 years who died during June 2021-December 2022 for cardiac or undetermine...
Source: MMWR Morb Mortal Wkl... - April 11, 2024 Category: Epidemiology Authors: Juventila Liko Paul R Cieslak Source Type: research
Assessment of Risk for Sudden Cardiac Death Among Adolescents and Young Adults After Receipt of COVID-19 Vaccine - Oregon, June 2021-December 2022
MMWR Morb Mortal Wkly Rep. 2024 Apr 11;73(14):317-320. doi: 10.15585/mmwr.mm7314a5.ABSTRACTCOVID-19 vaccination has been associated with myocarditis in adolescents and young adults, and concerns have been raised about possible vaccine-related cardiac fatalities in this age group. In April 2021, cases of myocarditis after COVID-19 vaccination, particularly among young male vaccine recipients, were reported to the Vaccine Adverse Event Reporting System. To assess this possibility, investigators searched death certificates for Oregon residents aged 16-30 years who died during June 2021-December 2022 for cardiac or undetermine...
Source: MMWR Morb Mortal Wkl... - April 11, 2024 Category: Epidemiology Authors: Juventila Liko Paul R Cieslak Source Type: research
Assessment of Risk for Sudden Cardiac Death Among Adolescents and Young Adults After Receipt of COVID-19 Vaccine - Oregon, June 2021-December 2022
MMWR Morb Mortal Wkly Rep. 2024 Apr 11;73(14):317-320. doi: 10.15585/mmwr.mm7314a5.ABSTRACTCOVID-19 vaccination has been associated with myocarditis in adolescents and young adults, and concerns have been raised about possible vaccine-related cardiac fatalities in this age group. In April 2021, cases of myocarditis after COVID-19 vaccination, particularly among young male vaccine recipients, were reported to the Vaccine Adverse Event Reporting System. To assess this possibility, investigators searched death certificates for Oregon residents aged 16-30 years who died during June 2021-December 2022 for cardiac or undetermine...
Source: MMWR Morb Mortal Wkl... - April 11, 2024 Category: Epidemiology Authors: Juventila Liko Paul R Cieslak Source Type: research
Assessment of Risk for Sudden Cardiac Death Among Adolescents and Young Adults After Receipt of COVID-19 Vaccine - Oregon, June 2021-December 2022
MMWR Morb Mortal Wkly Rep. 2024 Apr 11;73(14):317-320. doi: 10.15585/mmwr.mm7314a5.ABSTRACTCOVID-19 vaccination has been associated with myocarditis in adolescents and young adults, and concerns have been raised about possible vaccine-related cardiac fatalities in this age group. In April 2021, cases of myocarditis after COVID-19 vaccination, particularly among young male vaccine recipients, were reported to the Vaccine Adverse Event Reporting System. To assess this possibility, investigators searched death certificates for Oregon residents aged 16-30 years who died during June 2021-December 2022 for cardiac or undetermine...
Source: MMWR Morb Mortal Wkl... - April 11, 2024 Category: Epidemiology Authors: Juventila Liko Paul R Cieslak Source Type: research
Cardiac resident macrophages: The core of cardiac immune homeostasis
Cell Signal. 2024 Apr 8:111169. doi: 10.1016/j.cellsig.2024.111169. Online ahead of print.ABSTRACTCardiac resident macrophages (CRMs) are essential in maintaining the balance of the immune homeostasis in the heart. One of the main factors in the progression of cardiovascular diseases, such as myocarditis, myocardial infarction(MI), and heart failure(HF), is the imbalance in the regulatory mechanisms of CRMs. Recent studies have reported novel heterogeneity and spatiotemporal complexity of CRMs, and their role in maintaining cardiac immune homeostasis and treating cardiovascular diseases. In this review, we focus on the fun...
Source: Cellular Signalling - April 10, 2024 Category: Cytology Authors: Wenhui Cai Lu Lian Aolin Li Qianqian Zhang Mengmeng Li Yingyu Xie Junping Zhang Source Type: research
Sacubitril/Valsartan inhibits M1 type macrophages polarization in acute myocarditis by targeting C-type natriuretic peptide
In conclusion, Sac/Val exerts a protective effect in myocarditis by increasing CNP concentration and inhibiting M1 macrophages polarization.PMID:38581923 | DOI:10.1016/j.biopha.2024.116535 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 6, 2024 Category: Drugs & Pharmacology Authors: Changhu Liu Qi Long Han Yang Hongmin Yang Yaohan Tang Bingjun Liu Zihua Zhou Jing Yuan Source Type: research
CXCL4/CXCR3 axis regulates cardiac fibrosis by activating TGF ‐β1/Smad2/3 signaling in mouse viral myocarditis
ConclusionCXCL4 acts as a profibrotic factor in TGF- β1/Smad2/3 pathway-induced cardiac fibroblast activation and ECM synthesis, and eventually progresses to cardiac fibrosis. Therefore, our findings revealed the role of CXCL4 in VMC and unveiled its underlying mechanism. CXCL4 appears to be a potential target for the treatment of VMC. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - April 5, 2024 Category: Allergy & Immunology Authors: Jing Wei,
Dan ‐feng Wang,
Cong‐cong Cui,
Jia‐jia Tan,
Ming‐yu Peng,
Hong‐xiang Lu Tags: ORIGINAL ARTICLE Source Type: research
A comparison of four self-controlled study designs in an analysis of COVID-19 vaccines and myocarditis using five European databases
CONCLUSIONS: In the context of the known association between COVID-19 vaccines and myocarditis, we have demonstrated that two forms of SCRI and two forms of SCCS led to largely comparable results, possibly because of limited violation of the assumption of event-dependent exposures.PMID:38580517 | DOI:10.1016/j.vaccine.2024.03.043 (Source: Vaccine)
Source: Vaccine - April 5, 2024 Category: Allergy & Immunology Authors: Anna Schultze Ivonne Martin Davide Messina Sophie Bots Svetlana Belitser Juan Jos é Carreras-Martínez Elisa Correcher-Martinez Arantxa Urchuegu ía-Fornes Mar Mart ín-Pérez Patricia Garc ía-Poza Felipe Villalobos Meritxell Pallej à-Millán Carlo Alb Source Type: research
Mid- to long-term cardiac magnetic resonance findings in elite athletes recovered from COVID-19: results from an ongoing observational COVID-19 study at a German Olympic medical centre
CONCLUSION: Our findings suggest that the risk for mid- to long-term myocardial damage is very low to negligible in elite athletes. Our results do not allow conclusions to be drawn regarding myocardial injury in the acute phase of infection nor about possible long-term myocardial effects in the general population.PMID:38579332 | DOI:10.57187/s.3534 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Christopher Schneeweis Katharina Diebold Thomas Schramm Christine Syrek Hans-Georg Predel Robert Manka Jonas Zacher Source Type: research
A comparison of four self-controlled study designs in an analysis of COVID-19 vaccines and myocarditis using five European databases
CONCLUSIONS: In the context of the known association between COVID-19 vaccines and myocarditis, we have demonstrated that two forms of SCRI and two forms of SCCS led to largely comparable results, possibly because of limited violation of the assumption of event-dependent exposures.PMID:38580517 | DOI:10.1016/j.vaccine.2024.03.043 (Source: Vaccine)
Source: Vaccine - April 5, 2024 Category: Allergy & Immunology Authors: Anna Schultze Ivonne Martin Davide Messina Sophie Bots Svetlana Belitser Juan Jos é Carreras-Martínez Elisa Correcher-Martinez Arantxa Urchuegu ía-Fornes Mar Mart ín-Pérez Patricia Garc ía-Poza Felipe Villalobos Meritxell Pallej à-Millán Carlo Alb Source Type: research
Mid- to long-term cardiac magnetic resonance findings in elite athletes recovered from COVID-19: results from an ongoing observational COVID-19 study at a German Olympic medical centre
CONCLUSION: Our findings suggest that the risk for mid- to long-term myocardial damage is very low to negligible in elite athletes. Our results do not allow conclusions to be drawn regarding myocardial injury in the acute phase of infection nor about possible long-term myocardial effects in the general population.PMID:38579332 | DOI:10.57187/s.3534 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Christopher Schneeweis Katharina Diebold Thomas Schramm Christine Syrek Hans-Georg Predel Robert Manka Jonas Zacher Source Type: research
Mid- to long-term cardiac magnetic resonance findings in elite athletes recovered from COVID-19: results from an ongoing observational COVID-19 study at a German Olympic medical centre
CONCLUSION: Our findings suggest that the risk for mid- to long-term myocardial damage is very low to negligible in elite athletes. Our results do not allow conclusions to be drawn regarding myocardial injury in the acute phase of infection nor about possible long-term myocardial effects in the general population.PMID:38579332 | DOI:10.57187/s.3534 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Christopher Schneeweis Katharina Diebold Thomas Schramm Christine Syrek Hans-Georg Predel Robert Manka Jonas Zacher Source Type: research
Promising Potential of Curcumin and Related Compounds for Antiviral Drug Discovery
Med Chem. 2024 Apr 2. doi: 10.2174/0115734064277371240325105016. Online ahead of print.ABSTRACTViruses are acellular, microscopic, and mobile particles containing genetic particles, either DNA/RNA strands as nucleoproteins, responsible for 69,53,743 deaths till the year 2023. Curcumin and related compounds are among the areas of pivotal interest for researchers because of their versatile pharmacological profile. Chemically known as diferuloylmethane, which is a main constituent of turmeric along with demethoxycurcumin and bisdemethoxycurcumin, they have a broad spectrum of antiviral activity against viruses such as human i...
Source: Medicinal Chemistry - April 4, 2024 Category: Chemistry Authors: Archana Sharma Twinkle Sharma Rajveer Bhaskar Monika Ola Alok Sharma Vijay Kumar Thakur Prabodh Chander Sharma Source Type: research
Promising Potential of Curcumin and Related Compounds for Antiviral Drug Discovery
Med Chem. 2024 Apr 2. doi: 10.2174/0115734064277371240325105016. Online ahead of print.ABSTRACTViruses are acellular, microscopic, and mobile particles containing genetic particles, either DNA/RNA strands as nucleoproteins, responsible for 69,53,743 deaths till the year 2023. Curcumin and related compounds are among the areas of pivotal interest for researchers because of their versatile pharmacological profile. Chemically known as diferuloylmethane, which is a main constituent of turmeric along with demethoxycurcumin and bisdemethoxycurcumin, they have a broad spectrum of antiviral activity against viruses such as human i...
Source: Herpes - April 4, 2024 Category: Infectious Diseases Authors: Archana Sharma Twinkle Sharma Rajveer Bhaskar Monika Ola Alok Sharma Vijay Kumar Thakur Prabodh Chander Sharma Source Type: research
