Fatal ventricular arrhythmias in myocarditis: A review of current indications for defibrillator devices
J Cardiol. 2024 Mar 27:S0914-5087(24)00054-6. doi: 10.1016/j.jjcc.2024.03.007. Online ahead of print.ABSTRACTHistorically, patients with myocarditis were considered for implantable cardioverter defibrillator (ICD) utilization only in the chronic phase of the disease following the development of persistent cardiomyopathy refractory to medical therapy or occurrence of a major ventricular arrhythmic event. However, recent literature has indicated that ventricular arrhythmias are frequently reported even in the acute phase of the disease, challenging the long-standing perception that this disease process was largely reversible...
Source: Journal of Cardiology - March 29, 2024 Category: Cardiology Authors: Steven Imburgio Anmol Johal Hira Akhlaq Lauren Klei Anne Marie Arcidiacono Ndausung Udongwo Anton Mararenko Firas Ajam Joseph Heaton Riple Hansalia David Zagha Source Type: research
Fatal ventricular arrhythmias in myocarditis: A review of current indications for defibrillator devices
J Cardiol. 2024 Mar 27:S0914-5087(24)00054-6. doi: 10.1016/j.jjcc.2024.03.007. Online ahead of print.ABSTRACTHistorically, patients with myocarditis were considered for implantable cardioverter defibrillator (ICD) utilization only in the chronic phase of the disease following the development of persistent cardiomyopathy refractory to medical therapy or occurrence of a major ventricular arrhythmic event. However, recent literature has indicated that ventricular arrhythmias are frequently reported even in the acute phase of the disease, challenging the long-standing perception that this disease process was largely reversible...
Source: Journal of Cardiology - March 29, 2024 Category: Cardiology Authors: Steven Imburgio Anmol Johal Hira Akhlaq Lauren Klei Anne Marie Arcidiacono Ndausung Udongwo Anton Mararenko Firas Ajam Joseph Heaton Riple Hansalia David Zagha Source Type: research
Pentraxin 3 in Myocarditis: Proof-of-Principle Assessment as a Diagnostic and Prognostic Biomarker
AbstractPentraxin 3 (PTX3) is an acute phase protein produced in various tissues in response to microbial and sterile stimuli, which regulates the inflammation outcomes. PTX3 has not been investigated in myocarditis. Our aim was to assess circulating and cardiac tissue expression of PTX3 in 55 patients with myocarditis proven by magnetic resonance and/or endomyocardial biopsy. A major proportion of patients with myocarditis displayed significantly increased plasma PTX3 levels as compared with controls (26/30 vs. 0/10), with higher diagnostic yield than conventional biomarkers in the study group. Cardiac tissue analysis rev...
Source: Journal of Cardiovascular Translational Research - March 28, 2024 Category: Cardiology Source Type: research
Case report: Systemic lupus erythematosus combined with myocardial hypertrophy
CONCLUSION: Myocardial hypertrophy may be an important sign of active and prognostic assessment in SLE diagnosis and management. Similarly, when encountering cases of myocardial hypertrophy, the possibility of autoimmune disease should be considered in addition to common causes.PMID:38533913 | DOI:10.1002/iid3.1214 (Source: Atherosclerosis)
Source: Atherosclerosis - March 27, 2024 Category: Cardiology Authors: Shanshan Wang Xinfeng Wei Wenqing Yang Dan Zhang Source Type: research
Acute myocarditis: an overview of pathogenesis, diagnosis and management
Panminerva Med. 2024 Mar 27. doi: 10.23736/S0031-0808.24.05042-0. Online ahead of print.ABSTRACTAcute myocarditis encompasses a diverse presentation of inflammatory cardiomyopathies with infectious and non-infectious triggers. The clinical presentation is heterogeneous, from subtle symptoms like mild chest pain to life-threatening fulminant heart failure requiring urgent advanced hemodynamic support. This review provides a comprehensive overview of the current state of knowledge regarding the pathogenesis, diagnostic approach, management strategies, and directions for future research in acute myocarditis. The pathogenesis ...
Source: Panminerva Medica - March 27, 2024 Category: General Medicine Authors: Marina Zafeiri Kristopher Knott Temi Lampejo Source Type: research
Case report: Systemic lupus erythematosus combined with myocardial hypertrophy
ConclusionMyocardial hypertrophy may be an important sign of active and prognostic assessment in SLE diagnosis and management. Similarly, when encountering cases of myocardial hypertrophy, the possibility of autoimmune disease should be considered in addition to common causes. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 27, 2024 Category: Allergy & Immunology Authors: Shanshan Wang,
Xinfeng Wei,
Wenqing Yang,
Dan Zhang Tags: SHORT REPORT Source Type: research
Asiatic acid and madecassic acid cause cardiotoxicity via inflammation and production of excessive reactive oxygen species in zebrafish
In this study, sample quantification was done using liquid chromatography –tandem mass spectrometry. The cardiotoxicity of Centella total glycosides, asiaticoside, madecassoside, asiatic acid, and madecassic acid was evaluated using zebrafish and cell models. The zebrafish oxidative stress model and myocarditis model were used to explore further the mechanisms through w hich cardiotoxicity is achieved. Asiatic acid and madecassic acid caused zebrafish cardiotoxicity and H9C2 cell death. However, no toxicity effects were observed for asiaticoside and madecassoside in zebrafish, until the solution was saturated. The result...
Source: Journal of Applied Toxicology - March 26, 2024 Category: Toxicology Authors: Qingquan Guo,
Qiuru Li,
Wenyao Liang,
Yudong Zhang,
Chenyang Jiang,
Yihan Zhang,
Jianhua Tan,
Haishan Zhao Tags: RESEARCH ARTICLE Source Type: research
GSE261940 Soluble ST2 induces cardiac contractile dysfunction by repressing mitochondrial electron transport chain genes in cardiomyocytes during fulminant myocarditis
Contributors : Yan Zhuang ; Zhuo Zhang ; Huihui Li ; Kudusi Abuduwufuer ; Donghui Zhang ; Zheng Wen ; Chen Chen ; Dao W WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFulminant myocarditis (FM) is an acute fatal disease characterised by myocardial inflammation. Our previous study identified soluble growth stimulation- expressed gene 2 (sST2) as a sensitive and specific biomarker for early diagnosis of FM. However, its function in FM remains unclear.In the present study, we observed a marked elevation of sST2 in the plasma and hearts of mice with FM induced by coxsackieviru...
Source: GEO: Gene Expression Omnibus - March 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Case Illustration of the Natural History of Left Dominant Arrhythmogenic Cardiomyopathy
Conclusion: Arrhythmogenic cardiomyopathy manifests as a spectrum of disease processes that involve the right, left, or both ventricles. Mutations in the desmoplakin gene are often associated with a left dominant ventricular cardiomyopathy. Diagnosis remains difficult as the condition has no signature clinical presentation, and imaging findings are variable.PMID:38510230 | PMC:PMC10949047 | DOI:10.31486/toj.23.0057 (Source: Ochsner Journal)
Source: Ochsner Journal - March 21, 2024 Category: General Medicine Authors: Corry B Sanford Jerry Fan Yinan Hua Lazaros Nikolaidis Whitney Edmister Sarah Payne Hari Dandapantula Manik Veer Vinh Nguyen Source Type: research
