Case report of scrub typhus complicated by hypokalemia and multiple organ dysfunction syndrome
CONCLUSION: This report highlights the potential for atypical presentations of scrub typhus, including a previously undocumented association with hypokalemia. Although the contribution of hypokalemia to the patient's clinical course remains uncertain, this case underscores the importance of considering electrolyte imbalance in the management of patients with scrub typhus. Further research is warranted to better understand the relationship between scrub typhus and electrolyte imbalance.PMID:38477775 | PMC:PMC10926963 | DOI:10.1590/1516-3180.2023.0142.R1.08122023 (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - March 13, 2024 Category: General Medicine Authors: Li Chen Yi Deng Peiying Huang Sisi Lei Shuling Liu Weitao Lin Zhishang Li Jing Zeng Miaochun Huang Qiuping Huang Qihua Wu Haobo Zhang Bojun Chen Source Type: research
Case report of scrub typhus complicated by hypokalemia and multiple organ dysfunction syndrome
CONCLUSION: This report highlights the potential for atypical presentations of scrub typhus, including a previously undocumented association with hypokalemia. Although the contribution of hypokalemia to the patient's clinical course remains uncertain, this case underscores the importance of considering electrolyte imbalance in the management of patients with scrub typhus. Further research is warranted to better understand the relationship between scrub typhus and electrolyte imbalance.PMID:38477775 | PMC:PMC10926963 | DOI:10.1590/1516-3180.2023.0142.R1.08122023 (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - March 13, 2024 Category: General Medicine Authors: Li Chen Yi Deng Peiying Huang Sisi Lei Shuling Liu Weitao Lin Zhishang Li Jing Zeng Miaochun Huang Qiuping Huang Qihua Wu Haobo Zhang Bojun Chen Source Type: research
Case report of scrub typhus complicated by hypokalemia and multiple organ dysfunction syndrome
CONCLUSION: This report highlights the potential for atypical presentations of scrub typhus, including a previously undocumented association with hypokalemia. Although the contribution of hypokalemia to the patient's clinical course remains uncertain, this case underscores the importance of considering electrolyte imbalance in the management of patients with scrub typhus. Further research is warranted to better understand the relationship between scrub typhus and electrolyte imbalance.PMID:38477775 | PMC:PMC10926963 | DOI:10.1590/1516-3180.2023.0142.R1.08122023 (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - March 13, 2024 Category: General Medicine Authors: Li Chen Yi Deng Peiying Huang Sisi Lei Shuling Liu Weitao Lin Zhishang Li Jing Zeng Miaochun Huang Qiuping Huang Qihua Wu Haobo Zhang Bojun Chen Source Type: research
Analysis of Cytokine Profiles in Pediatric Myocarditis Multicenter Study
This study aims to evaluate the cytokine profiles of acute and fulminant myocarditis in children. Pediatric patients diagnosed with myocarditis were included in the study. Cytokine levels were measured using a multiplexed fluorescent bead-based immunoassay. Statistical analysis was performed to compare patient characteristics and cytokine levels between FM, AM, and healthy control (HC) groups. Principal component analysis (PCA) was applied to cytokine groups that were independent among the FM, AM, and HC groups. The study included 22 patients with FM and 14 with AM patients. We identified four cytokines that were significa...
Source: Pediatric Cardiology - March 13, 2024 Category: Cardiology Source Type: research
Myositis
induced by immune checkpoint inhibitors (ICIs) is an infrequent, potentially fatal, immune-related adverse event. It has higher incidence in patients who receive combination ICI therapy compared to monotherapy. Patients can present with clinical manifestation symptoms of myositis alone or in combination with myocarditis and/or myasthenia gravis, which significantly worsens the course and prognosis. Diagnosis can generally be made on the basis of clinical presentation, elevation of muscle enzymes, and electromyographic changes, but some patients may require a muscle biopsy. The first line of therapy is high-dose corticoste...
Source: Rheumatic Disease Clinics of North America - March 12, 2024 Category: Rheumatology Authors: Athira Jayan, Andrew L. Mammen, Maria E. Suarez-Almazor Source Type: research
Immune Checkpoint Inhibitor-induced Myositis
Myositis induced by immune checkpoint inhibitors (ICIs) is an infrequent, potentially fatal, immune-related adverse event. It has higher incidence in patients who receive combination ICI therapy compared to monotherapy. Patients can present with clinical manifestation symptoms of myositis alone or in combination with myocarditis and/or myasthenia gravis, which significantly worsens the course and prognosis. Diagnosis can generally be made on the basis of clinical presentation, elevation of muscle enzymes, and electromyographic changes, but some patients may require a muscle biopsy. The first line of therapy is high-dose co...
Source: Rheumatic Disease Clinics of North America - March 12, 2024 Category: Rheumatology Authors: Athira Jayan, Andrew L. Mammen, Maria E. Suarez-Almazor Source Type: research
IL-1RA autoantibodies: insights into mechanisms and associated diseases
Am J Transl Res. 2024 Feb 15;16(2):374-386. eCollection 2024.ABSTRACTThe association of neutralizing autoantibodies targeting interleukin-1 receptor antagonist (IL-1RA) with multisystem inflammatory syndrome, IgG4-related disease, and vaccine-related myocarditis is increasingly recognized. The detection of IL-1RA autoantibodies can be notably affected by the techniques and methods employed. Two categories of assays are available: solid-phase immunoassays, which detect binding of IL-1RA autoantibodies, and functional IL-1 signaling reporter cell assays, which offer greater specificity by determining whether circulating auto...
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Abdellatif Bouayad Source Type: research
Yohimbine Treatment Alleviates Cardiac Inflammation/Injury and Improves Cardiac Hemodynamics by Modulating Pro-Inflammatory and Oxidative Stress Indicators
This study emphasizes yohimbine's therapeutic benefit against LPS-induced myocarditis and associated inflammatory markers response by regulating the MAPK pathway.PMID:38466531 | DOI:10.1007/s10753-024-01985-9 (Source: Cell Research)
Source: Cell Research - March 11, 2024 Category: Cytology Authors: Anjali Veeram Taslim B Shaikh Rajwinder Kaur E Abhisheik Chowdary Sai Balaji Andugulapati Ramakrishna Sistla Source Type: research
Markers of Endothelial Dysfunction in Kawasaki Disease: An Update
Clin Rev Allergy Immunol. 2024 Mar 11. doi: 10.1007/s12016-024-08985-5. Online ahead of print.ABSTRACTKawasaki disease (KD) is a medium vessel vasculitis that has a special predilection for coronary arteries. Cardiovascular complications include the development of coronary artery abnormalities (CAAs) and myocarditis. Endothelial dysfunction (ED) is now recognized to be a key component in the pathogenesis of KD and is believed to contribute to the development of CAAs. ED has been evaluated by several clinical parameters. However, there is paucity of literature on laboratory markers for ED in KD. The evaluation of ED can be ...
Source: Atherosclerosis - March 11, 2024 Category: Cardiology Authors: Rajni Kumrah Taru Goyal Amit Rawat Surjit Singh Source Type: research
Role of vaccination in patients with human monkeypox virus and its cardiovascular manifestations
Ann Med Surg (Lond). 2024 Jan 4;86(3):1506-1516. doi: 10.1097/MS9.0000000000001674. eCollection 2024 Mar.ABSTRACTHuman monkeypox, caused by the monkeypox virus (MPXV), is an emerging infectious disease with the potential for human-to-human transmission and diverse clinical presentations. While generally considered milder than smallpox, it can lead to severe cardiovascular complications. The virus primarily spreads through contact with infected animals or through human-to-human transmission. Cardiovascular involvement in human monkeypox is rare but has been associated with myocarditis, pericarditis, arrhythmias, and even fu...
Source: Annals of Medicine - March 11, 2024 Category: Internal Medicine Authors: Khawaja Usama Maqbool Muhammad Talha Akhtar Shayan Ayub Fnu Simran Jahanzeb Malik Maria Malik Rafia Zubair Amin Mehmoodi Source Type: research
IL-1RA autoantibodies: insights into mechanisms and associated diseases
Am J Transl Res. 2024 Feb 15;16(2):374-386. eCollection 2024.ABSTRACTThe association of neutralizing autoantibodies targeting interleukin-1 receptor antagonist (IL-1RA) with multisystem inflammatory syndrome, IgG4-related disease, and vaccine-related myocarditis is increasingly recognized. The detection of IL-1RA autoantibodies can be notably affected by the techniques and methods employed. Two categories of assays are available: solid-phase immunoassays, which detect binding of IL-1RA autoantibodies, and functional IL-1 signaling reporter cell assays, which offer greater specificity by determining whether circulating auto...
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Abdellatif Bouayad Source Type: research
Role of vaccination in patients with human monkeypox virus and its cardiovascular manifestations
Ann Med Surg (Lond). 2024 Jan 4;86(3):1506-1516. doi: 10.1097/MS9.0000000000001674. eCollection 2024 Mar.ABSTRACTHuman monkeypox, caused by the monkeypox virus (MPXV), is an emerging infectious disease with the potential for human-to-human transmission and diverse clinical presentations. While generally considered milder than smallpox, it can lead to severe cardiovascular complications. The virus primarily spreads through contact with infected animals or through human-to-human transmission. Cardiovascular involvement in human monkeypox is rare but has been associated with myocarditis, pericarditis, arrhythmias, and even fu...
Source: Annals of Medicine - March 11, 2024 Category: Internal Medicine Authors: Khawaja Usama Maqbool Muhammad Talha Akhtar Shayan Ayub Fnu Simran Jahanzeb Malik Maria Malik Rafia Zubair Amin Mehmoodi Source Type: research
IL-1RA autoantibodies: insights into mechanisms and associated diseases
Am J Transl Res. 2024 Feb 15;16(2):374-386. eCollection 2024.ABSTRACTThe association of neutralizing autoantibodies targeting interleukin-1 receptor antagonist (IL-1RA) with multisystem inflammatory syndrome, IgG4-related disease, and vaccine-related myocarditis is increasingly recognized. The detection of IL-1RA autoantibodies can be notably affected by the techniques and methods employed. Two categories of assays are available: solid-phase immunoassays, which detect binding of IL-1RA autoantibodies, and functional IL-1 signaling reporter cell assays, which offer greater specificity by determining whether circulating auto...
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Abdellatif Bouayad Source Type: research
