Fatal systemic capillary leak syndrome in a patient with a COVID-19 infection
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3637-24. Online ahead of print.ABSTRACTA 29-year-old Japanese woman was admitted to our hospital with a fever, cardiogenic shock, and cardiac arrest. Laboratory data indicated multiple organ failure in addition to hemoconcentration, hypoalbuminemia, and myocardial damage. The coronary angiography findings were normal, and fulminant myocarditis was suspected. Venoarterial peripheral extracorporeal membrane oxygenation and an Impella CP left ventricular assist device were initiated, along with the administration of positive inotropic agents. However, hypovolemic shock an...
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Hiroaki Kawano Masataka Umeda Tomohiro Honda Ryosuke Iwasaki Shinji Okano Ryohei Akashi Tomohiro Koga Koichi Izumikawa Atsushi Kawakami Koji Maemura Source Type: research
A Rare Case of Overlapping Durvalumab-induced Myositis, Takotsubo-like Morphological Changes Caused by Myocarditis, and Myasthenia Gravis
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3028-23. Online ahead of print.ABSTRACTImmune checkpoint inhibitors can cause a range of immune-related adverse events, including myositis, Takotsubo cardiomyopathy, and myasthenia gravis. We herein report a rare case of a 78-year-old man with concurrent durvalumab-induced myositis, Takotsubo-like morphological changes caused by myocarditis, and myasthenia gravis. The patient initially required invasive ventilation and exhibited symptoms of myasthenia gravis after treatment with high-dose steroids. However, he subsequently achieved successful recovery after the adminis...
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Shoichiro Saito Shigeto Hontsu Junya Hiraoka Ai Yamanaka Nobuhiro Fujioka Daisuke Shimada Yosuke Okuda Kazuma Sugie Shigeo Muro Source Type: research
COVID-19 Vaccination-Related Myocarditis: What We Learned From Our Experience and What We Need to Do in The Future
Korean Circ J. 2024 Apr 1. doi: 10.4070/kcj.2024.0065. Online ahead of print.ABSTRACTCoronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 has led to a global health crisis with substantial mortality and morbidity. To combat the COVID-19 pandemic, various vaccines have been developed, but unexpected serious adverse events including vaccine-induced thrombotic thrombocytopenia, carditis, and thromboembolic events have been reported and became a huddle for COVID-19 vaccination. Vaccine-related myocarditis (VRM) is a rare but significant adverse event associated primarily with mRNA vacci...
Source: Korean Circulation Journal - April 24, 2024 Category: Cardiology Authors: Jae-Hyeong Park Kye Hun Kim Source Type: research
Fatal systemic capillary leak syndrome in a patient with a COVID-19 infection
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3637-24. Online ahead of print.ABSTRACTA 29-year-old Japanese woman was admitted to our hospital with a fever, cardiogenic shock, and cardiac arrest. Laboratory data indicated multiple organ failure in addition to hemoconcentration, hypoalbuminemia, and myocardial damage. The coronary angiography findings were normal, and fulminant myocarditis was suspected. Venoarterial peripheral extracorporeal membrane oxygenation and an Impella CP left ventricular assist device were initiated, along with the administration of positive inotropic agents. However, hypovolemic shock an...
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Hiroaki Kawano Masataka Umeda Tomohiro Honda Ryosuke Iwasaki Shinji Okano Ryohei Akashi Tomohiro Koga Koichi Izumikawa Atsushi Kawakami Koji Maemura Source Type: research
A Rare Case of Overlapping Durvalumab-induced Myositis, Takotsubo-like Morphological Changes Caused by Myocarditis, and Myasthenia Gravis
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3028-23. Online ahead of print.ABSTRACTImmune checkpoint inhibitors can cause a range of immune-related adverse events, including myositis, Takotsubo cardiomyopathy, and myasthenia gravis. We herein report a rare case of a 78-year-old man with concurrent durvalumab-induced myositis, Takotsubo-like morphological changes caused by myocarditis, and myasthenia gravis. The patient initially required invasive ventilation and exhibited symptoms of myasthenia gravis after treatment with high-dose steroids. However, he subsequently achieved successful recovery after the adminis...
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Shoichiro Saito Shigeto Hontsu Junya Hiraoka Ai Yamanaka Nobuhiro Fujioka Daisuke Shimada Yosuke Okuda Kazuma Sugie Shigeo Muro Source Type: research
COVID-19 Vaccination-Related Myocarditis: What We Learned From Our Experience and What We Need to Do in The Future
Korean Circ J. 2024 Apr 1. doi: 10.4070/kcj.2024.0065. Online ahead of print.ABSTRACTCoronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 has led to a global health crisis with substantial mortality and morbidity. To combat the COVID-19 pandemic, various vaccines have been developed, but unexpected serious adverse events including vaccine-induced thrombotic thrombocytopenia, carditis, and thromboembolic events have been reported and became a huddle for COVID-19 vaccination. Vaccine-related myocarditis (VRM) is a rare but significant adverse event associated primarily with mRNA vacci...
Source: Korean Circulation Journal - April 24, 2024 Category: Cardiology Authors: Jae-Hyeong Park Kye Hun Kim Source Type: research
A Rare Case of Overlapping Durvalumab-induced Myositis, Takotsubo-like Morphological Changes Caused by Myocarditis, and Myasthenia Gravis
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3028-23. Online ahead of print.ABSTRACTImmune checkpoint inhibitors can cause a range of immune-related adverse events, including myositis, Takotsubo cardiomyopathy, and myasthenia gravis. We herein report a rare case of a 78-year-old man with concurrent durvalumab-induced myositis, Takotsubo-like morphological changes caused by myocarditis, and myasthenia gravis. The patient initially required invasive ventilation and exhibited symptoms of myasthenia gravis after treatment with high-dose steroids. However, he subsequently achieved successful recovery after the adminis...
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Shoichiro Saito Shigeto Hontsu Junya Hiraoka Ai Yamanaka Nobuhiro Fujioka Daisuke Shimada Yosuke Okuda Kazuma Sugie Shigeo Muro Source Type: research
Fatal systemic capillary leak syndrome in a patient with a COVID-19 infection
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3637-24. Online ahead of print.ABSTRACTA 29-year-old Japanese woman was admitted to our hospital with a fever, cardiogenic shock, and cardiac arrest. Laboratory data indicated multiple organ failure in addition to hemoconcentration, hypoalbuminemia, and myocardial damage. The coronary angiography findings were normal, and fulminant myocarditis was suspected. Venoarterial peripheral extracorporeal membrane oxygenation and an Impella CP left ventricular assist device were initiated, along with the administration of positive inotropic agents. However, hypovolemic shock an...
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Hiroaki Kawano Masataka Umeda Tomohiro Honda Ryosuke Iwasaki Shinji Okano Ryohei Akashi Tomohiro Koga Koichi Izumikawa Atsushi Kawakami Koji Maemura Source Type: research
COVID-19 Vaccination-Related Myocarditis: What We Learned From Our Experience and What We Need to Do in The Future
Korean Circ J. 2024 Apr 1. doi: 10.4070/kcj.2024.0065. Online ahead of print.ABSTRACTCoronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 has led to a global health crisis with substantial mortality and morbidity. To combat the COVID-19 pandemic, various vaccines have been developed, but unexpected serious adverse events including vaccine-induced thrombotic thrombocytopenia, carditis, and thromboembolic events have been reported and became a huddle for COVID-19 vaccination. Vaccine-related myocarditis (VRM) is a rare but significant adverse event associated primarily with mRNA vacci...
Source: Korean Circulation Journal - April 24, 2024 Category: Cardiology Authors: Jae-Hyeong Park Kye Hun Kim Source Type: research
Fatal systemic capillary leak syndrome in a patient with a COVID-19 infection
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3637-24. Online ahead of print.ABSTRACTA 29-year-old Japanese woman was admitted to our hospital with a fever, cardiogenic shock, and cardiac arrest. Laboratory data indicated multiple organ failure in addition to hemoconcentration, hypoalbuminemia, and myocardial damage. The coronary angiography findings were normal, and fulminant myocarditis was suspected. Venoarterial peripheral extracorporeal membrane oxygenation and an Impella CP left ventricular assist device were initiated, along with the administration of positive inotropic agents. However, hypovolemic shock an...
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Hiroaki Kawano Masataka Umeda Tomohiro Honda Ryosuke Iwasaki Shinji Okano Ryohei Akashi Tomohiro Koga Koichi Izumikawa Atsushi Kawakami Koji Maemura Source Type: research
A Rare Case of Overlapping Durvalumab-induced Myositis, Takotsubo-like Morphological Changes Caused by Myocarditis, and Myasthenia Gravis
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3028-23. Online ahead of print.ABSTRACTImmune checkpoint inhibitors can cause a range of immune-related adverse events, including myositis, Takotsubo cardiomyopathy, and myasthenia gravis. We herein report a rare case of a 78-year-old man with concurrent durvalumab-induced myositis, Takotsubo-like morphological changes caused by myocarditis, and myasthenia gravis. The patient initially required invasive ventilation and exhibited symptoms of myasthenia gravis after treatment with high-dose steroids. However, he subsequently achieved successful recovery after the adminis...
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Shoichiro Saito Shigeto Hontsu Junya Hiraoka Ai Yamanaka Nobuhiro Fujioka Daisuke Shimada Yosuke Okuda Kazuma Sugie Shigeo Muro Source Type: research
COVID-19 Vaccination-Related Myocarditis: What We Learned From Our Experience and What We Need to Do in The Future
Korean Circ J. 2024 Apr 1. doi: 10.4070/kcj.2024.0065. Online ahead of print.ABSTRACTCoronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 has led to a global health crisis with substantial mortality and morbidity. To combat the COVID-19 pandemic, various vaccines have been developed, but unexpected serious adverse events including vaccine-induced thrombotic thrombocytopenia, carditis, and thromboembolic events have been reported and became a huddle for COVID-19 vaccination. Vaccine-related myocarditis (VRM) is a rare but significant adverse event associated primarily with mRNA vacci...
Source: Korean Circulation Journal - April 24, 2024 Category: Cardiology Authors: Jae-Hyeong Park Kye Hun Kim Source Type: research
Pfizer COVID19 vaccine is not associated with acute cardiovascular events excluding myocarditis – a national self-controlled case series study
ConclusionsThere was no increased risk for acute cardiovascular events (excluding myocarditis) in the risk period compared to the control period following administration of the second dose of Pfizer COVID19 vaccine. Mortality data raised no concerns either, but may have been biased. (Source: Israel Journal of Health Policy Research)
Source: Israel Journal of Health Policy Research - April 24, 2024 Category: International Medicine & Public Health Source Type: research
Research advances on molecular mechanism and natural product therapy of iron metabolism in heart failure
AbstractThe progression of heart failure (HF) is complex and involves multiple regulatory pathways. Iron ions play a crucial supportive role as a cofactor for important proteins such as hemoglobin, myoglobin, oxidative respiratory chain, and DNA synthetase, in the myocardial energy metabolism process. In recent years, numerous studies have shown that HF is associated with iron dysmetabolism, and deficiencies in iron and overload of iron can both lead to the development of various myocarditis diseases, which ultimately progress to HF. Iron toxicity and iron metabolism may be key targets for the diagnosis, treatment, and pre...
Source: European Journal of Medical Research - April 24, 2024 Category: Research Source Type: research
NASCI case of the month: desmoplakin cardiomyopathy masquerading as acute myocarditis
We present a case of a young patient with chest pain. Labs and cardiac imaging were suspicious for acute myocarditis. Genetic testing revealed a diagnosis of desmoplakin cardiomyopathy. Desmoplakin cardiomyopathy may be considered in patients with recurrent acute myocarditis or a family history of cardiac disease to avoid the potential for misdiagnosis. (Source: The International Journal of Cardiovascular Imaging)
Source: The International Journal of Cardiovascular Imaging - April 23, 2024 Category: Radiology Source Type: research
