IL-1RA autoantibodies: insights into mechanisms and associated diseases
Am J Transl Res. 2024 Feb 15;16(2):374-386. doi: 10.62347/NTVU5728. eCollection 2024.ABSTRACTThe association of neutralizing autoantibodies targeting interleukin-1 receptor antagonist (IL-1RA) with multisystem inflammatory syndrome, IgG4-related disease, and vaccine-related myocarditis is increasingly recognized. The detection of IL-1RA autoantibodies can be notably affected by the techniques and methods employed. Two categories of assays are available: solid-phase immunoassays, which detect binding of IL-1RA autoantibodies, and functional IL-1 signaling reporter cell assays, which offer greater specificity by determining ...
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Abdellatif Bouayad Source Type: research
