Promising Potential of Curcumin and Related Compounds for Antiviral Drug Discovery
Med Chem. 2024 Apr 2. doi: 10.2174/0115734064277371240325105016. Online ahead of print.ABSTRACTViruses are acellular, microscopic, and mobile particles containing genetic particles, either DNA/RNA strands as nucleoproteins, responsible for 69,53,743 deaths till the year 2023. Curcumin and related compounds are among the areas of pivotal interest for researchers because of their versatile pharmacological profile. Chemically known as diferuloylmethane, which is a main constituent of turmeric along with demethoxycurcumin and bisdemethoxycurcumin, they have a broad spectrum of antiviral activity against viruses such as human i...
Source: Medicinal Chemistry - April 4, 2024 Category: Chemistry Authors: Archana Sharma Twinkle Sharma Rajveer Bhaskar Monika Ola Alok Sharma Vijay Kumar Thakur Prabodh Chander Sharma Source Type: research
Promising Potential of Curcumin and Related Compounds for Antiviral Drug Discovery
Med Chem. 2024 Apr 2. doi: 10.2174/0115734064277371240325105016. Online ahead of print.ABSTRACTViruses are acellular, microscopic, and mobile particles containing genetic particles, either DNA/RNA strands as nucleoproteins, responsible for 69,53,743 deaths till the year 2023. Curcumin and related compounds are among the areas of pivotal interest for researchers because of their versatile pharmacological profile. Chemically known as diferuloylmethane, which is a main constituent of turmeric along with demethoxycurcumin and bisdemethoxycurcumin, they have a broad spectrum of antiviral activity against viruses such as human i...
Source: Medicinal Chemistry - April 4, 2024 Category: Chemistry Authors: Archana Sharma Twinkle Sharma Rajveer Bhaskar Monika Ola Alok Sharma Vijay Kumar Thakur Prabodh Chander Sharma Source Type: research
Promising Potential of Curcumin and Related Compounds for Antiviral Drug Discovery
Med Chem. 2024 Apr 2. doi: 10.2174/0115734064277371240325105016. Online ahead of print.ABSTRACTViruses are acellular, microscopic, and mobile particles containing genetic particles, either DNA/RNA strands as nucleoproteins, responsible for 69,53,743 deaths till the year 2023. Curcumin and related compounds are among the areas of pivotal interest for researchers because of their versatile pharmacological profile. Chemically known as diferuloylmethane, which is a main constituent of turmeric along with demethoxycurcumin and bisdemethoxycurcumin, they have a broad spectrum of antiviral activity against viruses such as human i...
Source: Medicinal Chemistry - April 4, 2024 Category: Chemistry Authors: Archana Sharma Twinkle Sharma Rajveer Bhaskar Monika Ola Alok Sharma Vijay Kumar Thakur Prabodh Chander Sharma Source Type: research
Mapping the interplay of immunoproteasome and autophagy in different heart failure phenotypes
Free Radic Biol Med. 2024 Apr 1:S0891-5849(24)00163-1. doi: 10.1016/j.freeradbiomed.2024.03.026. Online ahead of print.ABSTRACTProper protein degradation is required for cellular protein homeostasis and organ function. Particularly, in post-mitotic cells, such as cardiomyocytes, unbalanced proteolysis due to inflammatory stimuli and oxidative stress contributes to organ dysfunction. To ensure appropriate protein turnover, eukaryotic cells exert two main degradation systems, the ubiquitin-proteasome-system and the autophagy-lysosome-pathway. It has been shown that proteasome activity affects the development of cardiac dysfu...
Source: Free Radical Biology and Medicine - April 3, 2024 Category: Biology Authors: Christiane Ott Source Type: research
Mapping the interplay of immunoproteasome and autophagy in different heart failure phenotypes
Free Radic Biol Med. 2024 Apr 1:S0891-5849(24)00163-1. doi: 10.1016/j.freeradbiomed.2024.03.026. Online ahead of print.ABSTRACTProper protein degradation is required for cellular protein homeostasis and organ function. Particularly, in post-mitotic cells, such as cardiomyocytes, unbalanced proteolysis due to inflammatory stimuli and oxidative stress contributes to organ dysfunction. To ensure appropriate protein turnover, eukaryotic cells exert two main degradation systems, the ubiquitin-proteasome-system and the autophagy-lysosome-pathway. It has been shown that proteasome activity affects the development of cardiac dysfu...
Source: Free Radical Biology and Medicine - April 3, 2024 Category: Biology Authors: Christiane Ott Source Type: research
Artificial intelligence-enhanced risk stratification of cancer therapeutics-related cardiac dysfunction using electrocardiographic images
CONCLUSION: AI applied to baseline ECG images can stratify the risk of CTRCD associated with anthracycline or trastuzumab exposure.CONDENSED ABSTRACT: There is an unmet need for scalable and affordable biomarkers to stratify the risk of cancer therapeutics-related cardiac dysfunction (CTRCD). In this hospital system-based, decade-long cohort of patients without cardiomyopathy receiving anthracyclines or trastuzumab, a validated artificial intelligence algorithm applied to baseline electrocardiographic (AI-ECG) images identified individuals with a 2-fold and 4.8-fold risk of developing any cardiomyopathy or left ventricular...
Source: Cancer Control - April 2, 2024 Category: Cancer & Oncology Authors: Evangelos K Oikonomou Veer Sangha Lovedeep S Dhingra Arya Aminorroaya Andreas Coppi Harlan M Krumholz Lauren A Baldassarre Rohan Khera Source Type: research
Letter to the Editor: Myocarditis Associated With SARS-CoV-2 Vaccination Diagnosed by Cardiac MRI Requires Confirmation by Endomyocardial Biopsy
J Korean Med Sci. 2024 Apr 1;39(12):e124. doi: 10.3346/jkms.2024.39.e124.NO ABSTRACTPMID:38565180 | DOI:10.3346/jkms.2024.39.e124 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - April 2, 2024 Category: Biomedical Science Authors: Josef Finsterer Sounira Mehri Source Type: research
Letter to the Editor: Myocarditis Associated With SARS-CoV-2 Vaccination Diagnosed by Cardiac MRI Requires Confirmation by Endomyocardial Biopsy
J Korean Med Sci. 2024 Apr 1;39(12):e124. doi: 10.3346/jkms.2024.39.e124.NO ABSTRACTPMID:38565180 | DOI:10.3346/jkms.2024.39.e124 (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 2, 2024 Category: General Medicine Authors: Josef Finsterer Sounira Mehri Source Type: research
Letter to the Editor: Myocarditis Associated With SARS-CoV-2 Vaccination Diagnosed by Cardiac MRI Requires Confirmation by Endomyocardial Biopsy
J Korean Med Sci. 2024 Apr 1;39(12):e124. doi: 10.3346/jkms.2024.39.e124.NO ABSTRACTPMID:38565180 | DOI:10.3346/jkms.2024.39.e124 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - April 2, 2024 Category: Biomedical Science Authors: Josef Finsterer Sounira Mehri Source Type: research
Letter to the Editor: Myocarditis Associated With SARS-CoV-2 Vaccination Diagnosed by Cardiac MRI Requires Confirmation by Endomyocardial Biopsy
J Korean Med Sci. 2024 Apr 1;39(12):e124. doi: 10.3346/jkms.2024.39.e124.NO ABSTRACTPMID:38565180 | PMC:PMC10985500 | DOI:10.3346/jkms.2024.39.e124 (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 2, 2024 Category: General Medicine Authors: Josef Finsterer Sounira Mehri Source Type: research
Letter to the Editor: Myocarditis Associated With SARS-CoV-2 Vaccination Diagnosed by Cardiac MRI Requires Confirmation by Endomyocardial Biopsy
J Korean Med Sci. 2024 Apr 1;39(12):e124. doi: 10.3346/jkms.2024.39.e124.NO ABSTRACTPMID:38565180 | PMC:PMC10985500 | DOI:10.3346/jkms.2024.39.e124 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - April 2, 2024 Category: Biomedical Science Authors: Josef Finsterer Sounira Mehri Source Type: research
Letter to the Editor: Myocarditis Associated With SARS-CoV-2 Vaccination Diagnosed by Cardiac MRI Requires Confirmation by Endomyocardial Biopsy
J Korean Med Sci. 2024 Apr 1;39(12):e124. doi: 10.3346/jkms.2024.39.e124.NO ABSTRACTPMID:38565180 | PMC:PMC10985500 | DOI:10.3346/jkms.2024.39.e124 (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 2, 2024 Category: General Medicine Authors: Josef Finsterer Sounira Mehri Source Type: research
Letter to the Editor: Myocarditis Associated With SARS-CoV-2 Vaccination Diagnosed by Cardiac MRI Requires Confirmation by Endomyocardial Biopsy
J Korean Med Sci. 2024 Apr 1;39(12):e124. doi: 10.3346/jkms.2024.39.e124.NO ABSTRACTPMID:38565180 | PMC:PMC10985500 | DOI:10.3346/jkms.2024.39.e124 (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 2, 2024 Category: General Medicine Authors: Josef Finsterer Sounira Mehri Source Type: research
Letter to the Editor: Myocarditis Associated With SARS-CoV-2 Vaccination Diagnosed by Cardiac MRI Requires Confirmation by Endomyocardial Biopsy
J Korean Med Sci. 2024 Apr 1;39(12):e124. doi: 10.3346/jkms.2024.39.e124.NO ABSTRACTPMID:38565180 | PMC:PMC10985500 | DOI:10.3346/jkms.2024.39.e124 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - April 2, 2024 Category: Biomedical Science Authors: Josef Finsterer Sounira Mehri Source Type: research
Letter to the Editor: Myocarditis Associated With SARS-CoV-2 Vaccination Diagnosed by Cardiac MRI Requires Confirmation by Endomyocardial Biopsy
J Korean Med Sci. 2024 Apr 1;39(12):e124. doi: 10.3346/jkms.2024.39.e124.NO ABSTRACTPMID:38565180 | PMC:PMC10985500 | DOI:10.3346/jkms.2024.39.e124 (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 2, 2024 Category: General Medicine Authors: Josef Finsterer Sounira Mehri Source Type: research
