Chlamydia psittaci-related pleuro-myocarditis
Braz J Infect Dis. 2024 Apr 25:103739. doi: 10.1016/j.bjid.2024.103739. Online ahead of print.ABSTRACTChlamydia psittaci ‒ related community-acquired pneumonia associated to acute myocarditis was diagnosed in a young man with no medical history, and a professional exposition to birds. The diagnosis was confirmed with positive specific polymerase chain reaction in bronchoalveolar lavage. The patient was treated with spiramycin for two weeks with anti-inflammatory treatment for myocarditis for three months. Clinical and biological improvement was rapidly observed followed by normalization of electrocardiogram and chest CT ...
Source: Braz J Infect Dis - April 28, 2024 Category: Infectious Diseases Authors: Nour Sreiri Yousri Ben Abdallah Nabil Belfeki Timoth ée Klopfenstein Souheil Zayet Source Type: research
Severe acute myositis and myocarditis on initiation of 6-weekly pembrolizumab post-COVID-19 mRNA vaccination
In conclusion, we report a series of unusually severe myositis and myocarditis following PD-1 blockade and the COVID-19 mRNA vaccination.PMID:38663935 | DOI:10.1136/jitc-2023-008151 (Source: Cancer Control)
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Robert A Watson Weiyu Ye Chelsea A Taylor Elsita Jungkurth Rosalin Cooper Orion Tong Tim James Brian Shine Monika Hofer Damian Jenkins Robert Pell Eleni Ieremia Stephanie Jones David Maldonado-Perez Ian S D Roberts Nicholas Coupe Mark R Middleton Miranda Source Type: research
Viruses, Vol. 16, Pages 677: Caboxamycin Inhibits Heart Inflammation in a Coxsackievirus B3-Induced Myocarditis Mouse Model
ang-Jip Nam
Coxsackievirus B3 (CVB3) is a positive single-strand RNA genome virus which belongs to the enterovirus genus in the picornavirus family, like poliovirus. It is one of the most prevalent pathogens that cause myocarditis and pancreatitis in humans. However, a suitable therapeutic medication and vaccination have yet to be discovered. Caboxamycin, a benzoxazole antibiotic isolated from the culture broth of the marine strain Streptomyces sp., SC0774, showed an antiviral effect in CVB3-infected HeLa cells and a CVB3-induced myocarditis mouse model. Caboxamycin substantially decreased CVB3 VP1 production and cleav...
Source: Viruses - April 25, 2024 Category: Virology Authors: Hong-Gi Kim Prima F. Hillman You-Jeung Lee Ha-Eun Jeon Byung-Kwan Lim Sang-Jip Nam Tags: Article Source Type: research
Efficacy and safety of colchicine for the treatment of myopericarditis
Conclusion
In patients with first attack of pericarditis associated with myocardial involvement, colchicine was safe and efficacious for the reduction of recurrences. (Source: Heart)
Source: Heart - April 25, 2024 Category: Cardiology Authors: Collini, V., De Martino, M., Andreis, A., De Biasio, M., Gaspard, F., Paneva, E., Tomat, M., Deferrari, G. M., Isola, M., Imazio, M. Tags: Open access, Editor's choice Special populations Source Type: research
Eosinophilic myocarditis: systematic review
Conclusion
EMB is the mainstay for diagnostic testing for EM. CMR is potentially helpful for screening in appropriate clinical scenarios. Regarding treatment, there is no consensus regarding the optimal dosage of corticosteroids. Large clinical trials are warranted to further explore the utility of CMR in the diagnosis of EM and steroid regimen in treating EM. (Source: Heart)
Source: Heart - April 25, 2024 Category: Cardiology Authors: Techasatian, W., Gozun, M., Vo, K., Yokoyama, J., Nagamine, T., Shah, P., Vu, K., Zhang, J., Nishimura, Y. Tags: Systematic review Source Type: research
CXCL4:NLRP3-mediated pyroptosis product that regulates cardiac fibrosis
In this study, we induced Viral myocarditis (VMC) via infection of CVB3 to explore the relationship between pyroptosis and fibrosis. Our results showed that intraperitoneal injection of an NLRP3 inhibitor MCC950 or use of NLRP3-/- mice inhibited cardiac pyroptosis mediated by NLRP3 inflammasome in VMC. CXCL4 is a chemokine that has been reported to have pro-inflammatory and pro-fibrotic functions. In VMC, we further found that pyroptosis of Mouse myocardial fibroblasts (MCF) promoted the secretion of CXCL4 by activating Wnt/β-Catenin signaling. Subsequently, the transcriptome sequencing data showed that CXCL4 could promot...
Source: International Immunopharmacology - April 24, 2024 Category: Allergy & Immunology Authors: Jing Wei Ming Yu Peng Sai Nan Wang Hong Xiang Lu Source Type: research
COVID-19 Vaccination-Related Myocarditis: What We Learned From Our Experience and What We Need to Do in The Future
Korean Circ J. 2024 Apr 1. doi: 10.4070/kcj.2024.0065. Online ahead of print.ABSTRACTCoronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 has led to a global health crisis with substantial mortality and morbidity. To combat the COVID-19 pandemic, various vaccines have been developed, but unexpected serious adverse events including vaccine-induced thrombotic thrombocytopenia, carditis, and thromboembolic events have been reported and became a huddle for COVID-19 vaccination. Vaccine-related myocarditis (VRM) is a rare but significant adverse event associated primarily with mRNA vacci...
Source: Korean Circulation Journal - April 24, 2024 Category: Cardiology Authors: Jae-Hyeong Park Kye Hun Kim Source Type: research
Magnetic Resonance Imaging of Cardiac Involvement in COVID-19
Br J Radiol. 2024 Apr 24:tqae086. doi: 10.1093/bjr/tqae086. Online ahead of print.ABSTRACTThe COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to a diverse pattern of myocardial injuries, including myocarditis, which is linked to adverse outcomes in patients. Research indicates that myocardial injury is associated with higher mortality in hospitalized severe COVID-19 patients (75.8% versus 9.7%). Cardiovascular Magnetic Resonance (CMR) has emerged as a crucial tool in diagnosing both ischemic and non-ischemic myocardial injuries, providing detailed insights into the impact of COVID-19 on myocardial tissue and fun...
Source: The British Journal of Radiology - April 24, 2024 Category: Radiology Authors: Moezedin Javad Rafiee Matthias G Friedrich Source Type: research
Fatal systemic capillary leak syndrome in a patient with a COVID-19 infection
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3637-24. Online ahead of print.ABSTRACTA 29-year-old Japanese woman was admitted to our hospital with a fever, cardiogenic shock, and cardiac arrest. Laboratory data indicated multiple organ failure in addition to hemoconcentration, hypoalbuminemia, and myocardial damage. The coronary angiography findings were normal, and fulminant myocarditis was suspected. Venoarterial peripheral extracorporeal membrane oxygenation and an Impella CP left ventricular assist device were initiated, along with the administration of positive inotropic agents. However, hypovolemic shock an...
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Hiroaki Kawano Masataka Umeda Tomohiro Honda Ryosuke Iwasaki Shinji Okano Ryohei Akashi Tomohiro Koga Koichi Izumikawa Atsushi Kawakami Koji Maemura Source Type: research
A Rare Case of Overlapping Durvalumab-induced Myositis, Takotsubo-like Morphological Changes Caused by Myocarditis, and Myasthenia Gravis
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3028-23. Online ahead of print.ABSTRACTImmune checkpoint inhibitors can cause a range of immune-related adverse events, including myositis, Takotsubo cardiomyopathy, and myasthenia gravis. We herein report a rare case of a 78-year-old man with concurrent durvalumab-induced myositis, Takotsubo-like morphological changes caused by myocarditis, and myasthenia gravis. The patient initially required invasive ventilation and exhibited symptoms of myasthenia gravis after treatment with high-dose steroids. However, he subsequently achieved successful recovery after the adminis...
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Shoichiro Saito Shigeto Hontsu Junya Hiraoka Ai Yamanaka Nobuhiro Fujioka Daisuke Shimada Yosuke Okuda Kazuma Sugie Shigeo Muro Source Type: research
COVID-19 Vaccination-Related Myocarditis: What We Learned From Our Experience and What We Need to Do in The Future
Korean Circ J. 2024 Apr 1. doi: 10.4070/kcj.2024.0065. Online ahead of print.ABSTRACTCoronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 has led to a global health crisis with substantial mortality and morbidity. To combat the COVID-19 pandemic, various vaccines have been developed, but unexpected serious adverse events including vaccine-induced thrombotic thrombocytopenia, carditis, and thromboembolic events have been reported and became a huddle for COVID-19 vaccination. Vaccine-related myocarditis (VRM) is a rare but significant adverse event associated primarily with mRNA vacci...
Source: Korean Circulation Journal - April 24, 2024 Category: Cardiology Authors: Jae-Hyeong Park Kye Hun Kim Source Type: research
CXCL4:NLRP3-mediated pyroptosis product that regulates cardiac fibrosis
In this study, we induced Viral myocarditis (VMC) via infection of CVB3 to explore the relationship between pyroptosis and fibrosis. Our results showed that intraperitoneal injection of an NLRP3 inhibitor MCC950 or use of NLRP3-/- mice inhibited cardiac pyroptosis mediated by NLRP3 inflammasome in VMC. CXCL4 is a chemokine that has been reported to have pro-inflammatory and pro-fibrotic functions. In VMC, we further found that pyroptosis of Mouse myocardial fibroblasts (MCF) promoted the secretion of CXCL4 by activating Wnt/β-Catenin signaling. Subsequently, the transcriptome sequencing data showed that CXCL4 could promot...
Source: International Immunopharmacology - April 24, 2024 Category: Allergy & Immunology Authors: Jing Wei Ming Yu Peng Sai Nan Wang Hong Xiang Lu Source Type: research
Magnetic Resonance Imaging of Cardiac Involvement in COVID-19
Br J Radiol. 2024 Apr 24:tqae086. doi: 10.1093/bjr/tqae086. Online ahead of print.ABSTRACTThe COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to a diverse pattern of myocardial injuries, including myocarditis, which is linked to adverse outcomes in patients. Research indicates that myocardial injury is associated with higher mortality in hospitalized severe COVID-19 patients (75.8% versus 9.7%). Cardiovascular Magnetic Resonance (CMR) has emerged as a crucial tool in diagnosing both ischemic and non-ischemic myocardial injuries, providing detailed insights into the impact of COVID-19 on myocardial tissue and fun...
Source: The British Journal of Radiology - April 24, 2024 Category: Radiology Authors: Moezedin Javad Rafiee Matthias G Friedrich Source Type: research
A Rare Case of Overlapping Durvalumab-induced Myositis, Takotsubo-like Morphological Changes Caused by Myocarditis, and Myasthenia Gravis
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3028-23. Online ahead of print.ABSTRACTImmune checkpoint inhibitors can cause a range of immune-related adverse events, including myositis, Takotsubo cardiomyopathy, and myasthenia gravis. We herein report a rare case of a 78-year-old man with concurrent durvalumab-induced myositis, Takotsubo-like morphological changes caused by myocarditis, and myasthenia gravis. The patient initially required invasive ventilation and exhibited symptoms of myasthenia gravis after treatment with high-dose steroids. However, he subsequently achieved successful recovery after the adminis...
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Shoichiro Saito Shigeto Hontsu Junya Hiraoka Ai Yamanaka Nobuhiro Fujioka Daisuke Shimada Yosuke Okuda Kazuma Sugie Shigeo Muro Source Type: research
Fatal systemic capillary leak syndrome in a patient with a COVID-19 infection
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3637-24. Online ahead of print.ABSTRACTA 29-year-old Japanese woman was admitted to our hospital with a fever, cardiogenic shock, and cardiac arrest. Laboratory data indicated multiple organ failure in addition to hemoconcentration, hypoalbuminemia, and myocardial damage. The coronary angiography findings were normal, and fulminant myocarditis was suspected. Venoarterial peripheral extracorporeal membrane oxygenation and an Impella CP left ventricular assist device were initiated, along with the administration of positive inotropic agents. However, hypovolemic shock an...
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Hiroaki Kawano Masataka Umeda Tomohiro Honda Ryosuke Iwasaki Shinji Okano Ryohei Akashi Tomohiro Koga Koichi Izumikawa Atsushi Kawakami Koji Maemura Source Type: research
