Role of CCRL2 in the Pathogenesis of Experimental Autoimmune Myocarditis via P21-Activated Kinase 1/NOD-Like Receptor Protein 3 Pathway
This study aims to elucidate the effect of Chemokine (C C motif) receptor-like 2 (CCRL2) in experimental autoimmune myocarditis (EAM) occurrence and its potential regulatory mechanisms.EAM was simulated in a mouse model injected with α-myosin-heavy chain. The changes on EAM were assessed through histological staining of heart tissues, including measuring cardiac troponin I (cTnI), proinflammatory cytokines, transferase-mediated dUTP nick end labeling (TUNEL) assay, and cardiac function. Then, the heart tissues from the EAM mouse model and control groups were analyzed through transcriptome sequencing to identify the differ...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Lin Chen Jing Meng Jia Zheng Tingting Zhao Qi Li Chengzhi Lu Source Type: research
Clinical Value of Troponin Levels to Cardiac Function and Prognosis in Patients with Fulminant Myocarditis
This study aimed to investigate the association between cardiac Tn levels and the course of cardiac function, and prognosis in patients with fulminant myocarditis (FM) receiving percutaneous mechanical circulatory support (MCS).We used data from a multicenter retrospective registry, CHANGE PUMP 2, which included 216 patients with FM who required MCS. Among them, 141 patients whose Tn levels were available were analyzed. The patients were divided into low and high Tn groups according to the median values of TnT and TnI.The median age was 54 years, and 59.6% were male. The TnT and TnI on day 1 (at MCS initiation) were 3.8 (1...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Naoki Shibata Toru Kondo Takahiro Okumura Takahiro Imaizumi Kaoru Dohi Hideo Izawa Nobuyuki Ohte Tetsuya Amano Toyoaki Murohara CHANGE PUMP 2 investigators Source Type: research
Role of CCRL2 in the Pathogenesis of Experimental Autoimmune Myocarditis via P21-Activated Kinase 1/NOD-Like Receptor Protein 3 Pathway
This study aims to elucidate the effect of Chemokine (C C motif) receptor-like 2 (CCRL2) in experimental autoimmune myocarditis (EAM) occurrence and its potential regulatory mechanisms.EAM was simulated in a mouse model injected with α-myosin-heavy chain. The changes on EAM were assessed through histological staining of heart tissues, including measuring cardiac troponin I (cTnI), proinflammatory cytokines, transferase-mediated dUTP nick end labeling (TUNEL) assay, and cardiac function. Then, the heart tissues from the EAM mouse model and control groups were analyzed through transcriptome sequencing to identify the differ...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Lin Chen Jing Meng Jia Zheng Tingting Zhao Qi Li Chengzhi Lu Source Type: research
Clinical Value of Troponin Levels to Cardiac Function and Prognosis in Patients with Fulminant Myocarditis
This study aimed to investigate the association between cardiac Tn levels and the course of cardiac function, and prognosis in patients with fulminant myocarditis (FM) receiving percutaneous mechanical circulatory support (MCS).We used data from a multicenter retrospective registry, CHANGE PUMP 2, which included 216 patients with FM who required MCS. Among them, 141 patients whose Tn levels were available were analyzed. The patients were divided into low and high Tn groups according to the median values of TnT and TnI.The median age was 54 years, and 59.6% were male. The TnT and TnI on day 1 (at MCS initiation) were 3.8 (1...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Naoki Shibata Toru Kondo Takahiro Okumura Takahiro Imaizumi Kaoru Dohi Hideo Izawa Nobuyuki Ohte Tetsuya Amano Toyoaki Murohara CHANGE PUMP 2 investigators Source Type: research
Role of CCRL2 in the Pathogenesis of Experimental Autoimmune Myocarditis via P21-Activated Kinase 1/NOD-Like Receptor Protein 3 Pathway
This study aims to elucidate the effect of Chemokine (C C motif) receptor-like 2 (CCRL2) in experimental autoimmune myocarditis (EAM) occurrence and its potential regulatory mechanisms.EAM was simulated in a mouse model injected with α-myosin-heavy chain. The changes on EAM were assessed through histological staining of heart tissues, including measuring cardiac troponin I (cTnI), proinflammatory cytokines, transferase-mediated dUTP nick end labeling (TUNEL) assay, and cardiac function. Then, the heart tissues from the EAM mouse model and control groups were analyzed through transcriptome sequencing to identify the differ...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Lin Chen Jing Meng Jia Zheng Tingting Zhao Qi Li Chengzhi Lu Source Type: research
Clinical Value of Troponin Levels to Cardiac Function and Prognosis in Patients with Fulminant Myocarditis
This study aimed to investigate the association between cardiac Tn levels and the course of cardiac function, and prognosis in patients with fulminant myocarditis (FM) receiving percutaneous mechanical circulatory support (MCS).We used data from a multicenter retrospective registry, CHANGE PUMP 2, which included 216 patients with FM who required MCS. Among them, 141 patients whose Tn levels were available were analyzed. The patients were divided into low and high Tn groups according to the median values of TnT and TnI.The median age was 54 years, and 59.6% were male. The TnT and TnI on day 1 (at MCS initiation) were 3.8 (1...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Naoki Shibata Toru Kondo Takahiro Okumura Takahiro Imaizumi Kaoru Dohi Hideo Izawa Nobuyuki Ohte Tetsuya Amano Toyoaki Murohara CHANGE PUMP 2 investigators Source Type: research
Role of CCRL2 in the Pathogenesis of Experimental Autoimmune Myocarditis via P21-Activated Kinase 1/NOD-Like Receptor Protein 3 Pathway
This study aims to elucidate the effect of Chemokine (C C motif) receptor-like 2 (CCRL2) in experimental autoimmune myocarditis (EAM) occurrence and its potential regulatory mechanisms.EAM was simulated in a mouse model injected with α-myosin-heavy chain. The changes on EAM were assessed through histological staining of heart tissues, including measuring cardiac troponin I (cTnI), proinflammatory cytokines, transferase-mediated dUTP nick end labeling (TUNEL) assay, and cardiac function. Then, the heart tissues from the EAM mouse model and control groups were analyzed through transcriptome sequencing to identify the differ...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Lin Chen Jing Meng Jia Zheng Tingting Zhao Qi Li Chengzhi Lu Source Type: research
Clinical Value of Troponin Levels to Cardiac Function and Prognosis in Patients with Fulminant Myocarditis
This study aimed to investigate the association between cardiac Tn levels and the course of cardiac function, and prognosis in patients with fulminant myocarditis (FM) receiving percutaneous mechanical circulatory support (MCS).We used data from a multicenter retrospective registry, CHANGE PUMP 2, which included 216 patients with FM who required MCS. Among them, 141 patients whose Tn levels were available were analyzed. The patients were divided into low and high Tn groups according to the median values of TnT and TnI.The median age was 54 years, and 59.6% were male. The TnT and TnI on day 1 (at MCS initiation) were 3.8 (1...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Naoki Shibata Toru Kondo Takahiro Okumura Takahiro Imaizumi Kaoru Dohi Hideo Izawa Nobuyuki Ohte Tetsuya Amano Toyoaki Murohara CHANGE PUMP 2 investigators Source Type: research
Role of CCRL2 in the Pathogenesis of Experimental Autoimmune Myocarditis via P21-Activated Kinase 1/NOD-Like Receptor Protein 3 Pathway
This study aims to elucidate the effect of Chemokine (C C motif) receptor-like 2 (CCRL2) in experimental autoimmune myocarditis (EAM) occurrence and its potential regulatory mechanisms.EAM was simulated in a mouse model injected with α-myosin-heavy chain. The changes on EAM were assessed through histological staining of heart tissues, including measuring cardiac troponin I (cTnI), proinflammatory cytokines, transferase-mediated dUTP nick end labeling (TUNEL) assay, and cardiac function. Then, the heart tissues from the EAM mouse model and control groups were analyzed through transcriptome sequencing to identify the differ...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Lin Chen Jing Meng Jia Zheng Tingting Zhao Qi Li Chengzhi Lu Source Type: research
Clinical Value of Troponin Levels to Cardiac Function and Prognosis in Patients with Fulminant Myocarditis
This study aimed to investigate the association between cardiac Tn levels and the course of cardiac function, and prognosis in patients with fulminant myocarditis (FM) receiving percutaneous mechanical circulatory support (MCS).We used data from a multicenter retrospective registry, CHANGE PUMP 2, which included 216 patients with FM who required MCS. Among them, 141 patients whose Tn levels were available were analyzed. The patients were divided into low and high Tn groups according to the median values of TnT and TnI.The median age was 54 years, and 59.6% were male. The TnT and TnI on day 1 (at MCS initiation) were 3.8 (1...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Naoki Shibata Toru Kondo Takahiro Okumura Takahiro Imaizumi Kaoru Dohi Hideo Izawa Nobuyuki Ohte Tetsuya Amano Toyoaki Murohara CHANGE PUMP 2 investigators Source Type: research
Role of CCRL2 in the Pathogenesis of Experimental Autoimmune Myocarditis via P21-Activated Kinase 1/NOD-Like Receptor Protein 3 Pathway
This study aims to elucidate the effect of Chemokine (C C motif) receptor-like 2 (CCRL2) in experimental autoimmune myocarditis (EAM) occurrence and its potential regulatory mechanisms.EAM was simulated in a mouse model injected with α-myosin-heavy chain. The changes on EAM were assessed through histological staining of heart tissues, including measuring cardiac troponin I (cTnI), proinflammatory cytokines, transferase-mediated dUTP nick end labeling (TUNEL) assay, and cardiac function. Then, the heart tissues from the EAM mouse model and control groups were analyzed through transcriptome sequencing to identify the differ...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Lin Chen Jing Meng Jia Zheng Tingting Zhao Qi Li Chengzhi Lu Source Type: research
Clinical Value of Troponin Levels to Cardiac Function and Prognosis in Patients with Fulminant Myocarditis
This study aimed to investigate the association between cardiac Tn levels and the course of cardiac function, and prognosis in patients with fulminant myocarditis (FM) receiving percutaneous mechanical circulatory support (MCS).We used data from a multicenter retrospective registry, CHANGE PUMP 2, which included 216 patients with FM who required MCS. Among them, 141 patients whose Tn levels were available were analyzed. The patients were divided into low and high Tn groups according to the median values of TnT and TnI.The median age was 54 years, and 59.6% were male. The TnT and TnI on day 1 (at MCS initiation) were 3.8 (1...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Naoki Shibata Toru Kondo Takahiro Okumura Takahiro Imaizumi Kaoru Dohi Hideo Izawa Nobuyuki Ohte Tetsuya Amano Toyoaki Murohara CHANGE PUMP 2 investigators Source Type: research
Role of CCRL2 in the Pathogenesis of Experimental Autoimmune Myocarditis via P21-Activated Kinase 1/NOD-Like Receptor Protein 3 Pathway
This study aims to elucidate the effect of Chemokine (C C motif) receptor-like 2 (CCRL2) in experimental autoimmune myocarditis (EAM) occurrence and its potential regulatory mechanisms.EAM was simulated in a mouse model injected with α-myosin-heavy chain. The changes on EAM were assessed through histological staining of heart tissues, including measuring cardiac troponin I (cTnI), proinflammatory cytokines, transferase-mediated dUTP nick end labeling (TUNEL) assay, and cardiac function. Then, the heart tissues from the EAM mouse model and control groups were analyzed through transcriptome sequencing to identify the differ...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Lin Chen Jing Meng Jia Zheng Tingting Zhao Qi Li Chengzhi Lu Source Type: research
