NASCI case of the month: desmoplakin cardiomyopathy masquerading as acute myocarditis
We present a case of a young patient with chest pain. Labs and cardiac imaging were suspicious for acute myocarditis. Genetic testing revealed a diagnosis of desmoplakin cardiomyopathy. Desmoplakin cardiomyopathy may be considered in patients with recurrent acute myocarditis or a family history of cardiac disease to avoid the potential for misdiagnosis. (Source: The International Journal of Cardiovascular Imaging)
Source: The International Journal of Cardiovascular Imaging - April 23, 2024 Category: Radiology Source Type: research
Sheep abortions associated with Neospora caninum and Toxoplasma gondii infections in multiple flocks from Southern Brazil
This study verified the occurrence of these diseases in sheep fetuses from Santa Catarina State, Southern Brazil from 2015 to 2022. Sheep fetuses were necropsied with organ sampling for histopathology, and polymerase chain reaction (PCR) forNeospora caninum andToxoplasma gondii using the Nc5 and SAG2 targets, respectively, in frozen brain tissue. Microbiological culture and RT-PCR forPestivirus were conducted to discard other abortion causes. One positive fetus for toxoplasmosis was genotyped using multiplex multilocus nested PCR-RFLP (Mn-PCR-RFLP) with ten genetic markers. Fifty-five sheep fetuses were evaluated, with 10 ...
Source: Veterinary Research Communications - April 23, 2024 Category: Veterinary Research Source Type: research
Predicting Acute Cardiovascular Complications in COVID-19: Insights from a Specialized Cardiac Referral Department
CONCLUSIONS D-dimer and NT-proBNP, but not troponin T, are useful in differentiating CVDs in patients with COVID-19. ACS with COVID-19 increased in-hospital mortality independently from extent of lung involvement, while coexisting APE or AMyo did not.PMID:38644597 | DOI:10.12659/MSM.942612 (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 22, 2024 Category: Research Authors: Micha ł Machowski Aisha Ou-Pokrzewi ńska Katarzyna Perzanowska-Brzeszkiewicz Magdalena Ga łecka-Nowak Szymon Pacho Mateusz Jermakow Agnieszka W ójcik Milena Zoruk Andrzej Pruszczyk Karol Deutsch Marek Roik Andrzej Łabyk Piotr Palczewski Piotr Pruszcz Source Type: research
Targeting NLRP3 signaling reduces myocarditis-induced arrhythmogenesis and cardiac remodeling
Myocarditis substantially increases the risk of ventricular arrhythmia. Approximately 30% of all ventricular arrhythmia cases in patients with myocarditis originate from the right ventricular outflow tract (RV... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - April 22, 2024 Category: Biomedical Science Authors: Chye-Gen Chin, Yao-Chang Chen, Fong-Jhih Lin, Yung-Kuo Lin, Yen-Yu Lu, Tzu-Yu Cheng, Shih-Ann Chen and Yi-Jen Chen Tags: Research Source Type: research
Chronic Active Myocarditis After Transapical Transcatheter Aortic Valve Implantation
Circ J. 2024 Apr 20. doi: 10.1253/circj.CJ-23-0910. Online ahead of print.NO ABSTRACTPMID:38644167 | DOI:10.1253/circj.CJ-23-0910 (Source: Circulation Journal)
Source: Circulation Journal - April 21, 2024 Category: Cardiology Authors: Yuta Kobayashi Toshiyuki Nagai Kiwamu Kamiya Satonori Tsuneta Yasushige Shingu Kento Wakabayashi Kohsuke Kudo Yoshihiro Matsuno Satoru Wakasa Toshihisa Anzai Source Type: research
The protective effect of Macrostemonoside T from Allium macrostemon Bunge against Isoproterenol-Induced myocardial injury via the PI3K/Akt/mTOR signaling pathway
This study established an ISO-induced MI model in rats and assessed H9c2 cytotoxicity to examine MST's impact on MI. Various assays, including histopathological staining, TUNEL staining, immunohistochemical staining, DCFH-DA staining, JC-1 staining, ELISA technique, and Western blot (WB), were utilized to explore the potential molecular mechanisms of MI protection. In vivo experiments demonstrated that ISO caused myocardial fiber disorders, elevated cardiac enzyme levels, and apoptosis. However, pretreatment with MST significantly mitigated these detrimental changes. In vitro experiments revealed that MST boosted antioxida...
Source: International Immunopharmacology - April 20, 2024 Category: Allergy & Immunology Authors: Jianfa Wu Ying Cui Weixing Ding Jing Zhang Lulu Wang Source Type: research
Extracorporeal membrane oxygenation (ECMO) during aplasia: A bridge towards myopericarditis recovery after autologous hematopoietic stem cell transplant for systemic sclerosis and recent Coronarovirus disease (COVID-19) vaccination
This report illustrates, for the first time to our knowledge, that ECMO can be indicated despite aplasia during aHSCT and successfully used as a bridge towards heart function recovery in highly selected and fragile AD patients. We review the factors that may contribute to endothelial and myocardial stunning and acute reversible cardiac failure in SSc and aggravate intrinsic endothelial injury during the aHSCT procedure. These classically include: cyclophosphamide drug toxicity, viral infections and autoimmune activation with disease flair per se. In the COVID-19 pandemic times, acute myocarditis due to recent viral infecti...
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Carlotta Cacciatore Mathilde Baudet Estelle Jean Simona Presente Marylou Para Romain Sonneville Dimitri Arangalage Nassim Ait Abdallah Flore Sicre de Fontbrune Pedro Henrique Prata Benjamin Crichi Baptiste Hervier Nathalie Parquet Gilles Soulat Elie Mouss Source Type: research
Ivermectin ameliorates acute myocarditis via the inhibition of importin-mediated nuclear translocation of NF- κB/p65
CONCLUSIONS: Ivermectin inhibits the nuclear translocation of NF-κB/p65 and the expression of major pro-inflammatory cytokines in myocarditis. The therapeutic effects of IVM on viral and non-viral myocarditis models suggest its potential application in the treatment of acute myocarditis.PMID:38636372 | DOI:10.1016/j.intimp.2024.112073 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 18, 2024 Category: Allergy & Immunology Authors: Xu Gao Yunling Xuan Zhou Zhou Chen Chen Dao Wen Wang Zheng Wen Source Type: research
Multimodality imaging of eosinophilic myocarditis (loeffler ’s endocarditis) in a patient with idiopathic hypereosinophilic syndrome
AbstractEosinophilic myocarditis can result in endomyocardial fibrosis affecting both ventricles, leading to restrictive cardiomyopathy. Multimodality imaging is crucial for diagnosis, as demonstrated in this case of a patient presenting with symptoms of heart failure. (Source: The International Journal of Cardiovascular Imaging)
Source: The International Journal of Cardiovascular Imaging - April 18, 2024 Category: Radiology Source Type: research
Long ‐term efficacy and safety of tailored immunosuppressive therapy in immune‐mediated biopsy‐proven myocarditis: A propensity‐weighted study
ConclusionsProlonged tailored IS is effective and safe in BP immune-mediated myocarditis irrespective of histology and clinical presentation. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - April 17, 2024 Category: Cardiology Authors: Alida Linda Patrizia Caforio,
Andrea Silvio Giordani,
Anna Baritussio,
Davide Marcolongo,
Cristina Vicenzetto,
Giuseppe Tarantini,
Massimo Napodano,
Giuseppe Toscano,
Dario Gregori,
Gloria Brigiari,
Patrizia Bartolotta,
Elisa Carturan,
Monica Tags: Research Article Source Type: research
Immune checkpoint inhibitor related myositis: an observational, retrospective, pharmacovigilance study
CONCLUSIONS: Clinicians should be aware of the potential for ICI-associated myositis, as it can be particularly life-threatening, especially in elderly patients or when it occurs concurrently with other AEs such as myocarditis or severe myasthenia gravis.PMID:38629402 | DOI:10.1080/14740338.2024.2343023 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - April 17, 2024 Category: Drugs & Pharmacology Authors: Hezhe Lu Hui Yang Zhexin Ding Zhuoling An Yong Zhao Source Type: research
Overview of U.S. COVID-19 vaccine safety surveillance systems
This report describes the U.S. government's COVID-19 vaccine safety monitoring systems and programs used by the Centers for Disease Control and Prevention, the U.S. Food and Drug Administration, the Department of Defense, the Department of Veterans Affairs, and the Indian Health Service. Using the adverse event of myocarditis following mRNA COVID-19 vaccination as a model, we demonstrate how the multiple, complementary monitoring systems worked to rapidly detect, assess, and verify a vaccine safety signal. In addition, longer-term follow-up was conducted to evaluate the recovery status of myocarditis cases following vaccin...
Source: Vaccine - April 17, 2024 Category: Allergy & Immunology Authors: Julianne Gee Tom T Shimabukuro John R Su David Shay Margaret Ryan Sridhar V Basavaraju Karen R Broder Matthew Clark C Buddy Creech Francesca Cunningham Kristin Goddard Harrison Guy Kathryn M Edwards Richard Forshee Tanya Hamburger Anne M Hause Nicola P Kl Source Type: research
Immune checkpoint inhibitor related myositis: an observational, retrospective, pharmacovigilance study
CONCLUSIONS: Clinicians should be aware of the potential for ICI-associated myositis, as it can be particularly life-threatening, especially in elderly patients or when it occurs concurrently with other AEs such as myocarditis or severe myasthenia gravis.PMID:38629402 | DOI:10.1080/14740338.2024.2343023 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - April 17, 2024 Category: Drugs & Pharmacology Authors: Hezhe Lu Hui Yang Zhexin Ding Zhuoling An Yong Zhao Source Type: research
Overview of U.S. COVID-19 vaccine safety surveillance systems
This report describes the U.S. government's COVID-19 vaccine safety monitoring systems and programs used by the Centers for Disease Control and Prevention, the U.S. Food and Drug Administration, the Department of Defense, the Department of Veterans Affairs, and the Indian Health Service. Using the adverse event of myocarditis following mRNA COVID-19 vaccination as a model, we demonstrate how the multiple, complementary monitoring systems worked to rapidly detect, assess, and verify a vaccine safety signal. In addition, longer-term follow-up was conducted to evaluate the recovery status of myocarditis cases following vaccin...
Source: Vaccine - April 17, 2024 Category: Allergy & Immunology Authors: Julianne Gee Tom T Shimabukuro John R Su David Shay Margaret Ryan Sridhar V Basavaraju Karen R Broder Matthew Clark C Buddy Creech Francesca Cunningham Kristin Goddard Harrison Guy Kathryn M Edwards Richard Forshee Tanya Hamburger Anne M Hause Nicola P Kl Source Type: research
Adverse events of nivolumab plus ipilimumab versus nivolumab plus cabozantinib: a real-world pharmacovigilance study
ConclusionOur findings contribute to the selection and clinical management of NIVO-IPI and NIVO-CABO, which minimizes the risk of AEs for individual patients with mRCC by considering distinctive differences in the AE profiles. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 17, 2024 Category: Drugs & Pharmacology Source Type: research
