Ferulic acid lowers body weight and visceral fat accumulation via modulation of enzymatic, hormonal and inflammatory changes in a mouse model of high-fat diet-induced obesity.
This study investigated the possible anti-obesitogenic effects of FA in mice fed a high-fat diet (HFD) for 15 weeks. To assess the antiobesity potential of FA, 32 male Swiss mice, weighing 20-25 g (n=6-8 per group) were fed a normal diet (ND) or HFD, treated orally or not with either FA (10 mg/kg) or sibutramine (10 mg/kg) for 15 weeks and at the end of this period, the body weights of animals, visceral fat accumulation, plasma levels of glucose and insulin hormone, amylase and lipase activities, the satiety hormones ghrelin and leptin, and tumor necrosis factor-α (TNF-α) and monocyte chemoattractant protein-1 (MCH-1) we...
Source: Braz J Med Biol Res - January 4, 2017 Category: Research Authors: de Melo TS, Lima PR, Carvalho KM, Fontenele TM, Solon FR, Tomé AR, de Lemos TL, da Cruz Fonseca SG, Santos FA, Rao VS, de Queiroz MG Tags: Braz J Med Biol Res Source Type: research
A graphene tip coupled with liquid chromatography tandem mass spectrometry for the determination of four synthetic adulterants in slimming supplements
In this study, a graphene tip solid-phase extraction (Gtip SPE) and ultra-performance liquid chromatography tandem mass spectrometry (UPLC–MS/MS) method was established for determining fenfluramine, phenolphthalein, bumetanide, and sibutramine in slimming supplements. It was validated in terms of linearity (0.9985–0.9995), LOD (1.8ngmL−1), LOQ (5.6ngmL−1), intra-day precision (<5.1%), inter-day precision (<7.3%), and recovery (82.9–95.2%). Sibutramine is the most commonly used drug, which was detected in Bihais, Galong, and Aolist, with content 12.4, 3.6, 20.3mgg−1, respectively. Phenolphthalein w...
Source: Food Chemistry - January 3, 2017 Category: Food Science Source Type: research
Drug interventions for the treatment of obesity in children and adolescents.
CONCLUSIONS: This systematic review is part of a series of associated Cochrane reviews on interventions for obese children and adolescents and has shown that pharmacological interventions (metformin, sibutramine, orlistat and fluoxetine) may have small effects in reduction in BMI and bodyweight in obese children and adolescents. However, many of these drugs are not licensed for the treatment of obesity in children and adolescents, or have been withdrawn. Trials were generally of low quality with many having a short or no post-intervention follow-up period and high dropout rates (overall dropout of 25%). Future research sho...
Source: Cochrane Database of Systematic Reviews - November 28, 2016 Category: Journals (General) Authors: Mead E, Atkinson G, Richter B, Metzendorf MI, Baur L, Finer N, Corpeleijn E, O'Malley C, Ells LJ Tags: Cochrane Database Syst Rev Source Type: research
Can social media data lead to earlier detection of drug ‐related adverse events?
ConclusionsSocial media AE reporters were younger and focused on less‐serious and fewer types of AEs than FAERS reporters. The potential for social media to provide earlier indications of AEs compared with FAERS is uncertain. Our findings highlight some of the promises and limitations of online social media versus conventional pharmacovigilance sources and the need for careful interpretation of the results. © 2016 The Authors. Pharmacoepidemiology and Drug Safety published by John Wiley & Sons Ltd. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - September 6, 2016 Category: Drugs & Pharmacology Authors: Mei Sheng Duh, Pierre Cremieux, Marc Van Audenrode, Francis Vekeman, Paul Karner, Haimin Zhang, Paul Greenberg Tags: Original Report Source Type: research
Amyrins from Protium heptaphyllum Reduce High-Fat Diet-Induced Obesity in Mice via Modulation of Enzymatic, Hormonal And Inflammatory Responses
Planta Med DOI: 10.1055/s-0042-114222Obesity remains a global problem. In search of phytochemicals that have antiobesity potential, this study evaluated α,β-amyrin, a triterpenoid mixture from Protium heptaphyllum, on high-fat diet-induced obesity in mice. Groups of mice (n = 8) were fed a normal diet or a high-fat diet, and were orally treated or not treated with either α,β-amyrin (10 or 20 mg/kg) or sibutramine (10 mg/kg) for 15 weeks. Variables measured at termination were body weight, visceral fat accumulation, adipocyte surface area, peroxisome proliferator-activated receptor gamma, and lipoprotein lipase ...
Source: Planta Medica - August 14, 2016 Category: Drugs & Pharmacology Authors: Carvalho, Karine Maria Martins Bezerra de Melo, Tiago Sousa de Melo, Karina Moura Quinder é, Ana Luiza Gomes de Oliveira, Francisca Tuelly Bandeira Viana, Ana Fl ávia Seraine Custódio Nunes, Paulo Iury Gomes Quetz, Josiane da Silva Viana, Daniel de Ara Tags: Original Papers Source Type: research
Racemic compound and Conglomerate of Anhydrous Sibutramine Hydrochloride: A Rare Case of Relative Stability
CrystEngComm, 2016, Accepted Manuscript DOI: 10.1039/C6CE01123C, PaperFrederic Rosa, Philippe Negrier, Philippe ESPEAU The thermal behaviours of racemic sibutramine hydrochloride monohydrate as well as that of the anhydrous state were investigated by DSC. A new anhydrous solid was then put in evidence and... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)
Source: RSC - CrystEngComm latest articles - August 11, 2016 Category: Chemistry Authors: Frederic Rosa Source Type: research
Testing the usefulness of the number needed to treat to be harmed (NNTH) in benefit-risk evaluations: case study with medicines withdrawn from the European market due to safety reasons.
CONCLUSION: NNTH have potential of use as a supportive tool in benefit-risk re-evaluations of medicines and may help regulators to making decisions on drug safety.
PMID: 27467204 [PubMed - as supplied by publisher] (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - July 30, 2016 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Enantiomeric Separation of Sibutramine by Capillary Zone Electrophoresis
The chiral separation of sibutramine enantiomers was resolved succesfully by capillary zone electrophoresis using cyclodextrins (CDs) as chiral selectors. A complex screening of several different native and derivatized, neutral and ionized cyclodextrine derivatives was performed. The effects of buffer type, concentration and pH, cyclodextrin type and concentration, applied voltage, capillary temperature and injection parameters on the chiral resolution were examined. The best results on a very short fused silica capillary of 30 cm × 50 μm were obtained using a 50 mmol L-1 phosphate buffer containing 10 mmol L-1 randomly ...
Source: Journal of the Brazilian Chemical Society - June 23, 2016 Category: Chemistry Source Type: research
Adulteration of herbal sexual enhancers and slimmers: The wish for better sexual well-being and perfect body can be risky.
Abstract
The popularity of herbal medicines and dietary supplements is increasing all over the world due to the many side-effects assigned to synthetic drugs. Herbal remedies should be considered as safe, with no side-effects, but unfortunately, even if they are labelled as natural, large numbers of adulterants, not only with toxic heavy metals but also with undeclared synthetic substances, have been detected up to date. In this review, the most frequent instances of adulteration of herbal medicines and dietary supplements acting as sexual enhancers and slimming products are thoroughly discussed. The great...
Source: Food and Chemical Toxicology - June 19, 2016 Category: Food Science Authors: Skalicka-Woźniak K, Georgiev MI, Orhan IE Tags: Food Chem Toxicol Source Type: research
Simultaneous imaging of multiple neurotransmitters and neuroactive substances in the brain by desorption electrospray ionization mass spectrometry
Publication date: 1 August 2016 Source:NeuroImage, Volume 136 Author(s): Mohammadreza Shariatgorji, Nicole Strittmatter, Anna Nilsson, Patrik Källback, Alexandra Alvarsson, Xiaoqun Zhang, Theodosia Vallianatou, Per Svenningsson, Richard J.A. Goodwin, Per E. Andren With neurological processes involving multiple neurotransmitters and neuromodulators, it is important to have the ability to directly map and quantify multiple signaling molecules simultaneously in a single analysis. By utilizing a molecular-specific approach, namely desorption electrospray ionization mass spectrometry imaging (DESI-MSI),...
Source: NeuroImage - June 17, 2016 Category: Neuroscience Source Type: research
A Rare Case of Psychomotor Disturbances Linked to the Use of an Adulterated Dietary Supplement Containing Sibutramine
Conclusions: This is the first report we are aware of about a transient, chorea-like psychomotor movement disorder associated with sibutramine. Although the causal relationship between sibutramine and the patient's symptoms cannot be proven definitely, the temporal dimension does suggest sibutramine initiation and termination led to onset and resolution of symptoms, respectively. Furthermore, because of the widespread availability of adulterated food supplements containing sibutramine, physicians should be more aware of their implications for patients. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - May 1, 2016 Category: Neurology Tags: Case Reports Source Type: research
Adverse events associated with antiobesity medication use: analysis of the fda adverse event reporting system faers 1997–2015
Many antiobesity drugs were withdrawn from the market because of considerable adverse effects affecting tolerability and safety in the past two decades. Recently sibutramine was voluntarily withdrawn in 2010 due to increased risk of cardiovascular adverse events (AEs).The purpose of this study was to evaluate and describe the AEs associated with antiobesity medication. (Source: Value in Health)
Source: Value in Health - April 30, 2016 Category: Global & Universal Authors: X. Yue, Y. Xia, J.J. Guo Source Type: research
Psychotic symptoms associated with the use of dopaminergic drugs, in patients with cocaine dependence or abuse.
CONCLUSION: Few cases have been described, which suggests that the appearance of these symptoms is infrequent. The synergy of dopaminergic effects or the dopaminergic sensitization in chronic consumption are the explanatory theories proposed by the authors. In these cases, a relationship was found between taking these drugs and the appearance of psychotic symptoms. Given the low number of studies found, further research is required. The risk of psychotic symptoms seems to be acceptable if we compare it with the benefits for the patients but a closer monitoring seems to be advisable.
PMID: 27009114 [PubMed - as supp...
Source: Current Neuropharmacology - March 23, 2016 Category: Drugs & Pharmacology Authors: Roncero C, Abad AC, Padilla-Mata A, Ros-Cucurull E, Barral C, Casas M, Grau-López L Tags: Curr Neuropharmacol Source Type: research
Long-term effects of weight-reducing drugs in people with hypertension.
CONCLUSIONS: In people with elevated blood pressure, orlistat and sibutramine reduced body weight to a similar degree, while phentermine/topiramate reduced body weight to a greater extent. In the same trials, orlistat and phentermine/topiramate reduced blood pressure, while sibutramine increased it. We could include no trials investigating rimonabant, liraglutide, lorcaserin, or naltrexone/bupropion in people with elevated blood pressure. Long-term trials assessing the effect of orlistat, liraglutide, lorcaserin, phentermine/topiramate, or naltrexone/bupropion on mortality and morbidity are unavailable and needed. Rimonaba...
Source: Cochrane Database of Systematic Reviews - March 2, 2016 Category: Journals (General) Authors: Siebenhofer A, Jeitler K, Horvath K, Berghold A, Posch N, Meschik J, Semlitsch T Tags: Cochrane Database Syst Rev Source Type: research
