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Occurrence and removal rate of typical pharmaceuticals and personal care products (PPCPs) in an urban wastewater treatment plant in Beijing, China
Chemosphere. 2023 Jul 24:139644. doi: 10.1016/j.chemosphere.2023.139644. Online ahead of print.ABSTRACTThe occurrence and removal rate of 52 typical pharmaceuticals and personal care products (PPCPs) were investigated in a wastewater treatment plant in Beijing, China. Thirty-three PPCPs were found in the influent, with caffeine (CF, 11387.0 ng L-1) being the most abundant, followed by N,N-diethyl-meta-toluamide (DEET, 9568.4 ng L-1), metoprolol (MTP, 930.2 ng L-1), and diclofenac (DF, 710.3 ng L-1). After treatment processes, the cumulative concentration of PPCPs decreased from 2.54 × 104 ng L-1 to 1.44 × 103 ng L-1, wit...
Source: Chemosphere - July 26, 2023 Category: Chemistry Authors: Jia Liu Simin Ge Peng Shao Jianfeng Wang Yanju Liu Wei Wei Can He Lilan Zhang Source Type: research

Pharmaceutical Therapies for the Treatment of Obesity: A Network Meta-analysis
Clin Ther. 2023 Jul 1:S0149-2918(23)00194-7. doi: 10.1016/j.clinthera.2023.06.003. Online ahead of print.ABSTRACTPURPOSE: Despite the introduction of various pharmaceutical therapies for treating obesity, selecting the optimal treatment remains challenging for both patients and physicians. Therefore, in this network meta-analysis (NMA), we aim to simultaneously compare the available drugs for treating obesity to determine the most effective treatment options.METHODS: International databases, including PubMed, Web of Science, Scopus, Cochrane Library, and Embase, were searched for studies published from database inception t...
Source: Clinical Therapeutics - July 3, 2023 Category: Drugs & Pharmacology Authors: Mina Morsali Jalal Poorolajal Fatemeh Shahbazi Aliasghar Vahidinia Amin Doosti-Irani Source Type: research

An Indonesian slimming drug with undeclared ingredients causing harm
Analysis of the Indonesian slimming drug Sulami ® samples has shown adulteration with sibutramine and canrenone. Canrenone and sibutramine can cause serious side effects and toxicity. European regulators should take legal measures where possible. In addition, consumers should be warned against using the product. AbstractThis paper reports the presence of undeclared drugs in the herbal slimming supplement Sulami ®. The four cases of the adverse drug reactions related to Sulami® were reported to the Dutch Pharmacovigilance Centre (Lareb) or the Dutch Poisons Information Centre (DPIC). The analysis of all four collected sa...
Source: Drug Testing and Analysis - March 14, 2023 Category: Drugs & Pharmacology Authors: Sonja Koppel, Corine Ekhart, Chantal Roelen, Dana Ohana, Martin Kooijman, Florence Hunsel Tags: SHORT COMMUNICATION Source Type: research

An Indonesian slimming drug with undeclared ingredients causing harm
AbstractThis paper reports the presence of undeclared drugs in the herbal slimming supplement Sulami ®. The four cases of the adverse drug reactions related to Sulami® were reported to the Dutch Pharmacovigilance Centre (Lareb) or the Dutch Poisons Information Centre (DPIC). The analysis of all four collected samples revealed adulteration with sibutramine and canrenone. Both drugs can cause serio us adverse drug reactions. From a legal point of view, it is clear that Sulami® does not meet the legal requirement for safety. As defined in the European General Food Law Regulation (GFL) food business operators are responsibl...
Source: Drug Testing and Analysis - February 20, 2023 Category: Drugs & Pharmacology Authors: Sonja Koppel, Corine Ekhart, Chantal Roelen, Dana Ohana, Martin Kooijman, Florence Hunsel Tags: SHORT COMMUNICATION Source Type: research

Interventions associated with brown adipose tissue activation and the impact on energy expenditure and weight loss: A systematic review
ConclusionThough the impact of BAT activation and associated increases in energy expenditure on clinically meaningful weight loss is a topic of great interest, further data is needed to determine long-term feasibility and efficacy. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - December 9, 2022 Category: Endocrinology Source Type: research

Simultaneous detection of sibutramine and phenolphthalein in a diet jelly health food product that caused health problems
Anal Sci. 2022 Dec 6. doi: 10.1007/s44211-022-00217-0. Online ahead of print.NO ABSTRACTPMID:36472786 | DOI:10.1007/s44211-022-00217-0 (Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry)
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - December 6, 2022 Category: Chemistry Authors: Tomohide Fukiwake Sachiyo Oosawa Hiroki Yoshino Tatsuya Shinozuka Maki Nishimura Rie Ito Hiroshi Akiyama Source Type: research

Simultaneous detection of sibutramine and phenolphthalein in a diet jelly health food product that caused health problems
Anal Sci. 2022 Dec 6. doi: 10.1007/s44211-022-00217-0. Online ahead of print.NO ABSTRACTPMID:36472786 | DOI:10.1007/s44211-022-00217-0 (Source: Anal Sci)
Source: Anal Sci - December 6, 2022 Category: Chemistry Authors: Tomohide Fukiwake Sachiyo Oosawa Hiroki Yoshino Tatsuya Shinozuka Maki Nishimura Rie Ito Hiroshi Akiyama Source Type: research