Effects of amylin and bupropion/naltrexone on food intake and body weight are interactive in rodent models.
Abstract
Antagonism of opioid systems (e.g., with naltrexone) has been explored as an anti-obesity strategy, and is particularly effective when co-administered with dual inhibitors of dopamine and norepinephrine reuptake (e.g., bupropion). Previously, we demonstrated that amylin enhances the food intake lowering and weight loss effects of neurohormonal (e.g., leptin, cholecystokinin, melanocortins) and small molecule (e.g., phentermine, sibutramine) agents. Here, we sought to characterize the interaction of amylin with naltrexone/bupropion on energy balance. Wild-type and amylin knockout mice were similarl...
Source: European Journal of Pharmacology - January 5, 2013 Category: Drugs & Pharmacology Authors: Clapper JR, Athanacio J, Wittmer C, Griffin PS, D'Souza L, Parkes DG, Roth JD Tags: Eur J Pharmacol Source Type: research
Acute ischaemic colitis in a young woman.
Abstract
Although rare in young patients, acute ischaemic colitis can have devastating consequences. We detail the presentation and clinical course of a severe, progressive case of this disease related temporally to the recent ingestion of a sibutramine-containing herbal slimming agent procured on-line without prescription or medical indication in a young female that ultimately required emergency laparoscopic total colectomy with end ileostomy to prevent end organ failure.
PMID: 23240285 [PubMed - indexed for MEDLINE] (Source: Ir Med J)
Source: Ir Med J - October 1, 2012 Category: Journals (General) Authors: Levins K, Kelly O, Beausang A, Gulmann C, Harewood G, Cahill R Tags: Ir Med J Source Type: research
Effect of Olfactory Stimulation with Grapefruit Oil and Sibutramine in Obese Rats
Hadir Farouk1
, Baheia A. El-Sayeh2
, Sawsan S. Mahmoud1
, Ola A. Sharaf1
1Department of Pharmacology, National Research Center, Cairo, Egypt
2Department of Pharmacology, Faculty of Pharmacy, Cairo University, Cairo, EgyptABSTRACTBACKGROUND:Sibutramine (Sibutramine hydrochloride monohydrate) is an…The postEffect of Olfactory Stimulation with Grapefruit Oil and Sibutramine in Obese Rats appeared first onJPMS. (Source: Journal of Pakistan Medical Students)
Source: Journal of Pakistan Medical Students - September 14, 2011 Category: Universities & Medical Training Source Type: research
