Long-term effects of weight-reducing drugs in people with hypertension.
CONCLUSIONS: In people with elevated blood pressure, orlistat, phentermine/topiramate and naltrexone/bupropion reduced body weight; the magnitude of the effect was greatest with phentermine/topiramate. In the same trials, orlistat and phentermine/topiramate, but not naltrexone/bupropion, reduced blood pressure. One RCT of naltrexone/bupropion versus placebo showed no differences in all-cause mortality or cardiovascular mortality or morbidity after two years. The European Medicines Agency refused marketing authorisation for phentermine/topiramate due to safety concerns, while for lorcaserin the application for European mark...
Source: Cochrane Database of Systematic Reviews - January 17, 2021 Category: General Medicine Authors: Siebenhofer A, Winterholer S, Jeitler K, Horvath K, Berghold A, Krenn C, Semlitsch T Tags: Cochrane Database Syst Rev Source Type: research
Interrelated In Vitro Mechanisms of Sibutramine-Induced Cardiotoxicity.
This study aimed to demonstrate the toxicity profile of sibutramine, and thereby provide important implications for the development of more effective strategies in both clinical approaches and drug design studies. Action potentials (APs) were determined from freshly isolated ventricular cardiomyocytes with whole-cell configuration of current clamp as online. The maximum amplitude of APs (MAPs), the resting membrane potential (RMP), and AP duration from the repolarization phases were calculated from original records. The voltage-dependent K+-channel currents (IK) were recorded in the presence of external Cd2+ and both inwar...
Source: Cardiovascular Toxicology - January 3, 2021 Category: Cardiology Authors: Alyu F, Olgar Y, Degirmenci S, Turan B, Ozturk Y Tags: Cardiovasc Toxicol Source Type: research
Paper device for distance-based visual quantification of sibutramine adulteration in slimming products
Publication date: March 2021Source: Microchemical Journal, Volume 162Author(s): Pattaraporn Karamahito, Jirayu Sitanurak, Duangjai Nacapricha, Prapin Wilairat, Korbua Chaisiwamongkhol, Apichai Phonchai (Source: Microchemical Journal)
Source: Microchemical Journal - December 15, 2020 Category: Chemistry Source Type: research
Clopidogrel dosing: current successes and emerging factors for further consideration.
Abstract
This review aimed to evaluate the clinical success of clopidogrel dosing based on CYP2C19 genotype and to identify the relevant additional factors that may be useful for consideration by the clinician when dosing individuals with clopidogrel. The results indicated that genotype-guided dosing in individuals with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) is frequently practiced, although the advantages remain controversial. Demographic factors such as age, ethnicity and some comorbidities such as diabetes mellitus can potentially contribute to further refineme...
Source: Clinical Pharmacology and Therapeutics - September 23, 2020 Category: Drugs & Pharmacology Authors: Chetty M, Ravenstijn P, Manchandani P Tags: Clin Pharmacol Ther Source Type: research
Visual upconversion nanoparticle-based immunochromatographic assay for the semi-quantitative detection of sibutramine.
Abstract
Immunochromatographic assay (ICA) has been used widely for the onsite monitoring of illegal additives due to its simplicity, speed, and low cost. However, a scanner is commonly required for ICA to achieve quantitative results. In this work, we developed a visual semi-quantitative ICA for sibutramine, a banned additive in diet foods, without the need for a scanner for measurement. Monoclonal antibodies specific for sibutramine were raised and conjugated with upconversion nanoparticles (UCNPs) as the luminescent tracer. ICA was developed by employing multiple test lines to achieve the semi-quantitat...
Source: Analytical and Bioanalytical Chemistry - September 9, 2020 Category: Chemistry Authors: Zhang SW, Sun YY, Sun YM, Wang H, Li ZF, Xu ZL Tags: Anal Bioanal Chem Source Type: research
Smartphone-based colorimetric detection using gold nanoparticles of sibutramine in suspected food supplement products
Publication date: November 2020Source: Microchemical Journal, Volume 158Author(s): Korbua Chaisiwamongkhol, Shakiroh Labaidae, Sunisa Pon-in, Sakchaibordee Pinsrithong, Thanthapatra Bunchuay, Apichai Phonchai (Source: Microchemical Journal)
Source: Microchemical Journal - July 25, 2020 Category: Chemistry Source Type: research
Potentiometric CheqSol and Standardized Shake-Flask Solubility Methods are Complimentary Tools in Physicochemical Profiling.
Abstract
The solubility of three drugs (glimepiride, pioglitazone, sibutramine) with different acid/base properties and expected supersaturation behavior was examined in detail using the shake-flask (SF) and potentiometric (CheqSol) methods. Both uncharged (free) species and hydrochloride salts were used as starting materials. On the one hand, the SF method provided information about the thermodynamic solubility at any pH value, including the counterion-dependent solubility of ionic species. Additionally, this method easily allowed the identification of the solid phase in equilibrated solutions by powder X...
Source: European Journal of Pharmaceutical Sciences - March 13, 2020 Category: Drugs & Pharmacology Authors: Lucero-Borja D, Subirats X, Barbas R, Prohens R, Avdeef A, Ràfols C Tags: Eur J Pharm Sci Source Type: research
Molecules, Vol. 25, Pages 1193: Chemometric Analysis of Low-field 1H NMR Spectra for Unveiling Adulteration of Slimming Dietary Supplements by Pharmaceutical Compounds
Gilard
The recent introduction of compact or low-field (LF) NMR spectrometers that use permanent magnets, giving rise to proton (1H) NMR frequencies between 40 and 80 MHz, have opened up new areas of application. The two main limitations of the technique are its insensitivity and poor spectral resolution. However, this study demonstrates that the chemometric treatment of LF 1H NMR spectral data is suitable for unveiling medicines as adulterants of slimming dietary supplements (DS). To this aim, 66 DS were analyzed with LF 1H NMR after quick and easy sample preparation. A first PLS-DA model built with the LF 1H NMR spec...
Source: Molecules - March 5, 2020 Category: Chemistry Authors: Nao Wu St éphane Balayssac Sa ïda Danoun Myriam Malet-Martino V éronique Gilard Tags: Communication Source Type: research
Adsorption and determination of sibutramine in illegal slimming product using porous graphene ink-modified electrode.
Abstract
This work presents a new material, i.e., a porous graphene ink to modify on the GCE surface (PGr-ink/GCE) to improve sensitivity by increasing the surface area of the electrode for the electrochemical determination of sibutramine. The surface characterization and electrochemical adsorption behavior of the PGr-ink/GCE toward sibutramine were investigated using scanning electron microscopy (SEM), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), ATR-FTIR spectroscopy and square wave adsorptive stripping voltammetry (SWAdSV). The PGr-ink/GCE exhibited a distinctive anodic respons...
Source: Talanta - March 3, 2020 Category: Chemistry Authors: Saichanapan J, Promsuwan K, Limbut W Tags: Talanta Source Type: research
Effects of isolated or combined exposure to sibutramine and rosuvastatin on reproductive parameters of adult male rats
AbstractMany obese patients are exposed to hypolipidemic and serotonin ‐norepinephrine reuptake inhibitor (SNRI) drugs. Statins are one of the most marketed drugs in the world to treat dyslipidemia, while sibutramine, a SNRI drug, is prescribed in some countries to treat obesity and is detected as an additive in many adulterated weight loss supplements marketed world wide. Previous studies reported adverse effects of isolated exposure to these drugs on male rat reproductive parameters. In the present work, we further investigated male reproductive toxicity of these drugs, administered in isolation or combination in adult...
Source: Journal of Applied Toxicology - February 19, 2020 Category: Toxicology Authors: Patr ícia Villela Silva,
Cibele dos Santos Borges,
Josiane de Lima Rosa,
Tainá Louise Pacheco,
Thamiris Moreira Figueiredo,
Gabriel Adan Araújo Leite,
Marina Trevizan Guerra,
Janete Aparecida Anselmo‐Franci,
Gary Robert Klinefelter,
Wilma De Tags: RESEARCH ARTICLE Source Type: research
Effectiveness of Pharmacologic Interventions in the Management of Weight Gain in Patients With Severe Mental Illness: A Systematic Review and Meta-Analysis.
Conclusions: Metformin and topiramate were the most-studied agents for weight control in SMI and were considered efficacious and safe in promoting weight reduction compared to placebo in this population. More studies are required with larger sample sizes and in line with the recommendations from research from the obesity and metabolic field to better define guidelines for use of pharmacologic interventions to reduce weight gain in patients with SMI.
PMID: 31856432 [PubMed - in process] (Source: The Primary Care Companion for CNS Disorders)
Source: The Primary Care Companion for CNS Disorders - December 21, 2019 Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research
Benchtop NMR spectroscopy in the analysis of substandard and falsified medicines as well as illegal drugs
Publication date: Available online 21 October 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Peter H.J. Keizers, Frank Bakker, José Ferreira, Paul F.K. Wackers, Dion van Kollenburg, Eva van der Aa, Amy van BeersAbstractSubstandard and falsified medical products may cause harm to patients and fail to treat the diseases or conditions for which they were intended. It is therefore required to have analytical methods available to assess medical product quality. Benchtop NMR spectroscopy provides a generic, inherently quantitative, analytical method capable of separating specific signals from those of a...
Source: Journal of Pharmaceutical and Biomedical Analysis - October 22, 2019 Category: Drugs & Pharmacology Source Type: research
Fluoxetine for adults who are overweight or obese.
CONCLUSIONS: Low-certainty evidence suggests that off-label fluoxetine may decrease weight compared with placebo. However, low-certainty evidence suggests an increase in the risk for dizziness, drowsiness, fatigue, insomnia and nausea following fluoxetine treatment.
PMID: 31613390 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - October 14, 2019 Category: General Medicine Authors: Serralde-Zúñiga AE, Gonzalez Garay AG, Rodríguez-Carmona Y, Melendez G Tags: Cochrane Database Syst Rev Source Type: research
A new approach to Ion Exchange Cromatography with Conductivity Detection for adulterants investigation in dietary supplements.
Abstract
Adulterations in dietary supplements has significantly increase in the last years. This situation worries health authorities and requires auxiliary analytical tools focus in the investigation of illegal substances purposely added. The ion exchange chromatography with conductivity detection (IEC-CD) is a consolidated analytical technique for determination of inorganic compounds in different matrices. In pharmaceutical analysis, this technique has been applied to characterization of mainly impurities and degradation products. In this way, this work presents a new approach to ion exchange chromatogra...
Source: Biomedical Chromatography : BMC - July 30, 2019 Category: Biomedical Science Authors: Dal Molin TR, da Silveira GD, Leal GC, Müller LS, Muratt DT, de Carvalho LM, Viana C Tags: Biomed Chromatogr Source Type: research
