A case of psychosis associated with Pai You Guo slimming capsules containing sibutramine.
Authors: Shah KA, Abraham MA, Espinosa JB
PMID: 26231019 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - August 2, 2015 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
Analysis of 40 weight loss compounds adulterated in health supplements by liquid chromatography quadrupole linear ion trap mass spectrometry
In this study, a liquid chromatography‐tandem mass spectrometry (LC‐MS/MS) with scheduled multiple reaction monitoring (MRM) enhanced product ion (EPI) method was developed for simultaneous determination of 40 compounds with weight loss effect, including bisacodyl, phenolphthalein, and sibutramine and its metabolites, etc. They might be adulterated in health supplements to get prominent weight loss effect. The samples were analyzed using a Q‐Trap 5500 coupled with high performance liquid chromatography (HPLC) and a CORTECS ultra performance liquid chromatography (UPLC) C18 column (100 mm x 2.1 mm x1.6 µm). Scheduled...
Source: Drug Testing and Analysis - August 1, 2015 Category: Drugs & Pharmacology Authors: Yun Zeng, Yimin Xu, Chee‐Leong Kee, Min‐Yong Low, Xiaowei Ge Tags: Short communication Source Type: research
Correction to Grilo et al. (2015).
We examined rapid response among obese patients with binge-eating disorder (BED) in a randomized clinical trial testing antiobesity medication and self-help cognitive–behavioral therapy (shCBT), alone and in combination, in primary-care settings. Method: One hundred four obese patients with BED were randomly assigned to 1 of 4 treatments: sibutramine, placebo, shCBT + sibutramine, or shCBT + placebo. Treatments were delivered by generalist primary-care physicians and the medications were given double-blind. Independent assessments were performed by trained and monitored doctoral research clinicians monthly throughout tre...
Source: Journal of Consulting and Clinical Psychology - July 27, 2015 Category: Psychiatry & Psychology Authors: No authorship indicated Source Type: research
A descriptive study to provide evidence of the teratogenic and cellular effects of sibutramine and ephedrine on cardiac‐ and liver‐tissue of chick embryos
ABSTRACT
Exposure to drugs during pregnancy is a major concern, as some teratogenic compounds can influence normal foetal development. Although the use of drugs during pregnancy should generally be avoided, exposure of the developing foetus to teratogens may occur unknowingly since these compounds may be hidden in products that are being marketed as “all natural.” The aim of the current study was to investigate the possible teratogenic and cellular effects of sibutramine—a serotonin‐norepinephrine reuptake inhibitor used in the treatment of obesity—on the heart and liver tissue of chick embryos. Ephedrine was use...
Source: Microscopy Research and Technique - July 1, 2015 Category: Laboratory Medicine Authors: Hester Magdalena Oberholzer, Ciska Van Der Schoor, Helena Taute, Megan Jean Bester Tags: Research Article Source Type: research
Sibutramine, a serotonin–norepinephrine reuptake inhibitor, causes fibrosis in rats
In this study, using the same animal model, the effect of Sibutramine on lung morphology was investigated using histological evaluation of the terminal bronchiole and transmission electron microscopy evaluation of the respiratory tissue. From these results Sibutramine was found to induce lung fibrosis in Sprague-Dawley rats as increased collagen synthesis, mast cell accumulation and aggregates of Bronchus Associated Lymphoid Tissue (BALT) in the terminal bronchiole as well as increased collagen deposition in the respiratory tissue was seen. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - June 12, 2015 Category: Environmental Health Source Type: research
The effect of sibutramine prescribing in routine clinical practice on cardiovascular outcomes: a cohort study in the United Kingdom
p; I Douglas (Source: International Journal of Obesity)
Source: International Journal of Obesity - June 9, 2015 Category: Eating Disorders and Weight Management Authors: J F HayesK BhaskaranR BatterhamL SmeethI Douglas Source Type: research
Sibutramine, a serotonin-norepinephrine reuptake inhibitor, causes fibrosis in rats
In this study, using the same animal model, the effect of Sibutramine on lung morphology was investigated using histological evaluation of the terminal bronchiole and transmission electron microscopy evaluation of the respiratory tissue. From these results Sibutramine was found to induce lung fibrosis in Sprague-Dawley rats as increased collagen synthesis, mast cell accumulation and aggregates of Bronchus Associated Lymphoid Tissue (BALT) in the terminal bronchiole as well as increased collagen deposition in the respiratory tissue was seen. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - May 23, 2015 Category: Environmental Health Source Type: research
Regulatory alerts for dietary supplements in Canada and the United States, 2005-13.
CONCLUSION: Analysis of Canadian and U.S. regulatory alerts concerning dietary supplements revealed that more than 80% of the composite alerts were issued by Health Canada. The most common intended uses of supplements for which alerts were issued were sexual enhancement, weight loss, and bodybuilding or athletic performance. The most common reason for alerts was the presence of a pharmaceutical contaminant.
PMID: 25987692 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - May 21, 2015 Category: Drugs & Pharmacology Authors: Abe AM, Hein DJ, Gregory PJ Tags: Am J Health Syst Pharm Source Type: research
Past and present of antiobesity agents: Focus on monoamine modulators.
CONCLUSION: Recently approved medications for long-term management of obesity include lorcaserin, phentermine-topiramate, and naltrexone-bupropion. When these drugs are used to facilitate weight loss, pharmacists can play an important role in helping to ensure appropriate patient selection and monitoring.
PMID: 25873617 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - April 17, 2015 Category: Drugs & Pharmacology Authors: Khorassani FE, Misher A, Garris S Tags: Am J Health Syst Pharm Source Type: research
Evaluation of vibrational spectroscopic methods to identify and quantify multiple adulterants in herbal medicines.
Abstract
To counter the growth of herbal medicines adulterated with pharmaceuticals crossing borders, rapid, inexpensive and non-destructive analytical techniques, that can handle complex matrices, are required. Since mid-infrared (MIR), near infrared (NIR) and Raman spectroscopic techniques meet these criteria, their performance in identifying adulterants in seized weightloss herbal medicines is definitively determined. Initially a validated high pressure liquid chromatography methodology was used for reference identification and quantification of the adulterants sibutramine H2O·HCl, fenfluramine HCl and...
Source: Talanta - April 13, 2015 Category: Chemistry Authors: Rooney JS, McDowell A, Strachan CJ, Gordon KC Tags: Talanta Source Type: research
Obesity and Clinical Riskiness Relationship: Therapeutic Management by Dietary Antioxidant Supplementation-a Review.
Abstract
Obesity is a global health problem affecting all age groups, leading to many complications such as type 2 diabetes, systemic hypertension, cardiovascular disease, dyslipidemia, atherosclerosis, and stroke. Physiologically, obesity arises from metabolic changes in the tissues and organs of the human body; these changes result in an imbalance between energy intake and energy expenditure, which in turn results in increased fat accumulation in adipose tissue. Such fat accumulation predisposes individuals to development of several health problems. Two different obesity treatment drugs are currently on ...
Source: Applied Biochemistry and Biotechnology - April 12, 2015 Category: Biochemistry Authors: Hassan HA, El-Gharib NE Tags: Appl Biochem Biotechnol Source Type: research
Assessment of potential cardiovascular risks of methylphenidate in comparison with sibutramine: do we need a SCOUT (trial)?
Abstract
With the recent approval of methylphenidate (MPH) for treating attention-deficit/hyperactivity disorder (ADHD) in adults, the number of patients exposed will increase tremendously. The ongoing debate on the cardiovascular safety of MPH has triggered two large retrospective cohort studies in children and adolescents as well as in young to middle-aged adults. These studies looked into serious cardiovascular events (sudden cardiac death, acute myocardial infarction and stroke) as primary endpoints and concluded that MPH was safe after a mean duration of 2.1 years of follow-up in children a...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 17, 2015 Category: Neuroscience Source Type: research
Bupropion treatment increases epididymal contractility and impairs sperm quality with no effects on the epididymal sperm transit time of male rats
Abstract
Bupropion is a dopamine (DA) and norepinephrine (NE) reuptake inhibitor used as smoking cessation and antidepressant drug with a lower incidence of male sexual dysfunction. We showed previously that sibutramine, a norepinephrine/serotonine reuptake inhibitor, reduced male rat fertility. As there are no studies evaluating the impact of bupropion treatment on spermatic parameters and male fertility, we evaluated the effects of bupropion treatment (15 and 30 mg kg−1, 30 days) on sexual behavior, spermatic parameters and fertility of male Wistar rats and on the epididymal duct in vitro contractility. Bupropion...
Source: Journal of Applied Toxicology - February 3, 2015 Category: Toxicology Authors: Marilia Martins Cavariani, Luiz Ricardo Almeida Kiguti, Josiane Lima Rosa, Gabriel Adan Araújo Leite, Patrícia Villela e Silva, André Sampaio Pupo, Wilma De Grava Kempinas Tags: Research Article Source Type: research
Predicting meaningful outcomes to medication and self-help treatments for binge-eating disorder in primary care: The significance of early rapid response.
We examined rapid response among obese patients with binge-eating disorder (BED) in a randomized clinical trial testing antiobesity medication and self-help cognitive–behavioral therapy (shCBT), alone and in combination, in primary-care settings. Method: One hundred four obese patients with BED were randomly assigned to 1 of 4 treatments: sibutramine, placebo, shCBT + sibutramine, or shCBT + placebo. Treatments were delivered by generalist primary-care physicians and the medications were given double-blind. Independent assessments were performed by trained and monitored doctoral research clinicians monthly throughout tre...
Source: Journal of Consulting and Clinical Psychology - January 26, 2015 Category: Psychiatry & Psychology Authors: Grilo, Carlos M.; White, Marney A.; Masheb, Robin M.; Gueorguieva, Ralitza Source Type: research
The Effectiveness of Pharmaceutical Interventions for Obesity: Weight Loss With Orlistat and Sibutramine in a United Kingdom Population‐Based Cohort
ConclusionsOrlistat and sibutramine had early effects on weight loss, not sustained over three years. As new treatments for obesity are approved, their effectiveness should be measured in routine clinical practice, as effectiveness may be considerably less than seen in randomised trials. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - December 31, 2014 Category: Drugs & Pharmacology Authors: Ian J. Douglas, Krishnan Bhaskaran, Rachel L. Batterham, Liam Smeeth Tags: Pharmacoepidemiology Source Type: research
