The effect of anti‐obesity drugs on waist circumference: a mixed treatment comparison
ConclusionsOrlistat should be considered as an addition to lifestyle interventions in the treatment of obesity. Lorcaserin has recently been approved by the FDA and these results suggest it is similar in both efficacy and safety to orlistat. (Source: Diabetes, Obesity and Metabolism)
Source: Diabetes, Obesity and Metabolism - August 27, 2013 Category: Endocrinology Authors: Megan Chilton, Alison Dunkley, Patrice Carter, Melanie J Davies, Kamlesh Khunti, Laura J Gray Tags: Original Article Source Type: research
Time series analyses of the effect of FDA communications on use of prescription weight loss medications.
Conclusion: From 2008 to 2010, use of prescription weight loss medications was low and declined over time. FDA communications regarding the safety of these medications had limited effect on use.
PMID: 23929685 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - August 8, 2013 Category: Eating Disorders and Weight Management Authors: Block JP, Choudhry NK, Carpenter DP, Fischer MA, Brennan TA, Tong AY, Matlin OS, Shrank WH Tags: Obesity (Silver Spring) Source Type: research
Potent inhibition of cytochrome P450 2B6 by sibutramine in human liver microsomes.
Abstract
The present study was performed to evaluate the potency and specificity of sibutramine as an inhibitor of the activities of nine human CYP isoforms in liver microsomes. Using a cocktail assay, the effects of sibutramine on specific marker reactions of the nine CYP isoforms were measured in human liver microsomes. Sibutramine showed potent inhibition of CYP2B6-mediated bupropion 6-hydroxylation with an IC50 value of 1.61 μM and Ki value of 0.466 μM in a competitive manner at microsomal protein concentrations of 0.25 mg/ml; this was 3.49-fold more potent than the typical CYP2B6 inhibitor thio-TEPA...
Source: Chemico-Biological Interactions - June 15, 2013 Category: Molecular Biology Authors: Bae SH, Kwon MJ, Choi EJ, Zheng YF, Yoon KD, Liu KH, Bae SK Tags: Chem Biol Interact Source Type: research
Trends in counterfeits amphetamine-type stimulants after its prohibition in Brazil
This study represents the first step in the elucidation of falsification of ATS in Brazil. Considering the forensic intelligence these information are valuable in order to develop and establish a database that enables correlate samples from different locations and/or suppliers and to map the profile and trends of trafficking. (Source: Forensic Science International)
Source: Forensic Science International - May 18, 2013 Category: Forensic Medicine Authors: Kristiane de Cássia Mariotti, Rafael S. Ortiz, Daniele Z. Souza, Thayse C. Mileski, Pedro E. Fröehlich, Renata P. Limberger Tags: Research Articles Source Type: research
Rats on a High-energy Diet Showing No Weight Gain Present with Ultrastructural Changes Associated with Liver Fibrosis.
In conclusion, in female rats fed a high-energy diet that does not result in weight gain hepatic fibrosis occurs without steatosis. In these rats the co-administration of sibutramine increases the degree of fibrosis and steatosis develops. Although it has been widely believed that sibutramine is not hepatotoxic, this study clearly shows that at an ultrastructural level, rats fed a high-energy diet treated with sibutramine show signs of hepatotoxicity.
PMID: 23672266 [PubMed - as supplied by publisher] (Source: Ultrastructural Pathology)
Source: Ultrastructural Pathology - May 14, 2013 Category: Pathology Authors: Oberholzer HM, Bester MJ, van der Schoor C Tags: Ultrastruct Pathol Source Type: research
MRI allows for longitudinal quantitative analysis of body fat composition in rats: An analysis of sibutramine-associated changes at the group level
Abstract: Purpose: Body fat distribution changes are associated with multiple alterations in metabolism. Therefore, the assessment of body fat compartments by MRI in animal models is a promising approach to obesity research. Standard T1-weighted (T1w) whole body MRI was used here to quantify different effects in the subcutaneous and visceral fat compartments in rats under treatment with an anorexiant.Materials and methods: Twenty rats on a high caloric diet were investigated by the identical MRI protocol at baseline and after seven weeks. Ten rats received a treatment with sibutramine, 10 rats served as vehicle control gro...
Source: Magnetic Resonance Imaging - May 13, 2013 Category: Radiology Authors: Hans-Peter Müller, Heiko G. Niessen, Thomas Kaulisch, Albert C. Ludolph, Jan Kassubek, Detlef Stiller Tags: Original Contributions Source Type: research
The effect of sibutramine on platelet morphology of Spraque‐Dawley rats fed a high energy diet
ABSTRACT
The aim of this study was to investigate the effect of Sibutramine on platelet ultrastructure and discuss the morphological observations in relation to known physiological effects of the compound. Six‐week‐old, female Spraque‐Dawley rats were used in this study. The animals were placed on a high energy diet after which sibutramine administration followed. Blood was drawn on the day of termination and platelet rich plasma was obtained to prepare plasma smears for analysis. Scanning electron microscopy was used to investigate the ultrastructure of the platelets. Platelets of the Sibutramine‐treated animals s...
Source: Microscopy Research and Technique - April 11, 2013 Category: Laboratory Medicine Authors: Hester Magdalena Oberholzer, Ciska Schoor, Etheresia Pretorius Tags: Research Article Source Type: research
Orlistat reduces weight but its cost-effectiveness remains unclear
This study aimed to evaluate the effectiveness and cost effectiveness of three pharmacological interventions (orlistat, sibutramine and rimonabant) in obese patients in... (Source: Evidence-Based Nursing)
Source: Evidence-Based Nursing - March 8, 2013 Category: Nursing Authors: Veerman, L. Tags: Health policy, General practice / family medicine, Drugs: cardiovascular system, Stroke, Obesity (nutrition), Health service research, Health education, Obesity (public health) Primary healthcare Source Type: research
Treatment options for children with monogenic forms of obesity.
In conclusion, the management of monogenic obesities still remains a challenge.
PMID: 23428688 [PubMed - in process] (Source: World Review of Nutrition and Dietetics)
Source: World Review of Nutrition and Dietetics - March 2, 2013 Category: Nutrition Authors: Hainerová IA, Lebl J Tags: World Rev Nutr Diet Source Type: research
Sibutramine: Mania: case report
(Source: Reactions)
Source: Reactions - February 15, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research
Different Effects of Clopidogrel and Clarithromycin on the Enantioselective Pharmacokinetics of Sibutramine and its Active Metabolites in Healthy Subjects.
In this study, we assessed the effects of clopidogrel and clarithromycin, known CYP2B6 and CYP3A inhibitors, respectively, on the enantioselective disposition of racemic sibutramine in conjunction with CYP2B6 polymorphisms in humans. Sibutramine showed enantioselective plasma profiles with consistently higher concentrations of R-enantiomers. Clopidogrel and clarithromycin significantly increased the sibutramine plasma concentration, but their effects differed between enantiomers; a 2.2-fold versus 4.1-fold increase in the AUC in S-enantiomer and 1.8-fold versus 2.0-fold for the R-enantiomer, respectively. The AUCs of S- an...
Source: The Journal of Clinical Pharmacology - February 4, 2013 Category: Drugs & Pharmacology Authors: Shinde DD, Kim HS, Choi JS, Pan W, Bae SK, Yeo CW, Shon JH, Kim DH, Shin JG Tags: J Clin Pharmacol Source Type: research
Norepinephrine Transport Inhibition for Treatment of Vasovagal Syncope
CONCLUSIONIn this open label series, sibutramine prevented vasovagal syncope in most highly symptomatic patients. (Source: Journal of Cardiovascular Electrophysiology)
Source: Journal of Cardiovascular Electrophysiology - February 1, 2013 Category: Cardiology Authors: Robert S Sheldon, Debbie Ritchie, McRae RN Maureen, Satish Raj Tags: Original Clinical Source Type: research
Investigating the roles of different monoamine transmitters and impulse control using the 5-choice serial reaction time task
Previous studies have shown that drugs which block the reuptake of catecholamine neurotransmitters improve impulse control in diseases such as attention deficit hyperactivity disorder (ADHD). Serotonin-specific reuptake inhibitors (SSRI) lack efficacy in ADHD and have been linked to increased suicide risk. The present study investigated drugs with affinity for one or more of the monoamine reuptake transporters using the 5-choice serial reaction time task, a model of attention and impulsivity in rodents. We also tested the effects of the alpha2-adreoceptor antagonist, idazoxan and novel antidepressant, agomelatine, which bo...
Source: Journal of Psychopharmacology - January 23, 2013 Category: Psychiatry Authors: Humpston, C. S., Wood, C. M., Robinson, E. S. Tags: Original Papers Source Type: research
Sibutramine: Ischaemic colitis: case report
(Source: Reactions)
Source: Reactions - January 12, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research
Sibutramine: Cardiomyopathy: case report
(Source: Reactions)
Source: Reactions - January 12, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research
