Continued Risk of Dietary Supplements Adulterated with Approved and Unapproved Drugs: Assessment of the FDA Tainted Supplements Database 2007 through 2021
This article compares the determination of API adulteration in dietary supplement from the 10-year time-period of 2007-2016 to the most recent 5-year period of 2017-2021. From 2007 through 2021, 1,068 unique products have been found to be adulterated with APIs. Sexual enhancement and weight loss dietary supplements are the most common products adulterated with APIs. Phosphodiesterase-5 inhibitors are commonly included in sexual enhancement dietary supplements and a single product can include up to five APIs. Sibutramine, a drug removed from the market due to cardiovascular adverse events, is the most included adulterant AP...
Source: The Journal of Clinical Pharmacology - March 14, 2022 Category: Drugs & Pharmacology Authors: C Michael White Source Type: research
Continued Risk of Dietary Supplements Adulterated with Approved and Unapproved Drugs: Assessment of the FDA Tainted Supplements Database 2007 through 2021
This article compares the determination of API adulteration in dietary supplement from the 10-year time-period of 2007-2016 to the most recent 5-year period of 2017-2021. From 2007 through 2021, 1,068 unique products have been found to be adulterated with APIs. Sexual enhancement and weight loss dietary supplements are the most common products adulterated with APIs. Phosphodiesterase-5 inhibitors are commonly included in sexual enhancement dietary supplements and a single product can include up to five APIs. Sibutramine, a drug removed from the market due to cardiovascular adverse events, is the most included adulterant AP...
Source: The Journal of Clinical Pharmacology - March 14, 2022 Category: Drugs & Pharmacology Authors: C Michael White Source Type: research
Continued Risk of Dietary Supplements Adulterated with Approved and Unapproved Drugs: Assessment of the FDA Tainted Supplements Database 2007 through 2021
This article compares the determination of API adulteration in dietary supplement from the 10-year time-period of 2007-2016 to the most recent 5-year period of 2017-2021. From 2007 through 2021, 1,068 unique products have been found to be adulterated with APIs. Sexual enhancement and weight loss dietary supplements are the most common products adulterated with APIs. Phosphodiesterase-5 inhibitors are commonly included in sexual enhancement dietary supplements and a single product can include up to five APIs. Sibutramine, a drug removed from the market due to cardiovascular adverse events, is the most included adulterant AP...
Source: The Journal of Clinical Pharmacology - March 14, 2022 Category: Drugs & Pharmacology Authors: C Michael White Source Type: research
Quantitation of sibutramine in human hair using gas chromatography –isotope dilution tandem mass spectrometry
ConclusionsIt should be expected that the method established in this study would contribute to rapid determinations of sibutramine. To our knowledge, this is the first report describing quantitation of sibutramine in an authentic human hair sample by GC–MS/MS. (Source: Forensic Toxicology)
Source: Forensic Toxicology - December 14, 2021 Category: Forensic Medicine Source Type: research
Molecules, Vol. 26, Pages 6903: Adulteration of Weight Loss Supplements by the Illegal Addition of Synthetic Pharmaceuticals
Zyoud
Weight loss supplements that have illegal additives of pharmaceutical drugs or analogues have additional health risks, and customers may not be aware of what they are taking. This research is an essential investigation and quantification of illegally added pharmaceuticals or prescription medications, specifically fluoxetine, phenolphthalein, and sibutramine, in herbal weight loss supplements offered for sale in the United Arab Emirates (UAE). In this case, 137 weight loss supplements were collected and analyzed in this study. Reversed-phase high-performance liquid chromatography with UV absorption detection coup...
Source: Molecules - November 16, 2021 Category: Chemistry Authors: Ammar A. Jairoun Sabaa Saleh Al-Hemyari Moyad Shahwan Sa ’ed H. Zyoud Tags: Article Source Type: research
Adulteration of the Herbal Weight Loss Products by the Illegal Addition of Synthetic Antiobesity Medications: A Pilot Study
CONCLUSION: Since apothecaries have advised consumers to take at least two capsules a day, it seems that the blood concentration of sibutramine will likely rise beyond the therapeutic concentration and become toxic. Therefore, the usage of such products could pose serious risks to consumers' health.PMID:34336274 | PMC:PMC8294965 | DOI:10.1155/2021/9968730 (Source: Journal of Obesity)
Source: Journal of Obesity - August 2, 2021 Category: Eating Disorders & Weight Management Authors: Farzin Firozian Amir Nili-Ahmadabadi Shirin Moradkhani Miad Moulaei Zohreh Fasihi Davoud Ahmadimoghaddam Source Type: research
