Time Series Disturbance Detection for Hypothesis-Free Signal Detection in Longitudinal Observational Databases
ConclusionOverall, the disturbance algorithm approach shows promising capacity for detecting outliers, and shows tractability of the algorithmic approach for large-scale screening. The method offers an array of pattern types for detection and clinical review. (Source: Drug Safety)
Source: Drug Safety - February 21, 2018 Category: Drugs & Pharmacology Source Type: research
Drug-induced arterial hypertension - a frequently ignored cause of secondary hypertension: a review.
Authors: Diaconu CC, Dediu GN, Iancu MA
Abstract
The prevalence of hypertension is likely to grow during the future years, mainly due to aging of the population and increasing prevalence of obesity, as an important risk factor for hypertension. One of the main causes of secondary hypertension, frequently ignored, is represented by certain categories of drugs, that can induce hypertension, increase the blood pressure values in previously controlled hypertension, decrease the effects of antihypertensive medication or induce a hypertensive emergency. These drugs may be over-the-counter medications, illicit dr...
Source: Acta Cardiologica - January 4, 2018 Category: Cardiology Tags: Acta Cardiol Source Type: research
Cardiovascular Outcome Trials of Diabetes and Obesity Drugs: Implications for Conditional Approval and Early Phase Clinical Development
AbstractOver the past decade, clinical development and regulatory review of investigational drugs for diabetes and obesity have been guided by heightened standards for pre- and post-marketing assessment of cardiovascular safety. In high-risk patients with type 2 diabetes, several large multicentre cardiovascular outcome trials (CVOTs) have confirmed non-inferiority, i.e. cardiovascular safety for several glucose-lowering agents. More recent diabetes CVOTs have demonstrated major cardiovascular benefits for drugs representing two newer classes, sodium –glucose cotransporter (SGLT)-2 inhibition and glucagon-like peptide (G...
Source: Pharmaceutical Medicine - November 6, 2017 Category: Drugs & Pharmacology Source Type: research
Adulteration of Proprietary Chinese Medicines and Health Products with Undeclared Drugs: Experience of a Tertiary Toxicology Laboratory in Hong Kong
ConclusionsAdulteration of pCMs and health products with undeclared drugs poses severe health hazards to citizens. Public education and effective regulatory measures are essential to address the problem. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - October 1, 2017 Category: Drugs & Pharmacology Authors: Chor Kwan Ching, Sammy Pak Lam Chen, Hencher Han Chih Lee, Ying Hoo Lam, Sau Wah Ng, Mo Lung Chen, Magdalene Huen Yin Tang, Suzanne Suk San Chan, Candy Wai Yan Ng, Jana Wing Lan Cheung, Tina Yee Ching Chan, Nike Kwai Cheung Lau, Yeow Kuan Chong, Tony Wing Tags: DRUG SAFETY Source Type: research
Is zebrafish (Danio rerio) a tool for human ‐like metabolism study?
This study demonstrates that adult zebrafish can absorb, oxidize and excrete several metabolites in a manner similar to humans. Therefore, adult zebrafish seem to be a very promising tool to study human‐like metabolism when aiming to find analytical targets for doping control. (Source: Drug Testing and Analysis)
Source: Drug Testing and Analysis - September 1, 2017 Category: Drugs & Pharmacology Authors: Carina Souza Anselmo, Vinicius Figueiredo Sardela, Bernardo Fonseca Matias, Amanda Reis Carvalho, Valeria Pereira Sousa, Henrique Marcelo Gualberto Pereira, Francisco Radler Aquino Neto Tags: Perspective Source Type: research
Validation of an LC –MS/MS method for analysis of anti‐diabetic drugs in botanical dietary supplements labeled for blood sugar management
Abstract
We developed and validated a liquid chromatography–tandem mass spectrometry (LC–MS/MS) method to detect and quantitate 14 anti‐diabetic, 2 anti‐obesity, and 3 cholesterol‐lowering drugs in botanical dietary supplements marketed for blood sugar management. Many botanical dietary supplements which carry label statements related to blood sugar management are available over the Internet. Potential adulteration of such dietary supplements with anti‐diabetic and other prescription drugs, some of which have been removed from the market due to adverse events, is of concern. No significant matrix effects were o...
Source: Drug Testing and Analysis - August 29, 2017 Category: Drugs & Pharmacology Authors: Jun Ma, Rahul S. Pawar, Erich Grundel Tags: SHORT COMMUNICATION Source Type: research
Current and emerging pharmacotherapies for obesity in Australia
Conclusions The landscape of obesity treatment is changing rapidly. Of the new therapeutic options presented, all options have associated adverse events requiring long-term safety data, but the availability of new options is a welcome development. (Source: Obesity Research and Clinical Practice)
Source: Obesity Research and Clinical Practice - August 17, 2017 Category: Eating Disorders & Weight Management Source Type: research
Metabolic and Inflammatory Changes with Orlistat and Sibutramine Treatment in Obese Malaysian Subjects.
CONCLUSION: Nine months of treatment with orlistat and sibutramine not only reduced weight but also significantly improved BMI, WC, BF, VF, FPG, adiponectin, fasting insulin, HOMA%B, HOMA%S, HOMA-IR and hs-CRP. These improvements could prove useful in the reduction of metabolic and cardiovascular risks in obese subjects.
PMID: 28724846 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - July 21, 2017 Category: Universities & Medical Training Authors: Al-Tahami BAM, Al-Safi Ismail AA, Sanip Z, Yusoff Z, Shihabudin TMT, Singh TSP, Rasool AHG Tags: J Nippon Med Sch Source Type: research
Sensors, Vol. 17, Pages 1601: Rapid Surface Enhanced Raman Scattering (SERS) Detection of Sibutramine Hydrochloride in Pharmaceutical Capsules with a β-Cyclodextrin- Ag/Polyvivnyl Alcohol Hydrogel Substrate
Sibutramine hydrochloride (SH) is a banned weight-loss drug, but its illegal addition to health products is still rampant. This suggests a very urgent need for a fast and precise detection method for SH. Surface Enhanced Raman Scattering (SERS) is a promising candidate for this purpose, but the weak affinity between SH and bare metal limits its direct SERS detection. In the present work, β-cyclodextrin was capped in situ onto the surface of Ag nanoparticles to function as a scaffold to capture SH. The obtained Ag nanoparticles were encapsulated into polyvinyl alcohol (PVA) to fabricate a SERS active hydrogel with excellen...
Source: Sensors - July 10, 2017 Category: Biotechnology Authors: Lei Ouyang Zuyan Jiang Nan Wang Lihua Zhu Heqing Tang Tags: Article Source Type: research
Validation of an LC ‐MS/MS method for analysis of anti‐diabetic drugs in botanical dietary supplements labelled for blood sugar management
Abstract
We developed and validated a liquid chromatography tandem mass spectrometry (LC‐MS/MS) method to detect and quantitate 14 anti‐diabetic, 2 anti‐obesity and 3 cholesterol‐lowering drugs in botanical dietary supplements marketed for blood sugar management. Many botanical dietary supplements which carry label statements related to blood sugar management are available over the internet. Potential adulteration of such dietary supplements with anti‐diabetic and other prescription drugs, some of which have been removed from the market due to adverse events, is of concern. No significant matrix effects were obse...
Source: Drug Testing and Analysis - July 1, 2017 Category: Drugs & Pharmacology Authors: Jun Ma, Rahul S. Pawar, Erich Grundel Tags: SHORT COMMUNICATION Source Type: research
FDA Warnings Nurses can Include in Patient Education
* The Food and Drug Administration is urging consumers to avoid the following over-the-counter products or unapproved products that are sold online: PNC-27, promoted as a cancer drug; homeopathic baby teething products; weight-loss products containing sibutramine; and sexual enhancement products containing sildenafil. (Source: AJN)
Source: AJN - April 28, 2017 Category: Nursing Tags: Drug Watch Source Type: research
Determination of caffeine and identification of undeclared substances in dietary supplements and caffeine dietary exposure assessment.
Abstract
Caffeine is one of the most consumed stimulants in the world, and is a frequent ingredient of dietary supplements. The aims of this work were to validate a GC-MS method for the quantitation of caffeine and identification of other substances in supplements, mainly weight loss products, and to estimate the caffeine intake by consumers. Sample preparation included extraction with chloroform:water in ultrasonic bath, centrifugation and analysis of the organic layer for caffeine quantitation, and extraction with methanol for identification of other substances. A total of 213 samples of 52 supplement pr...
Source: Food and Chemical Toxicology - March 30, 2017 Category: Food Science Authors: da Justa Neves DB, Caldas ED Tags: Food Chem Toxicol Source Type: research
[Information quality and health risks in Spanish-language retail websites for Chinese herbal medicine].
CONCLUSION: Online health seekers should be warned about misinformation on retail websites for Chinese herbal medicine and directed to a Spanish government Web site for guidance in safely navigating the Internet for buying Chinese herbal medicine.
PMID: 28318753 [PubMed - as supplied by publisher] (Source: Gaceta Sanitaria)
Source: Gaceta Sanitaria - March 22, 2017 Category: Global & Universal Tags: Gac Sanit Source Type: research
Relation between weight loss and causes of death in patients with cardiovascular disease: finding from the SCOUT trial
Conclusion: The relationship between weight change and mortality differs for cardiovascular and noncardiovascular mortality. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - January 27, 2017 Category: Cardiology Tags: Research articles Source Type: research
Tramadol vs. Everything: 744 Drug Interactions and Counting
BY THOMAS BARROWS, MDA 43-year-old woman presented to our emergency department with complaints of anxiety, intermittent “cramping” in her left hand, and jerking movements of her body that had been going on for five days. She had depression following the death of her son 14 months earlier, for which she was started on Effexor 37.5 mg once daily two weeks earlier.One week before this visit, the patient had back pain and headache, for which she was evaluated at a local emergency department. She had lumbar x-rays showing mild degenerative changes in her spine and a normal head CT scan. The emergency physician...
Source: The Case Files - January 17, 2017 Category: Emergency Medicine Tags: Blog Posts Source Type: research
