Advancing Malaria Vaccination in Africa: Cameroon's Pioneering Effort and the Path Forward
Environ Health Insights. 2024 Mar 6;18:11786302241236013. doi: 10.1177/11786302241236013. eCollection 2024.NO ABSTRACTPMID:38449588 | PMC:PMC10916456 | DOI:10.1177/11786302241236013 (Source: Environmental Health Insights)
Source: Environmental Health Insights - March 7, 2024 Category: Environmental Health Authors: Olalekan John Okesanya Jerico Bautista Ogaya Emery Manirambona Chioma Ogochukwu Anorue Don Eliseo Lucero-Prisno Source Type: research
Advancing Malaria Vaccination in Africa: Cameroon's Pioneering Effort and the Path Forward
Environ Health Insights. 2024 Mar 6;18:11786302241236013. doi: 10.1177/11786302241236013. eCollection 2024.NO ABSTRACTPMID:38449588 | PMC:PMC10916456 | DOI:10.1177/11786302241236013 (Source: Environmental Health Insights)
Source: Environmental Health Insights - March 7, 2024 Category: Environmental Health Authors: Olalekan John Okesanya Jerico Bautista Ogaya Emery Manirambona Chioma Ogochukwu Anorue Don Eliseo Lucero-Prisno Source Type: research
Viral hepatitis –induced acute liver failure
AbstractViral hepatitis –induced acute liver failure (ALF) is a preventable cause for liver-related mortality worldwide. Viruses are the most common cause for ALF in developing nations in contrast to the west, where acetaminophen is largely responsible. Viruses may be hepatotropic or affect the liver secondary to a syste mic infection. In tropical countries, infections such as leptospirosis, scrub typhus and malaria can mimic the symptoms of ALF. Differentiating these ALF mimics is crucial because they require etiology-specific therapy. Treatment of viral hepatitis-induced ALF is two-pronged and directed towards pro vidi...
Source: Indian Journal of Gastroenterology - March 7, 2024 Category: Gastroenterology Source Type: research
Non-clinical toxicity and immunogenicity evaluation of a Plasmodium vivax malaria vaccine using Poly-ICLC (Hiltonol ®) as adjuvant
In conclusion, in these non-clinical models, repeated dose administrations of the PvCSP-All epitopes vaccine adjuvanted with a Poly-ICLC were immunogenic, safe, and well tolerated.PMID:38448321 | DOI:10.1016/j.vaccine.2024.02.070 (Source: Vaccine)
Source: Vaccine - March 6, 2024 Category: Allergy & Immunology Authors: Rodolfo F Marques Alba M Gimenez Ot ávia Caballero Andrew Simpson Andres M Salazar Rogerio Amino Steven Godin Ricardo T Gazzinelli Irene S Soares Source Type: research
Non-clinical toxicity and immunogenicity evaluation of a Plasmodium vivax malaria vaccine using Poly-ICLC (Hiltonol ®) as adjuvant
In conclusion, in these non-clinical models, repeated dose administrations of the PvCSP-All epitopes vaccine adjuvanted with a Poly-ICLC were immunogenic, safe, and well tolerated.PMID:38448321 | DOI:10.1016/j.vaccine.2024.02.070 (Source: Vaccine)
Source: Vaccine - March 6, 2024 Category: Allergy & Immunology Authors: Rodolfo F Marques Alba M Gimenez Ot ávia Caballero Andrew Simpson Andres M Salazar Rogerio Amino Steven Godin Ricardo T Gazzinelli Irene S Soares Source Type: research
Previous Malaria Exposures and Immune Dysregulation: Developing Strategies To Improve Malaria Vaccine Efficacy in Young Children
Am J Trop Med Hyg. 2024 Mar 5:tpmd230696. doi: 10.4269/ajtmh.23-0696. Online ahead of print.ABSTRACTAfter several decades in development, two malaria vaccines based on the same antigen and with very similar constructs and adjuvants, RTS,S/AS01 (RTS,S) and R21/Matrix-M (R21), were recommended by the WHO for widespread vaccination of children. These vaccines are much-needed additions to malaria control programs that, when used in conjunction with other control measures, will help to accelerate reductions in malaria morbidity and mortality. Although R21 is not yet available, RTS,S is currently being integrated into routine va...
Source: The American Journal of Tropical Medicine and Hygiene - March 5, 2024 Category: Tropical Medicine Authors: Katherine R Dobbs Harrysone E Atieli Clarissa Valim James G Beeson Source Type: research
Previous Malaria Exposures and Immune Dysregulation: Developing Strategies To Improve Malaria Vaccine Efficacy in Young Children
Am J Trop Med Hyg. 2024 Mar 5:tpmd230696. doi: 10.4269/ajtmh.23-0696. Online ahead of print.ABSTRACTAfter several decades in development, two malaria vaccines based on the same antigen and with very similar constructs and adjuvants, RTS,S/AS01 (RTS,S) and R21/Matrix-M (R21), were recommended by the WHO for widespread vaccination of children. These vaccines are much-needed additions to malaria control programs that, when used in conjunction with other control measures, will help to accelerate reductions in malaria morbidity and mortality. Although R21 is not yet available, RTS,S is currently being integrated into routine va...
Source: Am J Trop Med Hyg - March 5, 2024 Category: Infectious Diseases Authors: Katherine R Dobbs Harrysone E Atieli Clarissa Valim James G Beeson Source Type: research
Previous Malaria Exposures and Immune Dysregulation: Developing Strategies To Improve Malaria Vaccine Efficacy in Young Children
Am J Trop Med Hyg. 2024 Mar 5:tpmd230696. doi: 10.4269/ajtmh.23-0696. Online ahead of print.ABSTRACTAfter several decades in development, two malaria vaccines based on the same antigen and with very similar constructs and adjuvants, RTS,S/AS01 (RTS,S) and R21/Matrix-M (R21), were recommended by the WHO for widespread vaccination of children. These vaccines are much-needed additions to malaria control programs that, when used in conjunction with other control measures, will help to accelerate reductions in malaria morbidity and mortality. Although R21 is not yet available, RTS,S is currently being integrated into routine va...
Source: The American Journal of Tropical Medicine and Hygiene - March 5, 2024 Category: Tropical Medicine Authors: Katherine R Dobbs Harrysone E Atieli Clarissa Valim James G Beeson Source Type: research
Previous Malaria Exposures and Immune Dysregulation: Developing Strategies To Improve Malaria Vaccine Efficacy in Young Children
Am J Trop Med Hyg. 2024 Mar 5:tpmd230696. doi: 10.4269/ajtmh.23-0696. Online ahead of print.ABSTRACTAfter several decades in development, two malaria vaccines based on the same antigen and with very similar constructs and adjuvants, RTS,S/AS01 (RTS,S) and R21/Matrix-M (R21), were recommended by the WHO for widespread vaccination of children. These vaccines are much-needed additions to malaria control programs that, when used in conjunction with other control measures, will help to accelerate reductions in malaria morbidity and mortality. Although R21 is not yet available, RTS,S is currently being integrated into routine va...
Source: Am J Trop Med Hyg - March 5, 2024 Category: Infectious Diseases Authors: Katherine R Dobbs Harrysone E Atieli Clarissa Valim James G Beeson Source Type: research
Previous Malaria Exposures and Immune Dysregulation: Developing Strategies To Improve Malaria Vaccine Efficacy in Young Children
Am J Trop Med Hyg. 2024 Mar 5:tpmd230696. doi: 10.4269/ajtmh.23-0696. Online ahead of print.ABSTRACTAfter several decades in development, two malaria vaccines based on the same antigen and with very similar constructs and adjuvants, RTS,S/AS01 (RTS,S) and R21/Matrix-M (R21), were recommended by the WHO for widespread vaccination of children. These vaccines are much-needed additions to malaria control programs that, when used in conjunction with other control measures, will help to accelerate reductions in malaria morbidity and mortality. Although R21 is not yet available, RTS,S is currently being integrated into routine va...
Source: The American Journal of Tropical Medicine and Hygiene - March 5, 2024 Category: Tropical Medicine Authors: Katherine R Dobbs Harrysone E Atieli Clarissa Valim James G Beeson Source Type: research
Malaria vaccine efficacy, safety, and community perception in Africa: a scoping review of recent empirical studies
ConclusionMalaria vaccines protect against malaria infection in varying degrees, with severe side effects rarely occurring. Further research is required to improve vaccine efficacy and community involvement is needed to ensure successful widespread use in African communities. (Source: Infection)
Source: Infection - March 5, 2024 Category: Infectious Diseases Source Type: research
GSE228461 MCP-1 production regulated by ATG5 in inflammatory monocytes selectively modulates anti-malarial CD4+ Th1 response
Contributors : Wenyue Xu ; Taiping LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusA promising strategy to design effective malaria blood-stage vaccines is to induce parasite-specific CD4+ Th1 cell responses, but the regulatory mechanism of which is still largely unknown. Here, we showed that the ATG5-deficiency in myeloid cells significantly inhibit the growth of rodent blood-stage malaria parasites through specifically enhancing parasite-specific CD4+ Th1 cell responses. This effect was independent of ATG5-mediated canonical autophagy and non-canonical autophagy.Mechanistically...
Source: GEO: Gene Expression Omnibus - March 1, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Initial assessment of immigrant patients in primary care
Aten Primaria. 2024 Feb 27;56(7):102896. doi: 10.1016/j.aprim.2024.102896. Online ahead of print.ABSTRACTThe clinical interview of immigrant patients requires cultural competence to ensure good understanding and correct communication, in addition to collecting specific information that differs from that of native patients, such as origin and migratory route or cultural identity. Screening for latent tuberculosis infection is recommended in certain cases and screening for other infections, both cosmopolitan with a higher prevalence in migrants (HIV, syphilis, hepatitis B and C) and imported (Chagas, intestinal parasites, st...
Source: Atencion Primaria - February 28, 2024 Category: Primary Care Authors: Mar ía Ángeles González Martínez Mar ía Jesús Castaño Suero Marta Guerrero Mu ñoz Agust ín Francisco Rossetti Ethel Sequeira Aymar Carme Roca Saumell Source Type: research
