Research progress in the off-target effects of Bacille Calmette-Gu érin vaccine
Chin Med J (Engl). 2023 Dec 13. doi: 10.1097/CM9.0000000000002890. Online ahead of print.ABSTRACTBacille Calmette-Guérin (BCG) vaccine is designed to provide protection against tuberculosis (TB). However, numerous epidemiological, clinical, and immunological studies have shown that BCG vaccination affects neonatal and infant mortality, which may be related to the reduction of TB-unrelated infections and diseases by BCG vaccine. We aimed to discuss the off-target effects of BCG vaccine on un-TB infections and diseases, as well as the potential mechanism and influencing factors. Literature was retrieved mainly from PubMed u...
Source: Herpes - December 13, 2023 Category: Infectious Diseases Authors: Yanfei Wu Xiaoyin Zhang Li Zhou Jiayu Lu Fengcai Zhu Jingxin Li Source Type: research
Research progress in the off-target effects of Bacille Calmette-Gu érin vaccine
Chin Med J (Engl). 2023 Dec 13. doi: 10.1097/CM9.0000000000002890. Online ahead of print.ABSTRACTBacille Calmette-Guérin (BCG) vaccine is designed to provide protection against tuberculosis (TB). However, numerous epidemiological, clinical, and immunological studies have shown that BCG vaccination affects neonatal and infant mortality, which may be related to the reduction of TB-unrelated infections and diseases by BCG vaccine. We aimed to discuss the off-target effects of BCG vaccine on un-TB infections and diseases, as well as the potential mechanism and influencing factors. Literature was retrieved mainly from PubMed u...
Source: Cancer Control - December 13, 2023 Category: Cancer & Oncology Authors: Yanfei Wu Xiaoyin Zhang Li Zhou Jiayu Lu Fengcai Zhu Jingxin Li Source Type: research
Research progress in the off-target effects of Bacille Calmette-Gu érin vaccine
Chin Med J (Engl). 2023 Dec 13. doi: 10.1097/CM9.0000000000002890. Online ahead of print.ABSTRACTBacille Calmette-Guérin (BCG) vaccine is designed to provide protection against tuberculosis (TB). However, numerous epidemiological, clinical, and immunological studies have shown that BCG vaccination affects neonatal and infant mortality, which may be related to the reduction of TB-unrelated infections and diseases by BCG vaccine. We aimed to discuss the off-target effects of BCG vaccine on un-TB infections and diseases, as well as the potential mechanism and influencing factors. Literature was retrieved mainly from PubMed u...
Source: Chinese Medical Journal - December 13, 2023 Category: General Medicine Authors: Yanfei Wu Xiaoyin Zhang Li Zhou Jiayu Lu Fengcai Zhu Jingxin Li Source Type: research
Research progress in the off-target effects of Bacille Calmette-Gu érin vaccine
Chin Med J (Engl). 2023 Dec 13. doi: 10.1097/CM9.0000000000002890. Online ahead of print.ABSTRACTBacille Calmette-Guérin (BCG) vaccine is designed to provide protection against tuberculosis (TB). However, numerous epidemiological, clinical, and immunological studies have shown that BCG vaccination affects neonatal and infant mortality, which may be related to the reduction of TB-unrelated infections and diseases by BCG vaccine. We aimed to discuss the off-target effects of BCG vaccine on un-TB infections and diseases, as well as the potential mechanism and influencing factors. Literature was retrieved mainly from PubMed u...
Source: Chinese Medical Journal - December 13, 2023 Category: General Medicine Authors: Yanfei Wu Xiaoyin Zhang Li Zhou Jiayu Lu Fengcai Zhu Jingxin Li Source Type: research
Research progress in the off-target effects of Bacille Calmette-Gu érin vaccine
Chin Med J (Engl). 2023 Dec 13. doi: 10.1097/CM9.0000000000002890. Online ahead of print.ABSTRACTBacille Calmette-Guérin (BCG) vaccine is designed to provide protection against tuberculosis (TB). However, numerous epidemiological, clinical, and immunological studies have shown that BCG vaccination affects neonatal and infant mortality, which may be related to the reduction of TB-unrelated infections and diseases by BCG vaccine. We aimed to discuss the off-target effects of BCG vaccine on un-TB infections and diseases, as well as the potential mechanism and influencing factors. Literature was retrieved mainly from PubMed u...
Source: Chinese Medical Journal - December 13, 2023 Category: General Medicine Authors: Yanfei Wu Xiaoyin Zhang Li Zhou Jiayu Lu Fengcai Zhu Jingxin Li Source Type: research
Research progress in the off-target effects of Bacille Calmette-Gu érin vaccine
Chin Med J (Engl). 2023 Dec 13. doi: 10.1097/CM9.0000000000002890. Online ahead of print.ABSTRACTBacille Calmette-Guérin (BCG) vaccine is designed to provide protection against tuberculosis (TB). However, numerous epidemiological, clinical, and immunological studies have shown that BCG vaccination affects neonatal and infant mortality, which may be related to the reduction of TB-unrelated infections and diseases by BCG vaccine. We aimed to discuss the off-target effects of BCG vaccine on un-TB infections and diseases, as well as the potential mechanism and influencing factors. Literature was retrieved mainly from PubMed u...
Source: Chinese Medical Journal - December 13, 2023 Category: General Medicine Authors: Yanfei Wu Xiaoyin Zhang Li Zhou Jiayu Lu Fengcai Zhu Jingxin Li Source Type: research
Plasmodium knowlesi in pig-tailed macaques: a potential new model for malaria vaccine research
Plasmodium knowlesi is an established experimental model for basic and pre-clinical malaria vaccine research. Historically, rhesus macaques have been the most common host for malaria vaccine studies with P. knowl... (Source: Malaria Journal)
Source: Malaria Journal - December 13, 2023 Category: Infectious Diseases Authors: Melanie J. Shears, Rebekah A. Reynolds, Caroline J. Duncombe, Felicia N. Watson, Weston J. Staubus, Chris Chavtur, Annette M. Seilie, Tuan M. Tran, Sumana Chakravarty, Stephen L. Hoffman and Sean C. Murphy Tags: Research Source Type: research
Novel antibody competition binding assay identifies distinct serological profiles associated with protection
DiscussionThe newly developed serological equivalence assay will inform future vaccine design and possibly even adjuvant selection. This methodology can be adapted to other antigens and disease models, when a panel of relevant mAbs exists, and could offer a unique tool for comparing and down-selecting vaccine formulations. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - December 11, 2023 Category: Allergy & Immunology Source Type: research
Evaluation of a new fusion antigen, cd loop and HAP2-GCS1 domain (cd-HAP) of Plasmodium falciparum Generative Cell Specific 1 antigen formulated with various adjuvants, as a transmission blocking vaccine
Malaria is a major global health challenge, and for the elimination and eradication of this disease, transmission-blocking vaccines (TBVs) are a priority. Plasmodium falciparum Generative Cell Specific 1 (PfGCS1)... (Source: Malaria Journal)
Source: Malaria Journal - December 9, 2023 Category: Infectious Diseases Authors: Zeinab Pourhashem, Leila Nourani, Jafar J. Sani, Hemn Yousefi, Sakineh Pirahmadi, Mobina Sabouri, Abbasali Raz, Navid Dinparast Djadid, Sedigheh Zakeri and Akram Abouie Mehrizi Tags: Research Source Type: research
Interventions for improving coverage of childhood immunisation in low- and middle-income countries
CONCLUSIONS: Health education, home-based records, a combination of involvement of community leaders with health provider intervention, and integration of immunisation services may improve vaccine uptake. The certainty of the evidence for the included interventions ranged from moderate to very low. Low certainty of the evidence implies that the true effect of the interventions might be markedly different from the estimated effect. Further, more rigorous RCTs are, therefore, required to generate high-certainty evidence to inform policy and practice.PMID:38054505 | PMC:PMC10698843 | DOI:10.1002/14651858.CD008145.pub4 (Source...
Source: Cochrane Database of Systematic Reviews - December 6, 2023 Category: General Medicine Authors: Angela Oyo-Ita Olabisi Oduwole Dachi Arikpo Emmanuel E Effa Ekpereonne B Esu Yusentha Balakrishna Moriam T Chibuzor Chioma M Oringanje Chukwuemeka E Nwachukwu Charles S Wiysonge Martin M Meremikwu Source Type: research
Interventions for improving coverage of childhood immunisation in low- and middle-income countries
CONCLUSIONS: Health education, home-based records, a combination of involvement of community leaders with health provider intervention, and integration of immunisation services may improve vaccine uptake. The certainty of the evidence for the included interventions ranged from moderate to very low. Low certainty of the evidence implies that the true effect of the interventions might be markedly different from the estimated effect. Further, more rigorous RCTs are, therefore, required to generate high-certainty evidence to inform policy and practice.PMID:38054505 | PMC:PMC10698843 | DOI:10.1002/14651858.CD008145.pub4 (Source...
Source: Cochrane Database of Systematic Reviews - December 6, 2023 Category: General Medicine Authors: Angela Oyo-Ita Olabisi Oduwole Dachi Arikpo Emmanuel E Effa Ekpereonne B Esu Yusentha Balakrishna Moriam T Chibuzor Chioma M Oringanje Chukwuemeka E Nwachukwu Charles S Wiysonge Martin M Meremikwu Source Type: research
Merozoite surface protein 1 paralog is involved in the human erythrocyte invasion of a zoonotic malaria, Plasmodium knowlesi
The zoonotic malaria parasite Plasmodium knowlesi is an important public health concern in Southeast Asia. Invasion of host erythrocytes is essential for parasite growth, and thus, understanding the repertoire of parasite proteins that enable this process is vital for identifying vaccine candidates and how some species are able to cause zoonotic infection. Merozoite surface protein 1 (MSP1) is found in all malaria parasite species and is perhaps the most well-studied as a potential vaccine candidate. While MSP1 is encoded by a single gene in P. falciparum, all other human infective species (P. vivax, P. knowlesi, P. ovale,...
Source: Frontiers in cellular and infection microbiology - December 4, 2023 Category: Microbiology Source Type: research
Effective cell membrane tension protects red blood cells against malaria invasion
In this study, we use a theoretical model for lipid bilayer mechanics, cytoskeleton deformation, and membrane-merozoite interactions to systematically investigate the influence of effective RBC membrane tension, which includes contributions from the lipid bilayer tension, spontaneous tension, interfacial tension, and the resistance of cytoskeleton against shear deformation on the progression of membrane wrapping during the process of malaria invasion. Our model reveals that this effective membrane tension creates a wrapping energy barrier for a complete merozoite entry. We calculate the tension threshold required to impede...
Source: PLoS Computational Biology - December 4, 2023 Category: Biology Authors: Haleh Alimohamadi Source Type: research
Plasmodium falciparum population structure and genetic diversity of cell traversal protein for ookinetes and sporozoites (CelTOS) during malaria resurgences in Dielmo, Senegal
This study aimed at determining whether the diversity of PfCelTOS gene reflects the changes in malaria transmission that occurred between 2007 and 2014 in Dielmo, a Senegalese village, before and after the implementation of insecticide treated bed nets (ITNs). Of the 109 samples positive for PfCelTOS PCR, 96 (88%) were successfully sequenced and analysed for polymorphisms and population diversity. The number of segregating sites was higher during the pre-intervention period (13) and the malaria resurgences (11) than during the intervention period (5). Similarly, the number and diversity of haplotypes were higher during the...
Source: Infection, Genetics and Evolution - November 29, 2023 Category: Genetics & Stem Cells Authors: Am élé Nyedzie Wotodjo Mary Aigbiremo Oboh Cheikh Sokhna Nafissatou Diagne Fatoumata Di ène-Sarr Jean-Fran çois Trape Souleymane Doucour é Alfred Amambua-Ngwa Umberto D'Alessandro Source Type: research
Acquisition of complement fixing antibodies targeting Plasmodium falciparum merozoites in infants and their mothers in Uganda
ConclusionThis study indicates that complement-fixing antibodies against P. falciparum merozoites are produced in the mothers and placentally-transferred, and they are acquired in infants over time during the first years of life. Understanding early life immune responses is crucial for developing a functional, long lasting malaria vaccine. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - November 28, 2023 Category: Allergy & Immunology Source Type: research
