Vaccine Preventable Disease and Vaccine Hesitancy
Med Clin North Am. 2023 Nov;107(6):979-987. doi: 10.1016/j.mcna.2023.05.012. Epub 2023 Jul 11.ABSTRACTGlobal immunization programs have saved tens of millions of lives over the last 2 decades. Now, the recent successes of COVID-19 vaccines having saved more than 3 million lives in North America during the pandemic may open the door to accelerate technologies for other emerging infection vaccines. New vaccines for respiratory syncytial virus, norovirus, influenza, herpes simplex virus, shingles, dengue fever, enteric bacterial infections, malaria, and Chagas disease are advancing through clinical development and could becom...
Source: The Medical Clinics of North America - October 8, 2023 Category: General Medicine Authors: Peter J Hotez Source Type: research
Health service needs and perspectives of a rainforest conserving community in Papua New Guineas Ramu lowlands: a combined clinical and rapid anthropological assessment with parallel treatment of urgent cases
Conclusions
This study enabled service planning and demonstrated a need sufficient to acquire funding to establish primary care. In doing so, it aided Wanang’s community to develop sustainably, without sacrificing their forest home. (Source: BMJ Open)
Source: BMJ Open - October 6, 2023 Category: General Medicine Authors: Middleton, J., Colthart, G., Dem, F., Elkins, A., Fairhead, J., Hazell, R. J., Head, M. G., Inacio, J., Jimbudo, M., Jones, C. I., Laman, M., MacGregor, H., Novotny, V., Peck, M., Philip, J., Paliau, J., Pomat, W., Stockdale, J. A., Sui, S., Stewart, A. J Tags: Open access, Epidemiology Source Type: research
Malaria vaccine-related adverse events among children under 5 in sub-Saharan Africa: systematic review and meta-analysis protocol
Introduction
The RTS,S vaccine has been approved for use in children under 5 living in moderate to high malaria transmission areas. However, clinically important adverse events have been reported in countries in sub-Saharan Africa. This systematic review aims to assess the frequency, severity and clinical importance of vaccine-related adverse events.
Methods and analysis
This systematic review protocol has been prepared following robust methods and reported in line with the Preferred Reporting Items for Systematic reviews and Meta-Analyses for protocols guidelines. We will search PubMed, CINAHL, LILACS, Google Scholar, SC...
Source: BMJ Open - October 4, 2023 Category: General Medicine Authors: Ohene-Adjei, K., Asante, K. P., Akuffo, K. O., Tounaikok, N., Asiamah, M., Owiredu, D., Manu, A. A., Danso-Appiah, A. Tags: Open access, Global health Source Type: research
Daily briefing: Maybe volcanoes doomed the dinosaurs
Nature, Published online: 04 October 2023; doi:10.1038/d41586-023-03138-8A machine-learning algorithm suggests that volcanic activity, rather than an asteroid, killed the dinosaurs. Plus, quantum dots win the chemistry Nobel Prize and a second malaria vaccine to win global approval. (Source: Nature AOP)
Source: Nature AOP - October 4, 2023 Category: Research Authors: Flora Graham Source Type: research
Cheaper malaria vaccine recommended by the WHO
A second vaccine against the mosquito-borne disease should be available from next year, adding to the first that was launched in 2019 (Source: New Scientist - Health)
Source: New Scientist - Health - October 3, 2023 Category: Consumer Health News Source Type: research
STING activation promotes autologous type I interferon–dependent development of type 1 regulatory T cells during malaria
The development of highly effective malaria vaccines and improvement of drug-treatment protocols to boost antiparasitic immunity are critical for malaria elimination. However, the rapid establishment of parasite-specific immune regulatory networks following exposure to malaria parasites hampers these efforts. Here, we identified stimulator of interferon genes (STING) as a critical mediator of type I interferon production by CD4+ T cells during blood-stage Plasmodium falciparum infection. The activation of STING in CD4+ T cells by cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) stimulated IFNB gene transcript...
Source: Journal of Clinical Investigation - October 3, 2023 Category: Biomedical Science Authors: Yulin Wang, Fabian De Labastida Rivera, Chelsea L. Edwards, Teija C.M. Frame, Jessica A. Engel, Luzia Bukali, Jinrui Na, Susanna S. Ng, Dillon Corvino, Marcela Montes de Oca, Patrick T. Bunn, Megan S.F. Soon, Dean Andrew, Jessica R. Loughland, Jia Zhang, Source Type: research
Second malaria vaccine to win global approval is cheaper and easier to make
Nature, Published online: 03 October 2023; doi:10.1038/d41586-023-03115-1The World Health Organisation has recommended a shot called R21 to prevent the disease in children. (Source: Nature AOP)
Source: Nature AOP - October 3, 2023 Category: Research Authors: Miryam Naddaf Source Type: research
World Health Organization endorses much anticipated second malaria vaccine
The World Health Organization (WHO) today recommended widespread use of a second vaccine against malaria, a disease that kills more than half a million children each year, most of them in sub-Saharan Africa. The new vaccine, called R21/Matrix-M, follows in the footsteps of the first malaria vaccine, called Mosquirix or RTS,S, for which WHO
made a similar recommendation 2 years ago
. That vaccine, however, is in short supply, with only about 18 million doses expected to be available through 2025. The addition of a second vaccine is
“expected to close the gap between supply and demand, and has t...
Source: Science of Aging Knowledge Environment - October 2, 2023 Category: Geriatrics Source Type: research
Viruses, Vol. 15, Pages 2043: Exploring the Potential of Cytomegalovirus-Based Vectors: A Review
g
Hua Zhu
Viral vectors have emerged as powerful tools for delivering and expressing foreign genes, playing a pivotal role in gene therapy. Among these vectors, cytomegalovirus (CMV) stands out as a promising viral vector due to its distinctive attributes including large packaging capacity, ability to achieve superinfection, broad host range, capacity to induce CD8+ T cell responses, lack of integration into the host genome, and other qualities that make it an appealing vector candidate. Engineered attenuated CMV strains such as Towne and AD169 that have a ~15 kb genomic DNA deletion caused by virus passage guarantee...
Source: Viruses - October 2, 2023 Category: Virology Authors: Janine Zeng Dabbu Kumar Jaijyan Shaomin Yang Shakai Pei Qiyi Tang Hua Zhu Tags: Review Source Type: research
Bibliometric analysis of parasite vaccine research from 1990 to 2019
Vaccine. 2023 Sep 28:S0264-410X(23)01105-2. doi: 10.1016/j.vaccine.2023.09.035. Online ahead of print.ABSTRACTBibliometric and bibliographic analyses are popular tools for investigating publication metrics and thematic transitions in an expanding codex of biomedical literature. Bibliometric techniques have been employed in parasitology and vaccinology, with only a few malaria-specific literature analyses being reported specifically on parasite vaccines. The pursuit of parasite prophylactics is an important, global endeavour both medically and economically. As such, a comprehensive understanding of the research topics would...
Source: Vaccine - September 30, 2023 Category: Allergy & Immunology Authors: L A de Couvreur M J Cobo P J Kennedy J T Ellis Source Type: research
Bibliometric analysis of parasite vaccine research from 1990 to 2019
Vaccine. 2023 Sep 28:S0264-410X(23)01105-2. doi: 10.1016/j.vaccine.2023.09.035. Online ahead of print.ABSTRACTBibliometric and bibliographic analyses are popular tools for investigating publication metrics and thematic transitions in an expanding codex of biomedical literature. Bibliometric techniques have been employed in parasitology and vaccinology, with only a few malaria-specific literature analyses being reported specifically on parasite vaccines. The pursuit of parasite prophylactics is an important, global endeavour both medically and economically. As such, a comprehensive understanding of the research topics would...
Source: Vaccine - September 30, 2023 Category: Allergy & Immunology Authors: L A de Couvreur M J Cobo P J Kennedy J T Ellis Source Type: research
Promising malaria vaccine clears clinical hurdle, could get WHO endorsement next week
The world may soon have another powerful weapon against malaria, a disease that kills half a million people each year, most of them young children. Data from a trial involving 4800 children in four African countries suggest a vaccine developed at the University of Oxford, known as R21/MatrixM, provides significant protection against the disease. The results were posted
as a preprint this week
, and observers expect the World Health Organization (WHO) to announce its endorsement for use of the vaccine at a press conference scheduled for Monday.
That would make R21 the second WHO-approved vaccine for u...
Source: Science of Aging Knowledge Environment - September 29, 2023 Category: Geriatrics Source Type: research
Functional characterization of a conserved membrane protein, Pbs54, involved in gamete fertilization in Plasmodium berghei
In this study, we identified a conserved gene (PBANKA_0813300) in the rodent malaria parasite Plasmodium berghei, which encodes a protein of 54 kDa (designated as Pbs54). Localization studies indicated that Pbs54 is associated with the plasma membranes of gametes and ookinetes. Functional studies by gene disruption showed that the Δpbs54 parasites had no defect in asexual proliferation, gametocyte development, or gametogenesis. However, the interactions between male and female gametes were significantly decreased compared with wild-type parasites. The Δpbs54 lines did not show a further reduction in zygote and ookinete n...
Source: International Journal for Parasitology - September 29, 2023 Category: Parasitology Authors: Wei Pang Jie Bai Liying Zhu Fei Liu Yudi Wu Fan Yang Li Zheng Pengbo Liu Yaowen Zhang Meilian Wang Jun Li Xiaotong Zhu Liwang Cui Yaming Cao Source Type: research
Functional characterization of a conserved membrane protein, Pbs54, involved in gamete fertilization in Plasmodium berghei
In this study, we identified a conserved gene (PBANKA_0813300) in the rodent malaria parasite Plasmodium berghei, which encodes a protein of 54 kDa (designated as Pbs54). Localization studies indicated that Pbs54 is associated with the plasma membranes of gametes and ookinetes. Functional studies by gene disruption showed that the Δpbs54 parasites had no defect in asexual proliferation, gametocyte development, or gametogenesis. However, the interactions between male and female gametes were significantly decreased compared with wild-type parasites. The Δpbs54 lines did not show a further reduction in zygote and ookinete n...
Source: International Journal for Parasitology - September 29, 2023 Category: Parasitology Authors: Wei Pang Jie Bai Liying Zhu Fei Liu Yudi Wu Fan Yang Li Zheng Pengbo Liu Yaowen Zhang Meilian Wang Jun Li Xiaotong Zhu Liwang Cui Yaming Cao Source Type: research
Functional characterization of a conserved membrane protein, Pbs54, involved in gamete fertilization in Plasmodium berghei
In this study, we identified a conserved gene (PBANKA_0813300) in the rodent malaria parasite Plasmodium berghei, which encodes a protein of 54 kDa (designated as Pbs54). Localization studies indicated that Pbs54 is associated with the plasma membranes of gametes and ookinetes. Functional studies by gene disruption showed that the Δpbs54 parasites had no defect in asexual proliferation, gametocyte development, or gametogenesis. However, the interactions between male and female gametes were significantly decreased compared with wild-type parasites. The Δpbs54 lines did not show a further reduction in zygote and ookinete n...
Source: International Journal for Parasitology - September 29, 2023 Category: Parasitology Authors: Wei Pang Jie Bai Liying Zhu Fei Liu Yudi Wu Fan Yang Li Zheng Pengbo Liu Yaowen Zhang Meilian Wang Jun Li Xiaotong Zhu Liwang Cui Yaming Cao Source Type: research
