NIH-FDA Immunology Interest Group 1.11.23
Klaus Fr ü h ’ s research focuses on understanding the molecular interaction between viral pathogens and their hosts, particularly the identification and characterization of viral gene products that modulate the innate and adaptive immune responses. This knowledge is translated into the development and improvement of cytomegalovirus (CMV)-vectored vaccines which are unique in their ability to persistently maintain an immune shield of so called effector memory T cells, including highly unconventional (MHC-II and MHC-E) restricted CD8+ T cells. CMV vectored vaccines have shown protection in non-human primate models of AID...
Source: Videocast - All Events - December 13, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar: Defining malaria vaccine responses by single B cell IG sequencing and plasma IgG proteomics
IIG Seminar
Malaria elimination is a global priority and WHO has projected that malaria deaths could double due to COVID19-related health care disruptions. Vaccines have been pivotal for campaigns to eliminate or eradicate other infectious diseases. Malaria transmission blocking vaccines (TBVs) target surface antigens expressed by parasites during their development in mosquitoes in order to interrupt transmission and contribute to malaria elimination. We collected antigen-specific memory B cells from Malian adults immunized with TBV and obtained B cell receptor IG sequences that were used to define the antibody repertoire ...
Source: Videocast - All Events - June 15, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
CC Grand Rounds: 1) Experimental Blood Stage Infection to Study Malaria and 2) Progress on Malaria Vaccines
For more information go tohttps://clinicalcenter.nih.gov/about/news/grcurrent.htmlAir date: 4/22/2020 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - March 30, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Director's Seminar: Unraveling the mechanisms of immunity to malaria
NIH Director's Seminar Series
Approximately 500 million cases of P. falciparum malaria occur annually among the world ’ s poorest populations, claiming the lives of nearly a million children each year in Africa alone. The development of a malaria vaccine is widely viewed as a key step toward malaria control and possibly eradication, yet current malaria vaccine candidates confer only partial, short-lived protection at best. Optimism that a highly effective malaria vaccine can be developed stems in part from the observation that humans can acquire immunity to malaria through repeated P. falciparum infections. However, the...
Source: Videocast - All Events - January 14, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
CC Grand Rounds: 1) Update on Malaria Vaccines and 2) Chemoprophylaxis Vaccination (PfSPZ-CVac) Using Pyrimethamine
CC Grand Rounds: 1) Update on Malaria Vaccines and 2) Pyrimethamine Chemoprophylaxis (PfSPZ-CVac): A Novel Whole Sporozoite Malaria Vaccine ApproachFor more information go tohttp://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 1/16/2019 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 14, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
CC Grand Rounds: 1) Update on Malaria Vaccines and 2) Pyrimethamine Chemoprophylaxis (PfSPZ-CVac): A Novel Whole Sporozoite Malaria Vaccine Approach
For more information go tohttp://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 1/16/2019 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - December 18, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Team goes house to house to learn where new vaccine works best (Image 4)
Worldwide, malaria kills between 1 million and 3 million people per year. The majority are children in sub-Saharan Africa. [Image 4 of 5 related images. See Image 5.]
More about this image
Cameron Taylor, a University of North Carolina ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - September 15, 2017 Category: Science Source Type: video
Team goes house to house to learn where new vaccine works best (Image 2)
Malaria is endemic in Malawi, especially in the areas around Lake Malawi, the 350-mile-long lake that sits between Malawi, Mozambique and Tanzania. Malawi has a high infant mortality rate, declining life expectancy and an estimated 1 million orphans, mostly because of the HIV/AIDS epidemic. In ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - September 15, 2017 Category: Science Source Type: video
Team goes house to house to learn where new vaccine works best (Image 1)
Cameron Taylor, an undergraduate student at the University of North Carolina at Chapel Hill, spent two summers in Malawi, collecting data for a malaria vaccine trial. Each week, she took time out to play soccer with the neighborhood boys. [Image 1 of 5 related images. See (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - September 15, 2017 Category: Science Source Type: video
Burkitt lymphoma: a model of polymicrobial carcinogenesis and global oncology
NIH Director's Seminar
It has been just over 50 years since the description of Burkitt Lymphoma (BL) as an unusual tumor affecting jaws of African children. Seminal discoveries linked to BL includ Epstein-Barr virus, the first human virus linked to a human cancer, the linkage of BL to Plasmodium falciparum malaria, chromosomal translocations involving c-myc and immunoglobulin promoter elements, and demonstration of rapid and curative response to chemotherapy. Dubbed the Rosetta stone of cancer, BL became a complex model for carcinogenesis involving poly-microbes, immunity and host-genetics.
Fifty years later, many fundam...
Source: Videocast - All Events - February 24, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video
Understanding Protective Immunity by an Attenuated Malaria Vaccine: A Collaborative Effort in Science and Clinical Care to Achieve Successful Protocol Implementation
Presented by: (1) Ann Marie Matlock, RN, DNP, MSN, NE-BC Service Chief, Medical Surgical Specialties and Commander, United States Public Health Service, CC, NIH (2) Robert Seder, MD Chief, Cellular Immunology Section, Vaccine Research Center, NIAID, NIHCategory: Clinical Center Grand RoundsAired date: 05/07/2014 (Source: Videocast - All Events)
Source: Videocast - All Events - May 7, 2014 Category: Journals (General) Tags: Past Events Source Type: video
Understanding Protective Immunity by an Attenuated Malaria Vaccine: A Collaborative Effort in Science and Clinical Care to Achieve Successful Protocol Implementation
For more information go to http://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 5/7/2014 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - April 29, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video
Discovery of Vaccine and/or Drug Targets in Plasmodium Falciparum using Irradiated Long-Lived Merozoites
Presented by: Dr. David Narum, Malaria Vaccine Development Branch NIAID, NIHCategory: ProteomicsAired date: 11/07/2013 (Source: Videocast - All Events)
Source: Videocast - All Events - November 8, 2013 Category: Journals (General) Tags: Past Events Source Type: video
Bill Gates to Deliver 2013 David E. Barmes Global Health Lecture: Why the Future Needs Biomedical Innovation
The David E. Barmes Global Health Lecture is the single most important named lecture at NIH on global health. This year's speaker is Bill Gates. The lecture series honors the late David Edward Barmes, special expert for international health at NIDCR. The lecture was established in 2001 to honor his lifelong dedication to research aimed at improving health for people in low-income countries.
About Bill Gates:
Known for his philanthropy, Mr. Gates advocates for research and innovation to help people live healthy and productive lives. He also is an outspoken supporter of federal investment in basic scientific research.
I...
Source: Videocast - All Events - November 6, 2013 Category: Journals (General) Tags: Upcoming Events Source Type: video
Discovery of Vaccine and/or Drug Targets in Plasmodium Falciparum using Irradiated Long-Lived Merozoites
Development of a malaria vaccine, as well as, new drugs is crucial for the future control of Plasmodium falciparum, the most severe form of human malaria causing nearly a million deaths each year. Unfortunately, no licensed malaria vaccine is available and development of drug resistant parasites is a continual problem. To provide future opportunities for development, we aimed to identify the phenotypic difference(s) between a novel irradiated P. falciparum long-lived merozoite line and its parental line that displays up to a 20 fold increase in erythrocyte invasion rates, in vitro. Using the tools of systems biology, t...
Source: Videocast - All Events - October 28, 2013 Category: Journals (General) Tags: Upcoming Events Source Type: video
