Functional characterization of a conserved membrane protein, Pbs54, involved in gamete fertilization in Plasmodium berghei
In this study, we identified a conserved gene (PBANKA_0813300) in the rodent malaria parasite Plasmodium berghei, which encodes a protein of 54 kDa (designated as Pbs54). Localization studies indicated that Pbs54 is associated with the plasma membranes of gametes and ookinetes. Functional studies by gene disruption showed that the Δpbs54 parasites had no defect in asexual proliferation, gametocyte development, or gametogenesis. However, the interactions between male and female gametes were significantly decreased compared with wild-type parasites. The Δpbs54 lines did not show a further reduction in zygote and ookinete n...
Source: International Journal for Parasitology - September 29, 2023 Category: Parasitology Authors: Wei Pang Jie Bai Liying Zhu Fei Liu Yudi Wu Fan Yang Li Zheng Pengbo Liu Yaowen Zhang Meilian Wang Jun Li Xiaotong Zhu Liwang Cui Yaming Cao Source Type: research
Functional characterization of a conserved membrane protein, Pbs54, involved in gamete fertilization in Plasmodium berghei
In this study, we identified a conserved gene (PBANKA_0813300) in the rodent malaria parasite Plasmodium berghei, which encodes a protein of 54 kDa (designated as Pbs54). Localization studies indicated that Pbs54 is associated with the plasma membranes of gametes and ookinetes. Functional studies by gene disruption showed that the Δpbs54 parasites had no defect in asexual proliferation, gametocyte development, or gametogenesis. However, the interactions between male and female gametes were significantly decreased compared with wild-type parasites. The Δpbs54 lines did not show a further reduction in zygote and ookinete n...
Source: International Journal for Parasitology - September 29, 2023 Category: Parasitology Authors: Wei Pang Jie Bai Liying Zhu Fei Liu Yudi Wu Fan Yang Li Zheng Pengbo Liu Yaowen Zhang Meilian Wang Jun Li Xiaotong Zhu Liwang Cui Yaming Cao Source Type: research
Functional characterization of a conserved membrane protein, Pbs54, involved in gamete fertilization in Plasmodium berghei
In this study, we identified a conserved gene (PBANKA_0813300) in the rodent malaria parasite Plasmodium berghei, which encodes a protein of 54 kDa (designated as Pbs54). Localization studies indicated that Pbs54 is associated with the plasma membranes of gametes and ookinetes. Functional studies by gene disruption showed that the Δpbs54 parasites had no defect in asexual proliferation, gametocyte development, or gametogenesis. However, the interactions between male and female gametes were significantly decreased compared with wild-type parasites. The Δpbs54 lines did not show a further reduction in zygote and ookinete n...
Source: International Journal for Parasitology - September 29, 2023 Category: Parasitology Authors: Wei Pang Jie Bai Liying Zhu Fei Liu Yudi Wu Fan Yang Li Zheng Pengbo Liu Yaowen Zhang Meilian Wang Jun Li Xiaotong Zhu Liwang Cui Yaming Cao Source Type: research
Functional characterization of a conserved membrane protein, Pbs54, involved in gamete fertilization in Plasmodium berghei
In this study, we identified a conserved gene (PBANKA_0813300) in the rodent malaria parasite Plasmodium berghei, which encodes a protein of 54 kDa (designated as Pbs54). Localization studies indicated that Pbs54 is associated with the plasma membranes of gametes and ookinetes. Functional studies by gene disruption showed that the Δpbs54 parasites had no defect in asexual proliferation, gametocyte development, or gametogenesis. However, the interactions between male and female gametes were significantly decreased compared with wild-type parasites. The Δpbs54 lines did not show a further reduction in zygote and ookinete n...
Source: International Journal for Parasitology - September 29, 2023 Category: Parasitology Authors: Wei Pang Jie Bai Liying Zhu Fei Liu Yudi Wu Fan Yang Li Zheng Pengbo Liu Yaowen Zhang Meilian Wang Jun Li Xiaotong Zhu Liwang Cui Yaming Cao Source Type: research
Permafrost can imprison dangerous microbes for centuries. Will the Arctic thaw release them?
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Source: Science of Aging Knowledge Environment - September 27, 2023 Category: Geriatrics Source Type: research
Malaria vaccine coverage estimation using age-eligible populations and service user denominators in Kenya
The World Health Organization approved the RTS,S/AS01 malaria vaccine for wider rollout, and Kenya participated in a phased pilot implementation from 2019 to understand its impact under routine conditions. Vac... (Source: Malaria Journal)
Source: Malaria Journal - September 27, 2023 Category: Infectious Diseases Authors: Angela K. Moturi, Rose Jalang ’o, Anitah Cherono, Samuel K. Muchiri, Robert W. Snow and Emelda A. Okiro Tags: Research Source Type: research
Malaria cases could ebb in an even hotter world. But other diseases will get worse
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, was supported by the Pulitzer Center and the Vapnek Family Foundation.
In early July, on one of the hottest days ever recorded globally, Colin Carlson walked into a radio studio in Washington, D.C., to answer some questions about how a warming climate is affecting infectious diseases. Cases of locally transmitted malaria
in Florida and Texas
...
Source: Science of Aging Knowledge Environment - September 26, 2023 Category: Geriatrics Source Type: research
Expression of concern: A multi-stage plasmodium vivax malaria vaccine candidate able to induce long-lived antibody responses against blood stage parasites and robust transmission-blocking activity
(Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - September 20, 2023 Category: Microbiology Source Type: research
Malaria Vaccines: Progress to Date
AbstractMalaria is a mosquito-borne disease caused by protozoan parasites of the genusPlasmodium. Despite significant declines in malaria-attributable morbidity and mortality over the last two decades, it remains a major public health burden in many countries. This underscores the critical need for improved strategies to prevent, treat and control malaria if we are to ultimately progress towards the eradication of this disease. Ideally, this will include the development and deployment of a highly effective malaria vaccine that is able to induce long-lasting protective immunity. There are many malaria vaccine candidates in ...
Source: BioDrugs - September 20, 2023 Category: Drugs & Pharmacology Source Type: research
Elimination Strategy for Malaria in El Salvador: a Retrospective Study
This study retrospectively investigated the evolution of strategies utilized to reduce malaria incidence and eliminate it in El Salvador. A retrospective systematic review of the malaria cases from 1960 until 2019 was carried out by analyzing the data from the MOH surveillance system, as well as a historical analysis of documents from El Salvador MOH, PAHO/WHO, and UN El Salvador Malaria Eradication Program since its origin in the 1950s.Recent FindingsThe peak of malaria cases in the country was observed in 1980 with 95,835 cases when the Civil War started with a subsequent decline reaching 0 indigenous cases in 2017, 2018...
Source: Current Tropical Medicine Reports - September 18, 2023 Category: Tropical Medicine Source Type: research
Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS
Semin Immunol. 2023 Sep 15;70:101842. doi: 10.1016/j.smim.2023.101842. Online ahead of print.ABSTRACTVaccines are among the greatest inventions in medicine, leading to the elimination or control of numerous diseases, including smallpox, polio, measles, rubella, and, most recently, COVID-19. Yet, the effectiveness of vaccines varies among individuals. In fact, while some recipients mount a robust response to vaccination that protects them from the disease, others fail to respond. Multiple clinical and epidemiological factors contribute to this heterogeneity in responsiveness. Systems immunology studies fueled by advances in...
Source: Seminars in Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Djamel Nehar-Belaid Mark Sokolowski Sathyabaarathi Ravichandran Jacques Banchereau Damien Chaussabel Duygu Ucar Source Type: research
Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS
Semin Immunol. 2023 Sep 15;70:101842. doi: 10.1016/j.smim.2023.101842. Online ahead of print.ABSTRACTVaccines are among the greatest inventions in medicine, leading to the elimination or control of numerous diseases, including smallpox, polio, measles, rubella, and, most recently, COVID-19. Yet, the effectiveness of vaccines varies among individuals. In fact, while some recipients mount a robust response to vaccination that protects them from the disease, others fail to respond. Multiple clinical and epidemiological factors contribute to this heterogeneity in responsiveness. Systems immunology studies fueled by advances in...
Source: Seminars in Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Djamel Nehar-Belaid Mark Sokolowski Sathyabaarathi Ravichandran Jacques Banchereau Damien Chaussabel Duygu Ucar Source Type: research
Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS
Semin Immunol. 2023 Sep 15;70:101842. doi: 10.1016/j.smim.2023.101842. Online ahead of print.ABSTRACTVaccines are among the greatest inventions in medicine, leading to the elimination or control of numerous diseases, including smallpox, polio, measles, rubella, and, most recently, COVID-19. Yet, the effectiveness of vaccines varies among individuals. In fact, while some recipients mount a robust response to vaccination that protects them from the disease, others fail to respond. Multiple clinical and epidemiological factors contribute to this heterogeneity in responsiveness. Systems immunology studies fueled by advances in...
Source: Seminars in Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Djamel Nehar-Belaid Mark Sokolowski Sathyabaarathi Ravichandran Jacques Banchereau Damien Chaussabel Duygu Ucar Source Type: research
Decoding the invasive nature of a tropical pathogen of concern: The invasive non-Typhoidal Salmonella strains causing host-restricted extraintestinal infections worldwide
Microbiol Res. 2023 Sep 12;277:127488. doi: 10.1016/j.micres.2023.127488. Online ahead of print.ABSTRACTInvasive-Non-Typhoidal Salmonella (iNTS) are the major cause of health concern in the low-income, under-developed nations in Africa and Asia that lack proper sanitation facilities. Around 5% of the NTS cases give rise to invasive, extraintestinal diseases leading to focal infections like osteomyelitis, meningitis, osteoarthritis, endocarditis and neonatal sepsis. iNTS serovars like S. Typhimurium, S. Enteritidis, S. Dublin, S. Choleraesuis show a greater propensity to become invasive than others which hints at the geneti...
Source: Cell Research - September 16, 2023 Category: Cytology Authors: Dipasree Hajra Abhilash Vijay Nair Dipshikha Chakravortty Source Type: research
