Malaria Vaccine Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Variable long-term protection by radiation-, chemo-, and genetically-attenuated Plasmodium berghei sporozoite vaccines
Vaccine. 2023 Nov 24:S0264-410X(23)01335-X. doi: 10.1016/j.vaccine.2023.11.023. Online ahead of print.ABSTRACTLong-term protection against malaria remains one of the greatest challenges of vaccination against this deadly parasitic disease. Whole-sporozoite (WSp) malaria vaccine formulations, which target the Plasmodium parasite's pre-erythrocytic stages, include radiation-attenuated sporozoites (RAS), early- and late-arresting genetically-attenuated parasites (EA-GAP and LA-GAP, respectively), and chemoprophylaxis with sporozoites (CPS). Although all these four vaccine formulations induce protective immune responses in the...
Source: Vaccine - November 25, 2023 Category: Allergy & Immunology Authors: Diana Moita Helena Nunes-Caba ço Catarina R ôla Blandine Franke-Fayard Chris J Janse Ant ónio M Mendes Miguel Prud êncio Source Type: research

A premature newborn born to an adolescent girl with acute Ebola virus disease and malaria survives in a resource ‐limited setting in an Ebola treatment unit in DR Congo: “A case report”
Key Clinical MessageIn the acute phase of Ebola virus disease (EVD) premature neonatal survival is extremely rare. High mortality is related to prematurity, neonatal complications of Ebola, and precarious conditions of neonatal care in underresourced ETUs. This is a case of preterm neonatal survival in the setting of acute maternal EVD infection.AbstractThis case describes rare preterm newborn survival in the setting of an Ebola treatment unit in Eastern DRC. The neonate was born vaginally to an acutely ill 17-year-old mother who was vaccinated against Ebola virus after being identified as a contact of her father, who was ...
Source: Clinical Case Reports - November 22, 2023 Category: General Medicine Authors: Prince Imani ‐Musimwa, Emilie Grant, Micheline Feza‐Malira, Placide Mbala‐Kingebeni, Gisèle Buhoro‐Baabo, Espérence Zawadi‐Endanda, Rigo Fraterne‐Muhayangabo, Inès Claris‐Mwatsi, Zacharie Tsongo‐Kibendelwa, Olivier Nyakio‐Nge Tags: CASE REPORT Source Type: research

The patatin-like phospholipase PfPNPLA2 is involved in the mitochondrial degradation of phosphatidylglycerol during Plasmodium falciparum blood stage development
Plasmodium falciparum is an Apicomplexa responsible for human malaria, a major disease causing more than ½ million deaths every year, against which there is no fully efficient vaccine. The current rapid emergence of drug resistances emphasizes the need to identify novel drug targets. Increasing evidences show that lipid synthesis and trafficking are essential for parasite survival and pathogenesis, and that these pathways represent potential points of attack. Large amounts of phospholipids are needed for the generation of membrane compartments for newly divided parasites in the host cell. Parasite membrane homeostasis is ...
Source: Frontiers in cellular and infection microbiology - November 20, 2023 Category: Microbiology Source Type: research

Caregiver acceptance of malaria vaccination for children under 5 years of age and associated factors: cross-sectional household survey, Guinea and Sierra Leone, 2022
Malaria is a leading cause of death and reduced life span in Guinea and Sierra Leone, where plans for rolling out the malaria vaccine for children are being made. There is little evidence about caregiver accep... (Source: Malaria Journal)
Source: Malaria Journal - November 20, 2023 Category: Infectious Diseases Authors: Klara R öbl, Hanna-Tina Fischer, Alexandre Delamou, Abdul Karim Mbawah, Brogan Geurts, Lukas Feddern, Habibata Baldé, Ibrahima Kaba, Francisco Pozo-Martin, Heide Weishaar, Sara Menelik-Obbarius, Gerrit Burger, Viorela Diaconu, Achim Dörre and Charbel E Tags: Research Source Type: research

RTS,S/AS01 malaria vaccine pilot implementation in western Kenya: a qualitative longitudinal study to understand immunisation barriers and optimise uptake
Malaria is a significant public health threat in sub-Saharan Africa, particularly among children. The RTS,S/AS01 malaria vaccine reduces the risk and severity of malaria in children. RTS,S/AS01 was piloted in ... (Source: BMC Public Health)
Source: BMC Public Health - November 18, 2023 Category: Consumer Health News Authors: Jenna Hoyt, George Okello, Teresa Bange, Simon Kariuki, Mohamed F. Jalloh, Jayne Webster and Jenny Hill Tags: Research Source Type: research

COVID Perceptions among Pregnant Women Living in a Malaria Hyperendemic Rural Region in Uganda: A Cross-Sectional Study
Am J Trop Med Hyg. 2023 Nov 6:tpmd230464. doi: 10.4269/ajtmh.23-0464. Online ahead of print.ABSTRACTBoth SARS-CoV2 and Plasmodium falciparum infection during pregnancy increases the risk for adverse maternal and fetal outcomes, including abortion, severe disease, and death. Indeed, although malaria and COVID-19 show an overlapping clinical presentation, they require a profoundly different approach. The aim of this study was to explore COVID-19 awareness among pregnant women living in a P. falciparum hyperendemic region in rural Uganda. This cross-sectional, prospective study was conducted in one Hospital and two Health Cen...
Source: The American Journal of Tropical Medicine and Hygiene - November 6, 2023 Category: Tropical Medicine Authors: Francesco Vladimiro Segala Giulia Patti Lameck Olal Elda De Vita Nelson Olung Roberta Papagni James Amone Valentina Totaro Emmanuel Onapa Roberta Novara Benedict Ngole Mariangela L'Episcopia Samuel Okori Giovanni Dall'Oglio Jerry Ictho Carlo Severini Giov Source Type: research

COVID Perceptions among Pregnant Women Living in a Malaria Hyperendemic Rural Region in Uganda: A Cross-Sectional Study
Am J Trop Med Hyg. 2023 Nov 6:tpmd230464. doi: 10.4269/ajtmh.23-0464. Online ahead of print.ABSTRACTBoth SARS-CoV2 and Plasmodium falciparum infection during pregnancy increases the risk for adverse maternal and fetal outcomes, including abortion, severe disease, and death. Indeed, although malaria and COVID-19 show an overlapping clinical presentation, they require a profoundly different approach. The aim of this study was to explore COVID-19 awareness among pregnant women living in a P. falciparum hyperendemic region in rural Uganda. This cross-sectional, prospective study was conducted in one Hospital and two Health Cen...
Source: Am J Trop Med Hyg - November 6, 2023 Category: Infectious Diseases Authors: Francesco Vladimiro Segala Giulia Patti Lameck Olal Elda De Vita Nelson Olung Roberta Papagni James Amone Valentina Totaro Emmanuel Onapa Roberta Novara Benedict Ngole Mariangela L'Episcopia Samuel Okori Giovanni Dall'Oglio Jerry Ictho Carlo Severini Giov Source Type: research