COVID Perceptions among Pregnant Women Living in a Malaria Hyperendemic Rural Region in Uganda: A Cross-Sectional Study
Am J Trop Med Hyg. 2023 Nov 6:tpmd230464. doi: 10.4269/ajtmh.23-0464. Online ahead of print.ABSTRACTBoth SARS-CoV2 and Plasmodium falciparum infection during pregnancy increases the risk for adverse maternal and fetal outcomes, including abortion, severe disease, and death. Indeed, although malaria and COVID-19 show an overlapping clinical presentation, they require a profoundly different approach. The aim of this study was to explore COVID-19 awareness among pregnant women living in a P. falciparum hyperendemic region in rural Uganda. This cross-sectional, prospective study was conducted in one Hospital and two Health Cen...
Source: The American Journal of Tropical Medicine and Hygiene - November 6, 2023 Category: Tropical Medicine Authors: Francesco Vladimiro Segala Giulia Patti Lameck Olal Elda De Vita Nelson Olung Roberta Papagni James Amone Valentina Totaro Emmanuel Onapa Roberta Novara Benedict Ngole Mariangela L'Episcopia Samuel Okori Giovanni Dall'Oglio Jerry Ictho Carlo Severini Giov Source Type: research
COVID Perceptions among Pregnant Women Living in a Malaria Hyperendemic Rural Region in Uganda: A Cross-Sectional Study
Am J Trop Med Hyg. 2023 Nov 6:tpmd230464. doi: 10.4269/ajtmh.23-0464. Online ahead of print.ABSTRACTBoth SARS-CoV2 and Plasmodium falciparum infection during pregnancy increases the risk for adverse maternal and fetal outcomes, including abortion, severe disease, and death. Indeed, although malaria and COVID-19 show an overlapping clinical presentation, they require a profoundly different approach. The aim of this study was to explore COVID-19 awareness among pregnant women living in a P. falciparum hyperendemic region in rural Uganda. This cross-sectional, prospective study was conducted in one Hospital and two Health Cen...
Source: Am J Trop Med Hyg - November 6, 2023 Category: Infectious Diseases Authors: Francesco Vladimiro Segala Giulia Patti Lameck Olal Elda De Vita Nelson Olung Roberta Papagni James Amone Valentina Totaro Emmanuel Onapa Roberta Novara Benedict Ngole Mariangela L'Episcopia Samuel Okori Giovanni Dall'Oglio Jerry Ictho Carlo Severini Giov Source Type: research
A nanoparticle vaccine displaying the ookinete PSOP25 antigen elicits transmission-blocking antibody response against Plasmodium berghei
Safe and effective vaccines are crucial for the control and eventual elimination of malaria. Novel approaches to optimize and improve vaccine efficacy are urgently required. Nanoparticle-based delivery platfor... (Source: Parasites and Vectors)
Source: Parasites and Vectors - November 6, 2023 Category: Microbiology Authors: Guixiang Yao, Hui Min, Xinxin Yu, Fei Liu, Liwang Cui and Yaming Cao Tags: Research Source Type: research
Genetic diversity and natural selection of apical membrane antigen-1 (ama-1) in Cameroonian Plasmodium falciparum isolates
Gene. 2023 Nov 2:147956. doi: 10.1016/j.gene.2023.147956. Online ahead of print.ABSTRACTAntigenic variation associated with genetic diversity in global Plasmodium falciparum apical membrane antigen-1 (PfAMA-1) is a major impediment to designing an effective malaria vaccine. Here, we report the first study on genetic diversity and natural selection of the Pfama-1 gene in P. falciparum isolates from Cameroon. A total of 328 P. falciparum positive samples collected during 2016 and 2019 from five localities of Cameroon were analysed. The ectodomain coding fragment of Pfama-1 gene was amplified for polymorphism profiling and na...
Source: Gene - November 4, 2023 Category: Genetics & Stem Cells Authors: Joseph Hawadak Loick Pradel Kojom Foko Rodrigue Roman Dongang Nana Karmveer Yadav Veena Pande Aparup Das Vineeta Singh Source Type: research
Genetic diversity and natural selection of apical membrane antigen-1 (ama-1) in Cameroonian Plasmodium falciparum isolates
Gene. 2023 Nov 2:147956. doi: 10.1016/j.gene.2023.147956. Online ahead of print.ABSTRACTAntigenic variation associated with genetic diversity in global Plasmodium falciparum apical membrane antigen-1 (PfAMA-1) is a major impediment to designing an effective malaria vaccine. Here, we report the first study on genetic diversity and natural selection of the Pfama-1 gene in P. falciparum isolates from Cameroon. A total of 328 P. falciparum positive samples collected during 2016 and 2019 from five localities of Cameroon were analysed. The ectodomain coding fragment of Pfama-1 gene was amplified for polymorphism profiling and na...
Source: Gene - November 4, 2023 Category: Genetics & Stem Cells Authors: Joseph Hawadak Loick Pradel Kojom Foko Rodrigue Roman Dongang Nana Karmveer Yadav Veena Pande Aparup Das Vineeta Singh Source Type: research
Recent advance in the development of tuberculosis vaccines in clinical trials and virus-like particle-based vaccine candidates
Tuberculosis (TB) remains a serious public health threat around the world. An effective vaccine is urgently required for cost-effective, long-term control of TB. However, the only licensed vaccine Bacillus Calmette-Guerin (BCG) is limited to prevent TB for its highly variable efficacy. Substantial progress has been made in research and development (R&D) of TB vaccines in the past decades, and a dozen vaccine candidates, including live attenuated mycobacterial vaccines, killed mycobacterial vaccines, adjuvanted subunit vaccines, viral vector vaccines, and messenger RNA (mRNA) vaccines were developed in clinical trials t...
Source: Frontiers in Immunology - November 2, 2023 Category: Allergy & Immunology Source Type: research
Awareness and acceptability of malaria vaccine among caregivers of under-5 children in Northern Nigeria
This study assessed caregivers ’ awareness and ... (Source: Malaria Journal)
Source: Malaria Journal - October 31, 2023 Category: Infectious Diseases Authors: Mary Yetunde Ajayi and Daniel Chukwuyere Emeto Tags: Research Source Type: research
First malaria vaccine slashes early childhood mortality
In a major analysis in Africa, the first vaccine approved to fight malaria cut deaths among young children by 13% over nearly 4 years, the World Health Organization (WHO) reported last week. The huge evaluation of a pilot rollout of the vaccine, called RTS,S or Mosquirix and made by GlaxoSmithKline, also showed a 22% reduction in severe malaria in kids young enough to receive a three-shot series. Hundreds of thousands of children are born annually in the parts of Ghana, Kenya, and Malawi included in the analysis, for which WHO revealed the final data on 20 October at the annual meeting of the American Society of Tropical M...
Source: Science of Aging Knowledge Environment - October 24, 2023 Category: Geriatrics Source Type: research
A Glance on Nanovaccine: A Potential Approach for Disease Prevention
Curr Pharm Biotechnol. 2023 Oct 11. doi: 10.2174/0113892010254221231006100659. Online ahead of print.ABSTRACTThere are several vaccines available for preventing various bacterial and viral infections, but still, there are many challenges that require the development of noninvasive, more efficient, and active vaccines. The advancement in biotechnological tools has provided safer antigens, such as nucleic acids, proteins etc., but due to their lower immunogenic property, adjuvants of stronger immune response are required. Nanovaccines are effective vaccines when compared with conventional vaccines as they can induce both Hum...
Source: Current Pharmaceutical Biotechnology - October 20, 2023 Category: Biotechnology Authors: Akash Garg Himansu Chopra Talever Singh Ramkumar Chaudhary Rutvi Agrawal Abhishek Tankara Source Type: research
A Glance on Nanovaccine: A Potential Approach for Disease Prevention
Curr Pharm Biotechnol. 2023 Oct 11. doi: 10.2174/0113892010254221231006100659. Online ahead of print.ABSTRACTThere are several vaccines available for preventing various bacterial and viral infections, but still, there are many challenges that require the development of noninvasive, more efficient, and active vaccines. The advancement in biotechnological tools has provided safer antigens, such as nucleic acids, proteins etc., but due to their lower immunogenic property, adjuvants of stronger immune response are required. Nanovaccines are effective vaccines when compared with conventional vaccines as they can induce both Hum...
Source: Current Pharmaceutical Biotechnology - October 20, 2023 Category: Biotechnology Authors: Akash Garg Himansu Chopra Talever Singh Ramkumar Chaudhary Rutvi Agrawal Abhishek Tankara Source Type: research
A Glance on Nanovaccine: A Potential Approach for Disease Prevention
Curr Pharm Biotechnol. 2023 Oct 11. doi: 10.2174/0113892010254221231006100659. Online ahead of print.ABSTRACTThere are several vaccines available for preventing various bacterial and viral infections, but still, there are many challenges that require the development of noninvasive, more efficient, and active vaccines. The advancement in biotechnological tools has provided safer antigens, such as nucleic acids, proteins etc., but due to their lower immunogenic property, adjuvants of stronger immune response are required. Nanovaccines are effective vaccines when compared with conventional vaccines as they can induce both Hum...
Source: Current Pharmaceutical Biotechnology - October 20, 2023 Category: Biotechnology Authors: Akash Garg Himansu Chopra Talever Singh Ramkumar Chaudhary Rutvi Agrawal Abhishek Tankara Source Type: research
A Glance on Nanovaccine: A Potential Approach for Disease Prevention
Curr Pharm Biotechnol. 2023 Oct 11. doi: 10.2174/0113892010254221231006100659. Online ahead of print.ABSTRACTThere are several vaccines available for preventing various bacterial and viral infections, but still, there are many challenges that require the development of noninvasive, more efficient, and active vaccines. The advancement in biotechnological tools has provided safer antigens, such as nucleic acids, proteins etc., but due to their lower immunogenic property, adjuvants of stronger immune response are required. Nanovaccines are effective vaccines when compared with conventional vaccines as they can induce both Hum...
Source: Current Pharmaceutical Biotechnology - October 20, 2023 Category: Biotechnology Authors: Akash Garg Himansu Chopra Talever Singh Ramkumar Chaudhary Rutvi Agrawal Abhishek Tankara Source Type: research
A Glance on Nanovaccine: A Potential Approach for Disease Prevention
Curr Pharm Biotechnol. 2023 Oct 11. doi: 10.2174/0113892010254221231006100659. Online ahead of print.ABSTRACTThere are several vaccines available for preventing various bacterial and viral infections, but still, there are many challenges that require the development of noninvasive, more efficient, and active vaccines. The advancement in biotechnological tools has provided safer antigens, such as nucleic acids, proteins etc., but due to their lower immunogenic property, adjuvants of stronger immune response are required. Nanovaccines are effective vaccines when compared with conventional vaccines as they can induce both Hum...
Source: Current Pharmaceutical Biotechnology - October 20, 2023 Category: Biotechnology Authors: Akash Garg Himansu Chopra Talever Singh Ramkumar Chaudhary Rutvi Agrawal Abhishek Tankara Source Type: research
Billions boost next-generation COVID-19 vaccine and treatments
Six months after announcing the $5 billion
Project NextGen
to develop treatments and vaccines that can “stay ahead of COVID-19,” the U.S. government has awarded 20 contracts that reveal what much of that sum will support. The Department of Health and Human Services (HHS) announced on 13 October that up to $1.2 billion will go to three vaccine developers aiming to develop better shots, adding to another $1 billion already awarded to companies that will test them in yearlong, 10,000-person clinical trials. Another half-billion will support development of monoclonal antibodies (mAbs) that can block SARS-CoV-2 in...
Source: Science of Aging Knowledge Environment - October 19, 2023 Category: Geriatrics Source Type: research
IL-27 produced during acute malaria infection regulates Plasmodium-specific memory CD4 < sup > + < /sup > T cells
EMBO Mol Med. 2023 Oct 19:e17713. doi: 10.15252/emmm.202317713. Online ahead of print.ABSTRACTMalaria infection elicits both protective and pathogenic immune responses, and IL-27 is a critical cytokine that regulate effector responses during infection. Here, we identified a critical window of CD4+ T cell responses that is targeted by IL-27. Neutralization of IL-27 during acute infection with Plasmodium chabaudi expanded specific CD4+ T cells, which were maintained at high levels thereafter. In the chronic phase, Plasmodium-specific CD4+ T cells in IL-27-neutralized mice consisted mainly of CD127+ KLRG1- and CD127- KLRG1+ s...
Source: Molecular Medicine - October 19, 2023 Category: Molecular Biology Authors: Maria Lourdes Macalinao Shin-Ichi Inoue Sanjaadorj Tsogtsaikhan Hirotaka Matsumoto Ganchimeg Bayarsaikhan Jiun-Yu Jian Kazumi Kimura Yoshiaki Yasumizu Tsuyoshi Inoue Hiroki Yoshida Julius Hafalla Daisuke Kimura Katsuyuki Yui Source Type: research
