Hiding in plain sight: an epitope-based strategy for a subunit malaria vaccine
Trends Parasitol. 2023 Sep 6:S1471-4922(23)00197-6. doi: 10.1016/j.pt.2023.08.006. Online ahead of print.ABSTRACTRecent data suggest that approaches to developing a subunit blood-stage malaria vaccine may be misdirected. While antigenic polymorphism is recognized as a challenge, efforts to counter this have primarily involved enhancing the quantity and quality of antibody with potent adjuvants, identifying conserved target proteins, or combining multiple antigens to broaden the immune response. However, paradoxically, evidence has emerged that narrowing, rather than broadening, the immune response may be required to obtain...
Source: Trends in Parasitology - September 8, 2023 Category: Parasitology Authors: Michael F Good Stephanie K Yanow Source Type: research
Hiding in plain sight: an epitope-based strategy for a subunit malaria vaccine
Trends Parasitol. 2023 Sep 6:S1471-4922(23)00197-6. doi: 10.1016/j.pt.2023.08.006. Online ahead of print.ABSTRACTRecent data suggest that approaches to developing a subunit blood-stage malaria vaccine may be misdirected. While antigenic polymorphism is recognized as a challenge, efforts to counter this have primarily involved enhancing the quantity and quality of antibody with potent adjuvants, identifying conserved target proteins, or combining multiple antigens to broaden the immune response. However, paradoxically, evidence has emerged that narrowing, rather than broadening, the immune response may be required to obtain...
Source: Trends in Parasitology - September 8, 2023 Category: Parasitology Authors: Michael F Good Stephanie K Yanow Source Type: research
Hiding in plain sight: an epitope-based strategy for a subunit malaria vaccine
Trends Parasitol. 2023 Sep 6:S1471-4922(23)00197-6. doi: 10.1016/j.pt.2023.08.006. Online ahead of print.ABSTRACTRecent data suggest that approaches to developing a subunit blood-stage malaria vaccine may be misdirected. While antigenic polymorphism is recognized as a challenge, efforts to counter this have primarily involved enhancing the quantity and quality of antibody with potent adjuvants, identifying conserved target proteins, or combining multiple antigens to broaden the immune response. However, paradoxically, evidence has emerged that narrowing, rather than broadening, the immune response may be required to obtain...
Source: Trends in Parasitology - September 8, 2023 Category: Parasitology Authors: Michael F Good Stephanie K Yanow Source Type: research
Hiding in plain sight: an epitope-based strategy for a subunit malaria vaccine
Trends Parasitol. 2023 Sep 6:S1471-4922(23)00197-6. doi: 10.1016/j.pt.2023.08.006. Online ahead of print.ABSTRACTRecent data suggest that approaches to developing a subunit blood-stage malaria vaccine may be misdirected. While antigenic polymorphism is recognized as a challenge, efforts to counter this have primarily involved enhancing the quantity and quality of antibody with potent adjuvants, identifying conserved target proteins, or combining multiple antigens to broaden the immune response. However, paradoxically, evidence has emerged that narrowing, rather than broadening, the immune response may be required to obtain...
Source: Trends in Parasitology - September 8, 2023 Category: Parasitology Authors: Michael F Good Stephanie K Yanow Source Type: research
Hiding in plain sight: an epitope-based strategy for a subunit malaria vaccine
Trends Parasitol. 2023 Sep 6:S1471-4922(23)00197-6. doi: 10.1016/j.pt.2023.08.006. Online ahead of print.ABSTRACTRecent data suggest that approaches to developing a subunit blood-stage malaria vaccine may be misdirected. While antigenic polymorphism is recognized as a challenge, efforts to counter this have primarily involved enhancing the quantity and quality of antibody with potent adjuvants, identifying conserved target proteins, or combining multiple antigens to broaden the immune response. However, paradoxically, evidence has emerged that narrowing, rather than broadening, the immune response may be required to obtain...
Source: Trends in Parasitology - September 8, 2023 Category: Parasitology Authors: Michael F Good Stephanie K Yanow Source Type: research
Hiding in plain sight: an epitope-based strategy for a subunit malaria vaccine
Trends Parasitol. 2023 Sep 6:S1471-4922(23)00197-6. doi: 10.1016/j.pt.2023.08.006. Online ahead of print.ABSTRACTRecent data suggest that approaches to developing a subunit blood-stage malaria vaccine may be misdirected. While antigenic polymorphism is recognized as a challenge, efforts to counter this have primarily involved enhancing the quantity and quality of antibody with potent adjuvants, identifying conserved target proteins, or combining multiple antigens to broaden the immune response. However, paradoxically, evidence has emerged that narrowing, rather than broadening, the immune response may be required to obtain...
Source: Trends in Parasitology - September 8, 2023 Category: Parasitology Authors: Michael F Good Stephanie K Yanow Source Type: research
Hiding in plain sight: an epitope-based strategy for a subunit malaria vaccine
Trends Parasitol. 2023 Sep 6:S1471-4922(23)00197-6. doi: 10.1016/j.pt.2023.08.006. Online ahead of print.ABSTRACTRecent data suggest that approaches to developing a subunit blood-stage malaria vaccine may be misdirected. While antigenic polymorphism is recognized as a challenge, efforts to counter this have primarily involved enhancing the quantity and quality of antibody with potent adjuvants, identifying conserved target proteins, or combining multiple antigens to broaden the immune response. However, paradoxically, evidence has emerged that narrowing, rather than broadening, the immune response may be required to obtain...
Source: Trends in Parasitology - September 8, 2023 Category: Parasitology Authors: Michael F Good Stephanie K Yanow Source Type: research
RTS,S/AS01E vaccine defaults in Ghana: a qualitative exploration of the perspectives of defaulters and frontline health service providers
While Ghana has a good track record in the Expanded Programme on Immunization, there are substantial challenges with regards to subsequent vaccinations, particularly after the first year of life of the child. ... (Source: Malaria Journal)
Source: Malaria Journal - September 6, 2023 Category: Infectious Diseases Authors: Joshua Okyere, Vincent Bio Bediako, Josephine Akua Ackah, Emmanuella Acheampong, Bernard Afriyie Owusu, Wonder Agbemavi, Adanna Uloaku Nwameme, Edward Mberu Kamau and Emmanuel Asampong Tags: Research Source Type: research
THE HEALTH SYSTEM OF THE FIRST CZECHOSLOVAK REPUBLIC AND ITS ROLE IN COMBATING CONTAGIOUS DISEASES IMMEDIATELY AFTER THE FIRST WORLD WAR (THE 1920s)
Conclusion: The systematic development of new legislation contributed to the new Republic's proficiency at the task and the gradual reduction in the number of infectious diseases.PMID:37667608 (Source: Medical History)
Source: Medical History - September 5, 2023 Category: History of Medicine Authors: El żbieta Tabor Kamil Tabor Wojciech Pluskiewicz Source Type: research
THE HEALTH SYSTEM OF THE FIRST CZECHOSLOVAK REPUBLIC AND ITS ROLE IN COMBATING CONTAGIOUS DISEASES IMMEDIATELY AFTER THE FIRST WORLD WAR (THE 1920s)
Conclusion: The systematic development of new legislation contributed to the new Republic's proficiency at the task and the gradual reduction in the number of infectious diseases.PMID:37667605 (Source: Medical History)
Source: Medical History - September 5, 2023 Category: History of Medicine Authors: Andrej T óth Inka Kratochv ílová Luk áš Novotný Jakub Dr ábek V ěra Hellerová Martin Červený Val érie Tóthová Source Type: research
THE HEALTH SYSTEM OF THE FIRST CZECHOSLOVAK REPUBLIC AND ITS ROLE IN COMBATING CONTAGIOUS DISEASES IMMEDIATELY AFTER THE FIRST WORLD WAR (THE 1920s)
Conclusion: The systematic development of new legislation contributed to the new Republic's proficiency at the task and the gradual reduction in the number of infectious diseases.PMID:37667608 (Source: Medical History)
Source: Medical History - September 5, 2023 Category: History of Medicine Authors: El żbieta Tabor Kamil Tabor Wojciech Pluskiewicz Source Type: research
THE HEALTH SYSTEM OF THE FIRST CZECHOSLOVAK REPUBLIC AND ITS ROLE IN COMBATING CONTAGIOUS DISEASES IMMEDIATELY AFTER THE FIRST WORLD WAR (THE 1920s)
Conclusion: The systematic development of new legislation contributed to the new Republic's proficiency at the task and the gradual reduction in the number of infectious diseases.PMID:37667605 (Source: Medical History)
Source: Medical History - September 5, 2023 Category: History of Medicine Authors: Andrej T óth Inka Kratochv ílová Luk áš Novotný Jakub Dr ábek V ěra Hellerová Martin Červený Val érie Tóthová Source Type: research
