THE HEALTH SYSTEM OF THE FIRST CZECHOSLOVAK REPUBLIC AND ITS ROLE IN COMBATING CONTAGIOUS DISEASES IMMEDIATELY AFTER THE FIRST WORLD WAR (THE 1920s)
Conclusion: The systematic development of new legislation contributed to the new Republic's proficiency at the task and the gradual reduction in the number of infectious diseases.PMID:37667605 (Source: Medical History)
Source: Medical History - September 5, 2023 Category: History of Medicine Authors: Andrej T óth Inka Kratochv ílová Luk áš Novotný Jakub Dr ábek V ěra Hellerová Martin Červený Val érie Tóthová Source Type: research
THE HEALTH SYSTEM OF THE FIRST CZECHOSLOVAK REPUBLIC AND ITS ROLE IN COMBATING CONTAGIOUS DISEASES IMMEDIATELY AFTER THE FIRST WORLD WAR (THE 1920s)
Conclusion: The systematic development of new legislation contributed to the new Republic's proficiency at the task and the gradual reduction in the number of infectious diseases.PMID:37667605 | DOI:10.31952/amha.21.1.4 (Source: Medical History)
Source: Medical History - September 5, 2023 Category: History of Medicine Authors: Andrej T óth Inka Kratochv ílová Luk áš Novotný Jakub Dr ábek V ěra Hellerová Martin Červený Val érie Tóthová Source Type: research
THE HEALTH SYSTEM OF THE FIRST CZECHOSLOVAK REPUBLIC AND ITS ROLE IN COMBATING CONTAGIOUS DISEASES IMMEDIATELY AFTER THE FIRST WORLD WAR (THE 1920s)
Conclusion: The systematic development of new legislation contributed to the new Republic's proficiency at the task and the gradual reduction in the number of infectious diseases.PMID:37667605 | DOI:10.31952/amha.21.1.4 (Source: Medical History)
Source: Medical History - September 5, 2023 Category: History of Medicine Authors: Andrej T óth Inka Kratochv ílová Luk áš Novotný Jakub Dr ábek V ěra Hellerová Martin Červený Val érie Tóthová Source Type: research
Chemically augmented malaria sporozoites display an altered immunogenic profile
Despite promising results in malaria-naïve individuals, whole sporozoite (SPZ) vaccine efficacy in malaria-endemic settings has been suboptimal. Vaccine hypo-responsiveness due to previous malaria exposure has been posited as responsible, indicating the need for SPZ vaccines of increased immunogenicity. To this end, we here demonstrate a proof-of-concept for altering SPZ immunogenicity, where supramolecular chemistry enables chemical augmentation of the parasite surface with a TLR7 agonist-based adjuvant (SPZ-SAS(CL307)). In vitro, SPZ-SAS(CL307) remained well recognized by immune cells and induced a 35-fold increase in t...
Source: Frontiers in Immunology - August 31, 2023 Category: Allergy & Immunology Source Type: research
Induction of liver-resident memory T cells and protection at liver-stage malaria by mRNA-containing lipid nanoparticles
Recent studies have suggested that CD8+ liver-resident memory T (TRM) cells are crucial in the protection against liver-stage malaria. We used liver-directed mRNA-containing lipid nanoparticles (mRNA-LNPs) to induce liver TRM cells in a murine model. Single-dose intravenous injections of ovalbumin mRNA-LNPs effectively induced antigen-specific cytotoxic T lymphocytes in a dose-dependent manner in the liver on day 7. TRM cells (CD8+ CD44hi CD62Llo CD69+ KLRG1-) were induced 5 weeks after immunization. To examine the protective efficacy, mice were intramuscularly immunized with two doses of circumsporozoite protein mRNA-LNPs...
Source: Frontiers in Immunology - August 23, 2023 Category: Allergy & Immunology Source Type: research
