Initial assessment of immigrant patients in primary care
Aten Primaria. 2024 Feb 27;56(7):102896. doi: 10.1016/j.aprim.2024.102896. Online ahead of print.ABSTRACTThe clinical interview of immigrant patients requires cultural competence to ensure good understanding and correct communication, in addition to collecting specific information that differs from that of native patients, such as origin and migratory route or cultural identity. Screening for latent tuberculosis infection is recommended in certain cases and screening for other infections, both cosmopolitan with a higher prevalence in migrants (HIV, syphilis, hepatitis B and C) and imported (Chagas, intestinal parasites, st...
Source: Atencion Primaria - February 28, 2024 Category: Primary Care Authors: Mar ía Ángeles González Martínez Mar ía Jesús Castaño Suero Marta Guerrero Mu ñoz Agust ín Francisco Rossetti Ethel Sequeira Aymar Carme Roca Saumell Source Type: research
Initial assessment of immigrant patients in primary care
Aten Primaria. 2024 Feb 27;56(7):102896. doi: 10.1016/j.aprim.2024.102896. Online ahead of print.ABSTRACTThe clinical interview of immigrant patients requires cultural competence to ensure good understanding and correct communication, in addition to collecting specific information that differs from that of native patients, such as origin and migratory route or cultural identity. Screening for latent tuberculosis infection is recommended in certain cases and screening for other infections, both cosmopolitan with a higher prevalence in migrants (HIV, syphilis, hepatitis B and C) and imported (Chagas, intestinal parasites, st...
Source: Atencion Primaria - February 28, 2024 Category: Primary Care Authors: Mar ía Ángeles González Martínez Mar ía Jesús Castaño Suero Marta Guerrero Mu ñoz Agust ín Francisco Rossetti Ethel Sequeira Aymar Carme Roca Saumell Source Type: research
Initial assessment of immigrant patients in primary care
Aten Primaria. 2024 Feb 27;56(7):102896. doi: 10.1016/j.aprim.2024.102896. Online ahead of print.ABSTRACTThe clinical interview of immigrant patients requires cultural competence to ensure good understanding and correct communication, in addition to collecting specific information that differs from that of native patients, such as origin and migratory route or cultural identity. Screening for latent tuberculosis infection is recommended in certain cases and screening for other infections, both cosmopolitan with a higher prevalence in migrants (HIV, syphilis, hepatitis B and C) and imported (Chagas, intestinal parasites, st...
Source: Atencion Primaria - February 28, 2024 Category: Primary Care Authors: Mar ía Ángeles González Martínez Mar ía Jesús Castaño Suero Marta Guerrero Mu ñoz Agust ín Francisco Rossetti Ethel Sequeira Aymar Carme Roca Saumell Source Type: research
Initial assessment of immigrant patients in primary care
Aten Primaria. 2024 Feb 27;56(7):102896. doi: 10.1016/j.aprim.2024.102896. Online ahead of print.ABSTRACTThe clinical interview of immigrant patients requires cultural competence to ensure good understanding and correct communication, in addition to collecting specific information that differs from that of native patients, such as origin and migratory route or cultural identity. Screening for latent tuberculosis infection is recommended in certain cases and screening for other infections, both cosmopolitan with a higher prevalence in migrants (HIV, syphilis, hepatitis B and C) and imported (Chagas, intestinal parasites, st...
Source: Atencion Primaria - February 28, 2024 Category: Primary Care Authors: Mar ía Ángeles González Martínez Mar ía Jesús Castaño Suero Marta Guerrero Mu ñoz Agust ín Francisco Rossetti Ethel Sequeira Aymar Carme Roca Saumell Source Type: research
Characterization of merozoite-specific thrombospondin-related anonymous protein (MTRAP) in Plasmodium vivax and P. knowlesi parasites
Plasmodium vivax, the most widespread human malaria parasite, and P. knowlesi, an emerging Plasmodium that infects humans, are the phylogenetically closest malarial species that infect humans, which may induce cross-species reactivity across most co-endemic areas in Southeast Asia. The thrombospondin-related anonymous protein (TRAP) family is indispensable for motility and host cell invasion in the growth and development of Plasmodium parasites. The merozoite-specific TRAP (MTRAP), expressed in blood-stage merozoites, is supposed to be essential for human erythrocyte invasion. We aimed to characterize MTRAPs in blood-stage...
Source: Frontiers in cellular and infection microbiology - February 23, 2024 Category: Microbiology Source Type: research
Clinical formulation development of Plasmodium falciparum malaria vaccine candidates based on Pfs48/45, Pfs230, and PfCSP
Vaccine. 2024 Feb 21:S0264-410X(24)00202-0. doi: 10.1016/j.vaccine.2024.02.043. Online ahead of print.ABSTRACTTwo malaria transmission-blocking vaccine (TBV) candidates, R0.6C and ProC6C, have completed preclinical development including the selection of adjuvants, Alhydrogel® with or without the saponin based adjuvant Matrix-M™. Here, we report on the final drug product (formulation) design of R0.6C and ProC6C and evaluate their safety and biochemical stability in preparation for preclinical and clinical pharmacy handling. The point-of-injection stability studies demonstrated that both the R0.6C and ProC6C antigens are ...
Source: Vaccine - February 22, 2024 Category: Allergy & Immunology Authors: Jordan Plieskatt Peter Bang Grith Kr øyer Wood Mohammad Naghizadeh Susheel K Singh Matthijs M Jore Michael Theisen Source Type: research
Chronic malaria exposure is associated with inhibitory markers on T cells that correlate with atypical memory and marginal zone-like B cells
Clin Exp Immunol. 2024 Feb 22:uxae015. doi: 10.1093/cei/uxae015. Online ahead of print.ABSTRACTChronic immune activation from persistent malaria infections can induce immunophenotypic changes associated with T cell exhaustion. However, associations between T and B cells during chronic exposure remain undefined. We analyzed peripheral blood mononuclear cells from malaria-exposed pregnant women from Papua New Guinea and Spanish malaria-naïve individuals using flow cytometry to profile T cell exhaustion markers phenotypically. T cell lineage (CD3, CD4, CD8), inhibitory (PD1, TIM3, LAG3, CTLA4, 2B4) and senescence (CD28-) mar...
Source: Clinical and Developmental Immunology - February 22, 2024 Category: Allergy & Immunology Authors: Robert A Mitchell Itziar Ubillos Pilar Requena Joseph J Campo Maria Ome-Kaius Sarah Hanieh Alexandra Umbers Paula Samol Diana Barrios Alfons Jim énez Azucena Bardaj í Ivo Mueller Clara Men éndez Stephen Rogerson Carlota Doba ño Gemma Moncunill Source Type: research
Clinical formulation development of Plasmodium falciparum malaria vaccine candidates based on Pfs48/45, Pfs230, and PfCSP
Vaccine. 2024 Feb 21:S0264-410X(24)00202-0. doi: 10.1016/j.vaccine.2024.02.043. Online ahead of print.ABSTRACTTwo malaria transmission-blocking vaccine (TBV) candidates, R0.6C and ProC6C, have completed preclinical development including the selection of adjuvants, Alhydrogel® with or without the saponin based adjuvant Matrix-M™. Here, we report on the final drug product (formulation) design of R0.6C and ProC6C and evaluate their safety and biochemical stability in preparation for preclinical and clinical pharmacy handling. The point-of-injection stability studies demonstrated that both the R0.6C and ProC6C antigens are ...
Source: Vaccine - February 22, 2024 Category: Allergy & Immunology Authors: Jordan Plieskatt Peter Bang Grith Kr øyer Wood Mohammad Naghizadeh Susheel K Singh Matthijs M Jore Michael Theisen Source Type: research
ATG5-regulated CCL2/MCP-1 production in myeloid cells selectively modulates anti-malarial CD4 < sup > + < /sup > Th1 responses
This study demonstrated that ATG5 deficiency in myeloid cells can significantly inhibit the growth of rodent blood-stage malarial parasites by selectively enhancing parasite-specific CD4+ Th1 cell responses. This effect was independent of ATG5-mediated canonical and non-canonical autophagy. Mechanistically, ATG5 deficiency suppressed FAS-mediated apoptosis of LY6G- ITGAM/CD11b+ ADGRE1/F4/80- cells and subsequently increased CCL2/MCP-1 production in parasite-infected mice. LY6G- ITGAM+ ADGRE1- cell-derived CCL2 selectively interacted with CCR2 on CD4+ Th1 cells for their optimized responses through the JAK2-STAT4 pathway. T...
Source: Autophagy - February 18, 2024 Category: Cytology Authors: Yuanli Gao Suilin Chen Shiming Jiao Yongling Fan Xiuxiu Li Nie Tan Jiaqin Fang Luming Xu Yi Huang Jing Zhao Shuai Guo Taiping Liu Wenyue Xu Source Type: research
ATG5-regulated CCL2/MCP-1 production in myeloid cells selectively modulates anti-malarial CD4 < sup > + < /sup > Th1 responses
This study demonstrated that ATG5 deficiency in myeloid cells can significantly inhibit the growth of rodent blood-stage malarial parasites by selectively enhancing parasite-specific CD4+ Th1 cell responses. This effect was independent of ATG5-mediated canonical and non-canonical autophagy. Mechanistically, ATG5 deficiency suppressed FAS-mediated apoptosis of LY6G- ITGAM/CD11b+ ADGRE1/F4/80- cells and subsequently increased CCL2/MCP-1 production in parasite-infected mice. LY6G- ITGAM+ ADGRE1- cell-derived CCL2 selectively interacted with CCR2 on CD4+ Th1 cells for their optimized responses through the JAK2-STAT4 pathway. T...
Source: Autophagy - February 18, 2024 Category: Cytology Authors: Yuanli Gao Suilin Chen Shiming Jiao Yongling Fan Xiuxiu Li Nie Tan Jiaqin Fang Luming Xu Yi Huang Jing Zhao Shuai Guo Taiping Liu Wenyue Xu Source Type: research
ATG5-regulated CCL2/MCP-1 production in myeloid cells selectively modulates anti-malarial CD4 < sup > + < /sup > Th1 responses
This study demonstrated that ATG5 deficiency in myeloid cells can significantly inhibit the growth of rodent blood-stage malarial parasites by selectively enhancing parasite-specific CD4+ Th1 cell responses. This effect was independent of ATG5-mediated canonical and non-canonical autophagy. Mechanistically, ATG5 deficiency suppressed FAS-mediated apoptosis of LY6G- ITGAM/CD11b+ ADGRE1/F4/80- cells and subsequently increased CCL2/MCP-1 production in parasite-infected mice. LY6G- ITGAM+ ADGRE1- cell-derived CCL2 selectively interacted with CCR2 on CD4+ Th1 cells for their optimized responses through the JAK2-STAT4 pathway. T...
Source: Autophagy - February 18, 2024 Category: Cytology Authors: Yuanli Gao Suilin Chen Shiming Jiao Yongling Fan Xiuxiu Li Nie Tan Jiaqin Fang Luming Xu Yi Huang Jing Zhao Shuai Guo Taiping Liu Wenyue Xu Source Type: research
A Diversity Covering (DiCo) Plasmodium vivax apical membrane antigen-1 vaccine adjuvanted with RFASE/RSL10 yields high levels of growth-inhibitory antibodies
Vaccine. 2024 Feb 16:S0264-410X(24)00175-0. doi: 10.1016/j.vaccine.2024.02.029. Online ahead of print.ABSTRACTPlasmodium vivax malaria is increasingly recognized as a major global health problem and the socio-economic impact of P.vivax-induced burden is huge. Vaccine development against P. vivax malaria has been hampered by the lack of an in vitro culture system and poor access to P. vivax sporozoites. The recent generation of Plasmodium falciparum parasites that express a functional P. vivax AMA1 molecule has provided a platform for in vitro evaluation of PvAMA1 as a potential blood stage vaccine. Three so-called PvAMA1 D...
Source: Vaccine - February 16, 2024 Category: Allergy & Immunology Authors: Bart W Faber Lee M Yeoh Liriye Kurtovic Wim E M Mol Martin Poelert Elly Smits Roberto Rodriguez Garcia Marjolein Mandalawi-Van der Eijk Nicole van der Werff Annemarie Voorberg-van der Wel Edmond J Remarque James G Beeson Clemens H M Kocken Source Type: research
Trained immunity-inducing vaccines: Harnessing innate memory for vaccine design and delivery
Clin Immunol. 2024 Feb 9;261:109930. doi: 10.1016/j.clim.2024.109930. Online ahead of print.ABSTRACTWhile the efficacy of many current vaccines is well-established, various factors can diminish their effectiveness, particularly in vulnerable groups. Amidst emerging pandemic threats, enhancing vaccine responses is critical. Our review synthesizes insights from immunology and epidemiology, focusing on the concept of trained immunity (TRIM) and the non-specific effects (NSEs) of vaccines that confer heterologous protection. We elucidate the mechanisms driving TRIM, emphasizing its regulation through metabolic and epigenetic r...
Source: Clinical Immunology - February 11, 2024 Category: Allergy & Immunology Authors: Ilayda Baydemir Elisabeth A Dulfer Mihai G Netea Jorge Dom ínguez-Andrés Source Type: research
Cytokine gene polymorphisms implicated in the pathogenesis of Plasmodium falciparum infection outcome
Cytokines play a critical role in the immune mechanisms involved in fighting infections including malaria. Polymorphisms in cytokine genes may affect immune responses during an infection with Plasmodium parasites and immunization outcomes during routine administration of malaria vaccines. These polymorphisms can increase or reduce susceptibility to this deadly infection, and this may affect the physiologically needed balance between anti-inflammatory and pro-inflammatory cytokines. The purpose of this review is to present an overview of the effect of selected cytokine gene polymorphisms on immune responses against malaria....
Source: Frontiers in Immunology - February 9, 2024 Category: Allergy & Immunology Source Type: research
COVID-19 in patients presenting with malaria-like symptoms at a primary healthcare facility in Accra, Ghana
ConclusionIt may be difficult to use clinical characteristics to distinguish between patients with COVID-19 having malaria-like symptoms. Detection of IgM using RDTs may be useful in predicting CT values for SARS-CoV-2 real-time PCR and therefore transmission. (Source: PLoS One)
Source: PLoS One - February 9, 2024 Category: Biomedical Science Authors: Issabella Asamoah Source Type: research
