Normal Clinical Laboratory Ranges by Age and Sex, and Impact on Study Screening Outcomes in Rural Mali
We examined hematological and clinical chemistry parameters in healthy residents at two rural vaccine trial sites: Bancoumana and Doneguebougou in Mali, West Africa. During screening of clinical studies in 2018 and 2019, peripheral blood samples from 1,192 apparently healthy individuals age 6 months to 82 years were analyzed at a laboratory accredited by the College of American Pathologists for a complete blood count, and creatinine and/or alanine aminotransferase levels. Based on manufacturers' reference range values, which are currently used in Malian clinical laboratories, abnormal values were common in this healthy pop...
Source: Am J Trop Med Hyg - March 26, 2024 Category: Infectious Diseases Authors: M'Bouye Doucoure Amatigue Zeguime Amadou Niangaly Merepen A Guindo Justin Y A Doritchamou Mahamadoun H Assadou Abdoulaye Katile Moussa B Kanoute Sidiki Perou Adama Ouattara Sintry Sanogo Boucary Ouologuem Souleymane Traore Bakary Dao Drissa Dembele Mamady Source Type: research
Implementation of a Randomized, Placebo-Controlled Trial of Live Attenuated Malaria Sporozoite Vaccines in an Indonesian Military Study Population
We describe the manifold challenges of enrolling and immunizing 345 soldier participants at their home base in western Indonesia before their nearly 6,000-km voyage to eastern Indonesia, where they are being monitored for incident P. falciparum and Plasmodium vivax malaria cases during 9 months of exposure. The unique regulatory, ethical, and operational complexities of this trial demonstrate the importance of thorough planning, frequent communication, and close follow-up with stakeholders. Effective engagement with the military community and the ability to adapt to unanticipated events have proven key to the success of th...
Source: The American Journal of Tropical Medicine and Hygiene - March 26, 2024 Category: Tropical Medicine Authors: Khoriah Indrihutami Krisin Chand Rizka Fahmia Mutia Rahardjani Fitria Wulandari Decy Subekti Rintis Noviyanti Amin Soebandrio Noch T Mallisa I Made Mardika Waras Budiman Irwan Suriswan Yogi Ertanto Mei-Chun Chen Tooba Murshedkar Yonas Abebe B Kim Lee Sim Source Type: research
Normal Clinical Laboratory Ranges by Age and Sex, and Impact on Study Screening Outcomes in Rural Mali
We examined hematological and clinical chemistry parameters in healthy residents at two rural vaccine trial sites: Bancoumana and Doneguebougou in Mali, West Africa. During screening of clinical studies in 2018 and 2019, peripheral blood samples from 1,192 apparently healthy individuals age 6 months to 82 years were analyzed at a laboratory accredited by the College of American Pathologists for a complete blood count, and creatinine and/or alanine aminotransferase levels. Based on manufacturers' reference range values, which are currently used in Malian clinical laboratories, abnormal values were common in this healthy pop...
Source: The American Journal of Tropical Medicine and Hygiene - March 26, 2024 Category: Tropical Medicine Authors: M'Bouye Doucoure Amatigue Zeguime Amadou Niangaly Merepen A Guindo Justin Y A Doritchamou Mahamadoun H Assadou Abdoulaye Katile Moussa B Kanoute Sidiki Perou Adama Ouattara Sintry Sanogo Boucary Ouologuem Souleymane Traore Bakary Dao Drissa Dembele Mamady Source Type: research
Normal Clinical Laboratory Ranges by Age and Sex, and Impact on Study Screening Outcomes in Rural Mali
We examined hematological and clinical chemistry parameters in healthy residents at two rural vaccine trial sites: Bancoumana and Doneguebougou in Mali, West Africa. During screening of clinical studies in 2018 and 2019, peripheral blood samples from 1,192 apparently healthy individuals age 6 months to 82 years were analyzed at a laboratory accredited by the College of American Pathologists for a complete blood count, and creatinine and/or alanine aminotransferase levels. Based on manufacturers' reference range values, which are currently used in Malian clinical laboratories, abnormal values were common in this healthy pop...
Source: Am J Trop Med Hyg - March 26, 2024 Category: Infectious Diseases Authors: M'Bouye Doucoure Amatigue Zeguime Amadou Niangaly Merepen A Guindo Justin Y A Doritchamou Mahamadoun H Assadou Abdoulaye Katile Moussa B Kanoute Sidiki Perou Adama Ouattara Sintry Sanogo Boucary Ouologuem Souleymane Traore Bakary Dao Drissa Dembele Mamady Source Type: research
Implementation of a Randomized, Placebo-Controlled Trial of Live Attenuated Malaria Sporozoite Vaccines in an Indonesian Military Study Population
We describe the manifold challenges of enrolling and immunizing 345 soldier participants at their home base in western Indonesia before their nearly 6,000-km voyage to eastern Indonesia, where they are being monitored for incident P. falciparum and Plasmodium vivax malaria cases during 9 months of exposure. The unique regulatory, ethical, and operational complexities of this trial demonstrate the importance of thorough planning, frequent communication, and close follow-up with stakeholders. Effective engagement with the military community and the ability to adapt to unanticipated events have proven key to the success of th...
Source: Am J Trop Med Hyg - March 26, 2024 Category: Infectious Diseases Authors: Khoriah Indrihutami Krisin Chand Rizka Fahmia Mutia Rahardjani Fitria Wulandari Decy Subekti Rintis Noviyanti Amin Soebandrio Noch T Mallisa I Made Mardika Waras Budiman Irwan Suriswan Yogi Ertanto Mei-Chun Chen Tooba Murshedkar Yonas Abebe B Kim Lee Sim Source Type: research
Implementation of a Randomized, Placebo-Controlled Trial of Live Attenuated Malaria Sporozoite Vaccines in an Indonesian Military Study Population
We describe the manifold challenges of enrolling and immunizing 345 soldier participants at their home base in western Indonesia before their nearly 6,000-km voyage to eastern Indonesia, where they are being monitored for incident P. falciparum and Plasmodium vivax malaria cases during 9 months of exposure. The unique regulatory, ethical, and operational complexities of this trial demonstrate the importance of thorough planning, frequent communication, and close follow-up with stakeholders. Effective engagement with the military community and the ability to adapt to unanticipated events have proven key to the success of th...
Source: The American Journal of Tropical Medicine and Hygiene - March 26, 2024 Category: Tropical Medicine Authors: Khoriah Indrihutami Krisin Chand Rizka Fahmia Mutia Rahardjani Fitria Wulandari Decy Subekti Rintis Noviyanti Amin Soebandrio Noch T Mallisa I Made Mardika Waras Budiman Irwan Suriswan Yogi Ertanto Mei-Chun Chen Tooba Murshedkar Yonas Abebe B Kim Lee Sim Source Type: research
Normal Clinical Laboratory Ranges by Age and Sex, and Impact on Study Screening Outcomes in Rural Mali
We examined hematological and clinical chemistry parameters in healthy residents at two rural vaccine trial sites: Bancoumana and Doneguebougou in Mali, West Africa. During screening of clinical studies in 2018 and 2019, peripheral blood samples from 1,192 apparently healthy individuals age 6 months to 82 years were analyzed at a laboratory accredited by the College of American Pathologists for a complete blood count, and creatinine and/or alanine aminotransferase levels. Based on manufacturers' reference range values, which are currently used in Malian clinical laboratories, abnormal values were common in this healthy pop...
Source: The American Journal of Tropical Medicine and Hygiene - March 26, 2024 Category: Tropical Medicine Authors: M'Bouye Doucoure Amatigue Zeguime Amadou Niangaly Merepen A Guindo Justin Y A Doritchamou Mahamadoun H Assadou Abdoulaye Katile Moussa B Kanoute Sidiki Perou Adama Ouattara Sintry Sanogo Boucary Ouologuem Souleymane Traore Bakary Dao Drissa Dembele Mamady Source Type: research
Implementation of a Randomized, Placebo-Controlled Trial of Live Attenuated Malaria Sporozoite Vaccines in an Indonesian Military Study Population
We describe the manifold challenges of enrolling and immunizing 345 soldier participants at their home base in western Indonesia before their nearly 6,000-km voyage to eastern Indonesia, where they are being monitored for incident P. falciparum and Plasmodium vivax malaria cases during 9 months of exposure. The unique regulatory, ethical, and operational complexities of this trial demonstrate the importance of thorough planning, frequent communication, and close follow-up with stakeholders. Effective engagement with the military community and the ability to adapt to unanticipated events have proven key to the success of th...
Source: Am J Trop Med Hyg - March 26, 2024 Category: Infectious Diseases Authors: Khoriah Indrihutami Krisin Chand Rizka Fahmia Mutia Rahardjani Fitria Wulandari Decy Subekti Rintis Noviyanti Amin Soebandrio Noch T Mallisa I Made Mardika Waras Budiman Irwan Suriswan Yogi Ertanto Mei-Chun Chen Tooba Murshedkar Yonas Abebe B Kim Lee Sim Source Type: research
Normal Clinical Laboratory Ranges by Age and Sex, and Impact on Study Screening Outcomes in Rural Mali
We examined hematological and clinical chemistry parameters in healthy residents at two rural vaccine trial sites: Bancoumana and Doneguebougou in Mali, West Africa. During screening of clinical studies in 2018 and 2019, peripheral blood samples from 1,192 apparently healthy individuals age 6 months to 82 years were analyzed at a laboratory accredited by the College of American Pathologists for a complete blood count, and creatinine and/or alanine aminotransferase levels. Based on manufacturers' reference range values, which are currently used in Malian clinical laboratories, abnormal values were common in this healthy pop...
Source: Am J Trop Med Hyg - March 26, 2024 Category: Infectious Diseases Authors: M'Bouye Doucoure Amatigue Zeguime Amadou Niangaly Merepen A Guindo Justin Y A Doritchamou Mahamadoun H Assadou Abdoulaye Katile Moussa B Kanoute Sidiki Perou Adama Ouattara Sintry Sanogo Boucary Ouologuem Souleymane Traore Bakary Dao Drissa Dembele Mamady Source Type: research
Implementation of a Randomized, Placebo-Controlled Trial of Live Attenuated Malaria Sporozoite Vaccines in an Indonesian Military Study Population
We describe the manifold challenges of enrolling and immunizing 345 soldier participants at their home base in western Indonesia before their nearly 6,000-km voyage to eastern Indonesia, where they are being monitored for incident P. falciparum and Plasmodium vivax malaria cases during 9 months of exposure. The unique regulatory, ethical, and operational complexities of this trial demonstrate the importance of thorough planning, frequent communication, and close follow-up with stakeholders. Effective engagement with the military community and the ability to adapt to unanticipated events have proven key to the success of th...
Source: The American Journal of Tropical Medicine and Hygiene - March 26, 2024 Category: Tropical Medicine Authors: Khoriah Indrihutami Krisin Chand Rizka Fahmia Mutia Rahardjani Fitria Wulandari Decy Subekti Rintis Noviyanti Amin Soebandrio Noch T Mallisa I Made Mardika Waras Budiman Irwan Suriswan Yogi Ertanto Mei-Chun Chen Tooba Murshedkar Yonas Abebe B Kim Lee Sim Source Type: research
Normal Clinical Laboratory Ranges by Age and Sex, and Impact on Study Screening Outcomes in Rural Mali
We examined hematological and clinical chemistry parameters in healthy residents at two rural vaccine trial sites: Bancoumana and Doneguebougou in Mali, West Africa. During screening of clinical studies in 2018 and 2019, peripheral blood samples from 1,192 apparently healthy individuals age 6 months to 82 years were analyzed at a laboratory accredited by the College of American Pathologists for a complete blood count, and creatinine and/or alanine aminotransferase levels. Based on manufacturers' reference range values, which are currently used in Malian clinical laboratories, abnormal values were common in this healthy pop...
Source: The American Journal of Tropical Medicine and Hygiene - March 26, 2024 Category: Tropical Medicine Authors: M'Bouye Doucoure Amatigue Zeguime Amadou Niangaly Merepen A Guindo Justin Y A Doritchamou Mahamadoun H Assadou Abdoulaye Katile Moussa B Kanoute Sidiki Perou Adama Ouattara Sintry Sanogo Boucary Ouologuem Souleymane Traore Bakary Dao Drissa Dembele Mamady Source Type: research
Normal Clinical Laboratory Ranges by Age and Sex, and Impact on Study Screening Outcomes in Rural Mali
We examined hematological and clinical chemistry parameters in healthy residents at two rural vaccine trial sites: Bancoumana and Doneguebougou in Mali, West Africa. During screening of clinical studies in 2018 and 2019, peripheral blood samples from 1,192 apparently healthy individuals age 6 months to 82 years were analyzed at a laboratory accredited by the College of American Pathologists for a complete blood count, and creatinine and/or alanine aminotransferase levels. Based on manufacturers' reference range values, which are currently used in Malian clinical laboratories, abnormal values were common in this healthy pop...
Source: Am J Trop Med Hyg - March 26, 2024 Category: Infectious Diseases Authors: M'Bouye Doucoure Amatigue Zeguime Amadou Niangaly Merepen A Guindo Justin Y A Doritchamou Mahamadoun H Assadou Abdoulaye Katile Moussa B Kanoute Sidiki Perou Adama Ouattara Sintry Sanogo Boucary Ouologuem Souleymane Traore Bakary Dao Drissa Dembele Mamady Source Type: research
Implementation of a Randomized, Placebo-Controlled Trial of Live Attenuated Malaria Sporozoite Vaccines in an Indonesian Military Study Population
We describe the manifold challenges of enrolling and immunizing 345 soldier participants at their home base in western Indonesia before their nearly 6,000-km voyage to eastern Indonesia, where they are being monitored for incident P. falciparum and Plasmodium vivax malaria cases during 9 months of exposure. The unique regulatory, ethical, and operational complexities of this trial demonstrate the importance of thorough planning, frequent communication, and close follow-up with stakeholders. Effective engagement with the military community and the ability to adapt to unanticipated events have proven key to the success of th...
Source: Am J Trop Med Hyg - March 26, 2024 Category: Infectious Diseases Authors: Khoriah Indrihutami Krisin Chand Rizka Fahmia Mutia Rahardjani Fitria Wulandari Decy Subekti Rintis Noviyanti Amin Soebandrio Noch T Mallisa I Made Mardika Waras Budiman Irwan Suriswan Yogi Ertanto Mei-Chun Chen Tooba Murshedkar Yonas Abebe B Kim Lee Sim Source Type: research
Reinvestigation of diphenylmethylpiperazine analogues of pyrazine as new class of < em > Plasmodial < /em > cysteine protease inhibitors for the treatment of malaria
RSC Med Chem. 2024 Feb 1;15(3):1022-1037. doi: 10.1039/d3md00490b. eCollection 2024 Mar 20.ABSTRACTMalaria eradication is still a global challenge due to the lack of a broadly effective vaccine and the emergence of drug resistance to most of the currently available drugs as part of the mainline artemisinin-based combination therapy. A variety of experimental approaches are quite successful in identifying and synthesizing new promising pharmacophore hybrids with distinct mechanisms of action. Based on our recent findings, the current study demonstrates the reinvestigation of a series of diphenylmethylpiperazine and pyrazine...
Source: Cell Research - March 22, 2024 Category: Cytology Authors: Hari Madhav G Srinivas Reddy Zeba Rizvi Ehtesham Jameel Tarosh S Patel Abdur Rahman Vikas Yadav Sadaf Fatima Fatima Heyat Kavita Pal Amisha Minju-Op Naidu Subbarao Souvik Bhattacharjee Bharat C Dixit Puran Singh Sijwali Nasimul Hoda Source Type: research
A new malaria vaccination tool based on replication-competent Plasmodium falciparum parasites
EMBO Mol Med. 2024 Mar 21. doi: 10.1038/s44321-024-00056-8. Online ahead of print.NO ABSTRACTPMID:38514792 | DOI:10.1038/s44321-024-00056-8 (Source: Molecular Medicine)
Source: Molecular Medicine - March 22, 2024 Category: Molecular Biology Authors: Diana Moita Miguel Prud êncio Source Type: research
