GSE225556 IL-27 produced during acute malaria infection regulates Plasmodium-specific memory CD4+ T cells
Contributors : Maria-Lourdes M Macalinao ; Shin-Ichi Inoue ; Sanjaadorj Tsogtsaikhan ; Hirotaka Matsumoto ; Ganchimeg Bayarsaikhan ; Jiun-Yu Jian ; Kazumi Kimura ; Yoshiaki Yasumizu ; Tsuyoshi Inoue ; Hiroki Yoshida ; Julius Hafalla ; Daisuke Kimura ; Katsuyuki YuiSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusMalaria infection elicits both protective and pathogenic immune responses, and IL-27 is a critical cytokine that regulate effector responses during infection. Here, we identified a critical window of CD4+ T cell responses that is targeted by IL-27. Neutraliz...
Source: GEO: Gene Expression Omnibus - October 19, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Mus musculus Source Type: research
The implementation of infection prevention and control measures and health care utilisation in ACF-supported health facilities during the COVID-19 pandemic in Kinshasa, Democratic Republic of the Congo, 2020
CONCLUSIONS: The effectiveness of the triage and alert validation process was affected by the complexity of implementing a broad clinical definition in limited-resource settings with a pre-pandemic epidemiological profile characterised by infectious diseases with symptoms like COVID-19. Readily available testing capacity remains key for future pandemic response to improve the disease understanding and maintain health services.PMID:37846089 | DOI:10.1080/16549716.2023.2258711 (Source: Global Health Action)
Source: Global Health Action - October 17, 2023 Category: International Medicine & Public Health Authors: Chiara Altare Linda Matadi Basadia Natalya Kostandova Justus Nsio Mbeta Sophie Bruneau Caroline Antoine Marie Petry Source Type: research
The implementation of infection prevention and control measures and health care utilisation in ACF-supported health facilities during the COVID-19 pandemic in Kinshasa, Democratic Republic of the Congo, 2020
CONCLUSIONS: The effectiveness of the triage and alert validation process was affected by the complexity of implementing a broad clinical definition in limited-resource settings with a pre-pandemic epidemiological profile characterised by infectious diseases with symptoms like COVID-19. Readily available testing capacity remains key for future pandemic response to improve the disease understanding and maintain health services.PMID:37846089 | PMC:PMC10583608 | DOI:10.1080/16549716.2023.2258711 (Source: Global Health Action)
Source: Global Health Action - October 17, 2023 Category: International Medicine & Public Health Authors: Chiara Altare Linda Matadi Basadia Natalya Kostandova Justus Nsio Mbeta Sophie Bruneau Caroline Antoine Marie Petry Source Type: research
Safety and immunogenicity of BK-SE36/CpG malaria vaccine in healthy Burkinabe adults and children: a phase 1b randomised, controlled, double-blinded, age de-escalation trial
ConclusionBK-SE36/CpG was well-tolerated and immunogenic. These results pave the way for further proof-of-concept studies to demonstrate vaccine efficacy.Clinical trial registrationhttps://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=1921, PACTR201701001921166. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - October 16, 2023 Category: Allergy & Immunology Source Type: research
Antibodies elicited by Plasmodium falciparum circumsporozoite proteins lacking sequentially deleted C-terminal amino acids reveal mouse strain and epitopes specific differences
Vaccine. 2023 Oct 10:S0264-410X(23)01179-9. doi: 10.1016/j.vaccine.2023.10.009. Online ahead of print.ABSTRACTMalaria affects ∼ ¼ billion people globally and requires the development of additional tools to aid in elimination efforts. The recently approved RTS,S/AS01 vaccine represents a positive step, however, the moderate efficacy necessitates the development of more efficacious vaccines. PfCSP is a key target antigen for pre-erythrocytic vaccines aimed at preventing Plasmodium falciparum malaria infections. Epitopes within the central repeat region and at the junction of the repeat and N-terminal domain are well docum...
Source: Vaccine - October 12, 2023 Category: Allergy & Immunology Authors: Clifford T H Hayashi Yi Cao Fidel Zavala Hayk Simonyan Colin N Young Nirbhay Kumar Source Type: research
Antibodies elicited by Plasmodium falciparum circumsporozoite proteins lacking sequentially deleted C-terminal amino acids reveal mouse strain and epitopes specific differences
Vaccine. 2023 Oct 10:S0264-410X(23)01179-9. doi: 10.1016/j.vaccine.2023.10.009. Online ahead of print.ABSTRACTMalaria affects ∼ ¼ billion people globally and requires the development of additional tools to aid in elimination efforts. The recently approved RTS,S/AS01 vaccine represents a positive step, however, the moderate efficacy necessitates the development of more efficacious vaccines. PfCSP is a key target antigen for pre-erythrocytic vaccines aimed at preventing Plasmodium falciparum malaria infections. Epitopes within the central repeat region and at the junction of the repeat and N-terminal domain are well docum...
Source: Vaccine - October 12, 2023 Category: Allergy & Immunology Authors: Clifford T H Hayashi Yi Cao Fidel Zavala Hayk Simonyan Colin N Young Nirbhay Kumar Source Type: research
Half a million children die of malaria every year. Finally we can change that
Nature, Published online: 11 October 2023; doi:10.1038/d41586-023-03173-5With two vaccines available, this killer disease could now be eliminated — but will the world pull together to make it happen? (Source: Nature AOP)
Source: Nature AOP - October 11, 2023 Category: Research Source Type: research
Vaccine Preventable Disease and Vaccine Hesitancy
Med Clin North Am. 2023 Nov;107(6):979-987. doi: 10.1016/j.mcna.2023.05.012. Epub 2023 Jul 11.ABSTRACTGlobal immunization programs have saved tens of millions of lives over the last 2 decades. Now, the recent successes of COVID-19 vaccines having saved more than 3 million lives in North America during the pandemic may open the door to accelerate technologies for other emerging infection vaccines. New vaccines for respiratory syncytial virus, norovirus, influenza, herpes simplex virus, shingles, dengue fever, enteric bacterial infections, malaria, and Chagas disease are advancing through clinical development and could becom...
Source: Herpes - October 8, 2023 Category: Infectious Diseases Authors: Peter J Hotez Source Type: research
Vaccine Preventable Disease and Vaccine Hesitancy
Med Clin North Am. 2023 Nov;107(6):979-987. doi: 10.1016/j.mcna.2023.05.012. Epub 2023 Jul 11.ABSTRACTGlobal immunization programs have saved tens of millions of lives over the last 2 decades. Now, the recent successes of COVID-19 vaccines having saved more than 3 million lives in North America during the pandemic may open the door to accelerate technologies for other emerging infection vaccines. New vaccines for respiratory syncytial virus, norovirus, influenza, herpes simplex virus, shingles, dengue fever, enteric bacterial infections, malaria, and Chagas disease are advancing through clinical development and could becom...
Source: The Medical Clinics of North America - October 8, 2023 Category: General Medicine Authors: Peter J Hotez Source Type: research
