Implementation of a Randomized, Placebo-Controlled Trial of Live Attenuated Malaria Sporozoite Vaccines in an Indonesian Military Study Population

We describe the manifold challenges of enrolling and immunizing 345 soldier participants at their home base in western Indonesia before their nearly 6,000-km voyage to eastern Indonesia, where they are being monitored for incident P. falciparum and Plasmodium vivax malaria cases during 9 months of exposure. The unique regulatory, ethical, and operational complexities of this trial demonstrate the importance of thorough planning, frequent communication, and close follow-up with stakeholders. Effective engagement with the military community and the ability to adapt to unanticipated events have proven key to the success of this trial.PMID:38531102 | DOI:10.4269/ajtmh.23-0597

Source: Am J Trop Med Hyg - March 26, 2024 Category: Infectious Diseases Authors: Khoriah Indrihutami Krisin Chand Rizka Fahmia Mutia Rahardjani Fitria Wulandari Decy Subekti Rintis Noviyanti Amin Soebandrio Noch T Mallisa I Made Mardika Waras Budiman Irwan Suriswan Yogi Ertanto Mei-Chun Chen Tooba Murshedkar Yonas Abebe B Kim Lee Sim Source Type: research