Digital Twins and the Promise of Personalized Medicine
Can you guess the percentage of patients with Alzheimer’s on whom medication is ineffective? What about those with arthritis? Or cardiac arrhythmia? In fact, you don’t have to guess as the US Food and Drug Administration (FDA) already has the answers: 70%, 50% and 40% respectively. The percentage of patients for whom medications are ineffective range from 38-75% for varying conditions from depression to osteoporosis.
The main cause is because of the very genetic makeup of every individual. The latter is so different and their interaction so unique that therapies for the “average patient” might very well no...
Source: The Medical Futurist - March 19, 2020 Category: Information Technology Authors: Prans Tags: Future of Medicine Personalized Medicine digital health technology healthcare data digital twin technology design Source Type: blogs
Why Peak Viral Load makes temperature screening alone insufficient for COVID-19
By TONY ESTRELLA
And how South Korea and Taiwan’s approach to diagnosis and tracking is leading to positive results
By now, the sight of people wearing surgical masks, flinching at the sights and sounds of someone coughing or sneezing, governments restricting large gatherings, and sports leagues suspending or cancelling matches is familiar across the world.
Even though this newest coronavirus we now call COVID-19 is not the deadliest disease as measured by daily deaths, the concern over the outbreak is forcing urgent actions.
Daily deaths from COVID-19 compared to other diseases. Source: informationisbeautifu...
Source: The Health Care Blog - March 16, 2020 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Health Policy Source Type: blogs
Fight Aging! Newsletter, March 9th 2020
In this study, we intravenously administrated the young mitochondria into aged mice to evaluate whether energy production increase in aged tissues or age-related behaviors improved after the mitochondrial transplantation. The results showed that heterozygous mitochondrial DNA of both aged and young mouse coexisted in tissues of aged mice after mitochondrial administration, and meanwhile, ATP content in tissues increased while reactive oxygen species (ROS) level reduced. Besides, the mitotherapy significantly improved cognitive and motor performance of aged mice. Our study, at the first report in aged animals, not only prov...
Source: Fight Aging! - March 8, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The 7 Must-Haves For The Doctor Of the 21st Century
While Doctor Who is embracing change, casting two female leads in a row as the titular character following the series’ tradition of having male leads, real life doctors should take some cues from the fictional doctor when it comes to change. For ages, physicians have been relying on traditional methods when it comes to consulting patients and follow a rote template akin to the following: patients see the doctor who auscultates them with manual techniques, without forgetting the stethoscope, and will prescribe them some medication or lifestyle change. In specific cases, they will recommend a more detailed diagnostic metho...
Source: The Medical Futurist - March 5, 2020 Category: Information Technology Authors: Prans Tags: Future of Medicine Portable Diagnostics digital health smartphone healthcare systems digital stethoscope Source Type: blogs
Fight Aging! Newsletter, February 24th 2020
In conclusion, taller body height at the entry to adulthood, supposed to be a marker of early-life environment, is associated with lower risk of dementia diagnosis later in life. The association persisted when adjusted for educational level and intelligence test scores in young adulthood, suggesting that height is not just acting as an indicator of cognitive reserve.
A Comparison of Biological Age Measurement Approaches
https://www.fightaging.org/archives/2020/02/a-comparison-of-biological-age-measurement-approaches/
Researchers here assess the performance of a range of approaches to measuring biologica...
Source: Fight Aging! - February 23, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, February 17th 2020
Discussion of the Evolutionary Genetics of Aging
Thymic Involution Contributes to Immunosenescence and Inflammaging
The Potential for Exosome Therapies to Treat Sarcopenia
Correlations of Mitochondrial DNA Copy Number and Epigenetic Age Measures
Evidence for PASK Deficiency to Reduce the Impact of Aging in Mice
The Aging Retina, a Mirror of the Aging Brain
Evidence for Loss of Capillary Density to be Important in Heart Disease
Aspects of Immune System Aging Proceed More Rapidly in Men
Deacetylation of the NLRP3 Inflammasome as a Way to Control Chronic Inflammation
Transplantation of Senescent Cel...
Source: Fight Aging! - February 16, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Notes on the 2020 Longevity Therapeutics Conference in San Francisco
I recently attended the 2020 Longevity Therapeutics conference in San Francisco. I presented on the work ongoing at Repair Biotechnologies, but as is usually the case the more important parts of the visit took place outside the bounds of the conference proper. Longevity Therapeutics is one of the four or five core conferences for the longevity industry, at which you'll meet many of the early participants - a mix of scientists, entrepreneurs, and investors, and patient advocates. As such, most of the conference goers have already seen my updates, or are otherwise aware of the Repair Biotechnologies programs aimed at thymic ...
Source: Fight Aging! - February 10, 2020 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
New Membranes to Make Extracorporeal Oxygenation More Effective
When lungs fail because of acute respiratory distress and cannot be used to deliver oxygen to patients via conventional ventilation, extracorporeal membrane oxygenation (ECMO) has to be employed. ECMOs remove carbon dioxide from whole blood and replace it with oxygen thanks to a membrane oxygenator. While such artificial lungs are effective for short periods of time for many patients, for others this procedure is just too difficult. The gas exchange process performed by ECMOs is just too slow compared with what healthy lungs can achieve.
Now, researchers at Fraunhofer Institute for Applied Polymer Research (IAP) in Germ...
Source: Medgadget - February 3, 2020 Category: Medical Devices Authors: Medgadget Editors Tags: Anesthesiology Critical Care Emergency Medicine Materials Thoracic Surgery Source Type: blogs
Fight Aging! Newsletter, February 3rd 2020
In conclusion, this study suggests that epigenetic age acceleration is significantly associated with lung function in women older than 50 years. We hypothesised that this could be due to menopause. However, we have observed that menopause has minimal effect and therefore there is possibility of other unknown physiological factors at older age in females mediating the epigenetic age acceleration effect on lung function. While, it is still unknown what exactly epigenetic aging from DNA methylation measures, this study suggests it can be utilised as one of the important factors to assess women's lung health in old age. DNA me...
Source: Fight Aging! - February 2, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, January 27th 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 26, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Artificial Intelligence vs. Tuberculosis – Part 2
By SAURABH JHA, MD
Clever Hans
Preetham Srinivas, the head of the
chest radiograph project in Qure.ai, summoned Bhargava Reddy, Manoj Tadepalli, and
Tarun Raj to the meeting room.
“Get ready for an all-nighter, boys,”
said Preetham.
Qure’s scientists began investigating
the algorithm’s mysteriously high performance on chest radiographs from a new
hospital. To recap, the algorithm had an area under the receiver operating
characteristic curve (AUC) of 1 – that’s 100 % on multiple-choice question
test.
“Someone leaked the paper to AI,”
laughed Manoj.
“It’s an engineering college joke,...
Source: The Health Care Blog - January 24, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Artificial Intelligence Health Tech Health Technology @roguerad AI Saurabh Jha TB tuberculosis Source Type: blogs
Top Artificial Intelligence Companies in Healthcare to Keep an Eye On
The field of medical AI is buzzing. More and more companies set the purpose to disrupt healthcare with the help of artificial intelligence. Given how fast these companies come and go, it can prove to be hard to stay up-to-date with the most promising ones. Here, I collected the biggest names currently on the market ranging from start-ups to tech giants to keep an eye on in the future.
To further help you keep up with what A.I. brings to medicine, The Medical Futurist team made an easy-to-digest e-book about just that. I highly encourage you to read it and would love to hear about your thoughts!
Artificial Intelligence has ...
Source: The Medical Futurist - January 21, 2020 Category: Information Technology Authors: berci.mesko Tags: Artificial Intelligence Healthcare Design AI digital health genetics Innovation Personalized medicine pharma GC1 big data drug development healthcare companies medical imaging Source Type: blogs
Fight Aging! Newsletter, January 20th 2020
This study provides strong evidence that following a healthy lifestyle can substantially extend the years a person lives disease-free."
Commentary on Recent Evidence for Cognitive Decline to Precede Amyloid Aggregation in Alzheimer's Disease
https://www.fightaging.org/archives/2020/01/commentary-on-recent-evidence-for-cognitive-decline-to-precede-amyloid-aggregation-in-alzheimers-disease/
I can't say that I think the data presented in the research noted here merits quite the degree of the attention that it has been given in the popular science press. It is interesting, but not compelling if its role is ...
Source: Fight Aging! - January 19, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, January 13th 2020
In this study, we investigated the link between AF and senescence markers through the assessment of protein expression in the tissue lysates of human appendages from patients in AF, including paroxysmal (PAF) or permanent AF (PmAF), and in sinus rhythm (SR). The major findings of the study indicated that the progression of AF is strongly related to the human atrial senescence burden as determined by p53 and p16 expression. The stepwise increase of senescence (p53, p16), prothrombotic (TF), and proremodeling (MMP-9) markers observed in the right atrial appendages of patients in SR, PAF, and PmAF points toward multiple inter...
Source: Fight Aging! - January 12, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Easy-to-Remove Superhydrophobic Bandage Speeds Clotting of Wounds
Researchers at ETH Zurich and National University of Singapore have developed a new type of bandage that does not stick to the wound while helping blood to clot beneath it. This is the first time scientists have combined both properties in one material and the capability allows the bandage to promote healing and be easily removed or changed as necessary.
While their quest initially began with developing a material for coating heart and lung assist devices and artificial hearts, these researchers came upon an unexpected discovery. They developed and tried various superhydrophobic materials and one of them repelled blood...
Source: Medgadget - January 10, 2020 Category: Medical Devices Authors: Siavash Parkhideh Tags: Materials Medicine Plastic Surgery Source Type: blogs
