Reverse Potts Shunt for Pulmonary Arterial Hypertension in Children
Potts shunt was a surgical anastomosis between left pulmonary artery and descending aorta to improve pulmonary blood flow in cyanotic congenital heart disease with decreased pulmonary blood flow. It is a systemic to pulmonary shunt. The report was published one year after the Blalock-Taussig shunt which was also used for a similar purpose [1]. Later Potts shunt like other central aortopulmonary shunts, were discontinued because of higher risk of excessive pulmonary blood flow. A modified Blalock-Taussig shunt is still in use.
Reverse Potts shunt is a pulmonary to systemic shunt for relieving pulmonary arterial hypertensio...
Source: Cardiophile MD - August 4, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs
Fight Aging! Newsletter, August 2nd 2021
This study aimed to determine the association between: (i) cognitive decline and bone loss; and (ii) clinically significant cognitive decline on Mini Mental State Examination (MMSE) over the first 5 years and subsequent fracture risk over the following 10 years. A total of 1741 women and 620 men aged ≥65 years from the population-based Canadian Multicentre Osteoporosis Study were followed from 1997 to 2013. Over 95% of participants had normal cognition at baseline. After multivariable adjustment, cognitive decline was associated with bone loss in women but not men. Approximately 13% of participants experienced sign...
Source: Fight Aging! - August 1, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Causality in Medicine: Moving Beyond Correlation in Clinical Practice
A growing body of research suggests it ’s time to abandon outdated ideas about how to identify effective medical therapies.Paul Cerrato, senior research analyst and communications specialist, Mayo Clinic Platform, and John Halamka, M.D., president, Mayo Clinic Platform, wrote this article.“Correlation is not causation.” It’s a truism that researchers take for granted, and for good reason. The fact that event A is followed by event B doesn’t mean that A caused B. An observational study of 1,000 adults, for example, that found those taking high doses of vitamin C were less like ly to develop lung cancer doesn’t p...
Source: Life as a Healthcare CIO - July 23, 2021 Category: Information Technology Source Type: blogs
The Road to Low Cost Universal Cells and Tissues, For Transplantation into Any Patient
An area of intense interest in the academic and biotechnology communities is the development of cells that do not provoke an immune response due to mismatch of cell surface receptors. As a general rule, cells from one individual are rejected by any other individual. It is possible to minimize this outcome by eliminating MHC receptors, but there are other complex interactions between cell surface chemistry and portions of the immune system that can still act as a barrier to transplantation. A number of groups have developed approaches to address specific parts of this problem space, but no one winner has yet emerged. At the...
Source: Fight Aging! - July 20, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
More Than 25 Years of Competition and Collaboration Advance the Prediction of Protein Shapes
Proteins (such as hemoglobin, actin, and amylase) are workhorse molecules that contribute to virtually every activity in the body. Some of proteins’ many jobs include carrying oxygen from your lungs to the rest of your body (hemoglobin), allowing your muscles to move (actin and myosin), and digesting your food (amylase, pepsin, and lactase). All proteins are made up of chains of amino acids that fold into specific 3D structures, and each protein’s structure allows it to perform its distinct job. Proteins that are misfolded or misshapen can cause diseases such as Parkinson’s or cataracts.
While it’s straightforwa...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - July 14, 2021 Category: Research Authors: Chrissa Chverchko Tags: Molecular Structures Cool Tools/Techniques Modeling Proteins Scientific Process Source Type: blogs
Asthma Care And Digital Health
Right before her afternoon run, Rita pairs her smart preventer inhaler with her smartphone and takes two puffs. Checking the companion app, she finds that she took the right dose and waited for the recommended 30 seconds between inhalations. Relieved that her workout will not trigger her asthma symptoms, she begins tracking it on her smartwatch.
Following the 40 minute run, Rita checks her peak flow reading – or how well she exhales – with her smart, handheld peak flow monitor. This enables her to determine whether her workout caused any narrowing of her airways, which could lead to an asthma flare-up well b...
Source: The Medical Futurist - June 8, 2021 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: Artificial Intelligence in Medicine E-Patients Future of Medicine Future of Pharma Health Sensors & Trackers fda wearables asthma asthma care ADAMM smart patch DailyBreath asthmaTrack AsthmaMD Smart PeakFlow AioCare Propell Source Type: blogs
How Digital Health Technology Can Contribute To Asthma Care
Right before her afternoon run, Rita pairs her smart preventer inhaler with her smartphone and takes two puffs. Checking the companion app, she finds that she took the right dose and waited for the recommended 30 seconds between inhalations. Relieved that her workout will not trigger her asthma symptoms, she begins tracking it on her smartwatch.
Following the 40 minute run, Rita checks her peak flow reading – or how well she exhales – with her smart, handheld peak flow monitor. This enables her to determine whether her workout caused any narrowing of her airways, which could lead to an asthma flare-up well b...
Source: The Medical Futurist - June 8, 2021 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: Artificial Intelligence in Medicine E-Patients Future of Medicine Future of Pharma Health Sensors & Trackers fda wearables asthma asthma care ADAMM smart patch DailyBreath asthmaTrack AsthmaMD Smart PeakFlow AioCare Propell Source Type: blogs
Fight Aging! Newsletter, June 7th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - June 6, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senescent Cells as a Mechanism for Worse Outcomes in Transplantation of Older Organs
Senescent cells accumulate with age in tissues throughout the body. They secrete a mix of signals that provokes chronic inflammation, disruption of tissue maintenance, and changes in cell behavior that lead to pathology. Targeted clearance of senescent cells has been shown to produce rejuvenation in mice, a reversal of many different age-related conditions, particularly those strongly linked to the chronic inflammation of aging. In this context, researchers here discuss the presence of greater numbers of senescent cells in older tissues as an important mechanism determining outcomes for patients following organ transplanta...
Source: Fight Aging! - May 31, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, May 31st 2021
In conclusion, iMSC-sEVs could rejuvenate the senescence of NPCs and attenuate the development of IVDD.
Cell Signaling via Exosomes in the Development of Vascular Calcification
https://www.fightaging.org/archives/2021/05/cell-signaling-via-exosomes-in-the-development-of-vascular-calcification/
Vascular calcification is a feature of aging, a process in which cells in the blood vessel wall take on inappropriate identities and activities that are more appropriate to bone tissue. Evidence of recent years implicates chronic inflammation and the presence of senescent cells in this process. Senescent cells cau...
Source: Fight Aging! - May 30, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Targeting Senescent Cells to Reverse the Aging of the Kidneys
Senescent cells accumulate with age and cause a wide range of pathologies. They contribute in some way to near all of the common, ultimately fatal age-related conditions. Senescent cells secrete a mix of signals that produces chronic inflammation, disrupts tissue maintenance to encourage fibrosis, and changes the behavior of other cells for the worse in numerous ways. It is the signaling that allows the comparatively small fraction of senescent cells in any given aged tissue to cause such widespread harm.
Destroying senescent cells in a targeted fashion via the use of senolytic therapies has shown great promise in a...
Source: Fight Aging! - May 28, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, May 24th 2021
In conclusion, we showed that addition of resistance exercise training, but not dietary EAAs, to the myostatin inhibition further increased muscle mass through the attenuation of muscle protein breakdown with proportionate improvements in muscle strength. Interestingly, addition of dietary EAAs to the myostatin inhibition with or without resistance exercise training improved muscle quality. Thus, dissection of the underlying mechanisms behind the combined positive effect of dietary EAAs and resistance exercise training on muscle mass and quality can shed light on the discovery of effective therapeutics against muscle wasti...
Source: Fight Aging! - May 23, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Epistemology VI: Epidemiology
Epidemiology originally largely meant studying how infectious diseases spread, and that ' s still a major concern of epidemiologists. However, it also includes the study of any and every environmental or behavioral factor affecting human health. For example, the finding that smoking tobacco causes lung cancer (not to mention a bazillion other diseases) is an epidemiological finding. Epidemiology is largely an observational science, given the ethical prohibition against exposing humans to potentially hazardous conditions for experimental purposes. That ' s not to say it hasn ' t been done, with the victims being ...
Source: Stayin' Alive - May 17, 2021 Category: American Health Source Type: blogs
Invariant Natural Killer T Cells can be Provoked into Destroying Senescent Cells
Researchers here use the properties of a subset of natural killer T cells of the immune system in order to provoke these cells into greater activity without rousing the rest of the immune system into action. The outcome is that the activated natural killer T cells then destroy more senescent cells than would otherwise have been the case. Destroying senescent cells by any means leads to a dose-dependent degree of rejuvenation in older individuals, and that result is achieved here. This is an intriguing approach to the challenge of clearing senescent cells, and it will be interesting to watch its further development.
...
Source: Fight Aging! - May 17, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A transplant physician faces facts about his career
An excerpt from Exhale: Hope, Healing, and a Life in Transplant. Late one Wednesday night in the spring of 2013, I sat in the ICU at Tina ’s (aka Doctor D’s) bedside. She’d begun to deteriorate from chronic rejection of her lungs, and I had put her back on the waiting list for a second transplant. […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - May 11, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/david-weill" rel="tag" > David Weill, MD < /a > < /span > Tags: Physician Pulmonology Source Type: blogs
