Information for Readers
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 15, 2019 Category: Transplant Surgery Source Type: research
Bone Marrow Cells Transplant in Septic Mice Modulates Systemic Inflammatory Response via Cell–Cell Contact
Sepsis is a dynamic disease, displaying an inflammatory profile that varies over time and for each organ. Controlling the inflammatory response based in targeting a single molecule has been proved useless. We hypothesized that treatment with bone marrow-derived mononuclear cells (BMDMCs) may be more efficient to modulate the systemic inflammatory response to infection. Adult male Balb/c mice were subjected to cecal ligation and puncture (CLP) or endotoxemia model of experimental sepsis. BMDMCs were separated under Ficoll gradient and injected intravenously 1 h after the procedures. Cytokines concentration was quantified in...
Source: Shock - February 14, 2019 Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research
Patients Treated for Central Airway Stenosis After Lung Transplantation Have Persistent Airflow Limitation.
The objective of our study was to evaluate the impact of CAS on lung function after lung transplantation. MATERIAL AND METHODS All lung transplant recipients from June 2009 to August 2014 in a single center (Strasbourg, France) were retrospectively reviewed. RESULTS A total of 191 lung transplantations were performed: 175 bilateral, 15 single, and 1 heart-lung transplantation. Of the 161 bilateral lung-transplanted patients who survived>3 months, 22 (13.6%) developed CAS requiring endobronchial treatment. All these patients were treated by endoscopic balloon dilatation, and 9 additionally needed endobronchial stents. Re...
Source: Annals of Transplantation - February 14, 2019 Category: Transplant Surgery Authors: Mazzetta A, Porzio M, Riou M, Coiffard B, Olland A, Dégot T, Seitlinger J, Massard G, Renaud-Picard B, Kessler R Tags: Ann Transplant Source Type: research
Size Mismatching Increases Mortality Following Lung Transplantation in Pre-Adolescent Patients
Publication date: Available online 11 February 2019Source: The Annals of Thoracic SurgeryAuthor(s): Charles D. Fraser, Xun Zhou, Joshua C. Grimm, Alejandro Suarez-Pierre, Todd C. Crawford, Cecillia Lui, Errol L. Bush, Narutoshi Hibino, Marshall L. Jacobs, Luca A. Vricella, Christian MerloAbstractBackgroundThe impact of size mismatch between donor and recipient in pediatric lung transplantation (PLTx) is currently unknown. Previous studies in adults have suggested that oversized allografts are associated with improved outcomes following lung transplantation. We investigated this relationship in order to quantify its effect ...
Source: The Annals of Thoracic Surgery - February 12, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research
Risk of Anastomotic Dehiscence in Patients with Pulmonary Fibrosis Transplanted whilst Receiving Anti-Fibrotics: Experience of the Australian Lung Transplant Collaborative
This study aimed to establish the safety of anti-fibrotic therapy in the peri-transplant period, particularly with regards to healing of the bronchial anastomosis. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 12, 2019 Category: Transplant Surgery Authors: John A Mackintosh, Maitri Munsif, Lucy Ranzenbacher, Claire Thomson, Michael Musk, Gregory Snell, Allan Glanville, Daniel C. Chambers, Peter Hopkins Tags: Original Clinical Science Source Type: research
Surgical treatment of late left ventricular assist device outflow obstruction due to extrinsic compression
Outflow graft obstruction is a known and described complication following continuous-flow (CF) left ventricular assist device (LVAD) implantation1. Mechanisms include anastomotic stenosis, angulation, twisting, and external impingement from protective outer sleeves2. Although non-interventional strategies may be employed, physiologically important outflow graft obstruction typically requires intervention. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 12, 2019 Category: Transplant Surgery Authors: Keshava Rajagopal, Ismael A. Salas de Armas, Marwan F. Jumean, Igor D. Gregoric Source Type: research
A Novel Mechanism for Immune Regulation After Human Lung Transplantation
Lung transplantation is therapeutic for end-stage lung disease, but survival is limited due to bronchiolitis obliterans syndrome and restrictive chronic lung allograft dysfunction. We sought a common denominator in lung transplant recipients, analyzing risk factors that trigger immune responses that lead to bronchiolitis obliterans syndrome. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - February 12, 2019 Category: Cardiovascular & Thoracic Surgery Authors: T. Mohanakumar, Monal Sharma, Sandhya Bansal, Ranjithkumar Ravichandran, Michael A. Smith, Ross M. Bremner Source Type: research
Non-valvular cardiac aspergilloma: A rare presentation of a rare condition
A 50-yearold lady presented to hospital with blurred vision and pyrexia. She had previously undergone a renal transplant and was on standard immunosuppression therapy. In addition, she had recently been treated for invasive pulmonary aspergillosis. On this admission, she was diagnosed with endophthalmitis and a right ankle abscess. She was started on broad spectrum antimicrobials and the ankle collection was drained. She continued to have febrile episodes and a transthoracic echocardiogram revealed an echogenic mass in the left ventricle (Image 1 ░A). (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - February 12, 2019 Category: Cardiology Authors: RE Jones, KM Groom, Arvind Singh, Hugo Lai, Jason N Dungu, Filomena Medeiros, Aroon Lal, Rossella M Barbagallo Source Type: research
Epigenetic modification in 4T1 mouse breast cancer model by artificial light at night and melatonin - the role of DNA-methyltransferase.
The objective of the research was to evaluate effects of 1 × 30 min/midnight ALAN (134 µ Wcm-2, 460 nm) with or without nocturnal melatonin supplement on tumor development and epigenetic responses in 4T1 tumor-bearing BALB/c mice. Mice were monitored for body mass (Wb) and tumor volume for 3 weeks and thereafter urine samples were collected at regular intervals for determining daily rhythms of 6-sulfatoxymelatonin (6-SMT). Finally, mice were sacrificed and the tumor, lungs, liver, and spleen were excised for analyzing the total activity of DNA methyltransferases (DNMT) and glo...
Source: Chronobiology International - February 12, 2019 Category: Biology Authors: Agbaria S, Haim A, Fares F, Zubidat AE Tags: Chronobiol Int Source Type: research
A Case of Donor-Transmitted Non-Small Cell Lung Cancer After Liver Transplantation: An Unwelcome Guest.
Abstract Cancer transmission with organ donation has been previously reported with a variety of malignancies and organ transplants. The risk of transmission through organ transplantation from donors with a history of previously treated malignancies has been addressed by guidelines from transplant societies. Herein, we report a case of a patient who developed lung cancer confined to the liver after liver transplantation with no known history of malignancy in the donor. The suspicion of donor origin arose after positron emission tomography-computerized tomography scan showed metastatic lung cancer only involving the...
Source: The Oncologist - February 12, 2019 Category: Cancer & Oncology Authors: Sonbol MB, Halling KC, Douglas DD, Ross HJ Tags: Oncologist Source Type: research
A Comment on Helicobacter pylori and Lung Transplant Outcome: Is Serology the Ideal Diagnostic Approach?
Source: Lung - February 11, 2019 Category: Respiratory Medicine Source Type: research
The Use of Thromboelastography to Titrate Tranexamic Acid Therapy for Abatement of Lysis-Induced Hemorrhagic Complications During Venoarterial Extracorporeal Membrane Oxygenation
HEMOSTATIC COMPLICATIONS remain a leading cause of morbidity and death for patients supported with extracorporeal membrane oxygenation (ECMO), despite advances in circuit design and management of systemic anticoagulation and improvements in transfusion practices. This case describes the use of tranexamic acid (TXA) for a patient in whom hemorrhage (right pleural chest tube) associated with hyperfibrinolysis developed while the patient was awaiting lung transplantation and was being supported with venoarterial ECMO (VA-ECMO). (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - February 11, 2019 Category: Anesthesiology Authors: Troy G. Seelhammer, Jimmi Mangla, Onur Demirci Tags: Case Report Source Type: research
First Onset Herpesviral Infection and Lung Injury in Allogeneic Hematopoietic Cell Transplantation.
CONCLUSIONS: First onset herpesviral infection within 100 days post allogeneic hematopoietic cell transplant increases risk of pulmonary complications. Experimentally reactivating murine roseolovirus causes organ injury similar to phenotypes seen in human transplant recipients. PMID: 30742492 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - February 11, 2019 Category: Respiratory Medicine Authors: Zhou X, O'Dwyer DN, Xia M, Miller HK, Chan PR, Trulik K, Chadwick MM, Hoffman TC, Bulte C, Sekerak K, Wilke CA, Patel SJ, Yokoyama WM, Murray S, Yanik GA, Moore BB Tags: Am J Respir Crit Care Med Source Type: research
Prolonged Cold-Ischemia Induces Necroptotic Cell Death in Ischemia Reperfusion Injury and Contributes to Primary Graft Dysfunction After Lung Transplantation.
Abstract Primary graft dysfunction (PGD), a major cause of morbidity after lung transplantation, is linked to ischemia-reperfusion injury (IRI). Other factors such as preceding brain death (BD), hemorrhagic shock (HS), and pre-engraftment lung management are also important. We hypothesized that a multi-hit isogenic mouse model of lung transplantation is more closely linked to PGD than IRI alone. Left lung transplants were performed between inbred mice. A one-hit model of IRI was established by inducing cold ischemia (CI) to the donor lung at 0°C for 1h, 72h or 96h. Multi-hit models were established by inducing...
Source: Respiratory Care - February 11, 2019 Category: Respiratory Medicine Authors: Wang X, O'Brien ME, Yu J, Fu L, Zhang Q, Lu S, An X, McDyer JF, Mallampalli RK Tags: Am J Respir Cell Mol Biol Source Type: research
Nr5a2 promotes cancer stem cell properties and tumorigenesis in nonsmall cell lung cancer by regulating Nanog
In the present study, we have provided convincing evidence in vitro and in vivo demonstrating thatNr5a2 can induce lung cancer stem cells (CSC) properties and promote tumorigenesis and progression through transcriptional up ‐regulation of Nanog. AbstractLung cancer has the highest mortality rate due to late diagnosis and high incidence of metastasis. Cancer stem cells (CSCs) are a subgroup of cancer cells with self ‐renewal capability similar to that of normal stem cells (NSCs). While CSCs may play an important role in cancer progression, mechanisms underlying CSC self‐renewal and the relationship between self‐rene...
Source: Cancer Medicine - February 10, 2019 Category: Cancer & Oncology Authors: Ting Ye, Jingyuan Li, Zhiwei Sun, Yongli Liu, Liangsheng Kong, Shixia Zhou, Junlin Tang, Jianyu Wang, H. Rosie Xing Tags: ORIGINAL RESEARCH Source Type: research
Toxic Tacrolimus Concentrations Associated With Intravenous Use of Metoclopramide in a Lung Transplant Patient.
PMID: 30739475 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 10, 2019 Category: Drugs & Pharmacology Authors: Provenzani A, D'alessandro N, Polidori P Tags: Ann Pharmacother Source Type: research
The Amide Local Anesthetic Ropivacaine Attenuates Acute Rejection After Allogeneic Mouse Lung Transplantation
AbstractPurposeAcute allograft rejection after lung transplantation remains an unsolved hurdle. The pathogenesis includes an inflammatory response during and after transplantation. Ropivacaine, an amide-linked local anesthetic, has been shown to attenuate lung injury due to its anti-inflammatory effects. We hypothesized that the drug would also be able to attenuate acute rejection (AR) after allogeneic lung transplantation.MethodsAllogeneic, orthotopic, single left lung transplantation was performed between BALB/c (donors) and C57BL/6 (recipients) mice. Prior to explantation, lungs were flushed with normal saline with or w...
Source: Lung - February 9, 2019 Category: Respiratory Medicine Source Type: research
Coexistence an aberrant right subclavian artery with other congenital anomalies: case report and review of the literature
This article reports a rare coexistence of aberrant right subclavian artery with other congenital anomalies of the heart and great vessels in living men. (Source: Surgical and Radiologic Anatomy)
Source: Surgical and Radiologic Anatomy - February 8, 2019 Category: Anatomy Source Type: research
Lung transplantation for idiopathic pulmonary fibrosis
Publication date: Available online 6 February 2019Source: The Lancet Respiratory MedicineAuthor(s): Peter M George, Caroline M Patterson, Anna K Reed, Muhunthan ThillaiSummaryIdiopathic pulmonary fibrosis (IPF) is a progressive lung disease with a poor prognosis. Lung transplantation is the only intervention shown to increase life expectancy for patients with IPF, but it is associated with disease-specific challenges. In this Review, we discuss the importance of a proactive approach to the management of IPF comorbidities, including gastro-oesophageal reflux, pulmonary hypertension, coronary artery disease, and malignancy. ...
Source: The Lancet Respiratory Medicine - February 7, 2019 Category: Respiratory Medicine Source Type: research
Regulator of telomere length 1 (RTEL1) mutations are associated with heterogeneous pulmonary and extra-pulmonary phenotypes
Regulator of telomere length 1 (RTEL1) mutations have been evidenced in 5–9% of familial pulmonary fibrosis; however, the phenotype of patients with interstitial lung disease (ILD) and RTEL1 mutations is poorly understood. Whole exome sequencing was performed in 252 probands with ILD and we included all patients with ILD and RTEL1 mutation. RTEL1 expression was evaluated by immunochemistry in the lungs of controls, as well as in RTEL1 and telomerase reverse transcriptase (TERT) mutation carriers. We identified 35 subjects from 17 families. Median age at diagnosis of ILD was 53.1 years (range 28.0–80.6). Th...
Source: European Respiratory Journal - February 7, 2019 Category: Respiratory Medicine Authors: Borie, R., Bouvry, D., Cottin, V., Gauvain, C., Cazes, A., Debray, M.-P., Cadranel, J., Dieude, P., Degot, T., Dominique, S., Gamez, A. S., Jaillet, M., Juge, P.-A., Londono-Vallejo, A., Mailleux, A., Mal, H., Boileau, C., Menard, C., Nunes, H., Prevot, G Tags: Interstitial and orphan lung disease Original Articles: Interstitial lung diseases Source Type: research
Effect of terlipressin infusion therapy on recipient & #39;s hepatic and renal functions in living donor liver transplantations: Experience from a tertiary hospital
Conclusion: Terlipressin infusion was not found to be significantly effective among the liver and kidney function tests. Limitations: This may be a result of randomization defect of our retrospective study design. Many prospective randomized studies should be planned to reach more accurate results. (Source: Nigerian Journal of Clinical Practice)
Source: Nigerian Journal of Clinical Practice - February 7, 2019 Category: Rural Health Authors: P Karaaslan S Sevmis Source Type: research
[Editors' Choice] Transforming lung to treat type 1 diabetes
A tissue engineering strategy repurposes lung tissue for islet transplantation. (Source: Science Translational Medicine)
Source: Science Translational Medicine - February 6, 2019 Category: Biomedical Science Authors: Shen, K. Tags: Editors ' Choice Source Type: research
An integrated molecular diagnostic report for heart transplant biopsies using an ensemble of diagnostic algorithms
We previously reported a microarray-based diagnostic system for heart transplant endomyocardial biopsies (EMBs), using either 3-archetype (3AA) or 4-archetype (4AA) unsupervised algorithms to estimate rejection. The present study aimed to examine the stability of machine-learning algorithms in new biopsies, compare 3AA vs. 4AA algorithms, assess supervised binary classifiers trained on histologic or molecular diagnoses, create a report combining many scores into an ensemble of estimates, and examine possible automated sign-outs. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 6, 2019 Category: Transplant Surgery Authors: Michael D Parkes, Arezu Z Aliabadi, Martin Cadeiras, Marisa G Crespo-Leiro, Mario Deng, Eugene C Depasquale, Johannes Goekler, Daniel H Kim, Jon Kobashigawa, Alexandre Loupy, Peter Macdonald, Luciano Potena, Andreas Zuckermann, Philip F Halloran Tags: Original Clinical Science Source Type: research
The pleural mesothelium and tgf- β1 pathways in restrictive allograft syndrome – a pre-clinical investigation
Chronic lung allograft dysfunction (CLAD) hampers long-term survival after lung transplantation. Common fibrosis-related mechanisms in idiopathic pulmonary fibrosis and CLAD, instigated the consideration of investigating the differential regulation of pleural mesothelium and TGF- β1 in restrictive allograft syndrome (RAS). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 6, 2019 Category: Transplant Surgery Authors: Annelore Sacreas, Jan H. von der Th üsen, Thierry P.P. van den Bosch, Birgit Weynand, Erik K. Verbeken, Charlotte Debbaut, Dirk E. Van Raemdonck, Robin Vos, Stijn E. Verleden Source Type: research
Molecular Assessment of Rejection and Injury in Lung Transplant Biopsies
Improved understanding of lung transplant disease states is essential because failure rates are high, often due to chronic lung allograft dysfunction. However, histologic assessment of lung transplant transbronchial biopsies (TBBs) is difficult and often uninterpretable even with 10 pieces. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 6, 2019 Category: Transplant Surgery Authors: Kieran M Halloran, Michael D Parkes, Jessica Chang, Irina L Timofte, Gregory I Snell, Glen P Westall, Ramsey Hachem, Daniel Kreisel, Elbert Trulock, Antoine Roux, Stephen Juvet, Shaf Keshavjee, Peter Jaksch, Walter Klepetko, Philip F Halloran Tags: Original Clinical Science Source Type: research
An Evaluation of Inhaled Antibiotic Liposome versus Antibiotic Nanoplex in Controlling Infection in Bronchiectasis
Publication date: Available online 4 February 2019Source: International Journal of PharmaceuticsAuthor(s): The-Thien Tran, Hong Yu, Celine Vidaillac, Albert Y.H. Lim, John A. Abisheganaden, Sanjay H. Chotirmall, Kunn HadinotoAbstractInhaled antibiotic nanoparticles have emerged as an effective strategy to control infection in bronchiectasis lung owed to their mucus-penetrating ability. Using ciprofloxacin (CIP) as the model antibiotic, we evaluated dry powder inhaler (DPI) formulations of two classes of antibiotic nanoparticles (i.e. liposome and nanoplex) in their (1) physical characteristics (i.e. size, zeta potential, C...
Source: International Journal of Pharmaceutics - February 5, 2019 Category: Drugs & Pharmacology Source Type: research
Combination of pleuroparenchymal fibroelastosis with non-specific interstitial pneumonia and bronchiolitis obliterans as a complication of hematopoietic stem cell transplantation — Clues to a potential mechanism
We report a case of 30-year-old man who developed a unique combination of pleuroparenchymal fibroelastosis with cellular and fibrotic non-specific interstitial pneumonia (NSIP) and bronchiolitis obliterans (BO) sixteen years after hematopoietic stem cell transplantation. Histological examination revealed almost exclusive infiltration of CD3-positive T lymphocytes associated with lymphoepithelial lesions and multi-focal denudation of covering epithelial cells in all components. This case suggests PPFE, NSIP, and BO might be conditions of the same spectrum, pathogenetically related to chronic graft-versus-host disease. Immun...
Source: Respiratory Medicine Case Reports - February 5, 2019 Category: Respiratory Medicine Source Type: research
Phenotypical diversity of airway morphology in chronic lung graft vs. host disease after stem cell transplantation
Phenotypical diversity of airway morphology in chronic lung graft vs. host disease after stem cell transplantation, Published online: 05 February 2019; doi:10.1038/s41379-019-0203-2Phenotypical diversity of airway morphology in chronic lung graft vs. host disease after stem cell transplantation (Source: Modern Pathology)
Source: Modern Pathology - February 5, 2019 Category: Pathology Authors: Stijn E. Verleden John E. McDonough Helene Schoemans Christiane Knoop Johny Verschakelen Adriana Dubbeldam Matthieu N. Boone Luc Van Hoorebeke Erik Verbeken Birgit Weynand Dirk Van Raemdonck Geert M. Verleden Robin Vos Bart M. Vanaudenaerde Source Type: research
Thoracic transplant outcomes for idiopathic pulmonary hypertension in children
Idiopathic pulmonary hypertension (IPH) is an indication for lung transplantation (LTx) or combined heart-lung transplantation (HLTx) in the pediatric population. Overall, pulmonary vascular disease is the primary diagnosis for a large minority of children listed for lung transplant, especially those less than 6 years of age.1 However, the relatively low numbers of these surgical procedures performed in children limits accurate outcome data. Previously published work has included study cohorts ranging from 5 to 23 children, severely restricting the ability to predict post-thoracic transplant outcomes based on clinical char...
Source: The Journal of Heart and Lung Transplantation - February 5, 2019 Category: Transplant Surgery Authors: Richard Hubbard, Rebecca Miller, Dmitry Tumin, Joseph D. Tobias, Don Hayes Tags: Research Correspondence Source Type: research
T cells regulate lung transplant rejection in mice and men
(Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - February 5, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Jason M. Gauthier, Wenjun Li, Daniel Kreisel Source Type: research
Translational Research in Pulmonary Fibrosis
Pulmonary fibrosis refers to the development of diffuse parenchymal abnormalities in the lung that cause dyspnea, cough, hypoxemia, and impair gas exchange, ultimately leading to respiratory failure. Though pulmonary fibrosis can be caused by a variety of underlying etiologies, ranging from genetic defects to autoimmune diseases to environmental exposures, once fibrosis develops it is irreversible and most often progressive, such that fibrosis of the lung is one of the leading indications for lung transplantation. (Source: Translational Research)
Source: Translational Research - February 5, 2019 Category: Research Authors: Susan K. Mathai, David A. Schwartz Source Type: research
Artificial intelligence in cancer imaging: Clinical challenges and applications.
Abstract Judgement, as one of the core tenets of medicine, relies upon the integration of multilayered data with nuanced decision making. Cancer offers a unique context for medical decisions given not only its variegated forms with evolution of disease but also the need to take into account the individual condition of patients, their ability to receive treatment, and their responses to treatment. Challenges remain in the accurate detection, characterization, and monitoring of cancers despite improved technologies. Radiographic assessment of disease most commonly relies upon visual evaluations, the interpretations ...
Source: Clinical Prostate Cancer - February 5, 2019 Category: Cancer & Oncology Authors: Bi WL, Hosny A, Schabath MB, Giger ML, Birkbak NJ, Mehrtash A, Allison T, Arnaout O, Abbosh C, Dunn IF, Mak RH, Tamimi RM, Tempany CM, Swanton C, Hoffmann U, Schwartz LH, Gillies RJ, Huang RY, Aerts HJWL Tags: CA Cancer J Clin Source Type: research
Transplant outcomes for idiopathic pulmonary hypertension in children
Idiopathic pulmonary hypertension (IPH) is an indication for lung transplantation (LTx) or combined heart ‒lung transplantation (HLTx) in the pediatric population. Overall, pulmonary vascular disease is the primary diagnosis for a large minority of children listed for lung transplant, especially those (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 5, 2019 Category: Transplant Surgery Authors: Richard Hubbard, Rebecca Miller, Dmitry Tumin, Joseph D. Tobias, Don Hayes Tags: RESEARCH CORRESPONDENCE Source Type: research
First Human Use of a Wireless Coplanar Energy Transfer Coupled with a Continuous-flow Left Ventricular Assist Device
The driveline to power contemporary ventricular assist devices exiting the skin is associated with infection, and requires a holstered performance of the cardiac pump which reduces overall quality of life. Attempts to eliminate the driveline using transcutaneous energy transfer systems have been explored but have not succeeded in viable widespread application. The unique engineering of the coplanar energy transfer system is characterized by two large rings utilizing a coil within the coil topology e nsuring robust resonance energy transfer while allowing for a substantial (over 6 hours) unholstered circulatory suppor...
Source: The Journal of Heart and Lung Transplantation - February 4, 2019 Category: Transplant Surgery Authors: Yuryi Pya, Jiri Maly, Mahabbat Bekbossynova, Roman Salov, Stephan Schueler, Bart Meyns, Yigal Kassif, Massimo Massetti, Michael Zilbershlag, Ivan Netuka Source Type: research
Synergism of imatinib, vatalanib and everolimus in the prevention of chronic lung allograft rejection after lung transplantation (LTx) in rats.
In conclusion, the combination of mTORI and RTKIs might be a possible strategy in the prevention of CLAD and BO. PMID: 30706940 [PubMed - as supplied by publisher] (Source: Histology and Histopathology)
Source: Histology and Histopathology - February 3, 2019 Category: Cytology Tags: Histol Histopathol Source Type: research
Off-the-Shelf Cell Sheets as a Pleural Substitute for Closing Visceral Pleural Injuries.
Authors: Kanzaki M, Takagi R, Isaka T, Yamato M Abstract During pulmonary resections, removal of visceral pleura is frequently required, resulting in lung air leakage (LAL) and bleeding. Especially persistent LAL after pulmonary surgery has negative consequences. Current surgical procedures are ineffective in closing these visceral pleural injuries. Previously, the authors' laboratory has developed a novel and effective LAL sealant using tissue-engineered cell sheets harvested from temperature-responsive culture dishes. The clinical application of fresh fibroblast sheets (FSs) is limited by several problems related...
Source: Biopreservation and Biobanking - February 3, 2019 Category: Biomedical Science Tags: Biopreserv Biobank Source Type: research
Effect of sarcopenic overweight on lung transplant based on 3D reconstructed psoas muscle mass
ConclusionsSarcopenia was associated with poorer short-term outcome and sarcopenic overweight with poorer overall survival in lung transplant patients. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - February 2, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research
Beneficial Effects of Imatinib in a Patient with Suspected Pulmonary Veno-Occlusive Disease.
Abstract Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension (PH). The prognosis of PVOD patients remains poor, since no effective medical therapy is yet available. Imatinib is a tyrosine kinase inhibitor specific for platelet-derived growth factor receptor and is expected as a treatment option for pulmonary arterial hypertension (PAH). Recently, it has been reported that imatinib improved functional capacity of a patient with PVOD. We here report a patient with suspected PVOD who has been successfully treated with imatinib and is alive for 6 years after diagnosis. A 57-year-old woman ...
Source: The Tohoku Journal of Experimental Medicine - February 2, 2019 Category: Research Authors: Sato H, Sugimura K, Miura M, Konno R, Kozu K, Yaoita N, Shimizu T, Yamamoto S, Aoki T, Tatebe S, Satoh K, Shimokawa H Tags: Tohoku J Exp Med Source Type: research
Effect of sarcopenic overweight on lung transplant based on 3D reconstructed psoas muscle mass.
CONCLUSIONS: Sarcopenia was associated with poorer short-term outcome and sarcopenic overweight with poorer overall survival in lung transplant patients. PMID: 30721692 [PubMed - as supplied by publisher] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - February 2, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Suh JW, Paik HC, Yu WS, Song SH, Park MS, Kim SY, Lee JG Tags: Ann Thorac Surg Source Type: research
Jejuno-jejunal Intussusception in a Post-Lung Transplant Patient From a Gastrojejunostomy Tube: A case report
ConclusionsA heightened index of suspicion for this rare complication should exist with a presenting patient has signs of proximal bowel obstruction and CT evidence of intussusception. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - February 1, 2019 Category: Surgery Source Type: research
Immediate extubation after heart transplantation in a child by remifentanil-based ultra-fast anesthesia: A case report
Rationale: Ventilator-associated complications comprise important fatal aetiologies during heart transplantation. Ultra-fast anesthesia might provide the most effective measure to prevent this type of complication. Immediate extubation after heart transplantation (IEAHT) has recently been reported in adult patients. However, IEAHT in children is much more challenging due to limitations in anesthesia protocols. Recently, we managed to perform an ultra-fast anesthesia protocol combined with IEAHT during a heart transplant operation in a child, who had an excellent postoperative outcome. Patient concerns: A 13-year-old g...
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Successful extracorporeal membrane oxygenation support for severe acute diquat and glyphosate poisoning: A case report
Rationale: Because of the lack of an antidote or effective treatment, patients with severe acute diquat and glyphosate poisoning always died within a few hours. Extracorporeal membrane pulmonary oxygenation (ECMO), as an artificial heart-lung supporting system, can be applied to support lung that is expected to recover from reversible pathological damage. However, to our knowledge, the application of ECMO for patients with diquat and glyphosate poisoning has not been reported. Patient concerns: A 40-year-old man ingested in 100 ml of diquat (20 g/100 ml) and 400 ml glyphosate (41 g/100 ml) was admitted to ...
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
GSE109847 Transcriptome analysis of lung epithelial cells from various developmental stages (E13.5, E15.5, E18.5, P14, and P56)
Contributors : Kazushige Shiraishi ; Shigeyuki ShichinoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe investigated whether cell transplantation potential differs between the different developmental stages of the lungs. We found that epithelial cells derived from different developmental stages show different engraftment potential. To identify transcriptional signatures of epithelial cells that are associated with the phenomenon, we performed a time series transcriptome analysis of epithelial cells of the developing lungs. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - February 1, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Which Shall I Choose? Lung Transplantation Listing Preference for Individuals with Interstitial Lung Disease and Chronic Obstructive Pulmonary Disease
Annals of the American Thoracic Society,Volume 16, Issue 2, Page 193-195, February 2019. (Source: Annals of the American Thoracic Society)
Source: Annals of the American Thoracic Society - February 1, 2019 Category: Respiratory Medicine Authors: Kathleen J. Ramos Michael O. Harhay Michael S. Mulligan Source Type: research
Procedure Preference and Intention-to-Treat Outcomes after Listing for Lung Transplantation among U.S. Adults. A Cohort Study
Annals of the American Thoracic Society,Volume 16, Issue 2, Page 231-239, February 2019. (Source: Annals of the American Thoracic Society)
Source: Annals of the American Thoracic Society - February 1, 2019 Category: Respiratory Medicine Authors: Michaela R. Anderson Ashley Tabah Arindam RoyChoudhury David J. Lederer Source Type: research
Low IgG2 Level and Increased Risk of Infections in Lung Transplant Recipients
Our previous study has demonstrated that lung transplant (LT) recipients with severe hypogammaglobulinemia (HGG) are at increased risk for recurrent pneumonias and more antibiotic courses at 1-year post-transplant. The significance of IgG subclass deficiency has not yet been examined in the LT population. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Maylene Xie, Russell S. Traister, Kara E. Coffey, Joseph M. Pilewski, Andrej A. Petrov Source Type: research
Humoral Immunity in End-Stage Lung Disease Prior to Lung Transplantation
Hypogammaglobulinemia (HGG) has been reported in more than 60% of lung transplant (LT) recipients and decreased pneumococcal titers ( (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Kara E. Coffey, Russell S. Traister, Maylene Xie, Joseph M. Pilewski, Andrej A. Petrov Source Type: research
MiR-155 expressed in bone marrow-derived lymphocytes promoted lipopolysaccharide-induced acute lung injury through Ang-2-Tie-2 pathway.
Abstract Acute lung injury (ALI) is a type of diffuse lung inflammation with a high mortality rate. Studies show that miR-155 plays an important role in inflammation. Here, we investigated the role of miR-155 in lipopolysaccharide (LPS)-induced ALI. The mice with bone marrow transplantation between MiR-155 knockout and wild-type were used as animal models of LPS-induced sepsis. In response to LPS injection, ALI was less severe in miR-155 knockout mice than in wild-type mice, and mainly manifested as reduced pulmonary vascular leakage, pulmonary edema, and neutrophil infiltration. The expression levels of Ang-2 and...
Source: Biochemical and Biophysical Research communications - February 1, 2019 Category: Biochemistry Authors: Yan Y, Lou Y, Kong J Tags: Biochem Biophys Res Commun Source Type: research