Impact of donor lung colonized bacteria detected by next-generation sequencing on early post-transplant outcomes in lung transplant recipients
The effect of donor lung colonized bacteria on the prognosis of lung transplantation is not clear. We used the technique of next-generation sequencing (NGS) to detect the colonized bacteria from the lower resp... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - September 21, 2020 Category: Infectious Diseases Authors: Dong Liu, Ji Zhang, Bo Wu, Feng Liu, Shugao Ye, Hongmei Wang, Jian Lv, Xing Weng, Yan Chen, Weili Han and Jingyu Chen Tags: Research article Source Type: research
Berlin Heart EXCOR Paediatric Ventricular Assist Device: Does Weight Matter?
Berlin Heart EXCOR (BH) ventricular assist devices provide mechanical long-term circulatory support in children with end-stage heart failure, as a bridge to transplantation or to recovery. Most studies are from large-volume paediatric cardiac centres. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - September 21, 2020 Category: Cardiology Authors: Virginie Fouilloux, Fedoua El Louali, C élia Gran, Roland Henaine, François Roubertie, Caroline Chenu, Marion Fiorini, Stéphane Le Bel, Philippe Mauriat, Jean Neidecker, Loïc Macé, Bernard Kreitmann, Caroline Ovaert Tags: Original Article Source Type: research
Efficacy and safety of high-dose budesonide/formoterol in patients with bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplant.
Conclusions: Our study failed to show superior effect of high-dose budesonide/formoterol (320/9 µg) compared with low-dose. However, high-dose budesonide/formoterol was safe and there was no lung function deterioration. PMID: 32944330 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - September 20, 2020 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Conversion ratio of tacrolimus switching from intravenous infusion to oral administration after lung transplantation.
Authors: Yang C, Xi Y, Chen WY, Sang L, Liu DD, Zhang R, Chen SB, Zhang J, Pan JY, Xv YH, Nong LB, Li YM, Liu XQ Abstract Background: To investigate the conversion ratio of tacrolimus switching from intravenous infusion to oral administration in patients after lung transplantation. Methods: We retrospectively recruited patients received lung transplantation in the First Affiliated Hospital of Guangzhou Medical Hospital from January 2015 to June 2019. The blood concentration of tacrolimus administrated through intravenous infusion and oral administration were collected. The blood concentration, concentration/dos...
Source: Journal of Thoracic Disease - September 20, 2020 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Native lung pulmonary artery banding after single lung transplant for obliterative bronchiolitis
Publication date: Available online 17 September 2020Source: The Annals of Thoracic SurgeryAuthor(s): Chihiro Konoeda, Masaaki Sato, Yasutaka Hirata, Jun Nakajima (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - September 20, 2020 Category: Cardiovascular & Thoracic Surgery Source Type: research
Physiology of Extracorporeal Gas Exchange.
Authors: Bartlett RH Abstract Circulating venous blood outside the body, through an artificial lung (membrane oxygenator), and returning oxygenated blood to the patient is extracorporeal gas exchange. Oxygen and carbon dioxide exchange in a membrane lung is controlled by regulating blood flow, blood composition, and device design. With this control, lung function can be replaced for weeks by artificial organs. © 2020 American Physiological Society. Compr Physiol 10:879-891, 2020. PMID: 32941687 [PubMed - in process] (Source: Comprehensive Physiology)
Source: Comprehensive Physiology - September 19, 2020 Category: Physiology Tags: Compr Physiol Source Type: research
Mobile ECMO in COVID-19 patient: case report
AbstractAt July 25, 2020, WHO had recorded more than 16.1 million confirmed COVID-19 cases, 1% of them developed critical illness. These patients can experience rapid progression to profound hypoxemia and severe acute respiratory distress syndrome (ARDS). Some patients, despite receiving lung-protective ventilation and maximal medical therapy, develop refractory hypoxemia, rendering candidates for extracorporeal membrane oxygenation (ECMO) support. Centers with experience in this technique are available only in a few reference hospitals and some patients are too ill to be transferred with conventional mechanical ventilatio...
Source: Journal of Artificial Organs - September 19, 2020 Category: Transplant Surgery Source Type: research
The Effect of Pulmonary Disease on the Intraoperative Management of Lung Transplant Patients
Compared to other solid organ transplants, despite significant advances in preservation, anti-rejection, and anesthetic and surgical management, the morbidity and mortality of patients undergoing lung transplantation (LTX) remains high. This is complicated by a shortage of available organs, leading to the use of extended and marginal donors and reconditioning with ex vivo lung perfusion, by the heterogenicity of lung pathologies that are treated with LTX, and by the high incidence of chronic allograft rejection. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - September 19, 2020 Category: Anesthesiology Authors: Theresa A. Gelzinis Tags: Editorial Source Type: research
High Lung Transplant Center Volume is Associated with Increased Survival in Hospitalized Patients
Publication date: Available online 17 September 2020Source: The Annals of Thoracic SurgeryAuthor(s): Neel K. Ranganath, Jad Malas, Stacey Chen, Deane E. Smith, Stephanie H. Chang, Melissa B. Lesko, Luis F. Angel, Bonnie E. Lonze, Zachary N. Kon (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - September 18, 2020 Category: Cardiovascular & Thoracic Surgery Source Type: research
A self-powered bidirectional partition microfluidic chip with embedded microwells for highly sensitive detection of EGFR mutations in plasma of non-small cell lung cancer patients.
In conclusion, the developed chip has a potential in lung tumor genotyping and therapy monitoring for precision medicine, even other tumors. PMID: 32928434 [PubMed - in process] (Source: Talanta)
Source: Talanta - September 17, 2020 Category: Chemistry Authors: Wu W, Wu F, Zhang S, Ding X, Zhang T, Yang Y, Mu Y Tags: Talanta Source Type: research
Dermatological Disease in Australian Heart and Lung Transplant Recipients
Conclusion: Actinic keratosis and skin cancer are very frequent in Australian heart and lung transplant recipients and more common than non-malignant skin diseases. Routine dermatological surveillance at regular intervals is advised.Dermatology (Source: Dermatology)
Source: Dermatology - September 17, 2020 Category: Dermatology Source Type: research
Successful Lung Transplantation After Acellular Ex Vivo Lung Perfusion With Prone Positioning
Publication date: October 2020Source: The Annals of Thoracic Surgery, Volume 110, Issue 4Author(s): Hiromichi Niikawa, Toshihiro Okamoto, Kamal S. Ayyat, Ichiro Sakanoue, James J. Yun, Kenneth R. McCurry (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - September 17, 2020 Category: Cardiovascular & Thoracic Surgery Source Type: research
Cancers, Vol. 12, Pages 2654: Analysis of Bone Scans in Various Tumor Entities Using a Deep-Learning-Based Artificial Neural Network Algorithm —Evaluation of Diagnostic Performance
Cancers, Vol. 12, Pages 2654: Analysis of Bone Scans in Various Tumor Entities Using a Deep-Learning-Based Artificial Neural Network Algorithm—Evaluation of Diagnostic Performance Cancers doi: 10.3390/cancers12092654 Authors: Jan Wuestemann Sebastian Hupfeld Dennis Kupitz Philipp Genseke Simone Schenke Maciej Pech Michael C. Kreissl Oliver S. Grosser The bone scan index (BSI), initially introduced for metastatic prostate cancer, quantifies the osseous tumor load from planar bone scans. Following the basic idea of radiomics, this method incorporates specific deep-learning techniques (artificial n...
Source: Cancers - September 17, 2020 Category: Cancer & Oncology Authors: Jan Wuestemann Sebastian Hupfeld Dennis Kupitz Philipp Genseke Simone Schenke Maciej Pech Michael C. Kreissl Oliver S. Grosser Tags: Article Source Type: research
Pneumoperitoneum-induced pneumothorax during laparoscopic living donor hepatectomy: a case report
We present a living donor case with an unexpected large-volume pneumothorax diagnosed using lung ultrasound during a laparoscopic hepatectomy for liver transplantation (LT). (Source: BMC Surgery)
Source: BMC Surgery - September 16, 2020 Category: Surgery Authors: Min Suk Chae, Jueun Kwak, Kyungmoon Roh, Minhee Kim, Sungeun Park, Ho Joong Choi, Jaesik Park, Jung-Woo Shim, Hyung Mook Lee, Yong-Suk Kim, Young Eun Moon and Sang Hyun Hong Tags: Case report Source Type: research
Transcatheter Mitral Valve Intervention in Advanced Heart Failure
Unlike the taxonomy of cardiac valves based on location (pulmonary or aortic) or leaflet number (tricuspid), the mitral valve designation is an iconic one. Vesalius recognized the sheer complexity of this valve apparatus and chose to brand it after a bishop's headgear, the mitre, due to its likeness.1 Characteristically, physiological competence of the mitral valve is dependent on the competitive intersection of 5 distinct factors. These include an interplay between a) left atrial size (and possibly function), b) left ventricular dilation and contractile performance, c) chordal tendons and papillary muscle alignment, integ...
Source: The Journal of Heart and Lung Transplantation - September 16, 2020 Category: Transplant Surgery Authors: Mandeep R. Mehra, Maria Rosa Costanzo Source Type: research
Azithromycin prophylaxis after lung transplant is associated with improved overall survival
Azithromycin prophylaxis (AP) in lung transplant recipients has been shown to reduce the composite endpoint of death or chronic lung allograft dysfunction (CLAD) onset but without a clear effect on overall survival. Our program began using AP in 2010. We sought to evaluate the association between AP and survival, the risk of CLAD and baseline lung allograft dysfunction (BLAD). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - September 16, 2020 Category: Transplant Surgery Authors: David Li, Qiuli Duan, Justin Weinkauf, Ali Kapasi, Rhea Varughese, Alim Hirji, Dale Lien, Steven Meyer, Bryce Laing, Jayan Nagendran, Kieran Halloran Tags: Original Clinical Science Source Type: research
Dysphagia and medicine regimes in patients following lung transplant surgery: A retrospective review
. (Source: International Journal of Speech-Language Pathology)
Source: International Journal of Speech-Language Pathology - September 16, 2020 Category: Speech-Language Pathology Authors: Anna Miles Sujay Barua Naomi McLellan Lejla Brkic Source Type: research
Trends in nontuberculous mycobacteria infection in children and young people with cystic fibrosis
Respiratory infection with nontuberculous mycobacteria (NTM) has become a growing concern in children and young people with cystic fibrosis (CF) . Mycobacterium abscessus, in particular, has been associated with an increased decline in lung function and is a contraindication to lung transplantation in many centers [2,3]. Treatment regimens for M. abscessus are complex, prolonged and associated with significant adverse effects. Epidemiological studies of NTM in children with CF are limited and risk factors for infection are poorly understood. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - September 16, 2020 Category: Respiratory Medicine Authors: Noreen Zainal Abidin, Aaron Ions Gardner, Hannah-Louise Robinson, Iram J. Haq, Matthew F. Thomas, Malcolm Brodlie Tags: Short Communication Source Type: research
Oxy ‐RVAD support for lung transplant in the absence of inferior vena cava
In this report, we describe a patient with congenital absence of the inferior vena cava undergoing lung transplantation who required perioperative cardiopulmonary support. A percutaneous dual lumen cannula, Protek Duo, was connected in an Oxy ‐RVAD configuration to provide right ventricular and oxygenation support both intraoperatively and postoperatively to this patient. (Source: Journal of Cardiac Surgery)
Source: Journal of Cardiac Surgery - September 16, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Kyla Joubert, Takashi Harano, Joseph Pilewski, Pablo G. Sanchez Tags: CASE REPORT Source Type: research
Intraoperative management of a hybrid extracorporeal membrane oxygenation circuit for lung transplantation
AbstractBackgroundThe use of extracorporeal circulation (ECC) for intraoperative cardiopulmonary support during lung transplantation has been increasing in the recent years. Our group previously described a novel hybrid extracorporeal membrane oxygenation (ECMO) circuit for use in lung transplantation.TechniqueOur approach for intraoperative management of our novel hybrid ECMO circuit for lung transplantation is driven by two main goals: The first is to deliver management that ensures an appropriate balance between the native and ECMO cardiac outputs in order to provide a stable environment that promotes attenuation of isc...
Source: Journal of Cardiac Surgery - September 16, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Archer Kilbourne Martin, Barry A. Harrison, Ashley Virginia Fritz, Kevin P. Landolfo, Ian A. Makey, Basar Sareyyupoglu, Thomas E. Brown, James L. Johnson, Si M. Pham, Mathew Thomas Tags: HOW TO DO IT Source Type: research
MitraClip in Secondary Mitral Regurgitation as a Bridge to Heart Transplantation: 1-year Outcomes from the International MitraBridge Registry
Patients awaiting heart transplantation (HTx) often need bridging therapies to reduce worsening and progression of underlying disease. Limited data are available regarding the use of the MitraClip procedure in secondary mitral regurgitation for this clinical condition. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - September 16, 2020 Category: Transplant Surgery Authors: Cosmo Godino, Andrea Munaf ò, Andrea Scotti, Rodrigo Estévez-Loureiro, Antonio Portolés Hernández, Dabit Arzamendi, Estefanía Fernández Peregrina, Maurizio Taramasso, Neil P. Fam, Edwin C. Ho, Anita Asgar, Giancarlo Vitrella, Claudia Raineri, Marian Tags: Original Clinical Science Source Type: research
Extended-criteria uncontrolled DCD donor for a fragile recipient: a case report about a challenging yet successful lung transplantation
Publication date: Available online 14 September 2020Source: International Journal of Surgery Case ReportsAuthor(s): Valeria Musso, Paolo Mendogni, Vittorio Scaravilli, Letizia Corinna Morlacchi, Giorgio Alberto Croci, Alessandro Palleschi (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - September 15, 2020 Category: Surgery Source Type: research
Severe scoliosis with an impaired pulmonary allograft function after pediatric unilateral lung transplantation
AbstractLeft ‐unilateral single‐lobe lung transplantation from a living donor was performed in a 4-year-old boy who suffered from severe respiratory failure caused by bronchiolitis obliterans (BO) as a result of graft versus host disease (GVHD) after peripheral blood stem cell transplantation (PBSCT). The pa tient grew well during his early childhood years, with an excellent lung allograft function. However, severe thoracic scoliosis occurred 7 years after lung transplantation, which ultimately resulted in compression of the lung allograft followed by severe respiratory dysfunction, and the patient bec ame depende...
Source: General Thoracic and Cardiovascular Surgery - September 15, 2020 Category: Cardiovascular & Thoracic Surgery Source Type: research
Tracheobronchial Aspergillosis in a Lung Transplant Recipient.
PMID: 32943251 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - September 14, 2020 Category: Respiratory Medicine Authors: Sousa C, Damas C Tags: Arch Bronconeumol Source Type: research
Expression of Claudin-4 in Lung Ischemia-Reperfusion Injury in Experimental Lung Transplantation.
CONCLUSION: CLDN4 expressed in BALF and the pulmonary tissue during the first 5 h within 72 h of the PGD window are not associated by the deterioration of lung function, edema and lung histological injury, in LTx with CIT 50 min or 6 h, CLDN4 does not seem to be a valuable indicator of LIRI. PMID: 32900258 [PubMed - as supplied by publisher] (Source: Journal of Investigative Surgery)
Source: Journal of Investigative Surgery - September 11, 2020 Category: Surgery Tags: J Invest Surg Source Type: research
Immune benefit of combined heart and liver transplantation
Purpose of review Understanding the mechanisms involved in immune protection provided by a hepatic allograft is imperative as further therapies for highly sensitized patients could be developed and thus expanding the donor pool and improving outcomes. Recent findings The clinical data from immune protection comes mainly from combined liver and kidney transplants with excellent results in overall survival and also that of the allograft. This phenomenon has also been observed in dual liver transplants with heart, lung, skin and intestines, albeit with less data. In heart transplant recipients, the liver allograft has pr...
Source: Current Opinion in Organ Transplantation - September 10, 2020 Category: Surgery Tags: COMBINED HEART AND LIVER TRANSPLANTATION: Edited by Juliet Emamaullee and Eugene DePasquale Source Type: research
Dose to Lungs and Kidneys during Total Body Irradiation: Are We Delivering the Expected Dose?
Total Body irradiation (TBI)-based conditioning is key component for hemopoietic stem cell transplantation. TBI dose calculation is traditionally based on point-dose calculations based on estimates of body separation at different levels with the umbilicus as a reference point, an approach followed as standard protocol at most institutions. This homogenous dose calculation technique does not take into account tissue heterogeneity. Limited data exists for TPS-based TBI planning systems especially in the setting of lung and kidney partial transmission blocks, which is a void in our understanding of TBI dose delivery and is ex...
Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Philip Damron, Santanu Samanta, Yannick Poirier, Serena Mao, Narottam Lamichhane, Byongyong Yi, Pranshu Mohindra Source Type: research
Atrial septostomy in patients supported with venoarterial extracorporeal membrane oxygenation: Analysis of the IMPACT registry data.
Abstract BACKGROUND: Patients with severe cardiac dysfunction, supported on extra-corporeal membrane oxygenation (ECMO), develop left atrial hypertension and often warrant atrial decompression. The procedural risks and outcomes, however, are not well established. Objective of this study is to understand the utilization, safety, and outcomes of atrial septostomy in children supported on venoarterial ECMO utilizing the IMPACT registry database. METHODS: Data from 55 independent sites reporting to the registry was used for this descriptive study. Patients supported with cardiac ECMO that underwent percutaneous a...
Source: The International Journal of Artificial Organs - September 10, 2020 Category: Transplant Surgery Authors: Deshpande SR, Kennedy KF, Vincent RN, Maher KO Tags: Int J Artif Organs Source Type: research
First in vivo assessment of RAS-Q technology as lung support device for pulmonary hypertension.
CONCLUSION: A gas exchanger with a fully integrated compliance better unloads the right ventricle compared to a non-compliant gas exchanger and it can restore cardiac output to normal levels in cases of severe pulmonary hypertension. PMID: 32907461 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - September 10, 2020 Category: Transplant Surgery Authors: Verbelen T, Halwes M, Meyns B Tags: Int J Artif Organs Source Type: research
The natural language explanation algorithms for the lung cancer computer-aided diagnosis system
Publication date: August 2020Source: Artificial Intelligence in Medicine, Volume 108Author(s): Anna Meldo, Lev Utkin, Maxim Kovalev, Ernest Kasimov (Source: Artificial Intelligence in Medicine)
Source: Artificial Intelligence in Medicine - September 9, 2020 Category: Bioinformatics Source Type: research
Diffuse Alveolar Hemorrhage After Pediatric Hematopoietic Stem Cell Transplantation
We present a review of diffuse alveolar hemorrhage with a focus on its pathogenesis and treatment options. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - September 9, 2020 Category: Cancer & Oncology Source Type: research
Donor-Specific Antibody Characteristics Including Persistence and Complement-Binding Capacity Increase Risk for Chronic Lung Allograft Dysfunction
Chronic Lung Allograft Dysfunction (CLAD) is the major complication limiting long-term survival in lung transplant recipients (LTRs), with those developing donor-specific anti-HLA antibodies (DSA) previously found to have increased risk for CLAD. However, as DSA responses vary in timing of development, specificity, breadth, persistence and complement-binding capacity, we hypothesized that these characteristics would impact CLAD and survival outcomes. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - September 9, 2020 Category: Transplant Surgery Authors: Carlo J. Iasella, Christopher R. Ensor, Marilyn Marrari, Massimo Mangiola, Qingyong Xu, Eric Nolley, Cody A. Moore, Matthew R. Morrell, Joseph M. Pilewski, Pablo G. Sanchez, John F. McDyer, Adriana Zeevi Source Type: research
Recombinant Herpes Zoster Vaccine after Heart Transplantation: A Single Center Experience
Herpes zoster (HZ) results from reactivation of latent varicella zoster virus (VZV) often manifesting as a dermatomal rash leading to complications including post-herpetic neuralgia. It occasionally can be in multiple dermatomes or systemic.1 Diminished cellular immunity to VZV increases HZ risk.2 Solid organ transplant (SOT) recipients have a mixed, mainly cellular immune deficit due to chronic immunosuppression. HZ incidence in SOT is 9 times higher than the general population (22-28 vs 3-5/1000 person-years) and they are at increased risk for severe manifestations of HZ. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - September 9, 2020 Category: Transplant Surgery Authors: Maya H Barghash, Sarah Taimur, Meenakshi Rana, Jessica Behar, Donna M Mancini Tags: Research Correspondence Source Type: research
Impact of COVID-19 on Lung Transplant Activity in Germany —A Cross-Sectional Survey
Thorac Cardiovasc Surg DOI: 10.1055/s-0040-1715436The current COVID-19 pandemia affects health care systems worldwide, however, to a variable extent depending on the caseload in each country. We aimed to provide a cross-sectional overview of current limitations or adaptions in lung transplant programs in Germany in from January to May 2020 due to the COVID-19 pandemia caused by severe acute respiratory syndrome coronavirus 2. A cross-sectional survey assessing various aspects of lung transplant activity was sent to all active lung transplant programs (n = 12) in Germany. Eight centers (66%) responded to the s...
Source: The Thoracic and Cardiovascular Surgeon - September 8, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Michel, Sebastian Witt, Christian Gottlieb, Jens Aigner, Clemens Tags: Short Communication Source Type: research
The Curious Phenomenon of Early Cardiac Allograft Rejection with Hepatitis C Infected Donor Heart Transplants
In recent years, emerging data has demonstrated that organs from Hepatitis C Virus (HCV)-infected donors can be transplanted into uninfected recipients with excellent outcomes. Critical to this success is the use of pre-emptive or prophylactic direct-acting antiviral (DAA) therapy, with the intent to minimize any viral transmission and block viral replication. The optimal timing to employ such therapy, whether at the time of transplant or following the detection of viremia, remains a matter of ongoing debate. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - September 7, 2020 Category: Transplant Surgery Authors: Ann E. , Woolley, Steve K. Singh Tags: Editorial Source Type: research
Impact of broader geographic allograft sharing on outcomes and cost in smaller lung transplant centers
On November 24, 2017, Organ Procurement and Transplantation Network implemented a change to lung allocation replacing donor service area with a 250 nautical mile radius around donor hospitals. We sought to evaluate the experience of a small to medium size center following implementation. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - September 6, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Nathan Haywood, J. Hunter Mehaffey, Sarah Kilbourne, Hannah Mannem, Max Weder, Christine Lau, Alexander S. Krupnick, Avinash Agarwal Source Type: research
The impact of segmentation on whole-lung functional MRI quantification: Repeatability and reproducibility from multiple human observers and an artificial neural network.
CONCLUSIONS: Despite high overall agreement, there were systematic differences in lung segmentation between observers. This needs to be considered for longitudinal studies and could be overcome by using an ANN, which performs as good as human observers and fully automatizes MP-MRI post-processing. PMID: 32892445 [PubMed - as supplied by publisher] (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - September 6, 2020 Category: Radiology Authors: Willers C, Bauman G, Andermatt S, Santini F, Sandkühler R, Ramsey KA, Cattin PC, Bieri O, Pusterla O, Latzin P Tags: Magn Reson Med Source Type: research
Protective effects of isorhynchophylline against silicon-dioxide-induced lung injury in mice.
Authors: Qiu M, Yang Z, Bian M, Liu C, Zhao Y, Liu Q Abstract Inhalation of silicon dioxide (SD) results in pulmonary inflammatory responses and fibrosis. Isorhynchophylline (Isorhy) is the main alkaloid in the traditional Chinese herb Tripterygium wilfordii, which is reported to have anti-inflammatory activities in the nervous system. However, the effects of Isorhy on SD-induced pulmonary inflammation and fibrosis in mice are unknown. Male mice were exposed to a single dose of SD (2.5 mg/kg, intranasal inoculation) to induce pulmonary fibrosis (PF). The mice were woken up and immediately treated with Isorhy...
Source: Artificial Cells, Nanomedicine and Biotechnology - September 5, 2020 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Destructive and topical treatments of skin lesions in organ transplant recipients and relation to skin cancer
AbstractVarious treatments of keratotic skin lesions and early skin cancers are performed in organ transplant recipients (OTRs) at high risk of skin malignancies but the frequency of their use is unknown. We prospectively assessed the frequency of use of cryotherapy, diathermy, and topical therapies and also investigated their associations with background incidence of histologically-confirmed squamous-cell carcinoma (SCC) and basal cell carcinoma (BCC) in a cohort of OTRs in Queensland, Australia. Median follow-up ranged from 1.7 to 3.2 years across organ transplant groups. Among 285 kidney, 125 lung and 203 liver tr...
Source: Archives of Dermatological Research - September 5, 2020 Category: Dermatology Source Type: research
Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline (updated version)
AbstractThe novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, coronavirus disease 2019 (COVID-19), affecting more than seventeen million people around the world. Diagnosis and treatment guidelines for clinicians caring for patients are needed. In the early stage, we have issued “A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version)”; now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guid...
Source: Military Medical Research - September 4, 2020 Category: International Medicine & Public Health Source Type: research
Protective effects of isorhynchophylline against silicon-dioxide-induced lung injury in mice
Volume 48, Issue 1, December 2020, Page 1125-1134 . (Source: Artificial Cells, Blood Substitutes, and Biotechnology)
Source: Artificial Cells, Blood Substitutes, and Biotechnology - September 4, 2020 Category: Biotechnology Authors: Min Qiu Zheng Yang Mengni Bian Changxiao Liu Yunshan Zhao Quanli Liu Source Type: research
Intraoperative extracorporeal circulatory support in lung transplantation for pulmonary fibrosis
Publication date: Available online 3 September 2020Source: The Annals of Thoracic SurgeryAuthor(s): Jawad Salman, Beeke-Alina Bernhard, Fabio Ius, Reza Poyanmehr, Wiebke Sommer, Khalil Aburahma, Hani Alhadidi, Thierry Siemeni, Christian Kuehn, Murat Avsar, Axel Haverich, Gregor Warnecke, Igor Tudorache (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - September 3, 2020 Category: Cardiovascular & Thoracic Surgery Source Type: research
Common Criteria for Ex-vivo Lung Perfusion Have No Significant Impact on Post-Transplant Outcomes
Publication date: Available online 2 September 2020Source: The Annals of Thoracic SurgeryAuthor(s): Shuji Okahara, Bronwyn Levvey, Mark McDonald, Rohit D’Costa, Helen Opdam, David V. Pilcher, Gregory I. Snell (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - September 3, 2020 Category: Cardiovascular & Thoracic Surgery Source Type: research
Consequences of functional mitral regurgitation and atrial fibrillation in patients with left ventricular assist devices
This study aimed to investigate the characteristics and prognostic significance of FMR and AF in patients with LVADs. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - September 3, 2020 Category: Transplant Surgery Authors: Hideyuki Hayashi, Yoshifumi Naka, Joseph Sanchez, Hiroo Takayama, Paul Kurlansky, Yuming Ning, Veli K Topkara, Melana Yuzefpolskaya, Paolo C Colombo, Gabriel T Sayer, Nir Uriel, Koji Takeda Tags: Original Clinical Science Source Type: research
Late-onset "acute fibrinous and organising pneumonia" impairs long-term lung allograft function and survival
Acute fibrinous and organising pneumonia (AFOP) after lung transplantation is associated with a rapid decline in pulmonary function. However, the relation with chronic lung allograft dysfunction (CLAD) remains unclear. We investigated the association between detection of AFOP in lung allograft biopsies with clinically important endpoints. We reviewed lung allograft biopsies from 468 patients who underwent lung transplantation at the University Hospitals Leuven (2011–2017). AFOP was categorised as early new-onset (≤90 days post-transplant) or late new-onset (>90 days post-transplant); and associated wi...
Source: European Respiratory Journal - September 3, 2020 Category: Respiratory Medicine Authors: Vanstapel, A., Verleden, S. E., Weynand, B., Verbeken, E., De Sadeleer, L., Vanaudenaerde, B. M., Verleden, G. M., Vos, R., the Leuven Lung Transplant Group Tags: Interstitial and orphan lung disease Original Articles: Lung transplantation Source Type: research
Preservation by cold storage vs ex vivo normothermic perfusion of marginal donor hearts: clinical, histopathological and ultrastructural features.
To match clinical outcomes of heart transplantation against histopathological and ultrastructural characteristics of marginal grafts preserved by cold storage or ex vivo normothermic perfusion. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - September 3, 2020 Category: Transplant Surgery Authors: Sandro Sponga, Antonella Bonetti, Veronica Ferrara, Antonio Paolo Beltrami, Miriam Isola, Igor Vendramin, Nicoletta Finato, Fulvia Ortolani, Ugolino Livi Tags: Original Clinical Science Source Type: research
Predicting Antibiotic-Associated Virulence of Pseudomonas aeruginosa Using an ex vivo Lung Biofilm Model
ConclusionIn this initial study of six clinical isolates of P. aeruginosa showed high levels of antibiotic tolerance, with minimal effect on bacterial load and increased proteases production, which could negatively affect lung function. Thus, the ex vivo lung model has the potential to be effectively used in larger studies of antibiotic tolerance in in vivo-like biofilms, and show how sub optimal antibiotic treatment of biofilms may potentially contribute to exacerbations and eventual lung failure. We demonstrate a realistic model for understanding antibiotic resistance and tolerance in biofilms clinically and for molecule...
Source: Frontiers in Microbiology - September 2, 2020 Category: Microbiology Source Type: research
Clinical outcomes and survival following lung transplantation in patients with Alpha-1 antitrypsin deficiency
The primary intention of our study is to describe disease-specific outcomes in patients with alpha-1 antitrypsin deficiency (AATD) following lung transplantation (LT). (Source: Respiratory Medicine)
Source: Respiratory Medicine - September 2, 2020 Category: Respiratory Medicine Authors: Leonard Riley, Jorge Lascano Tags: Clinical Trial Paper Source Type: research
Durable Mechanical Circulatory Support Across the Asia Pacific Region
The Asia region consists of 48 countries with a population of 3.8 billion, extends from Saudi Arabia and Turkey in the west to the most eastern part of Russia. Asia-Pacific includes East Asia, South Asia, Southeast Asia, and Oceania. It extends from Pakistan in the west to Japan, Australia and New Zealand in the east1. Accurate data from Asia on heart transplantation is lacking as not all centers report their data to ISHLT registry. According to the Global Observatory on Donation and Transplantation (GODT), less than 0.4 heart transplants per million population are performed yearly compared to more than 7.5 per million in ...
Source: The Journal of Heart and Lung Transplantation - September 2, 2020 Category: Transplant Surgery Authors: Cumaraswamy Sivathasan, Christopher Hayward, Paul Jansz, Amul Kumar Sibal, Chen Chen, Ho Ka Lai Cally, Komarakshi Rajagopalan Balakrishnan, Yang Hyun Cho, Mohd.Nazeri Nordin, Joseph B. Barril, Feras Khaliel, Mandeep R. Mehra Tags: EDITORIAL Source Type: research
Use of Sacubitril-Valsartan in Blood Pressure Control with Left Ventricular Assist Devices
Blood pressure control is a cornerstone in management of patients supported with a Left Ventricular Assist Device (LVAD) . Adequate blood pressure control, with a target of mean blood pressure (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - September 2, 2020 Category: Transplant Surgery Authors: David Dobarro, Carles Diez-L ópez, David Couto-Mallón, Javier Castrodeza, Manuel Gómez-Bueno, Javier Tobar, Antonio Gonçalves, Maria Melendo-Viu, Scott McKenzie, Carlos Ortiz, Jose González-Costello Tags: Research Correspondence Source Type: research