Associated Pulmonary Hypertension Is an Independent Contributor to Exercise Intolerance in Chronic Fibrosing Interstitial Pneumonias
Conclusions: In patients with FIP, PVR is a significant contributor of 6MWD, independently from the extent of fibrosis on HRCT. These results strengthen both the rationale to use 6MWD as endpoint in FIP and to target APH with specific therapies.Respiration (Source: Respiration)
Source: Respiration - August 16, 2018 Category: Respiratory Medicine Source Type: research

Long-term Physical HRQOL Decreases after Single Lung as Compared to Double Lung Transplantation
ConclusionsThe trajectory of physical HRQOL in patients receiving SLT declines over time compared to DLT indicating that, in the longer-term, SLT recipients are more likely to have physical HRQOL scores that fall substantively below general population norms. Physical HRQOL after five years may be a consideration for lung allocation and patient counseling regarding expectations when recommending SLT or DLT. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - August 16, 2018 Category: Cardiovascular & Thoracic Surgery Source Type: research

[COLT: Ten years of research in lung transplantation, results and perspectives].
Authors: Tissot A, Foureau A, Brosseau C, Danger R, Roux A, Bernasconi E, Gomez C, Durand M, Picard BR, Le Pavec J, Claustre J, Lacoste P, Benmerad M, Pain M, Siroux V, Royer PJ, Mordant P, Reynaud-Gaubert M, Kessler R, Brugière O, Mornex JF, Dromer C, Dahan M, Knoop C, Boussaud V, Koutsokera A, Botturi-Cavaillès K, Durand E, Loy J, Nicod L, Pison C, Brouard S, Blanc FX, Magnan A, consortium COLT PMID: 30100530 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - August 15, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

Radiological findings of complications after lung transplantation
AbstractComplications following lung transplantation may impede allograft function and threaten patient survival. The five main complications after lung transplantation are primary graft dysfunction, post-surgical complications, alloimmune responses, infections, and malignancy.Primary graft dysfunction, a transient ischemic/reperfusion injury, appears as a pulmonary edema in almost every patient during the first three days post-surgery.Post-surgical dysfunction could be depicted on computed tomography (CT), such as bronchial anastomosis dehiscence, bronchial stenosis and bronchomalacia, pulmonary artery stenosis, and size ...
Source: Insights into Imaging - August 15, 2018 Category: Radiology Source Type: research

Prediction of transplant outcome after 24 ‐hour ex vivo lung perfusion using the Organ Care System in a porcine lung transplantation model
American Journal of Transplantation,Volume 0, Issue ja, -Not available-. (Source: American Journal of Transplantation)
Source: American Journal of Transplantation - August 14, 2018 Category: Transplant Surgery Authors: Wiebke Sommer , Jawad Salman , Murat Avsar , Klaus Hoeffler , Katharina Jansson , Thierry M. Siemeni , Ann ‐Kathrin Knoefel , Linda Ahrens , Reza Poyanmehr , Igor Tudorache , Peter Braubach , Danny Jonigk , Axel Haverich , Greg Source Type: research

Microbiological findings in bronchoalveolar lavage fluid from lung transplant patients in Sweden
Transplant Infectious Disease,Volume 0, Issue ja, -Not available-. (Source: Transplant Infectious Disease)
Source: Transplant Infectious Disease - August 14, 2018 Category: Transplant Surgery Authors: Anna Stj ärne Aspelund , Helena Hammarström , Malin Inghammar , Hillevi Larsson , Lennart Hansson , Gerdt C Riise , Vanda Friman , Bertil Christensson , Lisa I Påhlman Source Type: research

Pharmacotherapeutic approaches for transportation of anticancer agents via skin.
The objective of this review is to present insights into pharmacotherapeutic techniques, which can be used for transdermal delivery of anticancer agents through skin due to its potential to create a new frontier in treatment of cancer. PMID: 30095010 [PubMed - as supplied by publisher] (Source: Artificial Cells, Nanomedicine and Biotechnology)
Source: Artificial Cells, Nanomedicine and Biotechnology - August 12, 2018 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Effect of exogenous p51a gene on the growth and chemo sensitivity of human lung adenocarcinoma cell lines.
CONCLUSIONS: Exogenous p51A gene can increase its expression in A549 and NCI-H1299 cells, suppress cell growth and induce cell apoptosis. Moreover, it can also cooperate with chemotherapy and reduce the dose and side-effect. p51A gene can suppress tumours in spite of p53 status and p21 gene might be involved. It might become a new promising therapeutic gene of tumours, which will make up for the limitation of p53 gene therapy. PMID: 30095026 [PubMed - as supplied by publisher] (Source: Artificial Cells, Nanomedicine and Biotechnology)
Source: Artificial Cells, Nanomedicine and Biotechnology - August 12, 2018 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Seizures after transplantation
With the development of medical technology, transplantation has prevailed and become an important tool in the treatment of disease. According to the WHO ’s statistics, as of 2015, approximately 120000 cases of solid organ transplantation have been performed globally. Renal transplantation is the most common, followed by liver transplantation, heart transplantation, lung transplantation, hematopoietic stem cell transplantation, etc. [1]. And, in re cipients of transplantation, seizures usually occur during the postoperative period [2,3]. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - August 12, 2018 Category: Neurology Authors: Peijia Lin, Xin Tian, Xuefeng Wang Tags: Review Source Type: research

Rising to the Challenge of Unmet Need: Expanding the Lung Donor Pool
AbstractPurpose of ReviewThere is a shortage of lungs available to meet the needs of patient who require lung transplantation. Ex vivo lung perfusion (EVLP) has allowed for the assessment and reconditioning of extended criteria and high-risk donor lungs, allowing for an increased volume of lung transplants. Recently, an invested interest in the utilization donation after cardiac death (DCD) donors has surfaced, in which EVLP has played an important role.Recent FindingsClinical studies have shown that EVLP can recondition donor lungs that initially would be unacceptable for transplantation. In a recent study, the interventi...
Source: Current Respiratory Care Reports - August 11, 2018 Category: Respiratory Medicine Source Type: research

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-Fifth Adult Lung and Heart –Lung Transplant Report—2018; Focus Theme: Multiorgan Transplantation
This thirty-fifth adult lung and heart –lung transplant report summarizes data from 64,803 adult lung and 4,054 adult heart-lung transplants performed through June 30, 2017 and reported to the International Thoracic Organ Transplant Registry. With each year's report we now also provide more detailed analyses on a particular focus theme . Since 2013, these have been donor and recipient age; retransplantation; early graft failure; indication for transplant; and allograft ischemic time; and in 2018, multiorgan transplantation. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 11, 2018 Category: Transplant Surgery Authors: Daniel C. Chambers, Wida S. Cherikh, Samuel B. Goldfarb, Don Hayes, Anna Y. Kucheryavaya, Alice E. Toll, Kiran Khush, Bronwyn J. Levvey, Bruno Meiser, Joseph W. Rossano, Josef Stehlik, for the International Society for Heart and Lung Transplantation Tags: Original Clinical Science Source Type: research

Effect of exogenous p51a gene on the growth and chemo sensitivity of human lung adenocarcinoma cell lines
. (Source: Artificial Cells, Blood Substitutes, and Biotechnology)
Source: Artificial Cells, Blood Substitutes, and Biotechnology - August 10, 2018 Category: Biotechnology Authors: Qiming Shen Haoyou Wang Lin Zhang Source Type: research

Electrical Power to Run Ventricular Assist Devices Using Free-range Resonant Electrical Energy Delivery (FREE-D) System.
Models of power delivery within an intact organism have been limited to ionizing radiation and to some extent sound& magnetic waves for diagnostic purposes. Traditional electrical power delivery within intact human body relies on implanted batteries that limit the amount and duration of delivered power. The efficiency of current battery technology limits substantial demand to be met; such as continuous operation of an implantable artificial heart pump within a human body. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 10, 2018 Category: Transplant Surgery Authors: Benjamin H. Waters, Jiheum Park, J. Christopher Bouwmeester, John Valdovinos, Arnar Geirsson, Alanson P. Sample, Joshua R. Smith, Pramod Bonde Tags: Original Pre-Clinical Science Source Type: research

Influence of Lung Donor Agonal and Warm Ischemic Times on Early Mortality: Analyses from the ISHLT DCD Lung Transplant Registry
This study aimed to evaluate the impact of agonal time and warm ischemic time on early survival in Category III donation after circulatory death (DCD) donor lung transplants (LTx) using data reported to the International Society for Heart and Lung Transplantation (ISHLT) DCD LTx Registry. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 10, 2018 Category: Transplant Surgery Authors: Bronwyn Levvey, Shaf Keshavjee, Marcelo Cypel, Amanda Robinson, Michael Erasmus, Allan Glanville, Peter Hopkins, Michael Musk, Marshall Hertz, Kenneth McCurry, Dirk Van Raemdonck, Gregory Snell Tags: Original Clinical Science Source Type: research

Bridge to recovery in children on ventricular assist devices – protocol, predictors of recovery, and long-term follow-up
The majority of children supported with ventricular assist devices (VAD) are bridged to heart transplantation. Although bridge to recovery has been reported, low recovery patient numbers has precluded systematic analysis. The aim of this study was to delineate recovery rates, predictors of recovery, and to report the long-term follow-up after VAD explantation in children. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 10, 2018 Category: Transplant Surgery Authors: O. Miera, M. Germann, M.Y. Cho, J. Photiadis, E.M. Delmo Walter, R. Hetzer, F. Berger, K.R.L. Schmitt Tags: Original Clinical Science Source Type: research

Tacrolimus Granules for Oral Suspension as Post-Transplant Immunosuppression in Routine Medical Practice in France: The OPTIMOD Study.
CONCLUSIONS Results suggest that tacrolimus granules are well tolerated and effective in preventing transplant rejection when administered in routine practice in France. PMID: 30093607 [PubMed - in process] (Source: Annals of Transplantation)
Source: Annals of Transplantation - August 10, 2018 Category: Transplant Surgery Authors: Garaix F, Stern M, Lamy FX, Dubel L, Kamar N Tags: Ann Transplant Source Type: research

In vitro inhalation bioaccessibility for particle-bound hydrophobic organic chemicals: Method development, effects of particle size and hydrophobicity, and risk assessment.
Abstract Bioaccessibility of particle-bound hydrophobic organic contaminants and related particle size effects are significant for assessing the potential human health risk via inhalation exposure, but have not been clearly evaluated. To fill this knowledge gap, the present study developed an in vitro method to estimate the inhalation bioaccessibility of particulate polycyclic aromatic hydrocarbons (PAHs) using simulated human lung fluids, i.e., a modified Gamble's solution (MGS) and artificial lysosomal fluid (ALF) with Tenax as the absorption media. Assay parameters, namely incubation time (10 d) and influence...
Source: Environment International - August 10, 2018 Category: Environmental Health Authors: Xie SY, Lao JY, Wu CC, Bao LJ, Zeng EY Tags: Environ Int Source Type: research

iPSC-Derived Macrophages Effectively Treat Pulmonary Alveolar Proteinosis in Csf2rb-Deficient Mice
Publication date: Available online 9 August 2018Source: Stem Cell ReportsAuthor(s): Adele Mucci, Elena Lopez-Rodriguez, Miriam Hetzel, Serena Liu, Takuji Suzuki, Christine Happle, Mania Ackermann, Henning Kempf, Roman Hillje, Jessica Kunkiel, Ewa Janosz, Sebastian Brennig, Silke Glage, Jens P. Bankstahl, Sabine Dettmer, Thomas Rodt, Gudrun Gohring, Bruce Trapnell, Gesine Hansen, Cole TrapnellSummaryInduced pluripotent stem cell (iPSC)-derived hematopoietic cells represent a highly attractive source for cell and gene therapy. Given the longevity, plasticity, and self-renewal potential of distinct macrophage subpopulations, ...
Source: Stem Cell Reports - August 9, 2018 Category: Stem Cells Source Type: research

Stem cell therapy for lung diseases: From fundamental aspects to clinical applications.
Authors: Hosseinirad H, Rashidi M, Moghaddam MM, Tebyanian H, Nouraei S, Mirhosseini SA, Rasouli M, Habibian S Abstract The respiratory system is a complex group of organs in the human body, all of which are necessary in breathing. Due to its special anatomy and composition, after exposure to various damaging factors such as micro particles, carbon granules and toxic gases, the respiratory system can be affected by a variety of damage without return to its original state. Currently, the prevalence of lung diseases, including asthma, and chronic obstructive pulmonary diseases, such as emphysema, has increased remark...
Source: Cellular and Molecular Biology - August 9, 2018 Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-fifth Adult Heart Transplantation Report — 2018; Focus Theme: Multiorgan Transplantation
The past year has been notable for multiple celebrations and symposia around the globe commemorating the first heart transplant performed worldwide by Dr. Christiaan Barnard at Groote Schuur Hospital in Cape Town, South Africa, on December 3, 1967, and the first heart transplant performed in the United States by Dr. Norman Shumway at Stanford Hospital on January 6, 1968. Since then, the field of heart transplantation has grown dramatically, with steady increases in the number of heart transplants performed worldwide annually, accompanied by improvement in post-transplant survival and other favorable outcomes. (Source: The ...
Source: The Journal of Heart and Lung Transplantation - August 9, 2018 Category: Transplant Surgery Authors: Kiran Khush, Wida S. Cherikh, Daniel C. Chambers, Samuel Goldfarb, Don Hayes, Anna Y. Kucheryavaya, Bronwyn J. Levvey, Bruno Meiser, Joseph W. Rossano, Josef Stehlik, for the International Society for Heart and Lung Transplantation Tags: Original Clinical Science Source Type: research

Glycocalyx Degradation after Pulmonary Transplantation Surgery
Conclusion: Lung IRI caused glycocalyx degradation that contributed to neutrophil activation and adhesion. The administration of lidocaine was able to protect the lung from glycocalyx degradation.Eur Surg Res 2018;59:115 –125 (Source: European Surgical Research)
Source: European Surgical Research - August 8, 2018 Category: Surgery Source Type: research

Machine Learning Algorithms Utilizing Quantitative CT Features May Predict Eventual Onset of Bronchiolitis Obliterans Syndrome After Lung Transplantation
Publication date: September 2018Source: Academic Radiology, Volume 25, Issue 9Author(s): Eduardo J. Mortani Barbosa, Maarten Lanclus, Wim Vos, Cedric Van Holsbeke, William De Backer, Jan De Backer, James LeeRationale and ObjectivesLong-term survival after lung transplantation (LTx) is limited by bronchiolitis obliterans syndrome (BOS), defined as a sustained decline in forced expiratory volume in the first second (FEV1) not explained by other causes. We assessed whether machine learning (ML) utilizing quantitative computed tomography (qCT) metrics can predict eventual development of BOS.Materials and MethodsPaired inspirat...
Source: Academic Radiology - August 8, 2018 Category: Radiology Source Type: research

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty- first Pediatric Heart Transplantation Report – 2018; Focus Theme: Multiorgan Transplantation
This is an exciting time for pediatric thoracic organ transplantation. At the end of last year, we celebrated the 50th anniversary of the first orthotopic heart transplantation. Since then, the field of pediatric heart transplantation has grown dramatically and heart transplantation in children is now performed routinely at many centers throughout the world. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation is the largest source of worldwide heart transplant data with over 14,000 transplants in children reported. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 8, 2018 Category: Transplant Surgery Authors: Joseph W. Rossano, Wida S. Cherikh, Daniel C. Chambers, Samuel Goldfarb, Don Hayes, Kiran Khush, Anna Y. Kucheryavaya, Alice E. Toll, Bronwyn J. Levvey, Bruno Meiser, Josef Stehlik, for the International Society for Heart and Lung Transplantation Tags: Original Clinical Science Source Type: research

Uric acid and cellular and humoral alloimmunity
In a recently published article, Asleh et al. demonstrated that cardiac allograft recipients with a baseline serum urate higher than 7 mg/dL are at a two-fold higher risk for developing cardiac allograft vasculopathy (CAV) and that the increase in serum urate during follow-up is associated with plaque progression independently of renal function, sirolimus therapy, and other comorbidities. Εven though there are data about the role of urate in endothelial dysfunction and inflammation, the authors conclude that although serum urate may be a reliable biomarker for CAV progression, its implication in the pathogenesis of...
Source: The Journal of Heart and Lung Transplantation - August 8, 2018 Category: Transplant Surgery Authors: Theodoros Eleftheriadis, Georgios Pissas, Vassilios Liakopoulos, Ioannis Stefanidis Tags: Case Anecdotes, Comments and Opinions Source Type: research

Disparities in pulmonary fibrosis care in the United States: an analysis from the Nationwide Inpatient Sample
Idiopathic pulmonary fibrosis is a disease with high morbidity and mortality. Care for these patients, including lung transplantation, may provide significant benefits, but is resource-intensive and expensive.... (Source: BMC Health Services Research)
Source: BMC Health Services Research - August 8, 2018 Category: General Medicine Authors: Adam W. Gaffney, Steffie Woolhander, David Himmelstein and Danny McCormick Tags: Research article Source Type: research

Impaired CMV Immunity in Idiopathic Pulmonary Fibrosis Lung Transplant Recipients with Short Telomeres.
Abstract RATIONALE: CMV-related morbidities remain one of the most common complications after lung transplantation and have been linked to allograft dysfunction, but the factors that predict high-risk for CMV complications and effective immunity are incompletely understood. OBJECTIVES: To determine if short telomeres in idiopathic pulmonary fibrosis (IPF) lung transplant recipients (LTRs) predict the risk for CMV-specific T-cell immunity and viral control. METHODS: We studied IPF-LTRs (n=42) and age-matched non-IPF-LTRs (n=42) and assessed CMV outcomes. We measured lymphocyte telomere length (TL), DNA se...
Source: American Journal of Respiratory and Critical Care Medicine - August 8, 2018 Category: Respiratory Medicine Authors: Popescu I, Mannem H, Winters SA, Hoji A, Silveira F, McNally E, Pipeling MR, Lendermon EA, Morrell MR, Pilewski JM, Hanumanthu VS, Zhang Y, Gulati S, Shah PD, Iasella CJ, Ensor CR, Armanios M, McDyer JF Tags: Am J Respir Crit Care Med Source Type: research

Systemic Transplantation of Mesenchymal Stem Cells Modulates Endothelial Cell Adhesion Molecules Induced by Ovalbumin in Rat Model of Asthma
AbstractAchieving the optimal clinical outcome of mesenchymal stem cells (MSCs) is particularly dependent on fundamental understanding of therapeutic mechanisms. The current study was focused on the possible mechanisms by which rat bone marrow-derived mesenchymal stem cells (rBMMSCs) and/or conditioned media (CM) display broad immunomodulatory properties for ameliorating of asthma-related pathological changes. Male rats were divided equally into four experimental groups (n = 6): healthy rats received 50 μl PBS intravenously (group C), sensitized rats received 50 μl PBS intravenously (group OVA...
Source: Inflammation - August 7, 2018 Category: Allergy & Immunology Source Type: research

Stereotactic ablative radiotherapy for early-stage lung cancer following double lung transplantation
Development of primary lung cancer in donor lung post-lung transplantation is very rare, with few described cases. The safety of stereotactic ablative radiotherapy (SABR) for early-stage lung cancer arising fr... (Source: Radiation Oncology)
Source: Radiation Oncology - August 7, 2018 Category: Cancer & Oncology Authors: Hanbo Chen, Jussi Tikkanen, R. Gabriel Boldt and Alexander V. Louie Tags: Case report Source Type: research

Increasing Complexity of Thoracic Transplantation and The Rise of Multi-Organ Transplantation around the World – Insights from the ISHLT Registry
The ISHLT International Thoracic Organ Transplant Registry Report, now in its 35th annual iteration,1-4 provides insight into qualitative and the quantitative advances in the application of thoracic transplantation around the world. This year, the Transplant Registry Steering Committee selected multiorgan transplantation as the focus theme for the reports. The last decade has seen a gradual but considerable rise in multiorgan transplants, although their absolute rates remain low. Multiorgan transplant recipients present new challenges for the transplant team, increasing demands on the infrastructure, need for generation of...
Source: The Journal of Heart and Lung Transplantation - August 7, 2018 Category: Transplant Surgery Authors: Josef Stehlik, Daniel C. Chambers, Andreas Zuckermann, Mandeep R. Mehra, Kiran K. Khush Tags: Editorial Source Type: research

Outcomes of Patients with Right Ventricular Failure Requiring Short-Term Hemodynamic Support with Impella RP
Right Ventricular Failure (RVF) post-myocardial infarction,-cardiotomy or -Left Ventricular Assist Device (LVAD) implantation increases morbidity and mortality. RVF also contributes to prolonged length of hospital stay and higher costs of care. The aim of the study is to evaluate the efficacy and safety of the Impella RP (Abiomed, Danvers, MA) in patients with severe RVF in these clinical settings. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 7, 2018 Category: Transplant Surgery Authors: M. Anderson, L. Morris, D. Tang, G. Batsides, A. Kirtane, I. Hanson, P. Meraj, N. Kapur, W. O'Neill Tags: Original Clinical Science Source Type: research

The urgent lung allocation system in the scandiatransplant countries
Everywhere, the scarcity of donor organs makes optimal allocation systems necessary. In the Scandiatransplant countries, organs for lung transplantation are allocated nationally. To ensure shorter wait time for critically ill patients, the Scandiatransplant urgent lung allocation system (ScULAS) was introduced in 2009, giving supra-national priority to patients considered urgent. There were no predefined criteria for listing a patient as urgent, but each center was granted only three urgent calls per year. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 7, 2018 Category: Transplant Surgery Authors: Henrik Aur åen, Hans Henrik L. Schultz, Pekka Hämmäinen, Gerdt C. Riise, Hillevi Larsson, Lennart Hansson, Göran Dellgren, Michael Perch, Odd Geiran, Arnt E. Fiane, Martin Iversen, Are Martin Holm Tags: Original Clinical Science Source Type: research

Clinical Implications of the Total Artificial Heart: Adversity and Progress
The history of the SynCardia Total Artificial Heart – temporary (TAH-t; SynCardia Systems, LLC, Tuscon, AZ) is a fascinating medical tale of success, failure and perseverance that has highlighted the lives of many physicians, scientists and patients while episodically consuming the attention of the public. Although, perhaps not as dramatic as its f irst implantation in a human in 1982, a major and significant milestone in the history of this device was the Food and Drug Administration (FDA) approval of the SynCardia TAH-t in October of 2004 for bridge to transplant indication in the United States, culminating decades...
Source: The Journal of Heart and Lung Transplantation - August 7, 2018 Category: Transplant Surgery Authors: Francis D. Pagani Tags: Editorial Source Type: research

When REVEAL meets AMBITION, does it reveal more?
The first registry of patients with pulmonary arterial hypertension (PAH), established by the US National Heart, Lung, and Blood Institute (NHLBI) in 1981, reported a median survival of 2.8 years in the empirical therapy era.1 Shortly after bosentan was approved in the early 2000s, the French registry reported a one-year survival of 88% in patients with PAH,2 while the Chinese registry reported 1,3, and 5-year survivals of 68%, 38.9%, and 20.8% respectively, in patients with idiopathic and familial PAH who were treated with conventional therapies. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 7, 2018 Category: Transplant Surgery Authors: Hong-Da Zhang, Xi-Qi Xu, Zhi-Cheng Jing Tags: Invited Commentary Source Type: research

Response by Netuka et al. regarding the article “Evaluation of low-intensity anti-coagulation with a fully magnetically levitated centrifugal-flow circulatory pump – the MAGENTUM 1 study”
Cosgrove and Khalpey provide an insightful review regarding several key aspects of the Magentum-1 Study.1 They suggest that a “one size fits all” strategy for anticoagulation in mechanical circulatory support devices is unwise and that larger patient cohorts need examination to establish such targets. We agree with the authors; however, we believe that our investigation seeks to move the field forward towards the argum ent that when technology advances result in a reduction of thrombotic complications, it makes intuitive sense to begin to decrease the hazards that emanate from excessive anticoagulation. (Source...
Source: The Journal of Heart and Lung Transplantation - August 6, 2018 Category: Transplant Surgery Authors: Ivan Netuka, Jean M. Connors, Mandeep R. Mehra, Magentum 1 authors Tags: Case Anecdotes, Comments and Opinions Source Type: research

Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy
Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy, Published online: 06 August 2018; doi:10.1038/s41571-018-0075-2Chimeric antigen receptor (CAR) T cell therapies have impressive activity in the treatment of cancer but are associated with potentially fatal toxicities. In light of the approval of CAR T cell therapy for paediatric patients, a panel of experts from the Hematopoietic Stem Cell Transplantation (HSCT) Subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, the CAR T Cell Therapy-Associated Toxicity (CARTOX) Program at The University of...
Source: Nature Reviews Clinical Oncology - August 6, 2018 Category: Cancer & Oncology Authors: Kris M. Mahadeo Sajad J. Khazal Hisham Abdel-Azim Julie C. Fitzgerald Agne Taraseviciute Catherine M. Bollard Priti Tewari Christine Duncan Chani Traube David McCall Marie E. Steiner Ira M. Cheifetz Leslie E. Lehmann Rodrigo Mejia John M. Slopis Rajinder Source Type: research

Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy
Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy, Published online: 06 August 2018; doi:10.1038/s41571-018-0075-2Chimeric antigen receptor (CAR) T cell therapies have impressive activity in the treatment of cancer but are associated with potentially fatal toxicities. In light of the approval of CAR T cell therapy for paediatric patients, a panel of experts from the Hematopoietic Stem Cell Transplantation (HSCT) Subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, the CAR T Cell Therapy-Associated Toxicity (CARTOX) Program at The University of...
Source: Nature Clinical Practice Oncology - August 6, 2018 Category: Cancer & Oncology Authors: Kris M. Mahadeo Sajad J. Khazal Hisham Abdel-Azim Julie C. Fitzgerald Agne Taraseviciute Catherine M. Bollard Priti Tewari Christine Duncan Chani Traube David McCall Marie E. Steiner Ira M. Cheifetz Leslie E. Lehmann Rodrigo Mejia John M. Slopis Rajinder Source Type: research

Erratum
Schoenrath F, Kikhney J, Kursawe L, Hajduczenia MM, Schultze J, Potapov E, Krabatsch T, Kaufmann F, Falk V, Moter A.   Life on the driveline: Molecular detection and fluorescence in situ hybridization-based visualization of microbial species in patients with left ventricular assist devices.  J Heart Lung Transplant 2018;37(1):163-166. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 6, 2018 Category: Transplant Surgery Source Type: research

Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy.
Curry J, Featherston S, Foglesong J, Shoberu B, Gulbis A, Mireles ME, Hafemeister L, Nguyen C, Kapoor N, Rezvani K, Neelapu SS, Shpall EJ, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network Abstract In 2017, an autologous chimeric antigen receptor (CAR) T cell therapy indicated for children and young adults with relapsed and/or refractory CD19+ acute lymphoblastic leukaemia became the first gene therapy to be approved in the USA. This innovative form of cellular immunotherapy has been associated with remarkable response rates but is also associated with unique and often severe toxicities, which ...
Source: Clinical Lymphoma and Myeloma - August 6, 2018 Category: Cancer & Oncology Authors: Mahadeo KM, Khazal SJ, Abdel-Azim H, Fitzgerald JC, Taraseviciute A, Bollard CM, Tewari P, Duncan C, Traube C, McCall D, Steiner ME, Cheifetz IM, Lehmann LE, Mejia R, Slopis JM, Bajwa R, Kebriaei P, Martin PL, Moffet J, McArthur J, Petropoulos D, O'Hanlon Tags: Nat Rev Clin Oncol Source Type: research

Transplantation of Lungs Procured From a Donor with an Atrioesophageal Fistula
We report the case of procurement and transplantation of lungs from a young donor who died from an atrioesophageal fisula complicating catheter ablation for atrial fibrillation. Our case illustrates that structural damage to the left atrium is not an absolute contraindication to lung donation. As atrioesophageal fistulas are being increasingly recognized as a rare but often lethal complication of catheter ablation such donors can contribute to the expansion of the donor pool. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - August 4, 2018 Category: Cardiovascular & Thoracic Surgery Source Type: research

Co-existence of vocal cord dysfunction with pulmonary conditions other than asthma: A case series
ConclusionIt is important to recognize that VCD can exist with pulmonary conditions other than asthma. Lack of improvement in respiratory symptoms after appropriate treatment for VCD should alert the clinician to evaluate for additional conditions. (Source: Respiratory Medicine Case Reports)
Source: Respiratory Medicine Case Reports - August 3, 2018 Category: Respiratory Medicine Source Type: research

Diffuse alveolar hemorrhage is most often fatal and is affected by graft source, conditioning regiment toxicity, and engraftment kinetics.
Abstract Diffuse alveolar hemorrhage after hematopoietic stem cell transplantation is a frequently fatal complication with no standard therapy. Although significant changes in supportive and intensive care measures for hematopoietic stem cell transplantation patients have been made over the past decades, the impact of these changes on the incidence and outcome of patients with diffuse alveolar hemorrhage has not been examined. We analyzed 1228 patients who underwent allogeneic hematopoietic stem cell transplantation between 2008-2015 at the University of Minnesota to study the incidence, risk factors, and outcomes...
Source: Haematologica - August 3, 2018 Category: Hematology Authors: Keklik F, Alrawi EB, Cao Q, Bejanyan N, Rashidi A, Lazaryan A, Arndt P, Dincer EH, Bachanova V, Warlick ED, MacMillan ML, Arora M, Miller J, Brunstein CG, Weisdorf DJ, Ustun C Tags: Haematologica Source Type: research

Sepsis is associated with lack of monocyte HLA-DR expression recovery without modulating T-cell reconstitution after lung transplantation.
CONCLUSION: We found that sepsis is negatively correlated with the mHLA-DR expression but not adaptive T cell immune reconstitution. This finding highlights the importance of immunomonitoring after lung transplantation and questions the strategy of a lower immunosuppression therapy in context of sepsis. PMID: 30081187 [PubMed - as supplied by publisher] (Source: Transplant Immunology)
Source: Transplant Immunology - August 3, 2018 Category: Transplant Surgery Authors: Alingrin J, Coiffard B, Textoris J, Nicolino-Brunet C, Gossez M, Jarrot PA, Dignat-George F, Monneret G, Thomas PA, Leone M, Reynaud-Gaubert M, Papazian L Tags: Transpl Immunol Source Type: research

Transplantation of Lungs Procured From a Donor with an Atrioesophageal Fistula.
We report the case of procurement and transplantation of lungs from a young donor who died from an atrioesophageal fisula complicating catheter ablation for atrial fibrillation. Our case illustrates that structural damage to the left atrium is not an absolute contraindication to lung donation. As atrioesophageal fistulas are being increasingly recognized as a rare but often lethal complication of catheter ablation such donors can contribute to the expansion of the donor pool. PMID: 30081029 [PubMed - as supplied by publisher] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - August 3, 2018 Category: Cardiovascular & Thoracic Surgery Authors: Takahashi T, Gauthier JM, Albertin EK, Damiano RJ, Patterson GA, Bierhals AJ, Pasque MK, Hachem RR, Puri V, Kreisel D Tags: Ann Thorac Surg Source Type: research

Clinical implications of telomere dysfunction in lung fibrosis
Purpose of review Telomere attrition has been proposed as one of the aging hallmarks in pulmonary fibrosis. Telomere shortening and telomerase gene mutations have been widely evaluated in recent years. Reduced telomere length may be identified in a quarter of patients with sporadic idiopathic pulmonary fibrosis (IPF) and half of those cases with family aggregation. However, telomere studies have not transferred from the research field to the clinic. This review is focused on our current understanding of the pathogenic implication of telomere dysfunction in lung fibrosis and its relevance in the clinical setting. Recent ...
Source: Current Opinion in Pulmonary Medicine - August 2, 2018 Category: Respiratory Medicine Tags: INTERSTITIAL LUNG DISEASE: Edited by Francesco Bonella and Paolo Spagnolo Source Type: research

Non-invasive positive pressure ventilation in lung transplant recipients with acute respiratory failure: Beyond the perioperative period
ConclusionsNPPV is a viable option for lung transplant recipients with acute respiratory failure. Extreme caution should be exercised when used in patients with high severity of illness (APACHE III>78) and/or severe hypoxemia (PaO2/FiO2 ≤ 151). (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 2, 2018 Category: Gastroenterology Source Type: research

Aquagenic wrinkling of the palms in association with cystic fibrosis manifesting after a lung transplantation
A 28-year-old woman with cystic fibrosis presented with painful wrinkling of the palms shortly after immersion in water. She had undergone a bilateral single sequential lung transplant five months before. Pertinently, before this, she had been asymptomatic. Her signs and symptoms were consistent with aquagenic wrinking of the palms. Her immunosuppressive regime included tacrolimus 4.5 mg BD, mycophenolate mofetil 500 mg BD, and prednisolone 10 mg OD. Aquagenic wrinking of the palms is a rare condition in which white papules and plaques and excessive wrinkling of the palmar skin occur within minutes of water exposure. (Sour...
Source: Journal of the American Academy of Dermatology - August 2, 2018 Category: Dermatology Source Type: research

Examining the incidence and presentation of melanoma in thoracic transplant patients
Background: More than 90,000 heart and/or lung transplantations have occurred in the U.S. since 1988, with UNOS reporting a 20% increase in transplantations from 2012 through 2016. The immunosuppression vital to maintaining graft survival often comes with devastating consequences, one of which is a reported increase in cutaneous neoplasms. Understanding the incidence and presentation of melanoma in the thoracic transplant population is necessary for adequate disease surveillance. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 2, 2018 Category: Dermatology Source Type: research

Paraneoplastic pemphigus associated with Castleman disease and thyroid carcinoma
We report herein a 13-year-old girl with ocular and oral lesions and a posterior mediastinal mass that was diagnosed of a paraneoplastic pemphigus associated with Castleman disease. The patient developed a severe bronchiolitis obliterans despite an aggressive treatment with rituximab and intravenous immunoglobulin therapy, requiring lung transplant. During pre-transplantation studies, a thyroid nodule was detected and histopathology confirmed a thyroid carcinoma. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 2, 2018 Category: Dermatology Source Type: research

Skin cancer in transplant patients: Protection by skin of color
Background: Organ transplant recipients experience increased skin cancer rates secondary to their immunosuppressive regimens. These impacts on skin cancer rates occur within individual patient risk-profiles, which include factors such as skin tone. We sought to compare the rates of skin cancer development in a cohort of Caucasian and non-Caucasian liver and lung transplant recipients to better elucidate the protective effect of darker skin tone on post-transplantation skin cancer development. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 2, 2018 Category: Dermatology Source Type: research

Endotracheal catheter equipped with functional cuff produces clinically relevant positive end expiratory pressure: a bench study
AbstractRecently, we developed a novel endotracheal catheter with functional cuff (ECFC). Using such an ECFC and a regular ICU ventilator, we were able to generate clinically relevant tidal volume in a lung model and adult human sized animal. This ECFC allows co-axial ventilation without using a jet ventilator. The aim of this study was to determine if ECFC also could generate clinically relevant positive end expiratory pressure (PEEP). The experiment was conducted on a model lung and artificial trachea. Lung model respiratory mechanics were set to simulate those of an adult human being. The tip of the distal end of ECFC 1...
Source: Journal of Clinical Monitoring and Computing - August 2, 2018 Category: Information Technology Source Type: research