Predictive Utility of Lung Allocation Score for Retransplantation Outcomes
ConclusionsThe Lung Allocation Score achieved comparable, but poor, predictive utility for 1-year outcomes of primary LTx and rLTx. We found no evidence that Lung Allocation Score components should be weighted differently for rLTx candidates. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - October 23, 2018 Category: Cardiovascular & Thoracic Surgery Source Type: research
The First Living-Donor Lobar Lung Transplantation in Korea: a Case Report.
Authors: Choi S, Park SI, Lee GD, Kim HR, Kim DK, Jung SH, Yun TJ, Kim IO, Choi DK, Choi IC, Song JM, Hong SB, Shim TS, Jo KW, Lee SO, Do KH, Chae EJ Abstract Lung transplantation is the only treatment for end-stage lung disease, but the problem of donor shortage is unresolved issue. Herein, we report the first case of living-donor lobar lung transplantation (LDLLT) in Korea. A 19-year-old woman patient with idiopathic pulmonary artery hypertension received her father's right lower lobe and her mother's left lower lobe after pneumonectomy of both lungs in 2017. The patient has recovered well and is enjoying normal ...
Source: Journal of Korean Medical Science - October 23, 2018 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
Early Graft Dysfunction After Lung Transplantation
AbstractPurpose of ReviewPrimary graft dysfunction is an acute lung injury syndrome occurring immediately following lung transplantation. This review aims to provide an overview of the current understanding of primary graft dysfunction (PGD), including epidemiology, immunology, clinical outcomes, and management.Recent FindingsIdentification of donor and recipient factors allowing accurate prediction of PGD has been actively pursued. Improved understanding of the immunology underlying PGD has spurred interest in identifying relevant biomarkers. Work in PGD prediction, severity stratification, and targeted therapies continue...
Source: Current Respiratory Care Reports - October 22, 2018 Category: Respiratory Medicine Source Type: research
Connexin 43-Mediated Mitochondrial Transfer of iPSC-MSCs Alleviates Asthma Inflammation
This study provides a therapeutic strategy for targeting asthma inflammation.Graphical Abstract (Source: Stem Cell Reports)
Source: Stem Cell Reports - October 19, 2018 Category: Stem Cells Source Type: research
Bone marrow mesenchymal stem cells and condition media diminish inflammatory adhesion molecules of pulmonary endothelial cells in an ovalbumin-induced asthmatic rat model
Publication date: Available online 18 October 2018Source: Microvascular ResearchAuthor(s): Reza Rahbarghazi, Rana Keyhanmanesh, Mohammad Reza Aslani, Mehdi Hassanpour, Mahdi AhmadiAbstractObjectivesAlthough excitements related to stem cell therapeutic outcomes have been highlighted enormously in asthma, the vast majority of works were conducted by researchers in animal models. Elucidating the mechanisms underlying the therapeutic effects of MSCs in asthmatic rats will provide a rational basis for assuring maximal safety of future clinical application of stem cells. In the current study, we sought to investigate the possibl...
Source: Microvascular Research - October 19, 2018 Category: Biochemistry Source Type: research
ADAMTS-13 activity reduction in plasma of acute myeloid leukemia predicts poor prognosis after bone marrow transplantation.
Authors: Liu C, Han M, Zhao L, Zhu M, Xu Q, Song Y, Wang H Abstract OBJECTIVE: This research aimed to explore the significance of low activity of ADAMTS-13 in acute myeloid leukemia (AML) after bone morrow transplantation (BMT), and to evaluate the disease progress and prognosis of the patients with low or normal activity of ADAMTS-13 after BMT. METHODS: 46 AML patients were included in our research. ADAMTS-13 activity was measured before BMT. Their medical indicators were recorded one month after BMT. All the patients were followed up and their disease progression was evaluated afterwards. The medical indicato...
Source: Hematology - October 18, 2018 Category: Hematology Tags: Hematology Source Type: research
Factors Associated with Lung Function Recovery at the First Year after Lung Transplantation.
Abstract PURPOSE: Post-operative pulmonary function is an important prognostic factor for lung transplantation. The purpose of this study was to identify factors affecting recovery of forced expiratory volume in 1 second (FEV1) at the first year after lung transplantation. MATERIALS AND METHODS: We retrospectively reviewed the medical records of lung transplantation patients between October 2012 and June 2016. Patients who survived for longer than one year and who underwent pulmonary function test at the first year of lung transplantation were enrolled. Patients were divided into two groups according to wheth...
Source: Yonsei Medical Journal - October 18, 2018 Category: Universities & Medical Training Authors: Yoon BR, Park JE, Kim CY, Park MS, Kim YS, Chung KS, Song JH, Paik HC, Lee JG, Kim SY Tags: Yonsei Med J Source Type: research
Biotinylated naringenin intensified anticancer effect of gefitinib in urethane-induced lung cancer in rats: favourable modulation of apoptotic regulators and serum metabolomics.
Authors: Parashar P, Tripathi CB, Arya M, Kanoujia J, Singh M, Yadav A, Kumar A, Guleria A, Saraf SA Abstract Co-therapy through biotin modified nanoparticles (NPs) of gefitinib (Gnb) and naringenin (Nar) was investigated for its therapeutic and synergistic potential against lung cancer. The biotin-conjugated polymeric NPs (bty-Nar/Gnb) were developed using oil in water emulsion technique and optimized using central composite design. The formulations were subjected to various in vitro (A549 cell lines) and in vivo evaluations in urethane-induced lung cancer. Co-administration of Gnb and Nar NPs displayed a signific...
Source: Artificial Cells, Nanomedicine and Biotechnology - October 18, 2018 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
A fiducial-less tracking method for radiation therapy of liver tumors by diaphragm disparity analysis part 2: validation study by using clinical data
ConclusionWe proposed and investigated the fiducial-less tracking method to follow tumor motion in the real-time under the influence of respiration. The study shows the feasibility of accurately predicting the tumor ’s position with the use of lung-diaphragm border’s information through available kV images without gold fiducial markers. This developed diaphragm disparity-analysis-based approach, verified with clinically accepted errors, has the potential to replace fiducial markers in clinical applications. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - October 18, 2018 Category: Cancer & Oncology Source Type: research
Surgery for Patients with Alpha 1 Antitrypsin Deficiency: A Review
ConclusionsLung and liver transplantation in AATD patients are associated with very good long-term survival rates that are comparable to, and sometimes superior to, other transplant indications. Although not currently recommended in AATD, LVRS may have a role in a minority of patients. The value of Alpha 1 Antitrypsin (AAT) augmentation therapy following lung transplantation requires further study. Wherever possible, AAT therapy should be continued in the period around elective surgeries.SummaryAlthough AATD is a widely discussed and researched topic in the literature, surgical intervention for AATD, in addition to the man...
Source: The American Journal of Surgery - October 17, 2018 Category: Surgery Source Type: research
Time-dependent prognostic effects of recipient and donor age in adult heart transplantation
Recipient and donor age are well-known prognostic factors in adult heart transplantation. However, the association between donor and recipient age and their interaction and short- and long-term mortality is unknown. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - October 17, 2018 Category: Transplant Surgery Authors: Henrik Bergenfeldt, Lars H. Lund, Josef Stehlik, Bodil Andersson, Peter H öglund, Johan Nilsson Tags: Original Clinical Science Source Type: research
A Scoping Review of Key Health Items in Self-Report Instruments Used Among Solid Organ Transplant Recipients
AbstractThe overall aim of this scoping review of the literature is twofold: (1) to provide an overview of all instruments that have been used to assess health-related quality of life (HRQoL) after solid organ transplantation and (2) to provide a list of health items they include to support future studies on the development of a new-generation HRQoL instrument. All studies that administered any form of HRQoL instrument to post-transplant solid organ recipients were identified in a comprehensive search of PubMed (MEDLINE), Embase, and Web of Science, with a cut-off date of May 2018. The search used various combinations of t...
Source: The Patient - Patient-Centered Outcomes Research - October 16, 2018 Category: International Medicine & Public Health Source Type: research
Biotinylated naringenin intensified anticancer effect of gefitinib in urethane-induced lung cancer in rats: favourable modulation of apoptotic regulators and serum metabolomics
. (Source: Artificial Cells, Blood Substitutes, and Biotechnology)
Source: Artificial Cells, Blood Substitutes, and Biotechnology - October 16, 2018 Category: Biotechnology Authors: Poonam Parashar Chandra Bhushan Tripathi Malti Arya Jovita Kanoujia Mahendra Singh Abhishek Yadav Amit Kumar Anupam Guleria Shubhini A. Saraf Source Type: research
Pleuroparenchymal fibroelastosis as a histological background of autoimmune diseases
AbstractPatients with autoimmune disease –related interstitial lung disease (AID-ILD) occasionally develop radiologic pleuroparenchymal fibroelastosis (PPFE)–like lesions. However, the significance of AID as an etiology of PPFE has not been fully elucidated. The aim of this study is to verify the increase of elastic fibers in AID-ILD p atients and evaluate the prevalence of histological PPFE in patients with AID-ILD. We selected cases of clinically diagnosed AID-ILD and idiopathic pulmonary fibrosis (IPF), in which an autopsy had been performed or in which the patient had undergone pneumonectomy for lung transp...
Source: Virchows Archiv - October 16, 2018 Category: Pathology Source Type: research
Successful lung transplantation in an HIV seropositive patient with desquamative interstitial pneumonia: a case report
Until recently, lung transplantation was not considered in patients with human immunodeficiency virus (HIV). HIV seropositive patients with suppressed viral loads can now expect long-term survival with the adv... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - October 16, 2018 Category: Respiratory Medicine Authors: Shaun Ong, Robert D Levy, John Yee, Nilu Partovi, Andrew Churg, Philippe Rom éo, Jean Chalaoui, Roland Nador, Alissa Wright, Hélène Manganas and Christopher J Ryerson Tags: Case report Source Type: research
Surgery for Patients with Alpha 1 Antitrypsin Deficiency: A Review
Alpha 1 Antitrypsin Deficiency (AATD) is a genetic cause of emphysema/chronic obstructive pulmonary disease (COPD) and liver disease, making AATD patients a high-risk surgical group. Additionally, patients may eventually require lung and/or liver transplantation or lung volume reduction surgery (LVRS). This narrative review discusses perioperative considerations for elective procedures in AATD patients, and reviews patient outcomes in AATD-related transplantation and LVRS. (Source: American Journal of Surgery)
Source: American Journal of Surgery - October 16, 2018 Category: Surgery Authors: Martin Zamora Tags: Review Source Type: research
Usefulness of a temporary endovascular left ventricular assist system as a bridge to facilitate treatment of mediastinitis associated with a permanent device
Infections of the driveline exit site are very common and are one of the most common reasons for readmissions of patients with left ventricular assist devices (LVAD). The risk for LVAD infection increases with the duration of LVAD support and after 48 months it is among the top three reasons for death [1-3]. The rate of mortality from LVAD-related mediastinitis is as high as 70% [4,5]. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - October 15, 2018 Category: Transplant Surgery Authors: M. Mueller, E. Potapov, T. Krabatsch Tags: Case Anecdotes, Comments and Opinions Source Type: research
Lung transplantation in a patient with Niemann-Pick disease
A 62-year old non-smoker, Caucasian male was evaluated for lung transplantation based on severe upper-lobe predominant emphysema with superimposed fibrosis in the lower lung zones (Figure 1). The patient had no significant exposure history, and prior work-up for alpha-1-antitrypsin deficiency, autoimmune disease, and hypersensitivity pneumonitis was unremarkable. The diagnosis of Niemann Pick disease, type B was eventually established based on a compatible family history with an almost identical disease presentation in a sibling. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - October 15, 2018 Category: Transplant Surgery Authors: Hannah Mannem, Sarah Kilbourne, Max Weder Tags: Case Anecdotes, Comments and Opinions Source Type: research
Recovery, symptoms, and well ‐being one to five years after lung transplantation – A multi‐centre study
Scandinavian Journal of Caring Sciences, EarlyView. (Source: Scandinavian Journal of Caring Sciences)
Source: Scandinavian Journal of Caring Sciences - October 15, 2018 Category: Nursing Authors: Martina Lundmark, Annette Lennerling, Matilda Almgren, Anna Forsberg Source Type: research
Cardiopulmonary exercise testing provides additional prognostic information in cystic fibrosis.
oup Abstract RATIONALE: The prognostic value of cardiopulmonary exercise testing (CPET) for survival in cystic fibrosis (CF) in the context of current clinical management, when controlling for other known prognostic factors is unclear. OBJECTIVES: To determine the prognostic value of CPET-derived measures beyond peak oxygen uptake (VO2peak) following rigorous adjustment for other predictors. MEASUREMENTS AND MAIN RESULTS: Data from 10 CF-centers in Australia, Europe and North America were collected retrospectively. 510 patients completed a cycle CPET between January 2000 and December 2007, of which 433 f...
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2018 Category: Respiratory Medicine Authors: Hebestreit H, Hulzebos EH, Schneiderman JE, Karila C, Boas SR, Kriemler S, Dwyer T, Sahlberg M, Urquhart DS, Lands LC, Ratjen F, Takken T, Varanistkaya L, Rücker V, Hebestreit A, Usemann J, Radtke T, Prognostic value of CPET in CF study group Tags: Am J Respir Crit Care Med Source Type: research
T-Cell Receptors Targeting Kita-Kyushu Lung Cancer Antigen 1 (KK-LC-1)
Development of T-cell based immunotherapies for the treatment of various cancers has been challenged for decades by the lack of target antigens that are only expressed by cancer cells and not normal tissues. KK-LC-1 belongs to a family of tumor antigens known as cancer-testis antigens, which have restricted expression in immune-privileged germ cells and various cancers, and not in normal life-essential tissues. This makes KK-LC-1 an attractive target for T-cell based anti-cancer therapies.Inventors from the National Cancer Institute ’sExperimental Transplantation and Immunology Branch (NCI ETIB) have discovered two n...
Source: NIH OTT Licensing Opportunities - October 15, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research
Insights from the European Respiratory Society 2018 Annual International Congress in the fields of thoracic surgery and lung transplantation.
Authors: Hoek RAS, Gaitanakis S, Hellemons ME PMID: 30310690 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - October 14, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Incidence and Survival Rate of de novo Tumors in Liver Transplants
ConclusionIn our setting, excluding NMSC, the incidence is 8.8 times greater than estimations for the general population, with a high rate of lung cancer, so we should implement preventive and diagnostic strategies.ResumenIntroducciónLa mayor supervivencia del paciente trasplantado viene acompañada del aumento en la tasa de tumores de novo (TN) que representan la complicación tardía más frecuente. Podemos distinguir entre tumores de piel no melanoma (TPNM), síndrome linfoproliferativo postrasplante (SLPT) y tumores de órgano sólido (TOS). Nuestro objetivo es determina...
Source: Cirugia Espanola - October 14, 2018 Category: Surgery Source Type: research
Bilateral Lung Transplantation and Simultaneous Pectus Excavatum Correction Using the Nuss Technique
Publication date: Available online 13 October 2018Source: The Annals of Thoracic SurgeryAuthor(s): Daniel Valdivia, Markus Kamler, Clemens AignerAbstractSevere chest wall deformities are considered a contraindication for lung transplantation. A 38-year-old male with idiopathic pulmonary fibrosis and severe pectus excavatum with a Haller-Index of 4.3 was considered eligible and listed for lung transplantation. Bilateral sequential transplantation and simultaneous correction of the pectus excavatum was performed via anterolateral thoracotomies and Nuss-bar insertion with peripheral femoro-femoral veno-arterial ECMO support. ...
Source: The Annals of Thoracic Surgery - October 13, 2018 Category: Cardiovascular & Thoracic Surgery Source Type: research
Myostatin and other musculoskeletal markers in lung transplant recipients
AbstractRecipients of lung transplantation (LuTx) may experience impaired muscle function and bone metabolism even after rehabilitation. We investigated the potential use of musculoskeletal markers in identifying the impairment of muscle function and bone function in these patients. Biochemical parameters, bodily functions, and lung function of 37 LuTx recipients were evaluated at the time of their discharge from the hospital stay and about 6 months later. The biomarkers were also assessed in 30 healthy age and gender distribution-matched controls. Compared to controls, the negative muscle regulator myostatin was ele...
Source: Clinical and Experimental Medicine - October 13, 2018 Category: Research Source Type: research
Bilateral Lung Transplantation and Simultaneous Pectus Excavatum Correction Using the Nuss Technique.
Abstract Severe chest wall deformities are considered a contraindication for lung transplantation. A 38-year-old male with idiopathic pulmonary fibrosis and severe pectus excavatum with a Haller-Index of 4.3 was considered eligible and listed for lung transplantation. Bilateral sequential transplantation and simultaneous correction of the pectus excavatum was performed via anterolateral thoracotomies and Nuss-bar insertion with peripheral femoro-femoral veno-arterial ECMO support. TLC increased from 4.1l preoperative to 5.8l postoperative. This case demonstrates that a combined approach is feasible with good funct...
Source: The Annals of Thoracic Surgery - October 13, 2018 Category: Cardiovascular & Thoracic Surgery Authors: Valdivia D, Kamler M, Aigner C Tags: Ann Thorac Surg Source Type: research
Decontamination and Lung Transplantation of a Cystic Fibrosis Patient with Resistant Infections
We describe the use of a decontamination protocol that allowed for successful lung transplantation in a cystic fibrosis patient with necrotizing pneumonia from highly antibiotic-resistant pathogens (Burkholderia and psuedomonas species). This strategy may allow for successful lung transplantation in cystic fibrosis patients with multi-drug resistant infections previously considered non-transplantable. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - October 12, 2018 Category: Cardiovascular & Thoracic Surgery Source Type: research
The combined administration of parthenolide and ginsenoside CK in long circulation liposomes with targeted tLyp-1 ligand induce mitochondria-mediated lung cancer apoptosis.
CONCLUSION: The findings of this study indicated that combined application of natural products in nanocarriers could offer attractive therapeutic options. PMID: 30307334 [PubMed - as supplied by publisher] (Source: Artificial Cells, Nanomedicine and Biotechnology)
Source: Artificial Cells, Nanomedicine and Biotechnology - October 12, 2018 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
[Waiting List Management and Organ Allocation for Lung Transplantation 2018].
Authors: Kümmel A, Witt C, Schramm R, Wenker M, Buhl R, Gottlieb J Abstract In 2017 an amendment to the German transplant law concerning organ allocation and waiting list management became effective. This implies important consequences on lung transplant centers. Crucial innovations concern the transplant conference, indications for lung transplantation and waiting list management. Certain medical conditions now imply a restriction of waiting list enrollment for patients and there are new options for size-matching of donor lung and recipient. Moreover, the new amendment describes in detail how the clinical par...
Source: Pneumologie - October 12, 2018 Category: Respiratory Medicine Tags: Pneumologie Source Type: research
Effects of Pulmonary Hypertension and Right Ventricular Function in Short and Long-Term Kidney Function.
Authors: Naranjo M, Lo KB, Mezue K, Rangaswami J Abstract Pulmonary hypertension is not uncommon in patients with renal disease and vice versa; therefore, influences treatments and outcomes. There is a large body of literature on pulmonary hypertension in patients with kidney disease, its prognostic implications, economic burden, and management strategies. However, the converse, namely the hemodynamic effects of pulmonary hypertension on kidney function (acute and chronic kidney injury) is less studied and described. There is also increasing interest in the effects of pulmonary hypertension on kidney transplant out...
Source: Current Cardiology Reviews - October 12, 2018 Category: Cardiology Tags: Curr Cardiol Rev Source Type: research
Cystic Fibrosis: Emerging Understanding and Therapies.
Abstract Cystic fibrosis (CF) is the most common life-limiting genetic disease in Caucasian patients. Continued advances have led to improved survival, and adults with CF now outnumber children. As our understanding of the disease improves, new therapies have emerged that improve the basic defect, enabling patient-specific treatment and improved outcomes. However, recurrent exacerbations continue to lead to morbidity and mortality, and new pathogens have been identified that may lead to worse outcomes. In addition, new complications, such as CF-related diabetes and increased risk of gastrointestinal cancers, are c...
Source: Annual Review of Medicine - October 12, 2018 Category: General Medicine Authors: Rey MM, Bonk MP, Hadjiliadis D Tags: Annu Rev Med Source Type: research
HLA class II Eplet mismatch predicts De Novo DSA formation post lung transplant.
In this study of lung transplant recipients we prospectively examined the association between donor-recipient HLA eplet mismatches as defined by HLAMatchmaker (version 2.1) and de-novo anti-HLA donor-specific antibody (DSA) formation, as assessed by single antigen-bead solid phase assay. HLA class II eplet mismatch, when split at the median for the cohort, predicted the development of de-novo HLA class II DSA at 3 months but not at 12 months. Having previously shown that high HLA class II eplet mismatches was associated with CLAD, we now show that the same factors are associated with de-novo HLA class II DSA post-trans...
Source: Transplant Immunology - October 12, 2018 Category: Transplant Surgery Authors: Walton DC, Cantwell L, Hiho S, Ta J, Wright S, Sullivan LC, Snell GI, Westall GP Tags: Transpl Immunol Source Type: research
The combined administration of parthenolide and ginsenoside CK in long circulation liposomes with targeted tLyp-1 ligand induce mitochondria-mediated lung cancer apoptosis
. (Source: Artificial Cells, Blood Substitutes, and Biotechnology)
Source: Artificial Cells, Blood Substitutes, and Biotechnology - October 11, 2018 Category: Biotechnology Authors: Xin Jin Jianping Zhou Zhenhai Zhang Huixia Lv Source Type: research
Decontamination and Lung Transplantation of a Cystic Fibrosis Patient with Resistant Infections.
We describe the use of a decontamination protocol that allowed for successful lung transplantation in a cystic fibrosis patient with necrotizing pneumonia from highly antibiotic-resistant pathogens (Burkholderia and psuedomonas species). This strategy may allow for successful lung transplantation in cystic fibrosis patients with multi-drug resistant infections previously considered non-transplantable. PMID: 30316849 [PubMed - as supplied by publisher] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - October 11, 2018 Category: Cardiovascular & Thoracic Surgery Authors: Shah A, Pasrija C, Boulos F, Pham S, Griffith BP, Amoroso A, Sanchez PG, Kon ZN Tags: Ann Thorac Surg Source Type: research
Objective Donor Scoring System for Lung Transplantation
Publication date: Available online 9 October 2018Source: The Annals of Thoracic SurgeryAuthor(s): William M. Whited, Jaimin R. Trivedi, Victor H. van Berkel, Matthew P. FoxAbstractBackgroundThere is not an objective method to estimate post lung transplant (LTx) survival based solely on cumulative donor risk factors.MethodsThe UNOS thoracic transplant database was queried to identify patients who underwent lung transplant between 2005 and 2015. A cox-proportional hazard model was generated using a training set to identify donor risk factors significantly associated with post-transplant survival. Significant donor risk facto...
Source: The Annals of Thoracic Surgery - October 10, 2018 Category: Cardiovascular & Thoracic Surgery Source Type: research
Development and Preliminary Validation of the Lung Transplant Quality of Life (LT-QOL) Survey.
CONCLUSION: The LT-QOL is a new multidimensional instrument that characterizes and quantifies health-related quality of life in lung transplant recipients. PMID: 30303408 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 10, 2018 Category: Respiratory Medicine Authors: Singer JP, Soong A, Chen J, Shrestha P, Zhuo H, Gao Y, Greenland JR, Hays SR, Kukreja J, Golden J, Gregorich SE, Stewart AL Tags: Am J Respir Crit Care Med Source Type: research
BOS is associated with decreased HDAC2 from steroid resistant lymphocytes in the small airways.
This article is protected by copyright. All rights reserved. PMID: 30303525 [PubMed - as supplied by publisher] (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - October 10, 2018 Category: Allergy & Immunology Authors: Hodge G, Hodge S, Yeo A, Nguyen P, Hopkins E, Liu H, Holmes-Liew CL, Holmes M Tags: Clin Exp Immunol Source Type: research
The hepatotoxic potential of protein kinase inhibitors predicted with Random Forest and Artificial Neural Networks.
In this study, the structure-activity relationship of PKIs in relation to hepatotoxicity was investigated. A dataset of 165 PKIs was compiled and the probability of human hepatotoxicity with two different machine learning algorithms (Random Forest and Artificial Neural Networks) was analysed. The estimated probability of hepatotoxicity was generally high for single PKIs. However, depending on the target kinase of the PKI, a difference in hepatotoxic potential could be observed. The similarity of the PKIs to each other is caused by the conserved site of action of the protein kinases. Hepatotoxicity may therefore always be a...
Source: Toxicology Letters - October 10, 2018 Category: Toxicology Authors: Schöning V, Krähenbühl S, Drewe J Tags: Toxicol Lett Source Type: research
Transplantation experience as a predictor for quality of life during the first 6 months after lung transplantation
Clinical Transplantation, EarlyView. (Source: Clinical Transplantation)
Source: Clinical Transplantation - October 9, 2018 Category: Transplant Surgery Authors: Lutz Goetzmann, Annina Seiler, Christian Benden, Annette Boehler, Stefan B üchi, Josef Jenewein, Barbara Ruettner, Anett Mueller‐Alcazar, Roland Weierstall Source Type: research
Objective Donor Scoring System for Lung Transplantation.
Abstract BACKGROUND: There is not an objective method to estimate post lung transplant (LTx) survival based solely on cumulative donor risk factors. METHODS: The UNOS thoracic transplant database was queried to identify patients who underwent lung transplant between 2005 and 2015. A cox-proportional hazard model was generated using a training set to identify donor risk factors significantly associated with post-transplant survival. Significant donor risk factors were assigned a score based on their hazard ratio. Donor risk score was calculated for each patient by adding the individual donor risk factor scores...
Source: The Annals of Thoracic Surgery - October 9, 2018 Category: Cardiovascular & Thoracic Surgery Authors: Whited WM, Trivedi JR, van Berkel VH, Fox MP Tags: Ann Thorac Surg Source Type: research
Ex vivo perfusion induces a time ‐ and perfusate‐dependent molecular repair response in explanted porcine lungs
American Journal of Transplantation, EarlyView. (Source: American Journal of Transplantation)
Source: American Journal of Transplantation - October 8, 2018 Category: Transplant Surgery Authors: Peter Dromparis, Nader S. Aboelnazar, Siegfried Wagner, Sayed Himmat, Christopher W. White, Sanaz Hatami, Jessica G. Y. Luc, Silas Rotich, Darren H. Freed, Jayan Nagendran, Michael Mengel, Benjamin A. Adam Source Type: research
Lung bioengineering: advances and challenges in lung decellularization and recellularization.
Abstract PURPOSE OF REVIEW: Bioengineering the lung based on its natural extracellular matrix (ECM) offers novel opportunities to overcome the shortage of donors, to reduce chronic allograft rejections, and to improve the median survival rate of transplanted patients. During the last decade, lung tissue engineering has advanced rapidly to combine scaffolds, cells, and biologically active molecules into functional tissues to restore or improve the lung's main function, gas exchange. This review will inspect the current progress in lung bioengineering using decellularized and recellularized lung scaffolds and highli...
Source: Current Opinion in Organ Transplantation - October 8, 2018 Category: Transplant Surgery Authors: Uriarte JJ, Uhl FE, Rolandsson Enes SE, Pouliot RA, Weiss DJ Tags: Curr Opin Organ Transplant Source Type: research
GSE113090 Deep sequencing of transcript levels of human embryonic stem cell derived mesothelium (epithelial and mesenchymal forms) and mesothelium from neonatal mouse E15.5 of the heart, lung, liver and gut and ChIP-seq data of the mesenchymal form of mesothelium
Contributors : Stephen Dalton ; Thomas Colunga ; Miranda Hayworth ; Luoman Chen ; Kristopher L NazorSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusMesothelium is a multipotent resident progenitor cell of the coelomic organs that functions in organogenesis, repair and possible regeneration. We used hESCs to generate mesothelium of the epithelial and mesenchymal forms. Mesenchymal derivatives of mesothelium have been previously reported to function in tissue repair by promoting and participating in angiog...
Source: GEO: Gene Expression Omnibus - October 6, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Mus musculus Source Type: research
A case of Sirolimus induced interstitial lung disease after liver transplantation
We present a case of Sirolimus induced ILD that improved after discontinuation of Sirolimus. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - October 5, 2018 Category: Gastroenterology Source Type: research
Paclitaxel-loaded TPGS enriched self-emulsifying carrier causes apoptosis by modulating survivin expression and inhibits tumour growth in syngeneic mammary tumours.
Authors: Meher JG, Dixit S, Pathan DK, Singh Y, Chandasana H, Pawar VK, Sharma M, Bhatta RS, Konwar R, Kesharwani P, Chourasia MK Abstract Paclitaxel (PTX) in its commercial products exhibits adverse effects owing to excipients and also has poor oral bioavailability. Present work is directed towards development of tocopheryl polyethylene glycol succinate-assisted self-nanoemulsifying system (SEDDS) for oral delivery of PTX. Box-Behnken design of experiment was employed to optimize PTX-SEDDS and was characterized for droplet size (29.76 ± 2.64 nm), zeta potential (-21.46 ±&t...
Source: Artificial Cells, Nanomedicine and Biotechnology - October 5, 2018 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Point-of-care ultrasound in end-stage kidney disease: beyond lung ultrasound
The objective of this review is to describe the potential applications of POCUS in end-stage renal disease patients (ESRD). Recent findings With basic training, the clinician can perform pulmonary, vascular, cardiac, and abdominal POCUS at the bedside of ESRD patients. Pulmonary ultrasound can be used to quantify pulmonary congestion and for the differential diagnosis of dyspnea. Ultrasound of the inferior vena cava combined with simple cardiac ultrasound can be used to promptly investigate the mechanism of hemodynamic instability. Vascular ultrasound can be used for troubleshooting of arteriovenous fistula problems and...
Source: Current Opinion in Nephrology and Hypertension - October 5, 2018 Category: Urology & Nephrology Tags: DIALYSIS AND TRANSPLANTATION: Edited by J. Kevin Tucker and Anil Chandraker Source Type: research
On-pump beating CABG concomitant with bilateral living-donor lobar lung transplantation
Publication date: Available online 5 October 2018Source: Heart & LungAuthor(s): Koji Ueyama, So Miyahara, Yujiro Ide, Kazuhisa Sakamoto, Hideo Kanemitsu, Kazuhiro Yamazaki, Tadashi Ikeda, Akihiro Aoyama, Hiroshi Date, Kenji Minatoya (Source: Heart and Lung: The Journal of Acute and Critical Care)
Source: Heart and Lung: The Journal of Acute and Critical Care - October 5, 2018 Category: Respiratory Medicine Source Type: research
Reply to “The choice of antiviral therapy for hepatitis C recurrence after liver transplantation in the real world”
Publication date: Available online 2 October 2018Source: Journal of the Formosan Medical AssociationAuthor(s): Ming-Lung Yu (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - October 5, 2018 Category: General Medicine Source Type: research
An assessment of the Chinese medicinal Dendrobium industry: supply, demand and sustainability
ConclusionsThis review summarizes the species and cultivation history of medicinal herbs in the Dendrobium. The review can help inform future scientific research towards the TCM in Dendrobium, including mycorrhizal technology and microorganism fertilizer, pharmacological studies, the directed cultivation of varieties and diversified product. It is suggested that Dendrobium cultivation has a great potential to link the commercial TCM industry together with initiatives of biodiversity conservation. (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 5, 2018 Category: Drugs & Pharmacology Source Type: research
Systemic delivery of mesenchymal stem cells condition media in repeated doses acts as magic bullets in restoring IFN-γ/IL-4 balance in asthmatic rats
Publication date: 1 November 2018Source: Life Sciences, Volume 212Author(s): Rana Keyhanmanesh, Reza Rahbarghazi, Mohammad Reza Aslani, Mehdi Hassanpour, Mahdi AhmadiAbstractAimsWith respect to recent advantage in stem cell application, given the concern reported previously after stem cell transplantation, mesenchymal stem cell-derived conditioned media (MSC-CM) could be a potential approach to guarantee more safety and efficient outcomes than the current stem cell–based regenerative therapies.Main methodsMale rats were assigned into four experimental groups (n = 6); healthy rats (C group), OVA sensitized rats (S...
Source: Life Sciences - October 5, 2018 Category: Biology Source Type: research