Infections in liver and lung transplant recipients: a national prospective cohort
This study aimed to describe recipients ’ characteristics, and the frequency and etiology of infections and transplant outcome in liver and lung SOTs, and to investigate exposures associated to infection and death in liver transplant recipients. The study population included recipients of SOTs performed in Italy during a 1-year period i n ten Italian lung transplant units and eight liver transplant units. Data on comorbidities, infections, retransplantation, and death were prospectively collected using a web-based system, with a 6-month follow-up. The cumulative incidence of infection was 31.7% and 47.8% in liver and...
Source: European Journal of Clinical Microbiology and Infectious Diseases - February 18, 2018 Category: Microbiology Source Type: research
Lung Retransplantation: Practical and Ethical Considerations Raised by the Hannover Protocol
No abstract available (Source: Transplantation)
Source: Transplantation - February 17, 2018 Category: Transplant Surgery Tags: Commentaries Source Type: research
Tissue-Resident Lymphocytes in Solid Organ Transplantation: Innocent Passengers or the Key to Organ Transplant Survival?
Short-term outcomes of solid organ transplantation have improved dramatically over the past several decades; however, long-term survival has remained static over the same period, and chronic rejection remains a major cause of graft failure. The importance of donor, or “passenger,” lymphocytes to the induction of tolerance to allografts was recognized in the 1990s, but their precise contribution to graft acceptance or rejection has not been elucidated. Recently, specialized populations of tissue-resident lymphocytes in nonlymphoid organs have been described. These lymphocytes include tissue-resident memory T cel...
Source: Transplantation - February 17, 2018 Category: Transplant Surgery Tags: Reviews Source Type: research
Selective CD28 Inhibition Modulates Alloimmunity and Cardiac Allograft Vasculopathy in Anti–CD154-Treated Monkeys
Conclusions Induction with sc28AT promotes early cardiac allograft protection in hu5C8-treated NHPs. These results support further investigation of prolonged selective CD28 inhibition with CD40/CD154 blockade in NHP transplants. (Source: Transplantation)
Source: Transplantation - February 17, 2018 Category: Transplant Surgery Tags: Original Basic Science—General Source Type: research
Technique and Outcomes of Less Invasive Lung Retransplantation
Conclusions Less invasive retransplantation of the lung via sternum-sparing anterolateral thoracotomies and off-pump is a safe procedure with low associated morbidity and favorable midterm survival. (Source: Transplantation)
Source: Transplantation - February 17, 2018 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Heart failure following the norwood procedure: An analysis of the single ventricle reconstruction trial
Heart failure results in significant morbidity and mortality for young children with hypoplastic left heart syndrome (HLHS) following the Norwood procedure. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 17, 2018 Category: Transplant Surgery Authors: William T. Mahle, Chenwei Hu, Felicia Trachtenberg, JonDavid Menteer, Steven J. Kindel, Anne I. Dipchand, Marc E. Richmond, Kevin P. Daly, Heather T. Henderson, Kimberly Y. Lin, Michael McCulloch, Ashwin K. Lal, Kurt R. Schumacher, Jeffrey P. Jacobs, Andr Source Type: research
Perioperative desensitization – A promising strategy for overcoming the antibody barrier in heart transplantation
Incompatibility to HLA antigens was the sentinel barrier which historically limited solid organ transplantation. The development of the complement dependent cytotoxicity (CDC) assay by Terasaki half a century ago allowed estimation of rejection risk at transplantation.1 Subsequent emergence of effective immunosuppressive regimens led to significant expansion of transplantation as a suitable therapeutic option for end-stage organ disease. In heart transplantation, the resulting improvement in outcomes has led to a corresponding broadening of the indications for transplant. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 17, 2018 Category: Transplant Surgery Authors: Jignesh K. Patel Source Type: research
A strategy for prevention of fungal infections in lung transplantation: role of bronchoalveolar lavage fluid galactomannan and fungal culture
The optimal strategy for prevention of invasive fungal infections in lung transplant recipients remains undetermined. We studied a bronchoalveolar lavage fungal culture and galactomannan based strategy for prevention of invasive aspergillosis in lung transplant recipients (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 17, 2018 Category: Transplant Surgery Authors: Shahid Husain, Archana Bhaskaran, Coleman Rotstein, Yanhong Li, Alyajahan Bhimji, Rhea Pavan, Deepali Kumar, Atul Humar, Shaf Keshavjee, Lianne G. Singer Source Type: research
Immunopathogenesis of Primary Graft Dysfunction After Lung Transplantation
Publication date: March 2018 Source:The Annals of Thoracic Surgery, Volume 105, Issue 3 Author(s): Ankit Bharat, Daniel Kreisel (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - February 16, 2018 Category: Cardiovascular & Thoracic Surgery Source Type: research
Long-Term Survival in Bilateral Lung Transplantation for Scleroderma-Related Lung Disease
Conclusions Despite being at high risk for extrapulmonary complications, patients undergoing bilateral lung transplantation for scleroderma have similar 1-year and 5-year survival as those with restrictive lung disease. Transplantation is a reasonable treatment option for a carefully selected population of candidates. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - February 16, 2018 Category: Cardiovascular & Thoracic Surgery Source Type: research
Radiologic and Functional Analysis of Compensatory Lung Growth After Living-Donor Lobectomy
Conclusions The volume of ipsilateral residual lung increased, but its structural quality did not change before and after donor lobectomy. The existence of compensatory lung growth in adult humans was suggested by quantitative and qualitative computed tomography assessments. Graphical abstract (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - February 16, 2018 Category: Cardiovascular & Thoracic Surgery Source Type: research
First experience in Switzerland in Phe508del homozygous cystic fibrosis patients with end-stage pulmonary disease enrolled in a lumacaftor-ivacaftor therapy trial - preliminary results.
n C Abstract AIMS OF THE STUDY: Cystic fibrosis is the most common genetic disorder in Caucasians. The combination of the cystic fibrosis transmembrane conductance regulator (CFTR) corrector lumacaftor / potentiator ivacaftor (LUM/IVA) has been shown to increase forced expiratory volume in 1 second (FEV1) moderately, but predominantly reduce acute exacerbation rate (AER) in Phe508del homozygous cystic fibrosis patients; however, patients with FEV1
Source: Swiss Medical Weekly - February 16, 2018 Category: General Medicine Authors: Murer C, Huber LC, Kurowski T, Hirt A, Robinson CA, Bürgi U, Benden C Tags: Swiss Med Wkly Source Type: research
Information for Readers
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 15, 2018 Category: Transplant Surgery Source Type: research
A Novel Technique for En Bloc Kidney Transplantation from Infant Donors with Extremely Low Body Weight by using the Distal Abdominal Aorta as an Outflow Tract
In conclusion, this novel en bloc kidney transplantation technique using a modified arterial inflow and outflow tract can prevent vascular thrombosis and provide adequate graft function. This article is protected by copyright. All rights reserved. (Source: American Journal of Transplantation)
Source: American Journal of Transplantation - February 15, 2018 Category: Transplant Surgery Authors: Helong Dai, Longkai Peng, Fenghua Peng, Gongbin Lan, Yu Wang, Jingjing Chen, Lei Liu, Chen Gao, Yong Guo, Chunhua Fang, Manhua Nie, Wang Long, Shaojie Yu Tags: Original Article Source Type: research
Towards Donor Lung Recovery ‐ Gene Expression Changes During Ex Vivo Lung Perfusion of Human Lungs
This article is protected by copyright. All rights reserved. (Source: American Journal of Transplantation)
Source: American Journal of Transplantation - February 15, 2018 Category: Transplant Surgery Authors: Jonathan C. Yeung, Ricardo Zamel, William Klement, Xiao ‐Hui Bai, Tiago N. Machuca, Thomas K. Waddell, Mingyao Liu, Marcelo Cypel, Shaf Keshavjee Tags: Brief Communication Source Type: research
Clinical Outcomes of Lung Transplantation: Experience at Asan Medical Center.
Conclusion: Despite a high percentage of patients who required preoperative intensive care, the transplantation outcomes were acceptable. PMID: 29430425 [PubMed] (Source: Korean Journal of Thoracic and Cardiovascular Surgery)
Source: Korean Journal of Thoracic and Cardiovascular Surgery - February 14, 2018 Category: Cardiovascular & Thoracic Surgery Tags: Korean J Thorac Cardiovasc Surg Source Type: research
Adherence to Mediterranean and low-fat diets among heart and lung transplant recipients: a randomized feasibility study
Heart and lung transplant recipients are at a substantially increased risk of cardiovascular disease (CVD). Since both low-fat and Mediterranean diets can reduce CVD in immunocompetent people at high risk, we ... (Source: Nutrition Journal)
Source: Nutrition Journal - February 14, 2018 Category: Nutrition Authors: Timothy R. Entwistle, Ad èle C. Green, James E. Fildes and Kyoko Miura Tags: Research Source Type: research
Lung transplantation after allogeneic stem cell transplantation: a pan-European experience
This study assesses survival in highly selected patients undergoing lung transplantation for LONIPCs after SCT. SCT patients undergoing lung transplantation at 20 European centres between 1996 and 2014 were included. Clinical data pre- and post-lung transplantation were reviewed. Propensity score-matched controls were generated from the Eurotransplant and Scandiatransplant registries. Kaplan–Meier survival analysis and Cox proportional hazard regression models evaluating predictors of graft loss were performed. Graft survival at 1, 3 and 5 years of 84%, 72% and 67%, respectively, among the 105 SCT patients prove...
Source: European Respiratory Journal - February 14, 2018 Category: Respiratory Medicine Authors: Greer, M., Berastegui, C., Jaksch, P., Benden, C., Aubert, J., Roux, A., Lhuillier, E., Hirschi, S., Reynaud-Gaubert, M., Philit, F., Claustre, J., LePalud, P., Stern, M., Knoop, C., Vos, R., Verschuuren, E., Fisher, A., Riise, G., Hansson, L., Iversen, M Tags: Interstitial and orphan lung disease Original Articles: Rare lung disease Source Type: research
This article reviews the advantages and limitations of each technique used over the past few decades in clinical practice. The main limitation seems to be the capacity for tracheal tissue regeneration. The physiopathology behind this has yet to be fully understood. Research on stem cells sparked much interest and was thought to be a revolutionary technique; however, the poor long-term results of this approach highlight that there is a long way to go in this research field. Currently, an autologous tissue composite, with or without a tracheal allograft, is the only long-term working solution for every aetiology, despite its...
Source: European Respiratory Journal - February 14, 2018 Category: Respiratory Medicine Authors: Etienne, H., Fabre, D., Gomez Caro, A., Kolb, F., Mussot, S., Mercier, O., Mitilian, D., Stephan, F., Fadel, E., Dartevelle, P. Tags: Lung cancer Reviews Source Type: research
Early Fundoplication is Associated with Slower Decline in Lung Function After Lung Transplantation in Patients with Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD) is prevalent after lung transplantation. Fundoplication slows lung function decline in patients with GERD, but the optimal timing of fundoplication is unknown. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - February 13, 2018 Category: Cardiovascular & Thoracic Surgery Authors: Sreeja Biswas Roy, Shaimaa Elnahas, Rosemarie Serrone, Cassandra Haworth, Michael T. Olson, Paul Kang, Michael A. Smith, Ross M. Bremner, Jasmine Huang Source Type: research
Lung in a Box: Ex Vivo Lung Transplantation
THE HIGHEST NUMBER of recorded lung transplants in the United States was reached in 2015 with 2,072 lungs transplanted. Despite this increase, waitlist mortality is at the highest ever, with 16.5 deaths per 100 waitlist years.1 Only 65.3% of transplant candidates receive an organ within 1 year of appearing on the wait list. Nearly 7.5% of harvested lungs are discarded,2 and many donated lungs are rejected, representing an area of potential growth for the donor pool. Newer technologies such as ex vivo lung perfusion (EVLP) seek to improve the function of abandoned organs to increase the number of viable lungs for transplant...
Source: Journal of Cardiothoracic and Vascular Anesthesia - February 12, 2018 Category: Anesthesiology Authors: Elizabeth K. Healy Cotter, Jennifer M. Banayan, Tae H. Song, Mark A. Chaney, Hanjo Ko, Edward Cantu, Joshua Diamond, Stuart J. Weiss, Marcelo Cypel, Shaf Keshavjee Tags: Case Conference Source Type: research
Chronic infection sustained by a Pseudomonas aeruginosa High-Risk clone producing the VIM-1 metallo- β-lactamase in a cystic fibrosis patient after lung transplantation
The significance of chronic lung infection by multidrug-resistant (MDR) pathogens in Cystic Fibrosis (CF) transplanted patients remains controversial, and the available information is overall limited. Here we describe the case of a chronic infection, sustained by a metallo- β-lactamase (MBL)-producing P. aeruginosa strain, in a CF patient following lung transplantation. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - February 12, 2018 Category: Respiratory Medicine Authors: Simona Pollini, Claudia Mugnaioli, Daniela Dolce, Silvia Campana, Anna Silvia Neri, Giovanni Taccetti, Gian Maria Rossolini Tags: Short Communication Source Type: research
Efficacy and safety of trans ‐bronchial cryo in comparison with forceps biopsy in lung allograft recipients: analysis of 402 procedures
Abstract BackgroundTrans‐bronchial forceps biopsy (TBFB) is the gold standard to establish the presence of allograft rejection or infection after lung transplantation. We aimed to analyze the diagnostic yield and safety of Trans‐bronchial cryo biopsy (TBCB) in lung allografts. MethodsRetrospective analysis of 402 TBB procedures in 362 lung allograft recipients performed between 2011 to 2016 .Half cases (201) were done by TBCB and other half by TBFB. 100 random slides of TBB specimens from lung allografts were reviewed for artifacts, bleeding and histological evidence. ResultsBoth TBB groups were comparable in age, gend...
Source: Clinical Transplantation - February 12, 2018 Category: Transplant Surgery Authors: Evgeni Gershman, Elena Ridman, Ludmila Fridel, Osnat Shtraichman, Barak Perzov, Dror Rosengarten, Nader Abdel Rahim, Dorit Shitenberg, Mordechai R. Kramer Tags: Original Article Source Type: research
Cognitive improvement following ischemia/reperfusion injury induced by voluntary running ‑wheel exercise is associated with LncMALAT1‑mediated apoptosis inhibition.
Cognitive improvement following ischemia/reperfusion injury induced by voluntary running‑wheel exercise is associated with LncMALAT1‑mediated apoptosis inhibition. Int J Mol Med. 2018 Feb 12;: Authors: Shang JL, Cheng Q, Duan SJ, Li L, Jia LY Abstract Previous human and animal studies demonstrated that voluntary exercise may improve cognitive function and facilitate neuronal plasticity in ischemia/reperfusion (I/R) models. However, the possible underlying mechanisms remain to be elucidated. Metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1), a long noncoding RNA (lncRNA), may b...
Source: International Journal of Molecular Medicine - February 12, 2018 Category: Molecular Biology Authors: Shang JL, Cheng Q, Duan SJ, Li L, Jia LY Tags: Int J Mol Med Source Type: research
Esophageal motor disorders are frequent during pre and post lung transplantation. Can they influence lung rejection?
CONCLUSION: significant changes in esophageal motility were observed pre-LTx and particularly post-LTx; hypercontractile esophagus was a frequent EMD found post-LTx. EMD were more frequent in the group of patients that experienced organ rejection compared to the non-rejection group. EMD leading to an impaired esophageal clearance should be considered as an additional factor that contributes to LTx failure. PMID: 29421915 [PubMed - as supplied by publisher] (Source: Revista Espanola de Enfermedades Digestivas)
Source: Revista Espanola de Enfermedades Digestivas - February 11, 2018 Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
Changes in quality of life and functional capacity after lung transplantation: A single-center experience.
Authors: Ricotti S, Martinelli V, Caspani P, Monteleone S, Petrucci L, Dalla Toffola E, Klersy C Abstract Lung transplantation (LT) increases the life expectancy of patients affected by end stage pulmonary disease; specifically, its ultimate aims are to improve survival and health related quality of life (HRQoL). The aim of the present longitudinal study was to determine the HRQoL trajectory and changes in functional capacity from time of entry in the waiting list for LT to 2 year after LT. The study included sixty-nine outpatients enrolled in a single medical center when they entered the waiting list for LT and wh...
Source: Monaldi Archives for Chest Disease - February 10, 2018 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
Hydrostatic pressure gradient ultrafiltration device: A novel approach for extracellular fluid removal
The effectiveness of diuretic treatment can decrease over time due to reduced tubular luminal concentrations, distal tubular adaptation, uremia and increased central venous pressure.1 Diuretic resistance is associated with insufficient symptom relief, higher risk of HF worsening, and increased morbidity (re-hospitalization rates) and mortality.2,3 (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 9, 2018 Category: Transplant Surgery Authors: Yair Feld, Nitai Hanani, Maria Rosa Costanzo Source Type: research
Prognostic relevance of appropriate renal function evaluation in pulmonary arterial hypertension
Biomarkers are essential tools for disease management and prognostic evaluation in various clinical settings, including pulmonary arterial hypertension (PAH).1 They might be related to inner pathophysiological mechanisms or to direct consequences of disease progression. For instance, the hemodynamic impairment characteristic of PAH creates a condition of chronic low tissue perfusion, predisposing to different systemic organ failures. Renal failure is a clear example of this pathological state and its presence has been shown of clinical relevance in many different forms of cardiovascular disease, as left ventricular failure...
Source: The Journal of Heart and Lung Transplantation - February 9, 2018 Category: Transplant Surgery Authors: Jose Leonidas Alves-Jr, Rogerio Souza Source Type: research
Second Malignancies after Hematopoietic Stem Cell Transplantation
Opinion statementSecond malignancies are a rare but well-defined late complication after autologous and allogeneic hematopoietic stem-cell transplantation (SCT). Solid malignancies occur in up to 15% of patients 15 years after SCT with myeloablative conditioning, with no plateau in the incidence rates. They are responsible for 5–10% of late deaths after SCT. The incidence is increased with advanced age at SCT. The major risk factors are the use of total body irradiation, which is associated with adenocarci nomas and with chronic graft-versus-host disease which is associated with squamous cell cancers. There is ...
Source: Current Treatment Options in Oncology - February 8, 2018 Category: Cancer & Oncology Source Type: research
Performance of a second generation pulmonary capnotracking system for continuous monitoring of cardiac output
AbstractTechnologies for minimally-invasive cardiac output measurement in patients during surgery remain little used in routine practice. We tested a redeveloped system based on CO2 elimination (VCO2) by the lungs for use in ventilated patients, which can be seamlessly integrated into a modern anesthesia/monitoring platform, and provides automated, continuous breath-by-breath cardiac output monitoring. A prototype measurement system was constructed to measure VCO2 and end-tidal CO2 concentration with each breath. A baseline measurement of non-shunt cardiac output was made during a brief oscillating change in ventilator rat...
Source: Journal of Clinical Monitoring and Computing - February 8, 2018 Category: Information Technology Source Type: research
A quality improvement program to reduce the time on the lung transplant waiting list at the Nantes University Hospital
In 2010, the time on the lung transplant waiting list in Nantes University Hospital (NUH) was 9.2 months, compared to a French national median of about 4 months. The NUH transplant unit performs both heart and... (Source: Orphanet Journal of Rare Diseases)
Source: Orphanet Journal of Rare Diseases - February 8, 2018 Category: Internal Medicine Authors: Isabelle Danner-Boucher, V éronique Loppinet, Aurore Boxus, Claire Dary, Anne Brigitte Lambert, Marine Prieur, Céline Vallet and Adrien Tissot Tags: Research Source Type: research
Gingival ulceration in a 63-year-old lung transplant recipient
A 63-year-old Caucasian female was referred for evaluation of a painful left mandibular gingival ulceration of three weeks duration. The lesion was reported to have initially presented on the buccal surface of the left first molar but over the past week had grown in size and now also involved the lingual gingiva. According to the patient it was also becoming more painful. The patient had been administered clindamycin, metronidazole, and nystatin, however the lesion showed no response to these agents. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - February 8, 2018 Category: ENT & OMF Authors: Brain M. Will, Scott M. Peters, Sidney B. Eisig, John T. Grbic, Michael A. McKenzie, Angela J. Yoon, Elizabeth M. Philipone Tags: Clinicopathologic Conference Source Type: research
Role for Cela1 in Postnatal Lung Remodeling and AAT-deficient Emphysema.
CONCLUSIONS: Cela1 is important in physiologic and pathologic stretch-dependent remodeling processes in the postnatal lung. AAT is an important regulator of this process. Our findings provide proof-of-concept for the development of anti-Cela1 therapies to prevent and/or treat AAT-deficient emphysema. PMID: 29420065 [PubMed - as supplied by publisher] (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - February 8, 2018 Category: Respiratory Medicine Authors: Joshi R, Heinz A, Fan Q, Guo S, Monia B, Schmelzer CEH, Weiss AS, Batie M, Parameshwaran H, Varisco BM Tags: Am J Respir Cell Mol Biol Source Type: research
Carvacrol nanoemulsion evokes cell cycle arrest, apoptosis induction and autophagy inhibition in doxorubicin resistant-A549 cell line.
Authors: Khan I, Bahuguna A, Bhardwaj M, Pal Khaket T, Kang SC Abstract Carvacrol is a monoterpenoid flavonoid found abundantly in thyme plants. Its physiochemical instability and partial solubility in water is the principal limitation for its industrial use. Hence, we made a carvacrol nanoemulsion (CANE) using ultrasonication method and characterized it by dynamic light scattering (DLS) technique which revealed a negative surface charge (-29.89 mV) with 99.1 nm average droplet size. CANE effectively induced apoptosis in doxorubicin-resistant A549 lung carcinoma cells (A549DR) evident by the elevated ...
Source: Artificial Cells, Nanomedicine and Biotechnology - February 7, 2018 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
[Pulmonary granuloma in an immunodepressed patient].
CONCLUSION: Outside endemic areas and in the absence of hepatic involvement pulmonary alveolar echinococcosis can be difficult to diagnose. This case report focuses on the diagnostic criteria and treatment. PMID: 29395568 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - February 7, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
Efficacy of high ‐dose steroids for bronchiolitis obliterans syndrome post pediatric hematopoietic stem cell transplantation
Abstract BOS is the pulmonary manifestation of cGvHD post‐allogeneic HSCT. Survival and treatment of this often fatal complication have not improved over the last 20 years and there is no clear standard of care. For the past 10 years, BOS was treated in our center with monthly cycles of HDPS. We reviewed the outcomes of patients with post‐HSCT BOS who met the diagnostic criteria for BOS as per the NIH consensus and were treated with at least one cycle of methylprednisolone at a dose of 10‐30 mg/kg/d×3 d. We collected demographic and clinical data, responses to treatment and results of pulmon...
Source: Pediatric Transplantation - February 7, 2018 Category: Transplant Surgery Authors: Ehud Even ‐Or, Hasan Ghandourah, Muhammad Ali, Joerg Krueger, Neil B. Sweezey, Tal Schechter Tags: ORIGINAL ARTICLE Source Type: research
ISHLT Consensus Statement on Adult and Pediatric Airway Complications after Lung Transplantation: Definitions, Grading System and Therapeutics
Airway complications remain an important cause of morbidity and mortality after cardiothoracic transplantation. The reported incidence of airway ischemic complications varies widely, contributed to by a lack of a universally accepted grading system and standardized definitions. Furthermore, the majority of the existing classification systems fail to integrate the wide range of possible bronchial complications which may develop post lung transplant. Hence, a working group was created by the International Society for Heart and Lung transplantation with the aim of elaborating a universal definition of adult and pediatric airw...
Source: The Journal of Heart and Lung Transplantation - February 7, 2018 Category: Transplant Surgery Authors: Maria M. Crespo, Daniel P. McCarthy, Peter M. Hopkins, Stephen C. Clark, Marie Budev, Christian A. Bermudez, Christian Benden, Pirooz Eghtesady, Erika Lease, Lorriana Leard, Jonathan D ’Cunha, Christopher H. Wigfield, Marcelo Cypel, Joshua M. Diamond, J Source Type: research
Lung Transplantation from Hepatitis C Viremic Donors to Uninfected Recipients.
PMID: 29412687 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 7, 2018 Category: Respiratory Medicine Authors: Abdelbasit A, Hirji A, Halloran K, Weinkauf J, Kapasi A, Lien D, Nagendran J, Doucette K Tags: Am J Respir Crit Care Med Source Type: research
Chronic interstitial lung disease in children
Children's interstitial lung diseases (chILD) are increasingly recognised and contain many lung developmental and genetic disorders not yet identified in adult pneumology. Worldwide, several registers have been established. The Australasian Registry Network for Orphan Lung Disease (ARNOLD) has identified problems in estimating rare disease prevalence; focusing on chILD in immunocompetent patients, a period prevalence of 1.5 cases per million children and a mortality rate of 7% were determined. The chILD-EU register highlighted the workload to be covered per patient included and provided protocols for diagnosis and ini...
Source: European Respiratory Review - February 7, 2018 Category: Respiratory Medicine Authors: Griese, M. Tags: Interstitial and orphan lung disease Mini-review: Paediatric Year in Review Source Type: research
Bioengineering Human Lung Grafts on Porcine Matrix
Conclusions: Engineering and transplantation of viable lung grafts based on decellularized porcine lung scaffolds and human endothelial and epithelial cells is technically feasible. Further graft maturation will be necessary to enable higher-level functions such as mucociliary clearance, and ventilation-perfusion matching. (Source: Annals of Surgery)
Source: Annals of Surgery - February 6, 2018 Category: Surgery Tags: Original Articles Source Type: research
Patterns of kidney injury in pediatric nonkidney solid organ transplant recipients
The incidence of acute kidney injury (AKI) and its impact on chronic kidney disease (CKD) following pediatric nonkidney solid organ transplantation is unknown. We aimed to determine the incidence of AKI and CKD and examine their relationship among children who received a heart, lung, liver, or multiorgan transplant at the Hospital for Sick Children between 2002 and 2011. AKI was assessed in the first year posttransplant. Among 303 children, perioperative AKI (within the first week) occurred in 67% of children, and AKI after the first week occurred in 36%, with the highest incidence among lung and multiorgan recipients. Twe...
Source: American Journal of Transplantation - February 6, 2018 Category: Transplant Surgery Authors: C. Williams, K. Borges, T. Banh, J. Vasilevska ‐Ristovska, R. Chanchlani, V. L. Ng, A. I. Dipchand, M. Solomon, D. Hebert, S. J. Kim, B. C. Astor, R. S. Parekh Tags: ORIGINAL ARTICLE Source Type: research
Effect of Electrical Dyssynchrony on Left and Right Ventricular Mechanics in Children with Pulmonary Arterial Hypertension
Electrical and right ventricular (RV) mechanical dyssynchrony has been previously described in pediatric pulmonary arterial hypertension (PAH). Less is known about the relationship between electrical dyssynchrony and biventricular function. We applied cardiac MRI (CMR) to evaluate biventricular size and function with focus on left ventricular (LV) strain mechanics in pediatric PAH patients with and without electrical dyssynchrony. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 6, 2018 Category: Transplant Surgery Authors: Michal Sch äfer, Kathryn K. Collins, Lorna P. Browne, D. Dunbar Ivy, Steven Abman, Richard Friesen, Benjamin Frank, Brian Fonseca, Michael DiMaria, Kendall S. Hunter, Uyen Truong, Johannes C. von Alvensleben Source Type: research
A membrane-type surfactant protein D (SP-D) suppresses macrophage-mediated cytotoxicity in swine endothelial cells.
CONCLUSIONS: These findings indicate that the membrane-type SP-D serve as an effective therapeutic strategy for inhibiting macrophage-mediated xenograft rejection in xenotransplantation. PMID: 29425774 [PubMed - as supplied by publisher] (Source: Transplant Immunology)
Source: Transplant Immunology - February 6, 2018 Category: Transplant Surgery Authors: Jiaravuthisan P, Maeda A, Takakura C, Wang HT, Sakai R, Shabri AM, Lo PC, Matsuura R, Kodama T, Eguchi H, Okuyama H, Miyagawa S Tags: Transpl Immunol Source Type: research
Prolonged extracorporeal membrane oxygenation for pediatric necrotizing pneumonia due to Streptococcus pneumonia and influenza H1N1 co-infection: how long should we wait for native lung recovery?
This report shows that unexpected native lung recovery is possible even after prolonged loss of lung function an d that a previous healthy lung can recover from apparent irreversible lung injury. (Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - February 5, 2018 Category: Transplant Surgery Source Type: research
Role of Artificial Intelligence in the Care of Patients with Non-Small Cell Lung Cancer.
CONCLUSION: We present a review of the various applications of ML methods in NSCLC as it relates to improving diagnosis, treatment and outcomes. This article is protected by copyright. All rights reserved. PMID: 29405289 [PubMed - as supplied by publisher] (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - February 5, 2018 Category: Cancer & Oncology Authors: Rabbani M, Kanevsky J, Kafi K, Chandelier F, Giles FJ Tags: Eur J Clin Invest Source Type: research
Prevalence of Chagas Disease among Solid Organ-Transplanted Patients in a Nonendemic Country.
rave; J, Molina I Abstract Reactivation of Chagas disease in the chronic phase may occur after solid organ transplantation, which may result in high parasitemia and severe clinical manifestations such as myocarditis and meningoencephalitis. The aim of the present study is to describe the prevalence of Chagas disease among solid organ-transplanted patients in a tertiary hospital from a nonendemic country. A cross-sectional study was performed at Vall d'Hebron University Hospital (Barcelona, Spain) from April to September 2016. Chagas disease screening was performed through serological tests in adult patients coming...
Source: The American Journal of Tropical Medicine and Hygiene - February 5, 2018 Category: Tropical Medicine Authors: Salvador F, Sánchez-Montalvá A, Sulleiro E, Moreso F, Berastegui C, Caralt M, Pinazo MJ, Moure Z, Los-Arcos I, Len O, Gavaldà J, Molina I Tags: Am J Trop Med Hyg Source Type: research
Does recipient work status pre-transplant affect post-heart transplant survival? —A united network for organ sharing database review
Recipient-related factors such as education level and type of health insurance are known to affect heart transplantation outcomes. Preoperative employment status has shown an association with survival in abdominal organ transplant patients. We sought to evaluate the effect of work status of heart transplant (HTX) recipients at the time of listing and at the time of transplantation on short- and long-term survival. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 4, 2018 Category: Transplant Surgery Authors: Yazhini Ravi, Srihari K. Lella, Laurel A. Copeland, Kiumars Zolfaghari, Kathleen Grady, Sitaramesh Emani, Chittoor B. Sai-Sudhakar Source Type: research
Second annual report from the ISHLT mechanically assisted circulatory support (IMACS) registry
The second annual IMACS registry report includes over 14, 000 patients from 35 countries. Survival, adverse events, and an updated risk model is presented. Continuous flow pumps continue to dominate the world ’s experience. One and Two-year survival remains at 80% and 70%. Congenital heart disease and biventricular support are the most dominant risk factors. The database is poised for major novel analyses. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 4, 2018 Category: Transplant Surgery Authors: James K. Kirklin, Rongbing Xie, Jennifer Cowger, Theo M.M.H. de By, Takeshi Nakatani, Stephan Schueler, Rhiannon Taylor, Jenny Lannon, Paul Mohacsi, Jan Gummert, Daniel Goldstein, Kadir Caliskan, Margaret M. Hannan Source Type: research