Living Donor Lung Transplantation After Hematopoietic Stem Cell Transplantation From the Same Donor: A Risk Worth Taking
We report a successful case of father-to-child single-lobe LT, because of the complications of hematopoietic stem cell transplantation from the same donor, with initial low-dose immunosuppressive therapy and subsequent early discontinuation. Full donor chimerism was hypothesized to be a mechanism of transplant tolerance, and this postulated immunological benefit was deemed to outweigh the risks of living donation and the possible drawbacks of single compared with bilateral LT. Favorable size matching and donor's anatomy, accurate surgical planning, and specific expertise in pediatric transplantation also contributed to the...
Source: Chest - April 10, 2024 Category: Respiratory Medicine Authors: Stefania Camagni Lorenzo D'Antiga Fabiano Di Marco Lorenzo Grazioli Ezio Bonanomi Domenico Pinelli Marta Beretta Veronica Tintori Alessandro Lucianetti Michele Colledan Source Type: research
Living Donor Lung Transplantation After Hematopoietic Stem Cell Transplantation From the Same Donor: A Risk Worth Taking
We report a successful case of father-to-child single-lobe LT, because of the complications of hematopoietic stem cell transplantation from the same donor, with initial low-dose immunosuppressive therapy and subsequent early discontinuation. Full donor chimerism was hypothesized to be a mechanism of transplant tolerance, and this postulated immunological benefit was deemed to outweigh the risks of living donation and the possible drawbacks of single compared with bilateral LT. Favorable size matching and donor's anatomy, accurate surgical planning, and specific expertise in pediatric transplantation also contributed to the...
Source: Chest - April 10, 2024 Category: Respiratory Medicine Authors: Stefania Camagni Lorenzo D'Antiga Fabiano Di Marco Lorenzo Grazioli Ezio Bonanomi Domenico Pinelli Marta Beretta Veronica Tintori Alessandro Lucianetti Michele Colledan Source Type: research
Living Donor Lung Transplantation After Hematopoietic Stem Cell Transplantation From the Same Donor: A Risk Worth Taking
We report a successful case of father-to-child single-lobe LT, because of the complications of hematopoietic stem cell transplantation from the same donor, with initial low-dose immunosuppressive therapy and subsequent early discontinuation. Full donor chimerism was hypothesized to be a mechanism of transplant tolerance, and this postulated immunological benefit was deemed to outweigh the risks of living donation and the possible drawbacks of single compared with bilateral LT. Favorable size matching and donor's anatomy, accurate surgical planning, and specific expertise in pediatric transplantation also contributed to the...
Source: Chest - April 10, 2024 Category: Respiratory Medicine Authors: Stefania Camagni Lorenzo D'Antiga Fabiano Di Marco Lorenzo Grazioli Ezio Bonanomi Domenico Pinelli Marta Beretta Veronica Tintori Alessandro Lucianetti Michele Colledan Source Type: research
Living Donor Lung Transplantation After Hematopoietic Stem Cell Transplantation From the Same Donor: A Risk Worth Taking
We report a successful case of father-to-child single-lobe LT, because of the complications of hematopoietic stem cell transplantation from the same donor, with initial low-dose immunosuppressive therapy and subsequent early discontinuation. Full donor chimerism was hypothesized to be a mechanism of transplant tolerance, and this postulated immunological benefit was deemed to outweigh the risks of living donation and the possible drawbacks of single compared with bilateral LT. Favorable size matching and donor's anatomy, accurate surgical planning, and specific expertise in pediatric transplantation also contributed to the...
Source: Chest - April 10, 2024 Category: Respiratory Medicine Authors: Stefania Camagni Lorenzo D'Antiga Fabiano Di Marco Lorenzo Grazioli Ezio Bonanomi Domenico Pinelli Marta Beretta Veronica Tintori Alessandro Lucianetti Michele Colledan Source Type: research
Environment and lung health in a rapidly changing world
Extract
This issue of the European Respiratory Review features the first articles in a series of reviews entitled "Environment and lung health in a rapidly changing world". This series aims to highlight and dissect the complex intersections of environmental factors and their impact on human lung health. Additionally, the series addresses some more specific issues that we continue to face in the 21st century, including health inequity, the increasingly fast-paced integration of artificial intelligence (AI) into every day medical practice and climate change. (Source: European Respiratory Review)
Source: European Respiratory Review - April 10, 2024 Category: Respiratory Medicine Authors: Greene, C. M., Riha, R. L. Tags: Epidemiology, occupational and environmental lung disease Editorials Source Type: research
Using Artificial Intelligence to Predict Mechanical Ventilation Weaning Success in Patients with Respiratory Failure, Including Those with Acute Respiratory Distress Syndrome
J Clin Med. 2024 Mar 5;13(5):1505. doi: 10.3390/jcm13051505.ABSTRACTThe management of mechanical ventilation (MV) remains a challenge in intensive care units (ICUs). The digitalization of healthcare and the implementation of artificial intelligence (AI) and machine learning (ML) has significantly influenced medical decision-making capabilities, potentially enhancing patient outcomes. Acute respiratory distress syndrome, an overwhelming inflammatory lung disease, is common in ICUs. Most patients require MV. Prolonged MV is associated with an increased length of stay, morbidity, and mortality. Shortening the MV duration has ...
Source: Pain Physician - April 9, 2024 Category: Anesthesiology Authors: Tamar Stivi Dan Padawer Noor Dirini Akiva Nachshon Baruch M Batzofin Stephane Ledot Source Type: research
Impact of Blood Products Transfusion on Patients in the Immediate Post-Lung Transplant Period: A Cohort Study
CONCLUSIONS Among lung transplant recipients, PGD, ICU days, need for mechanical ventilation and ECMO support, and total composite events were significantly greater in patients who received blood transfusion perioperatively.PMID:38590090 | DOI:10.12659/AOT.943652 (Source: Annals of Transplantation)
Source: Annals of Transplantation - April 9, 2024 Category: Transplant Surgery Authors: Atif S Siddiqui Jawairia Shakil Source Type: research
Using Artificial Intelligence to Predict Mechanical Ventilation Weaning Success in Patients with Respiratory Failure, Including Those with Acute Respiratory Distress Syndrome
J Clin Med. 2024 Mar 5;13(5):1505. doi: 10.3390/jcm13051505.ABSTRACTThe management of mechanical ventilation (MV) remains a challenge in intensive care units (ICUs). The digitalization of healthcare and the implementation of artificial intelligence (AI) and machine learning (ML) has significantly influenced medical decision-making capabilities, potentially enhancing patient outcomes. Acute respiratory distress syndrome, an overwhelming inflammatory lung disease, is common in ICUs. Most patients require MV. Prolonged MV is associated with an increased length of stay, morbidity, and mortality. Shortening the MV duration has ...
Source: Pain Physician - April 9, 2024 Category: Anesthesiology Authors: Tamar Stivi Dan Padawer Noor Dirini Akiva Nachshon Baruch M Batzofin Stephane Ledot Source Type: research
Impact of Blood Products Transfusion on Patients in the Immediate Post-Lung Transplant Period: A Cohort Study
CONCLUSIONS Among lung transplant recipients, PGD, ICU days, need for mechanical ventilation and ECMO support, and total composite events were significantly greater in patients who received blood transfusion perioperatively.PMID:38590090 | DOI:10.12659/AOT.943652 (Source: Annals of Transplantation)
Source: Annals of Transplantation - April 9, 2024 Category: Transplant Surgery Authors: Atif S Siddiqui Jawairia Shakil Source Type: research
Impact of Blood Products Transfusion on Patients in the Immediate Post-Lung Transplant Period: A Cohort Study
CONCLUSIONS Among lung transplant recipients, PGD, ICU days, need for mechanical ventilation and ECMO support, and total composite events were significantly greater in patients who received blood transfusion perioperatively.PMID:38590090 | DOI:10.12659/AOT.943652 (Source: Annals of Transplantation)
Source: Annals of Transplantation - April 9, 2024 Category: Transplant Surgery Authors: Atif S Siddiqui Jawairia Shakil Source Type: research
Impact of Blood Products Transfusion on Patients in the Immediate Post-Lung Transplant Period: A Cohort Study
CONCLUSIONS Among lung transplant recipients, PGD, ICU days, need for mechanical ventilation and ECMO support, and total composite events were significantly greater in patients who received blood transfusion perioperatively.PMID:38590090 | PMC:PMC11015745 | DOI:10.12659/AOT.943652 (Source: Annals of Transplantation)
Source: Annals of Transplantation - April 9, 2024 Category: Transplant Surgery Authors: Atif S Siddiqui Jawairia Shakil Source Type: research
Impact of Blood Products Transfusion on Patients in the Immediate Post-Lung Transplant Period: A Cohort Study
CONCLUSIONS Among lung transplant recipients, PGD, ICU days, need for mechanical ventilation and ECMO support, and total composite events were significantly greater in patients who received blood transfusion perioperatively.PMID:38590090 | PMC:PMC11015745 | DOI:10.12659/AOT.943652 (Source: Annals of Transplantation)
Source: Annals of Transplantation - April 9, 2024 Category: Transplant Surgery Authors: Atif S Siddiqui Jawairia Shakil Source Type: research
Novel Strategies for Optimization of the Pre-transplant Donor Lung
AbstractPurpose of ReviewWhile the number of lung transplants continues to increase, there remains an imbalance between potential lung transplant candidates and acceptable donor lungs resulting in excess mortality. We sought to describe the current state of donor acceptance practices and highlight novel approaches that have the potential to result in an increase in acceptable lungs available for transplant.Recent FindingsIncreased utilization of lungs from donors with positive nucleic acid amplification tests for hepatitis C, donation after circulatory death, lungs conditioned for transplant at Centralized Lung Evaluation ...
Source: Current Respiratory Care Reports - April 9, 2024 Category: Respiratory Medicine Source Type: research
The role of coronary artery disease in lung transplantation: a propensity-matched analysis
CONCLUSION: In this cohort, relevant CAD was not associated with worse outcomes and should therefore not be considered a contraindication for LuTx. Nonetheless, cardiovascular events in CAD patients highlight the necessity of control of cardiovascular risk factors and a structured cardiac follow-up.PMID:38587564 | DOI:10.1007/s00392-024-02445-y (Source: Clin Med Res)
Source: Clin Med Res - April 8, 2024 Category: Research Authors: Enzo L üsebrink Nils Gade Paula Seifert Felix Ceelen Tobias Veit Fabian Fohrer Sabine Hoffmann Julia H öpler Leonhard Binzenh öfer Daniel Roden Inas Saleh Hugo Lanz Sebastian Michel Christian Schneider Michael Irlbeck Roland Tomasi Rudolf Hatz J örg H Source Type: research
The role of coronary artery disease in lung transplantation: a propensity-matched analysis
CONCLUSION: In this cohort, relevant CAD was not associated with worse outcomes and should therefore not be considered a contraindication for LuTx. Nonetheless, cardiovascular events in CAD patients highlight the necessity of control of cardiovascular risk factors and a structured cardiac follow-up.PMID:38587564 | DOI:10.1007/s00392-024-02445-y (Source: Clin Med Res)
Source: Clin Med Res - April 8, 2024 Category: Research Authors: Enzo L üsebrink Nils Gade Paula Seifert Felix Ceelen Tobias Veit Fabian Fohrer Sabine Hoffmann Julia H öpler Leonhard Binzenh öfer Daniel Roden Inas Saleh Hugo Lanz Sebastian Michel Christian Schneider Michael Irlbeck Roland Tomasi Rudolf Hatz J örg H Source Type: research
