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The Efficacy and Mechanism Evaluation of Treating Idiopathic Pulmonary fibrosis with the Addition of Co-trimoxazole (EME-TIPAC): study protocol for a randomised controlled trial
DiscussionThe trial is designed to test the hypothesis that treating IPF patients with co-trimoxazole will increase the time to death (all causes), lung transplant or first non-elective hospital admission compared to standard care (https://www.nice.org.uk/guidance/cg163), in patients with moderate to severe disease.The mechanistic aims are to investigate the effect on lung microbiota and other measures of infection, markers of epithelial injury and markers of neutrophil activity.Trial registrationInternational Standard Randomised Controlled Trials Number (ISRCTN) Registry, ID:17464641. Registered on 29 January 2015. (Source: Trials)
Source: Trials - February 5, 2018 Category: Research Source Type: clinical trials

Hyperpolarized Xenon MRI for Assessment of Pulmonary Function in Lung Transplant
Condition:   Pulmonary Surgical Procedures Interventions:   Drug: 129Xe MRI;   Drug: 133XE scintigraphy Sponsor:   Polarean Imaging Ltd. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 1, 2018 Category: Research Source Type: clinical trials

Infusion of Expanded Cord Blood Cells in Addition to Single Cord Blood Transplant in Treating Patients With Acute Leukemia, Chronic Myeloid Leukemia, or Myelodysplastic Syndromes
Conditions:   Acute Biphenotypic Leukemia;   Acute Lymphoblastic Leukemia in Remission;   Acute Myeloid Leukemia in Remission;   Blasts Under 10 Percent of Bone Marrow Nucleated Cells;   Blasts Under 5 Percent of Bone Marrow Nucleated Cells;   Chronic Myelogenous Leukemia, BCR-ABL1 Positive ;   Cytogenetic Abnormality;   High Risk Myelodysplastic Syndrome;   Myelodysplastic Syndrome With Excess Blasts;   Pancytopenia;   Refractory Anemia Interventions: &nb...
Source: ClinicalTrials.gov - January 15, 2018 Category: Research Source Type: clinical trials

Impact of Draining Significant Effusion on Gas Exchange and Lung Mechanics in Patient Under Mechanical Ventilation
Conditions:   Respiration, Artificial;   Pleural Effusion;   Ultrasonography Intervention:   Procedure: Drainage of the pleural effusion Sponsor:   Dokuz Eylul University Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 9, 2018 Category: Research Source Type: clinical trials

Belatacept Pilot Study in Lung Transplantation Immunosuppression in Lung Transplantation
Conditions:   Lung Transplant Rejection;   Antibody-mediated Rejection Interventions:   Drug: Belatacept;   Drug: Tacrolimus;   Drug: ATG;   Drug: Mycophenolate Mofetil;   Drug: Methylprednisolone;   Drug: Prednisone Sponsors:   Ramsey Hachem;   National Heart, Lung, and Blood Institute (NHLBI);   Bristol-Myers Squibb Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 1, 2018 Category: Research Source Type: clinical trials