Commissioning Healthcare Policy: Hospital Readmission and Its Price Tag
By ANISH KOKA MD  The message comes in over the office slack line at 1:05 pm. There are four patients in rooms, one new, 3 patients in the waiting room. Really, not an ideal time to deal with this particular message. “Kathy the home care nurse for Mrs. C called and said her weight yesterday was 185, today it is 194, she has +4 pitting edema, heart rate 120, BP 140/70 standing, 120/64 sitting” I know Mrs. C well. She has severe COPD from smoking for 45 of the last 55 years. Every breath looks like an effort because it is. The worst part of it all is that Mrs. C just returned home from the hospital just days...
Source: The Health Care Blog - January 10, 2019 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Hospitals Medicare Anish Koka hospital readmissions HRRP MedPAC Source Type: blogs

Fight Aging! Newsletter, January 7th 2019
This study suggests that advantages and disadvantages vary by environment and diet, however, which might explain why evolution has selected for multiple haplogroups rather than one dominant haplogroup. This is all interesting, but none of it stops the research community from engineering a globally better-than-natural human mitochondrial genome, and then copying it into the cell nucleus as a backup to prevent the well-known contribution of mitochondrial DNA damage to aging. Further, nothing stops us from keeping the haplogroups we have and rendering the effects of variants small and irrelevant through the development...
Source: Fight Aging! - January 6, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

How to ship a dead heart . . . with an assured life on delivery ?
Human body is intertwined collection of lives of Individual organs.We believe death occurs when brain dies , respiration stops and circulation ceases . Curiously ,when life ends , these organs  don’t die as a single unit . These three events can happen in any of the six possible permutations.Each organ takes different times to die after loss of life.It is like a crashed computer , where the mother board /RAM memory may be transferred to another and be functional . Out of these three , heart function appears to be supreme as it can function without the need of brain (Science of brain-death) and keep the body...
Source: Dr.S.Venkatesan MD - January 5, 2019 Category: Cardiology Authors: dr s venkatesan Tags: Heart transplantation donor heart transport transmedics Source Type: blogs

When AI Looks at X-Rays: Interview with Qure.ai CEO, Prashant Warier
If you follow the recent advances in medical technology and artificial intelligence, you may have heard people make bold claims that AI will replace tomorrow’s doctors. While there are still ways to go for technology to reach these sci-fi levels, many companies are actively designing AI systems that will accompany doctors or assist them with their daily tasks. One particularly challenging task has been to enable algorithms to examine medical images and make intelligent conclusions, create reports, or provide recommendations. Medgadget recently had the chance to ask Qure.ai’s CEO, Prashant Warier, about the stri...
Source: Medgadget - January 3, 2019 Category: Medical Devices Authors: Mohammad Saleh Tags: Exclusive Informatics Radiology Source Type: blogs

A Look Back at the Rejuvenation Research and Advocacy of 2018
Discussion of Mitochondrial Hormesis as an Approach to Slow Aging Cornelis (Cees) Wortel, Ichor Therapeutics Chief Medical Officer, on Rejuvenation Research and Its Engagement with the Established Regulatory System An Interview with a Programmed Aging Theorist An Interview with Reason at the Life Extension Advocacy Foundation An Interview on Mitochondrial Damage and Dysfunction in Aging An Interview with Vadim Gladyshev on Research into the Causes of Aging An Interview with Jim Mellon, and Update on Juvenescence A Lengthy Interview with Aubrey de Grey of the SENS Research Foundation An Interview with Peter de Keize...
Source: Fight Aging! - December 31, 2018 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs

Philips HealthWorks Supports Startups Using AI for Radiology, Ultrasound, and Oncology: Interview
In Philips innovation hubs located in Cambridge, Massachusetts, Eindhover, Netherlands, Bangalore, India, and Shanghai, China, 19 startups out of 750 applicants are taking part in an intensive, 12-week Philips HealthWorks program to accelerate their innovations. The focus of this program is leveraging artificial intelligence (AI) in healthcare with the goal to improve patient outcomes and the efficiency of care delivery. During the program, the 19 startups, representing 14 different countries, will validate their value propositions, build, test, and scale their ideas, and explore potential collaborations with Philips and o...
Source: Medgadget - December 19, 2018 Category: Medical Devices Authors: Michael Batista Tags: Exclusive Informatics Medicine Net News Oncology Radiology Society Source Type: blogs

Mission-Hostile Hospital Management: Quieter, but Still Pernicious After All These Years
Hospitals exist to take care of sick people, with the goal of making them better.  Hospitals employ and work with health care professionals, again who are sworn to put taking care of patients ahead of all other concerns.However, since we foundedHealth Care Renewal, we have noted striking examples of hospital leaders threatening their hospitals'fundamental mission and/or health care professionals'core values, which we dubbedmission-hostile management.  We also saw mission-hostile management affecting the broader health care industry, particularly pharmaceutical and device companies.  Most recently, the most s...
Source: Health Care Renewal - December 10, 2018 Category: Health Management Tags: hospitals imperial CEO managerialism mission-hostile management perverse incentives Source Type: blogs

Fight Aging! Newsletter, December 10th 2018
In conclusion, this is the first report to show that pyroptotic cell death occurs in the aging brain and that the inflammasome can be a viable target to decrease the oxidative stress that occurs as a result of aging. Reducing Levels of Protein Manufacture Slows Measures of Aging in Nematodes https://www.fightaging.org/archives/2018/12/reducing-levels-of-protein-manufacture-slows-measures-of-aging-in-nematodes/ Researchers here demonstrate that an antibiotic slows aging in nematode worms, providing evidence for it to work through a reduction in protein synthesis. Beyond a slowing of aging, one of the con...
Source: Fight Aging! - December 9, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Ignorance based cardiology : How common is “ myocardial congestion ” in cardiac failure ?
We learn from basic physiology  lessons that human body is made up of 60 % water. What about heart ? There is no reason for the heart should behave differently from rest of the body . If my  assumptions are correct when the normal heart weighs 300g  , 180g of which should be  be water. The same thing could be applicable for LV mass( * Reference requested) Is there myocardial congestion in cardiac failure ? Genesis of edema in any tissue depends on local hydrostatic pressures, tissue resistive forces, osmotic balance, and cell membrane permeability. In the myocardium individual contri...
Source: Dr.S.Venkatesan MD - November 27, 2018 Category: Cardiology Authors: dr s venkatesan Tags: cardiac failure Cardiac MRI Cardio Nephrology effect of dialysis on myocardial water content lv amss and myocardial edema myocardial edema and ckd chronic kidney failure myocardial interstitial edema myocardial water imaging water logging Source Type: blogs

Fight Aging! Newsletter, October 8th 2018
This article, unfortunately paywalled, is interesting to note as a mark of the now increasingly energetic expansion of commercial efforts in longevity science. David Sinclair has been building a private equity company to work in many areas relevant to this present generation of commercial longevity science; while I'm not sold on his primary research interests as the basis for meaningful treatments for aging, he is diversifying considerably here, including into senolytics, the clearance of senescent cells demonstrated to produce rejuvenation in animal studies. This sort of approach to business mixes aspects of investing and...
Source: Fight Aging! - October 7, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

New Artificial Intelligence Software Spots Lung Nodules on CT Scans
Detecting lung nodules on CT scans is central to diagnosing cancer and the earlier that can be accomplished the better the outcome. Currently, only about two thirds of detectable nodules are actually spotted by trained professionals. Researchers at University of Central Florida have been working on an artificial intelligence program that can review CT scans and spot nodules with near perfect accuracy. Their software, called S4ND, relies on deep learning techniques, coupled with more than 1,000 previously captured lung CT scans, to point out suspect lesions. The Central Florida team built a 3D convolutional neural network t...
Source: Medgadget - August 27, 2018 Category: Medical Devices Authors: Editors Tags: Informatics Radiology Thoracic Surgery Source Type: blogs

Fight Aging! Newsletter, August 27th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - August 26, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, August 13th 2018
We report that the disruption of excitation-contraction coupling contributes to impaired force generation in the mouse model of Sod1 deficiency. Briefly, we found a significant reduction in sarcoplasmic reticulum Ca2+ ATPase (SERCA) activity as well as reduced expression of proteins involved in calcium release and force generation. Another potential factor involved in EC uncoupling in Sod1-/- mice is oxidative damage to proteins involved in the contractile response. In summary, this study provides strong support for the coupling between increased oxidative stress and disruption of cellular excitation contraction mac...
Source: Fight Aging! - August 12, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

AI-Based Medical Imaging Expected to Generate $2 billion by 2023
Artificial intelligence (AI) will soon become common place in radiology, and the rise of algorithm-driven technology in the medical imaging industry is poised to generate $2 billion annually by 2023, according to a report from Signify Research, a United Kingdom-based healthcare data research firm.AI has slowly been transforming the imaging market with advanced methods in assisting physicians with disease detection and diagnosis and quantification processes. At last year ’s Radiological Society of North America, the spotlightwas on AI, and various software platforms showed off their deep learning-based technologi...
Source: radRounds - August 10, 2018 Category: Radiology Authors: Julie Morse Source Type: blogs

Decellularized Lungs Successfully Transplanted in Pigs
Researchers recently reported initial success in a transplant of decellularized lungs in pigs, though there is still a way to go in order to prove the ability to produce a completely functional lung in this way. In the decellularization process, donor lungs are stripped of their cells, leaving behind the extracellular matrix and its chemical cues for cell growth. The lung is then repopulated with cells derived from samples taken from the eventual recipient of the transplant. This minimizes the risk of transplant rejection. Decellularization is a short-cut technology, a way to work around the present inability to pro...
Source: Fight Aging! - August 6, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Where Is the Boundary to Augment Life?
Cloning, CRISPR and gene editing, synthetic life forms, and longevity. The latest scientific discoveries are able to offset the natural order of human existence and meddle with sacred questions of life and death. Even so, does gaining insight into the secrets of being mean it should also be put into practice? Are we aware of the consequences? Where are the boundaries to augment life? Life, death and the coin for Charon the Ferryman In Japanese folklore, the Shinigami, gods or spirits of death came to the persons who were destined to die and invited them over the threshold of life and death. In ancient Egypt, Anubis, having...
Source: The Medical Futurist - July 28, 2018 Category: Information Technology Authors: nora Tags: Bioethics Cyborgization artificial intelligence augmentation bioethical cloning CRISPR death future gene editing Health Healthcare life longevity research synthetic life Source Type: blogs

Fight Aging! Newsletter, July 23rd 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - July 22, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Oral Hygiene and Dysphagia —Care and Complications
In a recent online chat, John R. Ashford emphasized the importance of good oral hygiene to the overall health of dysphagia patients and infection control. Participant: If a participant were to remember or put into practice only one idea from your session, what would that one key takeaway be? John R. Ashford: Every patient must receive oral hygiene. Not just for social or hygiene reasons, but as a preventative for complicating illnesses. Participant: What is your recommendation on alternating solids with water (or other liquid consistency) as a means of helping oral hygiene? Ashford: Of course, rinsing a...
Source: American Speech-Language-Hearing Association (ASHA) Press Releases - July 16, 2018 Category: Speech-Language Pathology Authors: John Ashford Tags: Academia & Research Health Care Private Practice Schools Slider Speech-Language Pathology Dysphagia oral care oral hygiene Source Type: blogs

Fight Aging! Newsletter, July 16th 2018
We presently forget 98% of everything we experience. That will go away in favor of perfect, controllable, configurable memory. Skills and knowledge will become commodities that can be purchased and installed. We will be able to feel exactly as we wish to feel at any given time. How we perceive the world will be mutable and subject to choice. How we think, the very fundamental basis of the mind, will also be mutable and subject to choice. We will merge with our machines, as Kurzweil puts it. The boundary between mind and computing device, between the individual and his or her tools, will blur. Over the course of the ...
Source: Fight Aging! - July 15, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, July 9th 2018
In this study, senescent cell distribution and quantity in vastus lateralis muscle were examined in young human adults after a single bout of resistance exercise. To determine the effects of dietary protein availability around exercise on senescent cell quantity and macrophage infiltration of skeletal muscle, two isocaloric protein supplements (14% and 44% in calorie) were ingested before and immediately after an acute bout of resistance exercise, in a counter-balanced crossover fashion. An additional parallel trial was conducted to compare the outcome of muscle mass increment under the same dietary conditions after 12 wee...
Source: Fight Aging! - July 8, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

FDA Approves Zephyr Endobronchial Valve, a Minimally Invasive Implant for Severe Emphysema
The FDA approved a new medical device for patients suffering from severe emphysema. The Pulmonx Zephyr Endobronchial Valve is a one-way valve system to be implanted through the airways using a traditional bronchoscope. The valve is integrated into a stent that expands against a bronchiole to block off air flowing in and only allow it to flow out. As the trapped air flows out, ventilation/perfusion mismatch is improved, and the device relieves pressure on the healthy lung to allow for better breathing. The available data is from a multi-center study of 190 patients with severe emphysema (the LIBERATE trial), comparing Zephy...
Source: Medgadget - July 2, 2018 Category: Medical Devices Authors: Ben Ouyang Tags: Medicine Thoracic Surgery Source Type: blogs

Fight Aging! Newsletter, June 25th 2018
In this study, we investigate mitochondrial energetics and mtDNA methylation in senescent cells, and evaluate the potential of humanin and MOTS-c as novel senolytics or SASP modulators that can alleviate symptoms of frailty and extend health span by targeting mitochondrial bioenergetics. Exercise versus the Hallmarks of Aging https://www.fightaging.org/archives/2018/06/exercise-versus-the-hallmarks-of-aging/ The paper I'll point out today walks through the ways in which exercise is known to beneficially affect the Hallmarks of Aging. The Hallmarks are a list of the significant causes of aging that I dis...
Source: Fight Aging! - June 24, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The EBM Wars: When Evidence has a Price – The ECMO Trials (Part 2)
By ANISH KOKA   The year was 1965, the place was Boston Children’s and a surgery resident named Robert Bartlett took his turn at the bedside of a just born baby unable to breathe.  This particular baby couldn’t breathe because of a hole in the diaphragm that had allowed the intestines to travel up into the thoracic cage, and prevent normal development of the lungs.  In 1965, Robert Bartlett was engaged in the cutting edge treatment of the time – squeeze a bag that forced oxygenated air into tiny lungs and hope there was enough functioning lung tissue to participate in gas exchange to allow ...
Source: The Health Care Blog - June 17, 2018 Category: Consumer Health News Authors: anish_koka Tags: Uncategorized Source Type: blogs

MKSAP: 58-year-old man with idiopathic pulmonary fibrosis (IPF)
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 58-year-old man is evaluated in follow-up for idiopathic pulmonary fibrosis (IPF), which was diagnosed 2 years ago. He has cough and shortness of breath and now requires supplemental oxygen at rest. Previous evaluations have not identified any cause for his symptoms other than progressive IPF. He has participated in pulmonary rehabilitation and continues in a maintenance program. He is a lifelong nonsmoker. His medical history is otherwise unremarkable, and he takes no medications. On physical examinat...
Source: Kevin, M.D. - Medical Weblog - June 16, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Pulmonology Source Type: blogs

Fight Aging! Newsletter, June 11th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - June 10, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, June 4th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - June 3, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Can Present Stem Cell Therapies Improve Vaccine Response in the Elderly?
Mesenchymal stem cell therapies fairly reliably reduce chronic inflammation for some period of time following the transplantation of cells. The cells don't survive long in the patient, and this effect is mediated by the signals they produce while present. Chronic inflammation causes many issues, including a disruption of tissue maintenance and regeneration. It contributes directly to the progression of numerous age-related conditions, including the components of frailty syndrome, but it is an open question as to the degree to which it is required to maintain the current state of those conditions. If inflammation is suppres...
Source: Fight Aging! - May 28, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, May 28th 2018
This study indicates that frailty and other age-related diseases could be prevented and significantly reduced in older adults. Getting our heart risk factors under control could lead to much healthier old ages. Unfortunately, the current obesity epidemic is moving the older population in the wrong direction, however our study underlines how even small reductions in risk are worthwhile." The study analysed data from more than 421,000 people aged 60-69 in both GP medical records and in the UK Biobank research study. Participants were followed up over ten years. The researchers analysed six factors that could impa...
Source: Fight Aging! - May 27, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Choosing life with a VAD (ventricular assist device)
Rain splattered, blurring my view of the Massachusetts state highway. The rental car’s wipers squeaked as they dragged across the windshield. Though I was briefly tempted to turn back, I kept driving. The man with the battery-operated heart had invited me to his home, and I didn’t want to be late. I am a critical care doctor. Throughout the course of my training, I have learned how to manage a ventilator, how to treat sepsis, how to sort out the causes of renal failure. But what I didn’t learn is what comes after for those who do not die, whose lives are extended by days, months, or even years as a result...
Source: Harvard Health Blog - May 21, 2018 Category: Consumer Health News Authors: Daniela J. Lamas, MD Tags: End of life Health Heart Health Managing your health care Source Type: blogs

The Roller Coaster Ride of Grief
I was talking with someone recently about grief when she said that it felt like being on a roller coaster ride. This person is facing the impending death of a loved one even as there is no definitive timeline per the treatment team. We spoke of the dynamic of anticipatory grief and the ways in which it impacts the process of letting go of this person as she plans her future in the face of his eventual absence. I have found both in my therapeutic practice and in my personal life, that anticipatory grief genuinely effects mourners, although a 2006 article published in the Counseling, Psychology, and Health Journal quest...
Source: World of Psychology - May 15, 2018 Category: Psychiatry & Psychology Authors: Edie Weinstein, MSW, LSW Tags: Aging Family Grief and Loss Health-related Interview Peer Support Personal anticipatory grief Cancer grieving Mourning widow widower Source Type: blogs

Real World Evidence (RWE) vs Randomized Control Trials (RCT): The Battle For the Future of Medicine
By DAVID SHAYWITZ, MD Randomized control trials – RCTs – rose to prominence in the twentieth century as physicians and regulators sought to evaluate rigorously the performance of new medical therapies; by century’s end, RCTs had become, as medical historian Laura Bothwell has noted, “the gold standard of medical knowledge,” occupying the top position of the “methodologic heirarch[y].” The value of RCTs lies in the random, generally blinded, allocation of patients to treatment or control group, an approach that when properly executed minimizes confounders (based on the presumption t...
Source: The Health Care Blog - May 15, 2018 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Source Type: blogs

The Case For Real World Evidence (RWE)
By DAVID SHAYWITZ, MD Randomized control trials – RCTs – rose to prominence in the twentieth century as physicians and regulators sought to evaluate rigorously the performance of new medical therapies; by century’s end, RCTs had become, as medical historian Laura Bothwell has noted, “the gold standard of medical knowledge,” occupying the top position of the “methodologic heirarch[y].” The value of RCTs lies in the random, generally blinded, allocation of patients to treatment or control group, an approach that when properly executed minimizes confounders (based on the presumption t...
Source: The Health Care Blog - May 15, 2018 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Source Type: blogs

Fight Aging! Newsletter, May 14th 2018
This study found that professional chess players had shorter lifespans than those players who had careers outside of chess and argued that this might be due to the mental strain of international chess competition. In the present study, we focused on survival of International Chess Grandmasters (GMs) which represent players, of whom most are professional, at the highest level. In 2010, the overall life expectancy of GMs at the age of 30 years was 53.6 years, which is significantly greater than the overall weighted mean life expectancy of 45.9 years for the general population. In all three regions examined, mean life...
Source: Fight Aging! - May 13, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

MKSAP: 35-year-old woman is evaluated for intermittent fever
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 35-year-old woman is evaluated for intermittent fever, sweats, fatigue, and dull midchest pain of 2 weeks’ duration. Medical history is significant for liver transplantation 6 months ago for primary biliary cirrhosis; she was seronegative for cytomegalovirus and Epstein-Barr virus, and her donor was positive for both. Results of pretransplant testing for tuberculosis were negative. She received valganciclovir prophylaxis for 3 months after transplantation. Medications are tacrolimus, prednisone, ...
Source: Kevin, M.D. - Medical Weblog - May 12, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Allergies & Immunology Infectious Disease Source Type: blogs

Exclusive: BeCare Link ’s Innovative App for Multiple Sclerosis Patients
BeCare Link  has created a mobile application (“BeCare MS Link” in the Google Play app store) that connects patients to physicians and researchers to provide unprecedented levels of insight into multiple sclerosis (MS) and other neurodegenerative diseases. As paraphrased from a MS patient: “Much of MS is what is happening in your head, and you need the objective evidence that maybe things are not going as badly as you think.” A typical physician’s visit can only provide a snapshot in time of a patient’s overall well-being and functional status, with a patient’s self-recorded l...
Source: Medgadget - May 10, 2018 Category: Medical Devices Authors: Alice Ferng Tags: Exclusive Medicine Neurology Rehab Source Type: blogs

Everything ECMO!
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog In specialist centres, extracorporeal membrane oxygenation (ECMO) is a now a mainstay of the management of cardio/respiratory failure refractory to other measures. However, much of the clinical information required to care for ECMO patients at the bedside remains inaccessible to learners. To address this, the creation of a free-to-access educational ECMO blog post is now a requirement for completion of the Alfred ICU ECMO Accreditation Certificate. These &ld...
Source: Life in the Fast Lane - April 29, 2018 Category: Emergency Medicine Authors: Chris Nickson Tags: Education Everything ECMO extracorporeal life support Extracorporeal membrane oxygenation INTENSIVE Source Type: blogs

Fight Aging! Newsletter, April 23rd 2018
In conclusion, a debate exists on whether aging is a disease in itself. Some authors suggest that physiological aging (or senescence) is not really distinguishable from pathology, while others argue that aging is different from age-related diseases and other pathologies. It is interesting to stress that the answer to this question has important theoretical and practical consequences, taking into account that various strategies capable of setting back the aging clock are emerging. The most relevant consequence is that, if we agree that aging is equal to disease, all human beings have to be considered as patients to be treat...
Source: Fight Aging! - April 22, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, April 16th 2018
This study demonstrates that small peptide domains derived from native protein amelogenin can be utilized to construct a mineral layer on damaged human enamel in vitro. Six groups were prepared to carry out remineralization on artificially created lesions on enamel: (1) no treatment, (2) Ca2+ and PO43- only, (3) 1100 ppm fluoride (F), (4) 20 000 ppm F, (5) 1100 ppm F and peptide, and (6) peptide alone. While the 1100 ppm F sample (indicative of common F content of toothpaste for homecare) did not deliver F to the thinly deposited mineral layer, high F test sample (indicative of clinical varnish treatment) formed mainly C...
Source: Fight Aging! - April 15, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

TransMedics ’ Lung Preservation System Approved in U.S. for Double Transplants
TransMedica, based in Andover, Massachusetts, won FDA approval to introduce its Organ Care System (OCS) LUNG for use in standard double lung transplant procedures. The approval was based on the INSPIRE Trial, which the company touts as being the largest lung preservation for transplantation trial ever. Twenty one institutions around the world were involved comparing the OCS LUNG to existing cold storage systems, and the results showed that the new system is both safe and effective for preserving donor lungs within defined criteria. OCS LUNG is a portable system that perfuses, ventilates, and monitors the lungs as they...
Source: Medgadget - April 12, 2018 Category: Medical Devices Authors: Editors Tags: Cardiac Surgery Thoracic Surgery Source Type: blogs

Journalistic Views of Aging and Longevity Have Yet to Reach Maturity
While journalistic treatment of serious rejuvenation research has improved greatly over the past decade, the mainstream media remains decidedly childish at times. Much of the profession of journalism works hard at producing the appearance of educated folk paid to play the fool, writing for an imagined audience of inattentive, ignorant peers, while ensuring that their education slips through the mask just enough to be seen. It degrades the author and insults the world at large. Everyone in this picture is better than they are portrayed, capable of introspection and self-determination. I noted the article here because it vee...
Source: Fight Aging! - April 12, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Three Recent Papers on the Use of Senolytic Therapies to Address Age-Related Disease
We present concepts of the immune response to tissue trauma as well as the interactions with SnCs and the local tissue environment. Finally, we discuss therapeutic implications of targeting SnCs in treating osteoarthritis. (Source: Fight Aging!)
Source: Fight Aging! - April 11, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Making Electronic Health Records Great Again
By ROBERT WACHTER and JEFF GOLDSMITH After a blizzard of hype surrounding the electronic health record (EHR), health professionals are now in full backlash mode against this complex new tool. They are rightly seen as a major cause of professional burnout among physicians and nurses: Clinicians are spending almost half their professional time typing, clicking, and checking boxes on electronic records. They can and must be made into useful, easy-to-use tools that liberate, rather than oppress, clinicians. Performing several tasks, badly. The EHR is a lot more than merely an electronic version of the patient&rs...
Source: The Health Care Blog - April 7, 2018 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Source Type: blogs

Fix the EHR!
By ROBERT WACHTER and JEFF GOLDSMITH After a blizzard of hype surrounding the electronic health record (EHR), health professionals are now in full backlash mode against this complex new tool. They are rightly seen as a major cause of professional burnout among physicians and nurses: Clinicians are spending almost half their professional time typing, clicking, and checking boxes on electronic records. They can and must be made into useful, easy-to-use tools that liberate, rather than oppress, clinicians. Performing several tasks, badly. The EHR is a lot more than merely an electronic version of the patient&rs...
Source: The Health Care Blog - April 7, 2018 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Source Type: blogs

Arterys Receives FDA Clearance for Lesion and Tumor Detection Program
Arterys, the San Francisco-based medical imaging company, has just been granted Food and Drug Administration 510(k) clearance for their new Oncology AI suite that detects and tracks lesions and tumors in the liver and lungs using artificial intelligence (AI). The clearance marks the latest accomplishment forArterys. At this year ’s annual Radiological Society of North America conference, they introducedMICA, a system that uses scalable GPU architecture to improve workloads. The AI Suite analyzes specific nodules and lesions as a radiologist would by automating segmentation with impeccable accuracy. Clinicians are abl...
Source: radRounds - April 7, 2018 Category: Radiology Authors: Julie Morse Source Type: blogs

Fight Aging! Newsletter, March 26th 2018
In conclusion, senescence of vascular cells promotes the development of age-related disorders, including heart failure, diabetes, and atherosclerotic diseases, while suppression of vascular cell senescence ameliorates phenotypic features of aging in various models. Recent findings have indicated that specific depletion of senescent cells reverses age-related changes. Although the biological networks contributing to maintenance of homeostasis are extremely complex, it seems reasonable to explore senolytic agents that can act on specific cellular components or tissues. Several clinical trials of senolytic agents are currentl...
Source: Fight Aging! - March 25, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Cellular Senescence in the Cardiovascular and Metabolic Diseases of Aging
In conclusion, senescence of vascular cells promotes the development of age-related disorders, including heart failure, diabetes, and atherosclerotic diseases, while suppression of vascular cell senescence ameliorates phenotypic features of aging in various models. Recent findings have indicated that specific depletion of senescent cells reverses age-related changes. Although the biological networks contributing to maintenance of homeostasis are extremely complex, it seems reasonable to explore senolytic agents that can act on specific cellular components or tissues. Several clinical trials of senolytic agents are currentl...
Source: Fight Aging! - March 23, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, March 19th 2018
In this study, we did not observe significant age-dependent upregulation of the prominent SASP cytokine Il6 in any tissue, although an upward trend was observed that was consistent in magnitude with previous observations in the heart and kidney. This modest age-related upward trend could be explained by a previous report which demonstrated that senescent cell-secreted IL-6 acts in an autocrine manner, reinforcing the senescent state, rather than inducing senescence or promoting dysfunction in neighboring cells. The decreased expression of Il6 with age we observed in the hypothalamus could be indicative of a lack or ...
Source: Fight Aging! - March 18, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Oregon Health & Science University ’s Artificial Heart Ready for Animal Trials
Researchers at the Oregon Health & Science University (OHSU) are developing an artificial heart that may one day serve as a long-term replacement for failing natural hearts. This would be a major development, as the only FDA approved artificial heart, the SynCardia temporary Total Artificial Heart , is only meant as a “bridge” to a transplant. OHSU’s device is intended to be applicable to patients as young as 10 years old and should also fit most adults. Unlike many previously designed artificial hearts, the new device has few parts that are subject to failure. A rod made of a titanium ...
Source: Medgadget - March 12, 2018 Category: Medical Devices Authors: Editors Tags: Cardiac Surgery Cardiology Source Type: blogs

When you learn about a person ’s story, you can’t ignore it
I had the honor and privilege of rotating for three weeks on the transplant service where I experienced a lot of great medicine, surgery and the ethics that intertwines them.  One late night on service I had the opportunity to travel to a different hospital and help the team harvest a liver and kidneys from a donor.  Never had I seen anything more amazing than what I witnessed that night in my 24 years of life.  When I first met the patient, she was already draped and prepped for surgery, supported by ventilators, and declared brain dead.  I never saw her face.  I said a small, quiet prayer over he...
Source: Kevin, M.D. - Medical Weblog - March 4, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/julia-cartledge" rel="tag" > Julia Cartledge < /a > Tags: Education Medical school Surgery Source Type: blogs

Digital Health Best Practices For Policy Makers: A Free Report
Where should the line be drawn when deciding whether or not to adopt disruptive technologies? As digital health brings up plenty of ethical questions, legal issues, and safety concerns, The Medical Futurist Institute decided to collect the best examples of how governments worldwide tried to adopt digital health. We hope it inspires other policy-makers to take the first steps in shaping their healthcare regulations. Our common goal is to arrive at a better future of healthcare Disruptive technologies spread around like wildfire, but healthcare systems are crumbling under the pressure of problems and changes. So, The Medical...
Source: The Medical Futurist - March 1, 2018 Category: Information Technology Authors: nora Tags: Digital Health Research Healthcare Policy digital health strategy digital innovation future health policy Medicine technology Source Type: blogs