Endothelin-1 Levels in Exercise-Induced Pulmonary Hypertension
Purpose: Endothelin-1 (ET-1), a potent vasoconstrictor, is elevated in heart failure as well as in pulmonary arterial hypertension (PAH). We sought to assess ET-1 levels in exercise induced pulmonary hypertension (EI-PH). EI=PH is a cause of decreased exercise capacity and is associated with a decreased life expectancy. EI-PH may precede the development of resting PH in a proportion of patients at risk, such as in thosewith PAH, and heart failure with preserved ejection fraction (HFpEF). EI-PH is thought to represent an intermediate stage between normal pulmonary pressure and overt PH. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , H. Brink, K. Dhar, B. Lowes Source Type: research
Camphor Quality of Life Scores for Patients Diagnosed with Pulmonary Arterial Hypertension in Brazil and Colombia
Purpose: Our aim was to investigate the health-related quality of life (HRQoL) of patients living with pulmonary hypertension (PAH) in a cross-section of patients in Brazil and Colombia using a disease specific HRQoL tool. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: C. Vizza, R. Klok, J. Harley, M. Small, J. White, Source Type: research
Comparison of the Prognostic Value of Right Atrial Volume, Area, and Emptying Fraction in Patients with Pulmonary Artery Hypertension
Purpose: With increasing use of volumetric assessment in echocardiography, the prognostic importance of right atrial (RA) volume in PAH is not known. We conducted a single center retrospective study to compare the prognostic value of RA volume, area, and emptying fraction in patients with PAH. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: D. Mohama, P. Worapongsatitaya, F. Kazmirczak, K. Prins, S. Prisco, W. Edward, Source Type: research
Low Right Atrial Emptying Fraction is a Better Predictor of Incident Atrial Fibrillation and Flutter in Patients with Pulmonary Arterial Hypertension
Purpose: Left atrial remodeling is associated with increased risk of atrial fibrillation and flutter (AF/AFL), but little is known about the risk of AF/AFL due to right atrial (RA) structural and functional remodeling in pulmonary arterial hypertension (PAH). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: P. Worapongsatitaya, D. Mohama, F. Kazmirczak, K. Prins, S.Z. Prisco, E.K. Weir, Source Type: research
Prognostic Significance of Positive Vasoreactivity Test in Pulmonary Arterial Hypertension is Affected by Age
Purpose: A positive vasoreactivity test (VRt) is used for treatment selection and considered an indicator of good prognosis in patients with idiopathic, hereditary, and drug-associated pulmonary arterial hypertension (IPAH/HPAH/DPAH). However, its reliability across ages is unknown. We investigated hemodynamics, risk status, treatment patterns, and transplantation-free (TF) survival in patients with a positive VRt by age. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , G. Radegran, E. Bjorklund, A. Hjalmarsson, M. Nisell, J. Papageorgiou, S. Soderberg, H. Wahlander, B. Kjellstrom Source Type: research
Treatment Patterns for Pulmonary Arterial Hypertension (PAH) and Chronic Thromboembolic Pulmonary Hypertension (CTEPH) in Finland Between 2008 and 2020 - A Descriptive Real-World Cohort Study (FINPAH)
Purpose: Treatment patterns of PAH and CTEPH in Finland are unknown. The ESC/ERS guidelines have evolved to recommend early escalation of treatment for PAH. The purpose of the study was to evaluate how well the Finnish treatment patterns follow guidelines, and how treatment initiation is related to treatment outcomes. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , P. Simonen, H. Tuunanen, P. Leskel ä, T. Harju, P. Jääskeläinen, C. Asseburg, M. Oksanen, E. Soini, C. Wennerström, A. Puhakka Source Type: research
A Transthoracic Echocardiography (TTE) Based PH Detection Model Using View Agnostic Classifier
Purpose: Pulmonary hypertension (PH) is a cardiopulmonary condition characterized by increased pressure in the pulmonary arteries, right heart failure and early demise. Early and accurate detection of PH is crucial for timely management and improved patient outcomes. Although recommended in the European Society of Cardiology/European Respiratory Society (ESC/ERS) guidelines as the non-invasive modality to screen for PH, transthoracic echocardiography (TTE) often misses PH; particularly for patients specified as low risk by the guidelines. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: P. Damasceno, S. Fadnavis, N. Emaminejad, A. Ulloa Cerna, C. Parmar, K. Standish, T. Mansi, P. Dunnmon, T. Yardibi, Source Type: research
Improvements in Pulmonary Artery Compliance After Balloon Pulmonary Angioplasty Depend on Baseline Pulmonary Vascular Resistance
Purpose: Chronic thromboembolic pulmonary hypertension (CTEPH) results in functional limitation from right ventricular dysfunction and ventilatory inefficiency. Treatments, including balloon pulmonary angioplasty (BPA), help by decreasing RV afterload. The afterload comprises pulmonary vascular resistance (PVR, static resistance to flow) and pulmonary artery compliance (PAC, pulsatile resistance). Patients with CTEPH and low PVR have shown both clinical and functional benefits from BPA therapy despite the low static afterload. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , E. Oliveros, H. Zhao, A. Vaidya, V. Lakhter, P.R. Forfia, W. Auger, R. Bashir Source Type: research
Enhancing Exercise Capacity in Exercise-Induced Pulmonary Hypertension: A Retrospective Study of Riociguat Therapy
Purpose: Exercise-induced pulmonary hypertension (EIPH) patients have preserved LV function, normal resting PAWP, and abnormal pulmonary vascular response during exercise. The new ACC/AHA definition is exercise mPAP/CO ratio>3 mmHg/L/min. Managing EIPH remains challenging due to a lack of consensus. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , R. Vunnam, A. Azmeen, R. Zolty Source Type: research
Total Artificial Heart as Bridge to Transplant in a Patient with Cardiogenic Shock, Biventricular Thrombi, and Multisystem Thromboembolic Events
Introduction: Patients with cardiogenic shock and multisystem thromboembolic events have a high mortality and are at increased risk of complications despite use of advanced heart failure therapies including temporary and durable mechanical circulatory support and orthotopic heart transplantation (OHT). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Kumar, R.I. Goldberg, B. Kadosh, A. Singh, A. Reyentovich, D.E. Smith, N. Moazami Source Type: research
From Prescription to Predicament: Hydroxychloroquine (HCQ)-Induced Cardiogenic Shock (CS)
We present a case of biopsy-proven HCQ-induced CS successfully managed with tMCS as a bridge to recovery. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Al-Busaidi, R. Gilead, D.H. Brahmbhatt, Y. Xie, N. Aleksova, A. Luk, J. Duero Posada, Y. Moayedi, M.A. Seidman, M. Laflamme, R.J. Cusimano, J. Alvarez, E. Fan, H. Faghfoury, F. Billia Source Type: research
Concomitant Diagnosis of Myotonic Dystrophy (DM) and Takotsubo Cardiomyopathy (CM) Treated with Extracorporeal Membrane Oxygenation (ECMO)
Introduction: Myotonic dystrophy type 1 (DM1) is an inherited, autosomal dominant disease caused by repeat CTG expansions in the DMPK gene. It is associated with atrial and ventricular arrhythmias, conduction issues, and cardiomyopathy. In one study, endomyocardial biopsy of DM patients showed fibrosis and fatty infiltration. Takotsubo CM is characterized by sudden onset of typical pattern of left ventricular dysfunction after emotional stress. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , E. Katznelson, R. Murphy, C. Liu, C. Zhang, L. Kim, B. Worku, Y. Naka, R. Bhatt, N. Wan, J. McLeod, D. Lu, I. Sobol Source Type: research
Daratumumab Monotherapy in Combination with VA ECMO as a Bridge to Heart Transplantation for Al Amyloid Cardiomyopathy
Introduction: AL amyloidosis is a systemic disease that can affect multiple different organ systems. Cardiac involvement is common and carries a high mortality rate. Traditional chemotherapy regimens are not well tolerated in the setting of decompensated heart failure. Monotherapy with daratumumab has shown efficacy in reducing light chain production. The physiologic and anatomical characteristics of cardiac amyloidosis pose significant challenges when considering temporary circulatory support for patients presenting with cardiogenic shock. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: A. Doshi, , N. Cyrille, R. Garcia, P. Patel, T. Frank, S. Gulati, S. Zouzoulas, J. Singh, J. Mishkin Source Type: research
A Terrible Bloody Tamponade: A Case of Delayed Hemorrhagic Cardiac Tamponade Post Left Atrial Appendage Occlusion
Introduction: Left atrial appendage occlusion (LAAO) is a noninferior alternative for stroke prevention in atrial fibrillation, particularly in patients with contraindications to long term anticoagulation. Delayed (>7 days) cardiac tamponade is a rare complication of LAAO with incidence of 0.8%. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: S. Allihien, S. Ibrahim, S. Shreyas, D.B. Haithcock, T. Magruder, Source Type: research
Measured Resting Energy Expenditure and Predicted Basal Metabolic Rate Early After Left Ventricular Assist Device Implantation
Purpose: Fat free mass (FFM) increases over the first 6 months of left ventricular assist device (LVAD) support for patients with advanced heart failure with reduced ejection fraction (HFrEF), but concurrent resting energy expenditure (REE) and predicted basal metabolic rate (BMR) changes have not been studied. We hypothesized that measured REE (adjusted for FFM which is the major determinant of metabolic rate) would be highest at the baseline of LVAD implantation, when the HFrEF syndrome was most active. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , B. Sweigart, S. Hummel, J. Chery, E. Saltzman, A. Vest Source Type: research
