Towards Engraftment of New Stem Cells into Damaged Lungs
Perhaps the most important challenge in the field of regenerative medicine is to enable engraftment and survival of transplanted cells, allowing new cell populations to replace those made damaged or dysfunctional due to age, injury, or other causes. Despite some advances, survival of transplanted cells remains a significant challenge. Here is one example of signs of progress on this front, however. Judging by the recent past, solutions discovered by researchers are likely to continue to be tissue specific. This implies that a great deal more work lies ahead in order to build a usefully broad toolkit to allow creation and t...
Source: Fight Aging! - September 6, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Why It Is Important To Understand Multimodal Large Language Models In Healthcare
The future of medicine is undoubtedly inextricably linked to the development of artificial intelligence (AI). Although this revolution has been brewing for years, the past few months marked a major change, as algorithms finally moved out of the specialized labs and into our daily lives.
The public debut of Large Language Models (LLMs), like ChatGPT which became the fastest-growing consumer application of all time, has been a roaring success. LLMs are machine learning models trained on a vast amount of text data which enables them to understand and generate human-like text based on the patterns and structures they̵...
Source: The Medical Futurist - September 5, 2023 Category: Information Technology Authors: Andrea Koncz Tags: TMF Artificial Intelligence in Medicine large language models multimodal AI multimodal large language models multimodal LLM Source Type: blogs
Fight Aging! Newsletter, August 28th 2023
In conclusion, we identified 20 genes with significant evolutionary signals unique to long-lived species, which provided new insight into the lifespan extension of mammals and might bring new strategies to extend human lifespan.
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Trials of Xenotransplantation of Pig Organs into Humans Continue
https://www.fightaging.org/archives/2023/08/trials-of-xenotransplantation-of-pig-organs-into-humans-continue/
Researchers have genetically engineered pigs to overcome the known barriers to transplantation of pig organs into humans, and have reached the stage of conducting transplants i...
Source: Fight Aging! - August 27, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Weekly Roundup – August 19, 2023
Welcome to our Healthcare IT Today Weekly Roundup. Each week, we’ll be providing a look back at the articles we posted and why they’re important to the healthcare IT community. We hope this gives you a chance to catch up on anything you may have missed during the week.
Helping Children With Gamified Interactive Physiotherapy. Psychiatrist Dr. Geoff Frost struggled to encourage pediatric patients with spinal muscular atrophy to do their necessary exercises. As he explained to Colin Hung, that’s why Raft Digital Therapeutics created a game called Cloud Bazaar to captures a child’s movement as a way to advance...
Source: EMR and HIPAA - August 19, 2023 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT Healthcare IT Today Weekly Roundup Source Type: blogs
Deep Learning for Medical Imaging: Use Cases and Network Types
Conclusion
Medical image analysis solutions powered by deep learning technologies can reduce the risk of diagnostic errors and ensure timely interventions. But how to implement such a tool successfully? The key to successful deployment is cooperation with an experienced machine-learning solutions provider. Professional technical experts will help you choose an optimal architecture for your clinic’s specific goals and ensure effective model training.
About Mariia Kovalova
Mariia Kovalova is a Healthcare Technology Researcher at Itransition, a custom software development company headquartered in Denver, CO. Having work...
Source: EMR and HIPAA - August 18, 2023 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning Health IT Company Healthcare IT CNN Convolutional Neural Networks Deep Learning GAN Generative Adversarial Networks Healthcare AI Healthcare Neural Networks Itransition MADGAN Mariia Kovalova Medical Imaging Source Type: blogs
Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo.
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Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging
https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/
It seem...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Extracellular Vesicles from Young Cardiac Progenitor Cells Produce Benefits in Old Mice
The signaling environment in the body is generated by cells, communication mediated by the molecules that cells release and take up, many of which are packaged into extracellular vesicles. This signaling changes profoundly between development and adult life, and then again in important ways with advancing age. In principle, providing aged tissues with the signals passed back and forth during embryonic development will spur greater maintenance and regeneration. In practice, tissues are systems of great and only partially understood complexity, and attempts to beneficially manipulate signaling in this way are still very much...
Source: Fight Aging! - August 4, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, July 24th 2023
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells.
Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senescent Human Lung Fibroblasts Produce Lung Fibrosis when Transplanted into Mice
From the evidence accumulated to date in animal models and studies of human tissue, it seems clear that senescent cells play an important role in the development of fibrosis in a variety of tissues. Fibrosis is a dysfunction of normal tissue maintenance processes, an excessive deposition of collagen extracellular matrix that is disruptive to tissue structure and function. Senescent cells secrete signals that encourage both growth and inflammation, and that sort of signaling sustained for the long term may be necessary for the development of fibrosis. Many age-related fibrotic diseases exist, in lungs, liver, and heart for ...
Source: Fight Aging! - July 21, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Pulmonary Arterial Hypertension: Unraveling Its Impact On Heart And Lungs
Conclusion
Navigating the complexities of Pulmonary Arterial Hypertension (PAH) might seem daunting. However, with the right knowledge and proactive approach, it’s possible to manage the condition and maintain a good quality of life.
PAH, a unique type of high blood pressure affecting the arteries in the lungs, can put extra strain on the heart. Over time, this can lead to heart failure. The condition’s root cause may vary, from genetic factors to other health issues like heart defects, liver disease, or autoimmune diseases. Remember, sometimes the cause remains unknown, resulting in idiopathic pulmonary ...
Source: The EMT Spot - July 19, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Fight Aging! Newsletter, June 26th 2023
This study explored the association between different cooking fuel types and the risk of cancer and all-cause mortality among seniors constructing Cox regression models. Data were obtained by linking waves of 6, 7, and 8 of the Chinese Longitudinal Healthy Longevity Survey, which included a total of 7,269 participants who were 65 years old and over. Cooking fuels were categorized as either biomass, fossil, or clean fuels. And the effects of switching cooking fuels on death risk were also investigated using Cox regression models.
The results indicate that, compared with the users of clean fuels, individuals using bio...
Source: Fight Aging! - June 25, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Tytocare ’s AI-Powered Wheeze Detection Impresses with Thoughtful Design
Earlier this year, Tytocare received FDA approval for its AI-based solution that analyzes lung sounds captured via its handheld home care device. The thoughtful way that the AI was incorporated into the overall design of the solution is impressive. The AI blends seamlessly into the background and feels like a natural addition to the workflow. Exactly the way technology ideally is supposed to work in healthcare.
AI as co-pilot, Clinician as pilot
Tyto Insights for Wheeze Detection, looks for specific lung sounds in the lung recordings that may suggest wheezing. Wheezing is an indicator that there may be a respiratory issue ...
Source: EMR and HIPAA - June 7, 2023 Category: Information Technology Authors: Colin Hung Tags: AI/Machine Learning Ambulatory Clinical Health IT Company Healthcare IT Hospital - Health System Telemedicine and Remote Monitoring Artificial Intelligence Clinical Decision Support Eran Hertzmann home care Home Smart Clinic lung s Source Type: blogs
Fight Aging! Newsletter, May 15th 2023
In this study, we examined the average telomere length and telomerase activity, as well as the formation of telomere associated foci (TAFs) and the mRNA expression levels of the shelterin components in cultured primary cells of Spalax, a long-lived, hypoxia-tolerant, and cancer-resistant blind mole-rat species.
We showed that with cell passages, Spalax fibroblasts demonstrated significant shortening in telomere length, similar to rat cells, and in line with the processes observed earlier in tissues. We also demonstrated that the average telomere length in Spalax fibroblasts was significantly higher than the average ...
Source: Fight Aging! - May 14, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Secure Your Hospital ’ s Future: The Critical Need for Robust Telemedicine Security
The following is a guest article by Narinder Singh, Co-Founder and CEO at LookDeep Health
In 2016, attackers gained unauthorized access to Banner Health’s systems through the payment processing system used in the organization’s food and beverage outlets and used it as a gateway to access patient information. The risk of security breaches through indirect access to other systems, like telemedicine solutions, can expose the entire health system.
As inpatient telemedicine experiences rapid growth within hospitals, it presents unique challenges to Chief Information Officers (CIOs) and Chief Security Officers (CSOs)...
Source: EMR and HIPAA - May 12, 2023 Category: Information Technology Authors: Guest Author Tags: C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System Security and Privacy Telemedicine and Remote Monitoring Hospital Security Isolate Networks LookDeep Health Medical Device Security Medical Devices Microsoft Source Type: blogs
Fight Aging! Newsletter, May 8th 2023
In conclusion, NAT mitigated age-associated cerebral injury in mice through gut-brain axis. The findings provide novel evidence for the effect of NAT on anti-aging, and highlight the potential application of NAT as an effective intervention against age-related diseases.
Retinal Cell Reprogramming Restores Vision in Non-Human Primate Study
https://www.fightaging.org/archives/2023/05/retinal-cell-reprogramming-restores-vision-in-non-human-primate-study/
Early applications of in vivo cellular reprogramming to medicine are cautiously focused on retinal regeneration. The eye is as close to an isolated system...
Source: Fight Aging! - May 7, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
